LOCUS       NM_199463               6138 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus dual serine/threonine and tyrosine protein kinase
            (Dstyk), mRNA.
ACCESSION   NM_199463 XM_222647
VERSION     NM_199463.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6138)
  AUTHORS   Lee,J.Y.W., Hsu,C.K., Michael,M., Nanda,A., Liu,L., McMillan,J.R.,
            Pourreyron,C., Takeichi,T., Tolar,J., Reid,E., Hayday,T.,
            Blumen,S.C., Abu-Mouch,S., Straussberg,R., Basel-Vanagaite,L.,
            Barhum,Y., Zouabi,Y., Al-Ajmi,H., Huang,H.Y., Lin,T.C., Akiyama,M.,
            Lee,J.Y.Y., McLean,W.H.I., Simpson,M.A., Parsons,M. and
            McGrath,J.A.
  TITLE     Large Intragenic Deletion in DSTYK Underlies Autosomal-Recessive
            Complicated Spastic Paraparesis, SPG23
  JOURNAL   Am J Hum Genet 100 (2), 364-370 (2017)
   PUBMED   28157540
REFERENCE   2  (bases 1 to 6138)
  AUTHORS   Sanna-Cherchi,S., Sampogna,R.V., Papeta,N., Burgess,K.E.,
            Nees,S.N., Perry,B.J., Choi,M., Bodria,M., Liu,Y., Weng,P.L.,
            Lozanovski,V.J., Verbitsky,M., Lugani,F., Sterken,R., Paragas,N.,
            Caridi,G., Carrea,A., Dagnino,M., Materna-Kiryluk,A.,
            Santamaria,G., Murtas,C., Ristoska-Bojkovska,N., Izzi,C., Kacak,N.,
            Bianco,B., Giberti,S., Gigante,M., Piaggio,G., Gesualdo,L.,
            Vukic,D.K., Vukojevic,K., Saraga-Babic,M., Saraga,M., Gucev,Z.,
            Allegri,L., Latos-Bielenska,A., Casu,D., State,M., Scolari,F.,
            Ravazzolo,R., Kiryluk,K., Al-Awqati,Q., D'Agati,V.D.,
            Drummond,I.A., Tasic,V., Lifton,R.P., Ghiggeri,G.M. and
            Gharavi,A.G.
  TITLE     Mutations in DSTYK and dominant urinary tract malformations
  JOURNAL   N Engl J Med 369 (7), 621-629 (2013)
   PUBMED   23862974
REFERENCE   3  (bases 1 to 6138)
  AUTHORS   Peng,J., Dong,W., Chen,Y., Mo,R., Cheng,J.F., Hui,C.C., Mohandas,N.
            and Huang,C.H.
  TITLE     Dusty protein kinases: primary structure, gene evolution, tissue
            specific expression and unique features of the catalytic domain
  JOURNAL   Biochim Biophys Acta 1759 (11-12), 562-572 (2006)
   PUBMED   17123648
REFERENCE   4  (bases 1 to 6138)
  AUTHORS   Zha,J., Zhou,Q., Xu,L.G., Chen,D., Li,L., Zhai,Z. and Shu,H.B.
  TITLE     RIP5 is a RIP-homologous inducer of cell death
  JOURNAL   Biochem Biophys Res Commun 319 (2), 298-303 (2004)
   PUBMED   15178406
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY429675.1.
            
            On Nov 15, 2004 this sequence version replaced NM_199463.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY429675.1, AY208851.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132262, SAMD00132264
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..6138
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q13"
     gene            1..6138
                     /gene="Dstyk"
                     /gene_synonym="DustyPK; Ripk5"
                     /note="dual serine/threonine and tyrosine protein kinase"
                     /db_xref="GeneID:304791"
                     /db_xref="RGD:735051"
     exon            1..334
                     /gene="Dstyk"
                     /gene_synonym="DustyPK; Ripk5"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..2853
                     /gene="Dstyk"
                     /gene_synonym="DustyPK; Ripk5"
                     /EC_number="2.7.12.1"
                     /note="dusty PK; receptor-interacting
                     serine/threonine-protein kinase 5; receptor interacting
                     protein kinase 5; dusty protein kinase"
                     /codon_start=1
                     /product="dual serine/threonine and tyrosine protein
                     kinase"
                     /protein_id="NP_955750.1"
                     /db_xref="GeneID:304791"
                     /db_xref="RGD:735051"
                     /translation="MEADGQSWSGESVSGPGPGGGGMIRELCRGFGRYRRYLGRLRQN
                     LRETQKFFRDIKCSHSHSCPSSPAGGGAAELGPAGDVAAAPLPAGQLSCISFPPMEEK
                     YLQQIVDHLPCILILGQDCNAKCQLLNLLLAVRVLPTLKLDSDESCKLRRLRFTYGTR
                     TQVSLALPGQYELVHTLASHQDNWETIPEEDLEVQEDSEDTARVLADLEVTMHHALLQ
                     EVDIVVAPCHSHRPAVDVLSDLANDFLPVITYALHKDELSERDEQELQEIRKYFSFPV
                     FFFKVPTLEIIRSSSGRADSERSPLSGQLMDLGYLSSSHRNCMASDQDCRAQSMLVEQ
                     SEKLRQLSTFSHQLLQTRLVDAAKALNAVHSHCLDIFINQAFDMQRDLQITPKRLEYT
                     RKKENELYESLMNIANRKQEEMKDMIVETLNTMKEELLDDAANMEFKDVIVPENGETV
                     GTREIKSCIRQIQELIISRLNQAVANKLISSVDYLRESFVGTLERCLQSLEKSQDVSV
                     HITSNYLKQILNAAYHVEVTFHSGSSVTRMLWEQIKQIIQRITWVNPPTITLEWKRKV
                     AQEAIDSLSASKLAKSICSQFRTRLNSSHEAFAASLRQLEAGHSGRLEKTEDLWLKVR
                     KDHAPRLARLSLESRSLQDVLLHRKPKLGQELGRGQYGVVYLCDNWGGHFPCALKSVV
                     PPDEKHWNDLALEFHYMRSLPKHERLVDLHGSVIDYNYGGGSSVAVLLIMERLHRDLY
                     TGLKAGLSLETRLQIALDVVEGIRFLHSQGLVHRDIKLKNVLLDKQNRAKITDLGFCK
                     PEAMMSGSIVGTPIHMAPELFTGKYDNSVDVYAFGILFWYICSGSIKLPEAFERCASK
                     DHLWNNVRRGTRPERLPVFDEECWQLMEACWDGDPSKRPLLGIVQPILRSIMDRLCKC
                     DSERPSRGLDDST"
     exon            335..723
                     /gene="Dstyk"
                     /gene_synonym="DustyPK; Ripk5"
                     /inference="alignment:Splign:2.1.0"
     exon            724..1387
                     /gene="Dstyk"
                     /gene_synonym="DustyPK; Ripk5"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1620
                     /gene="Dstyk"
                     /gene_synonym="DustyPK; Ripk5"
                     /inference="alignment:Splign:2.1.0"
     exon            1621..1704
                     /gene="Dstyk"
                     /gene_synonym="DustyPK; Ripk5"
                     /inference="alignment:Splign:2.1.0"
     exon            1705..1881
                     /gene="Dstyk"
                     /gene_synonym="DustyPK; Ripk5"
                     /inference="alignment:Splign:2.1.0"
     exon            1882..2011
                     /gene="Dstyk"
                     /gene_synonym="DustyPK; Ripk5"
                     /inference="alignment:Splign:2.1.0"
     exon            2012..2168
                     /gene="Dstyk"
                     /gene_synonym="DustyPK; Ripk5"
                     /inference="alignment:Splign:2.1.0"
     exon            2169..2301
                     /gene="Dstyk"
                     /gene_synonym="DustyPK; Ripk5"
                     /inference="alignment:Splign:2.1.0"
     exon            2302..2415
                     /gene="Dstyk"
                     /gene_synonym="DustyPK; Ripk5"
                     /inference="alignment:Splign:2.1.0"
     exon            2416..2530
                     /gene="Dstyk"
                     /gene_synonym="DustyPK; Ripk5"
                     /inference="alignment:Splign:2.1.0"
     exon            2531..2665
                     /gene="Dstyk"
                     /gene_synonym="DustyPK; Ripk5"
                     /inference="alignment:Splign:2.1.0"
     exon            2666..6125
                     /gene="Dstyk"
                     /gene_synonym="DustyPK; Ripk5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagcgctagg gggcgggagg aggggccggg ccagcggcgc agccagccgc aaagacagcg
       61 ggctgagcga tggaggccga cgggcagtcg tggtccggcg agtccgtgtc gggcccgggc
      121 ccggggggcg gcggaatgat ccgcgagctg tgccggggct tcggccgcta ccgccgctac
      181 ctgggacggc tgcggcagaa cctgcgtgag acccagaagt tcttccgcga catcaagtgc
      241 tcccacagtc acagttgtcc ctcctccccc gcgggcggcg gcgcggcgga gcttggccct
      301 gccggcgacg tcgccgcagc cccgctgcca gcgggccagc tgagctgcat ttcctttcca
      361 cctatggaag agaagtatct gcagcagatc gtggatcacc tcccctgtat actgatcctc
      421 ggccaggact gtaatgccaa gtgccagctg ttgaacctgc tgttggcggt gcgggtgctt
      481 cccaccctca agctggacag tgacgagagc tgtaagcttc ggcgcctccg cttcacctac
      541 gggactcgga ctcaggtcag cctggcgctg cccggtcagt atgagctggt gcacacactg
      601 gcttcccacc aggacaactg ggagaccatc cctgaggagg acctggaggt tcaagaagac
      661 agtgaggaca ctgcccgtgt gttagctgac cttgaggtga caatgcacca tgctctccta
      721 caggaagtgg acattgtggt ggcaccatgc cacagccacc ggcctgcagt agatgttctg
      781 agtgacttgg caaatgattt cttgcctgtg ataacctacg cacttcacaa agatgaactc
      841 tctgaacggg atgagcaaga gcttcaggaa attagaaagt atttctcgtt tcctgtgttc
      901 ttcttcaaag tacctacact ggagatcatc cgctcttcca gtgggcgagc agacagtgaa
      961 cgatcaccac tgtctgggca gctaatggac ctgggctacc tgagcagcag tcacaggaac
     1021 tgcatggcct ctgaccagga ctgcagagct cagagcatgt tggtggagca aagtgagaaa
     1081 ctgaggcagc tgagtacgtt ttctcaccag ctgctacaga cccgcctcgt ggatgcagcc
     1141 aaggccctga atgcggtgca cagccactgc cttgacatct ttattaacca ggcttttgac
     1201 atgcagcggg acctgcagat cactcccaaa cgcctagaat atactagaaa aaaggagaat
     1261 gagttgtatg agtcattgat gaatatcgcc aaccgaaagc aagaggaaat gaaggatatg
     1321 atcgttgaga cacttaacac catgaaagag gagcttctgg atgatgctgc caacatggag
     1381 ttcaaagatg tcattgtccc tgagaatgga gagacagttg ggaccagaga gatcaaatcc
     1441 tgcatccgac agatccagga gctcatcatc tccagactta accaggcagt ggccaacaag
     1501 ctcatcagct ctgtggatta cctacgggaa agcttcgtgg ggaccctgga gcggtgtcta
     1561 cagagccttg aaaagtcaca ggatgtctca gtgcacatta ccagcaatta tctcaaacag
     1621 atcttaaatg ccgcttacca tgttgaagtc acttttcact cggggtcctc agttacacgg
     1681 atgctttggg aacaaatcaa gcagatcatc cagcgtatca catgggtgaa tccacccacc
     1741 atcaccctag agtggaagag gaaggtggcc caggaagcca tcgacagcct cagtgcctcc
     1801 aaactggcca agagcatttg cagccagttc cgtactcggc tcaatagttc gcacgaggct
     1861 tttgcggcct ccttgaggca gctggaagct ggccattcag gccgtctgga gaaaactgaa
     1921 gatctgtggc ttaaggttcg aaaagaccac gccccccgtc tggcccgcct ttcactagag
     1981 agccggtctt tacaggacgt cttgcttcac cgtaaaccta aattaggaca ggaactaggc
     2041 cggggccaat atggtgtggt gtacctgtgt gacaactggg ggggacactt cccttgtgcc
     2101 ctcaagtcag ttgttcctcc agacgagaag cactggaacg acctggcgtt ggagtttcac
     2161 tacatgaggt ctttgccaaa gcatgagcgg ctggtagatc tccatggctc agtcattgac
     2221 tacaactacg gtggcggctc cagcgttgct gtgttgctga ttatggagcg gctgcaccgg
     2281 gacctctaca cagggctgaa ggctgggctt tccctggaga cacgtttgca aatagctctg
     2341 gacgtggtgg agggaatccg ctttctgcac agccaggggc ttgttcatcg ggatatcaaa
     2401 ctgaaaaatg tgctgctgga caaacaaaac cgtgccaaga tcactgactt aggattctgc
     2461 aaaccagaag ctatgatgtc aggcagcatt gtgggaacac cgattcatat ggcccctgaa
     2521 cttttcacag gaaagtatga taattctgtg gacgtctatg cttttgggat ccttttctgg
     2581 tatatctgct ccggctctat caagctccct gaggcatttg agaggtgtgc gagcaaagac
     2641 catctctgga ataatgtgcg cagagggacc cgtccggagc gtcttcctgt gtttgatgag
     2701 gagtgctggc agttgatgga ggcctgttgg gatggtgacc cctccaagag gcctctcttg
     2761 ggcattgtcc aacctatact ccgaagcatt atggaccggc tctgcaagtg cgattctgag
     2821 cggcctagca gaggactaga tgactctacc tgaagacaac acccgtctct tccactctgt
     2881 tccttccttc cctctcacct tttggccttg gggagaattt gtcatttgtt cactaaggga
     2941 gctcccaagg gaactggtgc ttgttggcag cttgaggcct tcttgggtag agacggctcc
     3001 tgggcagcga agaattcagt gactgtttag tattcatgct gccttacact gagcaaaaga
     3061 ttgttgctcg agaatgtgat gttctggctg agaactgaca aggaggcaac tgttaccact
     3121 gtctgttcac tgtgtgtctc tgaaacaagc gagcctgcag tgcagggcat ctgtccaacg
     3181 gtagagacca cttagaaaca tgaccttagt tcaggattgt atggtcacaa aggcaaaacc
     3241 agcctagcca aatatacctt gtggttgtct ggttcttgtt ccttatagcc aggatctcag
     3301 gttgttgtta cagtcagagc ccaggaggca gctggacgtg aagctgtctg tccccacaac
     3361 ccagtgtgtt tacattgcca gggccaggaa gccctggttt ctgtggggca gagctaaccc
     3421 agaacagaat ctgtttgatt cttatgtctt tccccaccct ctacccttct ttttcctcag
     3481 aaaggaggga ataagccaga taatatggta cttagactta agcatctaat cagaaataga
     3541 ctttaatttt gttgttttta atgggatgta gcccaggcta gccttaagtc catccttatt
     3601 cctcagcctc catagtgctg ggattatagg catgtgctac catgaatagc ttctaactat
     3661 ataactcact cctttcttct tctgtctagg gatcagtccc actgctcaga tttgctggta
     3721 agcactcccc tatgagctat gctccagctt catatagctt ttaaagttca ctttgaacac
     3781 gcggcaccgt gagccctggt aactgtgcaa tggagcatgg tggtctaaac actcacagct
     3841 cttcagaaat gccatgtaat actttctaca tgcaaactgt aatggacaag tgatgggcca
     3901 gtgtctttgg gttccttggc tctggctcat tttggcagaa tgcttagtct agcttttaaa
     3961 attttaatac ctactcaact gtacttagtt actctacctg agggtcaaca cgttgtcctc
     4021 tggagacagt aggatgtaag gaagacaagg agtcaagaaa gaagaaatga gtcatctctg
     4081 ctaattaggt ccgtggtgta tgaaacttga ggtcttgggg agttaggaga ctgctgaccc
     4141 ttgttcctga ggctcgccgt agtatggagg cagtagctgc agtatgaaat tctattccta
     4201 acattctttg gaccatttag cccattctca gactcttaag tgggaggtta gatttttttt
     4261 ttcccttcat ccagaatctc ttttcagtct cctgtcaggt tacaggttcc ttcttttagt
     4321 tttaagtcat ttcccatcaa tttctgccca gtgggaggag cagagaggct taatgcctct
     4381 cattaaaggg catccaagga agcccctagg ttttcctgaa agtgtctggg caagccaaag
     4441 cccatgttgg gggtctttgg tgttggtatt tcaatgctca gcgggctgag tatgtgaaca
     4501 cgcatgtcta gtgtgtgtat attactttat aacattgtaa gctaattttg gattctatgt
     4561 ttttcggcat cattatttca gagataaaat gccatgaaat gtactgtact gtttatcact
     4621 tgggaggacg ctgcctggtc agagacgtgt ggtggcactt gagtagtcca gggctccaca
     4681 gggccaacgt tttgaagatt tacctctggg ctgagggagg aagaaaggtg acatgaagag
     4741 ttacctgtat tgtgtgtcat ccttcagaat gtttccataa gggcagttta ctccagccca
     4801 acagggacac ccacctactt cttgggagct gaatgtctgg ctactcattt tgccttggaa
     4861 tggagtgaca gacttttcag cagagcaatc agaagaaatg ccggccaagt cagggcactc
     4921 atctgcgccc cagagttgca tgtgcagcac agatgactgg cttcttgact gagcaatctt
     4981 tcactgttct caggaagagg actatcctgg ttgttgccag accaaagaga gtcacttctg
     5041 actcgatcaa gtttaagggg cagggctagg cagcctggtt ctaagtgtaa cactaatgct
     5101 caagaaaacc gaggaaaggc tgcactgctg ttacagccag agcaggagaa tggtaaactg
     5161 aacacctgtc agctccccaa atgcatttct gtattttgct taagctgtca aacaggttag
     5221 agcactcagg gtatgtgtag ttcagtggta gaatgtgctt agcctgcaca tggccgtggg
     5281 ttcagtgtct agtaccaaaa aaaaaaaaaa aaaaaaaaaa agacacaaag gtcaaaggga
     5341 ggttagaatg tttttcctga cagcagtggc ctggggtagt agggctgcac agtgacaact
     5401 gcactaaatg acactttatt gttactgttg tcttatttag cactgagaca cccagggcat
     5461 gggtgagaac agtcacactt agggaaactg aggcaccctt tggtcttgtt ctaggggtgc
     5521 cctgtttgtt tgatcaaact tactgggaga cctcccaaga ccatgttctg tcaggaggga
     5581 gtaagtaacc gccttggaaa agtgcatccc aaagaaggag ctgctttaag tgtttggaac
     5641 ttgcattttg tatttgttgg gtcaaacaac ccacatattc cttaaaagaa aatgaggatt
     5701 tagttttcta aatgttgggg tatgtgagat agcgctggtg taatattcga gagcatcggg
     5761 aagggctggc cttaaaagac acctggacca caaactcccc tacaggtttc agatagtact
     5821 gttgttctta agagctttat ttttaactcc atttgcttta ttagcctcta gtgtgattgt
     5881 catagtggtg gagaatgtac acatacctga catcatcaga gacaccaagt agccctgaga
     5941 gctcacgagg aaattagtct ggatggcctg ctggtttttg ggttttgtgg gtgttttttt
     6001 ggttgggttt attttttttt gtctttatgt aatgttttta tttgttttaa agaactaatg
     6061 tttattacag tgttatataa aagtataaca tattaagtgt atagaataaa gtgcaataac
     6121 aaaaaaaaaa aaaaaaaa
//
