LOCUS       XM_017596784           16863 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus dystonin (Dst), transcript variant
            X18, mRNA.
ACCESSION   XM_017596784
VERSION     XM_017596784.2
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051344.1) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            [WARNING] On Feb 22, 2024 this sequence was replaced by
            XM_017596784.3.
            
            On Jan 21, 2021 this sequence version replaced XM_017596784.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..16863
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /sex="male"
                     /tissue_type="kidney"
                     /geo_loc_name="USA: Wisconsin, Milwaukee, Medical College
                     of Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..16863
                     /gene="Dst"
                     /note="dystonin; Derived by automated computational
                     analysis using gene prediction method: Gnomon. Supporting
                     evidence includes similarity to: 39 ESTs, 6 Proteins, and
                     100% coverage of the annotated genomic feature by RNAseq
                     alignments, including 15 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:316313"
                     /db_xref="RGD:1306566"
     CDS             82..16863
                     /gene="Dst"
                     /codon_start=1
                     /product="dystonin isoform X18"
                     /protein_id="XP_017452273.1"
                     /db_xref="GeneID:316313"
                     /db_xref="RGD:1306566"
                     /translation="MIAAAFLVLLRPYSIQCALFLLLLLLGTIATIIFFCCWHRKLQK
                     GRHPMKSVFSGRSRSRDAALRSHHFRSEGFRASPRHIRRRVAAAAAARLEEVKPVVEV
                     HHQSEQESSGRKRRIKKISRVQPEFYHSVQGASTRRPSSGNASYRCSMSSSADFSDED
                     DFSQKSGSASPAPGDTLPWNLPKHERSKRKIQGGSVLDPAERAVLRIADERDKVQKKT
                     FTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPRERDFLKTLRLVSATA
                     ACECEQHEEVEDEDKGPREKGRMRFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNP
                     KLTLGLIWTIILHFQISDIHVTGESEDMSAKERLLLWTQQATEGYAGVRCENFTTCWR
                     DGKLFNAIIHKYRPDLIDMNTVAVQSNLANLEHAFYVAEKIGVIRLLDPEDVDVSSPD
                     EKSVITYVSSLYDAFPKVPEGGEGIGANDVEVKWIEYQNMVNYLIQWIRHHVVTMSER
                     TFPNNPLELKALYNQYLQFKEKEIPPKETEKSKIKRLYKLLEIWIEFGRIKLLQGYHP
                     NDIEKEWGKLIIAMLEREKALRPEVERLDMLQQIATRVQRDSVSCEDKLMLARNALQS
                     DSKRLESGVQFQNEAEIAGYILECENLLRQHVIDVQILLDGKYYQAEQLVQRVAKLRD
                     EILALRNECSAVYSKGRMLTTEQTKLMISGITQSLNSGFAQTLHPSLNSGLTQSLTPS
                     LTSSSVTSGLSSGMTSRLTPSVTPAYTPGFPSVVAPNFSVGVEPNSLQTLKLMQIRKP
                     LLKSSLLDQNLTEEEVNMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVH
                     RAIEEFESSLKEAKISEIQMTAPLKLSYTDKLHRLESQYAKLLNTSRNQERHLDTLHN
                     FVTRATNELIWLNEKEESEVAYDWSERNSNVARKKGYHAELMRELEQKEESIKAVQEI
                     AEQLLLESHPARLTIEAYKAAMQTQWSWILQLCQCVEQHIQENTAYFEFFNDAKEATD
                     YLRNLKDAIQRKYVCDRSSSIRKLEDLVQESMEEKEELLQYRSVVAGLMGRAKTVVQL
                     KPRNPDNPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVP
                     SVCFTVPPPNKEAVDFANRIEQQYQSVLTLWHESHVNMKSIVSWHYLVNEIDRIRASN
                     VASIKTMLPGEHQQVLSNLQSRLEDFLEDSQESQIFSGSDITQLEKEVNVCRKYYQEL
                     LKSAEREEQEESVYNLYVSEVRNIRLRLESCEDRLIRQIRTPLERDDLHESMLRITEQ
                     EKLKKELERLKDDLEAITNKCEEFFSQAADSPSVPALRSELSVVLQSMSQIYSMSATY
                     VEKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLMSTLKQWRSEVDEK
                     REVFHALEDELQKAKAISDEMFKTHKERDLDFDWHKEKADQLVERWQSVHVQIDNRLR
                     DLEGIGKSLKHYRDSYHPLDDWIQQIETTQRKIQENQPENSKALAVQLNQQKMLVSEI
                     EVKQSKMDECQKYSEQYSAAVKDYELQTMTYRAMVDSQQKSPMKRRRIQSSADLIIQE
                     FMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLDEEKKQHVEKAKELQKWVSNIS
                     ETLGDGERAGKPHFSKQQISSKEISAKKEQFSEALQNTQIFLAKHGDKLTEEDRSDLE
                     KQVKTLQEGYNLLFSESLKQQELQPSGEAKVKVEEKVVAERQQEYKEKLQGLCDLLTQ
                     TENRLISHQETFVIGDGTVELKKYQSKQEELQRDMQGSTQALAEIVRNTEIFLKESGD
                     ELSQEDKALIEQKLNEAKVKCEQLNLKAEQSTKELDKVVTAALKEETEKVAAARQLEE
                     SKTKIENLLNWLSNVEKDSEGSGRLHTQPLEQNGTHLHEGDGTSEAGEEDEVNGNLLE
                     TDAEGHGGMTEGNLNQQYEKVKAQHEKIVAQHQAVIMATQSAQALLEKQGHHLSPEEK
                     EKLQANVQELKAHYETVLAECEKKVKLTHSLQEELEKFDADCGEFEHWLQQSEQELEN
                     LEAGADDLSGLTDKLARQKSFSEDVISHKGDLRYITISGNRVMEAAKSCSKRDGDRIG
                     KDSLETSATHREVQTKLDQVTDRFRCLYSKCSVLGNNLKDLVDKYQHYEDASCGLLSG
                     LQACEAKASRHLLEPIALDPKNLQRQLEETKALQGQISSQQAAVEKLKKTAEVLLDAK
                     GSLLPAKNDIQKTLDDIVGRYDDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGS
                     VESSLVKQGQVPLNSTALQDLISKNIMLDQDITGRQSSINAMNEKVKTFIETTDPSTA
                     SSLQAKMKDLSARFSEASQKHKEKLAKMVELKSKVEEFEKLSDKLQTFLETQSQALTE
                     VDMPGKDVPELSQHMQESTTKFLEHRKDLEALHSLLKEISSHGLPGDKALVFEKTNNL
                     SKKFKELEDTIQEKKEALSSCQEQLSAFHDLAQSLKTWIKETTKQVPIVKPSFGTEDL
                     EKSLEETKKLQEKWSLKTPEIHKANNSGVSLCNLLSALISPAKAIAAARSGGVILNGE
                     GTDTNTQDFLANKGLTSIKTDMTDISHSYEDLGLLLKDKIVELNTKLSKLQKAQEESS
                     AMMQWLQKMNKTASRWRQTPTPADSESVKIQVEQNKSFEAELKQNVNKVQELKDKLAE
                     LLKENPEAPEAPSWKQTMAEMDTKWQELNQLTIDRQQKLEESSNNLSQFQTTEAQLKQ
                     WLVEKELMVSVLGPLSTDPNMLNTQKQQAQILLQEFDTRKPQYEQLTAAGQGILSRPG
                     EDPSLHGIVKEQLAAVTQKWDNLTGQLRDRCDWIDQAIVKSTQYQSLLRSLSGTLTEL
                     DEKLSSSLISGTLPDAVNQQLEAAQKLKQEIEQQTPKIKEAQTLCEDLSALVKEEYLR
                     AELSRQLEGVLKSFKDIEQKTENHVQHLQSACASSHQFQQMSKDFQAWLDAKKEEQRN
                     SPPISAKLDVLESLLKAQKDFGKTFTEQSNIYEKTVAEGENLLSKTQGAEKAALQLQL
                     NTIKTDWDRFRKQVKEREEKLKESLEKALRYREQVDTLQPWVDKCQHSLESVKLSLDP
                     ADTERSITELKTLQKEMDHHFGTLELLNNSANSLLSVCEVDKEVVTEGNKSLIQKVNV
                     VTEQLQSKKVSLENMAQKFKEFQEVSKDAKRQLQDTKEQLEVYQSLGPQACSNKHLTM
                     LQAQQKSLQTLKHQVDSARRLAQDLVMEATDPKGTSDVLSQAETLAEEHRGLSQQVDE
                     KCSFLETKLQGLGHFQNTIREMFSQFTEFDDELDSMAPVGRDVETLQKQKASMQTFLK
                     KLEALITSNDSANRTCKMMLATEETSPDLIGVKRDLEALSKQCNKLLDRAKTREEQVS
                     GATEKLEEFHRKLEEFSTLLQKAEEHEESQGPVGTETDAINQQLDVFKIFQKEEIEPL
                     QAKQQDVNWLGQGLIQSAAANTCTQGLEHDLDSINARWKTLNKKVAQRTSQLQEALLH
                     CGRFQDALESLLSWMADTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLEDRKSTVEA
                     IKREGEKIAASAEPADRVKLSRQLSLLDSRWEMLLSRAEARNRQLEGISVVAQEFHET
                     LEPLNEWLTAVEKKLANSEPIGTQAPKLEEQIAQHKALQEDILLRKQSVDQALLNGLE
                     LLKQTTGDEVLIIQDKLEAIKARYKDITKLSADVAKTLEHALQLAGQLQSKHKELCNW
                     LDRVEVELLSYETQGLKGEAASQVQERQKELKNEVRNNKALLDSLNEVSSALLELVPW
                     RAREGLEKTVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETQKK
                     LMSLGCIRLEQDQTSAQLQAQKAFTMDILRHKDIIDELVTSGHKIMTTSSEEEKQSMK
                     KKLDKVLKKYDAICQINSERHLQLERAQSLVSQFWETYEELWPWLMETQQIISQLPAP
                     ALEYETLRRQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPKEGVHIQEKYVAADT
                     LYSQIKEDVKKRAVVLDEAISQSTQFHDKIDQILESLERIAERLRQPPSISAEVEKIK
                     EQIGENKSVSVDMEKLQPLYETLRQRGEEMIARSEGTEKDISAKAVQDKLDQMVFIWG
                     SIHTLVEDREAKLLDVMELAEKFWCDHMSLVVTTKDTQDFIRDLEDPGIDPSVVKQQQ
                     EAAEAIREEIDGLQEELDMVITLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWK
                     DRIDRLGEAMQAAVQYQDGLQAIFDWVDIAGNKLATMSPIGTDLETVKQQIEELKQFK
                     SEAYQQQIEMERLNHQAELLLKKVTEEVDKHTVQDPLMELKLIWDSLDERIVSRQHKL
                     EGALLALGQFQHALDELLAWLTHTKGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAH
                     QSTVEAVNKAGNDLIESSEGEEASNLQYKLRILNQRWQDILEKTDQRKQQLDSALRQA
                     KGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAREQLNAHMEVCTAFAIKEETYKNL
                     MLRGQQMLARCPRSVETNIDQDITNLKEKWESVKSKLNEKKTKLEEALHLAMEFHNSL
                     QDFINWLTQAEQTLNVASRPSLILDTILFQIDEHKVFANEVNSHREQIIELDKTGTHL
                     KYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDEARKRAKQFHEAWSKLMEWL
                     EDSEKSLDSELEIANDPDKIKAQLVQHKEFQKSLGGKHSVYDTTNRTGRSLKEKTSLA
                     DDTLKLENMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQ
                     LAEDQPVHGDIDLVMNLIDNHKVFQKELGKRTSSVQALKRSARELIEGSRDDSSWVRV
                     QMQELSTRWETVCALSISKQTRLESALQQAEEFHSVVHTLLEWLAEAEQTLRFHGALP
                     DDEDALRTLIEQHKEFMKKLEEKRAELNKATGMGDALLTACHPDSITTIKHWITIIQA
                     RFEEVLAWAKQHQQRLAGALAGLIAKQELLENLLAWLQWAETTLTEKDKEVIPQEIEE
                     VKTLIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPPSLQSHIPVLDKGRAGRKRFPA
                     SGLYPSGSQTQIETKNPRANLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDF
                     DIWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILSSKFPTSRLEMSAVA
                     DIFDRDGDGYIDYYEFVAALHPNKDAYKPITDADKIEDEVTRQVAKCKCAKRFQVEQI
                     GDNKYRFFLGNQFGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCRVHHHGSK
                     MLRSESNSSITATQPTLAKGRTNMELREKFILADGASQGMAAFRPRGRRSRPSSRGAS
                     PNRSTSASSHACQAASPQVPAAASTPKGTPIQGSKLRLPGYLSGKGFHSGEDNALITT
                     AASRVRTQFAESRKTPSRPGSRAGSKAGSRASSRRGSDASDFDISEIQSVCSDVETVP
                     QTHRPAPRAGSRPSTAKPSKIPTPQRKSPASKLDKSSKR"
ORIGIN      
        1 cgccccgcgt cccgcgccca gcgcccagcg cgctctgcag cctcagcccc gcgccgcacg
       61 gccccccgcc tcgcccgcac catgatcgcc gccgctttcc tcgttctgct gagaccctac
      121 agcatccaat gtgccctctt cctcttgttg ctcttgctgg gcaccatcgc caccatcatc
      181 ttcttctgct gctggcaccg caagctccag aaagggaggc atccgatgaa atcggtcttt
      241 tcgggtcgtt ccagaagcag agatgctgcc ctgagatctc atcactttcg ttctgaggga
      301 ttccgagcga gcccccgaca catcaggagg cgagttgcag cggctgcagc tgcccggctg
      361 gaagaagtga agcctgtggt ggaagttcac catcagagtg agcaagagtc atcagggagg
      421 aagcggagga tcaagaaaat tagccgggtg cagccggaat tctatcactc tgttcaaggt
      481 gcttcaacca gaaggcctag ctccgggaac gcgtcctacc gctgttctat gtcctcctct
      541 gcggattttt ctgacgagga tgatttcagc cagaaatctg gttcagcatc tccagctcct
      601 ggagacacct taccctggaa tttgcctaag cacgagagat ccaaaagaaa gattcaaggg
      661 ggctcagtgc tggaccccgc cgagagggcc gtgcttcgga tagcagatga gcgggacaaa
      721 gttcaaaaga aaacatttac aaaatggata aatcagcatc tcatgaaggt tcgcaagcac
      781 gtgaacgatc tctacgagga tctgcgggac gggcacaatt tgatctccct cctggaggtt
      841 ctgtccggag acaccttgcc gagggagcga gactttttga agaccttacg gttggtgagt
      901 gcaacagcag catgcgagtg tgagcagcat gaggaggtgg aggatgagga caaggggccc
      961 cgagagaagg gtcggatgcg ctttcacagg ctacagaatg tacagattgc actcgactat
     1021 ttgaaaagac gccaggtgaa gttagtgaac attaggaatg atgacataac agatgggaac
     1081 cccaagctga cgttggggtt gatatggaca ataattctgc acttccagat atctgacatc
     1141 catgtcaccg gagagtcaga ggacatgtct gcgaaagaaa ggttgctgct gtggacacag
     1201 caggcgacag aaggttatgc cggagtgcgg tgtgaaaact tcactacctg ctggagagat
     1261 gggaagctat ttaatgccat cattcataaa tacaggccgg acctgataga catgaatact
     1321 gttgctgttc aaagcaacct tgcgaattta gagcatgctt tttatgtagc tgaaaaaatc
     1381 ggtgtgatca gacttctgga ccccgaagat gtcgacgtct cttccccgga cgaaaagtca
     1441 gtgataacct atgtgtcctc cctctacgat gcatttccca aagtccccga aggcggcgaa
     1501 ggcattggtg caaacgatgt tgaagtcaag tggattgaat accagaacat ggtgaactac
     1561 ctcatccagt ggatcagaca ccacgtggtc acaatgtctg agagaacatt tcctaacaac
     1621 cctctagaac tcaaggcact ttataatcag tatttacagt tcaaagagaa agaaatccca
     1681 ccaaaggaga cagagaaatc aaaaattaaa cggctgtata aattattaga gatttggatt
     1741 gagtttgggc gcatcaaact ccttcaaggt tatcatccca acgacatcga aaaggagtgg
     1801 ggcaaactca tcatcgccat gctcgagcgg gagaaggcac tgcgtcctga ggtggagagg
     1861 ttggatatgc tgcagcagat tgctacccga gttcagaggg atagcgtcag ctgtgaggac
     1921 aaactcatgc tcgcccgaaa tgctctccag tctgattcca aaagattgga gtcgggagtg
     1981 cagtttcaga acgaagcaga aattgccggg tatatacttg aatgtgagaa ccttctacgc
     2041 cagcacgtga ttgacgttca gattctgcta gatgggaagt actaccaggc cgagcagctg
     2101 gtgcagaggg ttgccaagct gcgtgatgaa attctggcct taaggaatga atgttccgcg
     2161 gtgtacagca aaggacgcat gctgaccacg gagcagacca agctcatgat atcaggaatc
     2221 actcaaagct tgaactcagg atttgcacag accttacacc ccagtctgaa ctcagggcta
     2281 acccagagtt taaccccttc cttgacgtct tctagcgtga cttccggctt gtcgtccggg
     2341 atgacgtccc gcctgacgcc gtcggttact ccggcgtata cacctgggtt cccatcagta
     2401 gtagctccaa acttcagtgt aggagtagag ccaaattcat tacagaccct gaagctaatg
     2461 cagatccgaa agccccttct aaagtcatct ttgctggacc agaacttgac agaagaggaa
     2521 gtcaatatga aatttgttca agatctcttg aactgggttg atgagatgca ggtgcagctg
     2581 gaccgcactg aatggggctc agatctgcca agtgttgaaa gccatttaga aaaccataaa
     2641 aatgtccacc gagccattga agaatttgaa tctagtctta aggaggctaa aattagtgag
     2701 atccagatga cggcgcctct gaagctctct tacacggata agttgcacag actagagagt
     2761 cagtacgcta aactcctgaa cacatccaga aatcaggagc ggcacctcga tacgctccac
     2821 aactttgtaa cccgggcaac taacgaactt atctggttga atgaaaagga ggagtcagaa
     2881 gttgcctatg actggagtga gaggaacagc aacgtcgccc ggaagaaagg ctaccacgcg
     2941 gaactgatgc gggagctgga gcagaaggag gaaagtatta aagccgttca ggagatcgca
     3001 gagcagctgc ttctggaaag ccacccagcc cgcttgacca tagaggcata caaagcagcc
     3061 atgcagacac agtggagctg gatcctacag ctgtgccagt gtgtggagca gcacattcag
     3121 gagaacactg cctattttga gtttttcaat gatgccaaag aagccaccga ttacctaagg
     3181 aatctgaaag acgccattca gcgcaagtac gtctgtgacc gatccagcag cattcgcaaa
     3241 ctggaagacc tcgtccagga gtccatggag gaaaaggagg agctcctgca gtaccgaagc
     3301 gtggtggccg ggctgatggg gcgagcaaag acggtcgtgc agctgaagcc acggaatcct
     3361 gacaacccac tcaaaacgtc catcccgatc aaagctatct gtgactacag acagattgag
     3421 ataaccattt acaaagacga cgaatgtgtc ttggcaaaca actctcaccg cgccaagtgg
     3481 aaggtcatca gtcccaccgg aaacgaggcc atggtcccgt ctgtgtgctt taccgtcccc
     3541 ccaccaaaca aagaagcggt tgactttgcc aacagaatcg agcaacagta tcagagtgtc
     3601 ctcactcttt ggcatgagtc tcacgtaaac atgaagagta tagtgtcctg gcattatctc
     3661 gtcaatgaaa ttgacagaat ccgggctagt aacgtggctt cgataaagac aatgttgcct
     3721 ggcgaacacc agcaggttct cagtaatctc cagtcccgct tggaagattt tctggaggat
     3781 agccaggaat cccaaatatt ttcaggctcg gatataactc aactagaaaa ggaagtgaat
     3841 gtatgtagga agtattatca agagcttctc aagtctgcag aaagagagga gcaagaggag
     3901 tctgtgtaca atctgtacgt ctcagaagtg cgcaacatcc ggcttcgcct ggagagctgt
     3961 gaagaccggt tgattcggca gatccggacg cctctggaaa gagatgacct acacgaaagc
     4021 atgttgagaa tcacggagca ggagaaactg aagaaagagc tggaacggct taaagacgac
     4081 ttggaggcga tcacaaataa gtgtgaagag tttttcagcc aagcggcaga ttccccatcc
     4141 gtccctgccc tgcgatcaga gctcagcgtg gtcctccaga gcatgagtca gatctactcc
     4201 atgtctgcca cttacgtaga gaagttgaag actgttaatt tggttttaaa aaacacccaa
     4261 gctgcagaag cccttgtcaa actctacgaa accaagctgt gtgaagaaga agcagtcata
     4321 gctgacaaga ataacattga gaatttaatg agtacgttaa agcaatggcg atcagaagta
     4381 gatgagaaga gagaggtgtt ccacgcgttg gaagacgagt tgcagaaagc gaaagccatc
     4441 agtgacgaga tgttcaagac acacaaagaa cgggaccttg actttgactg gcacaaagaa
     4501 aaggcagacc agctcgtgga aaggtggcag agtgttcacg tccagatcga caacaggctg
     4561 cgggacttag aagggatcgg gaagtccctg aagcactaca gggactccta ccaccctcta
     4621 gatgactgga tccagcaaat cgaaacgacc cagagaaaaa ttcaggaaaa tcagccagaa
     4681 aacagcaaag ctctggccgt acagctgaac caacagaaga tgctggtatc tgaaatagag
     4741 gtgaagcaga gcaaaatgga cgagtgtcag aaatactcgg agcagtactc agctgccgtc
     4801 aaggactatg aattgcaaac aatgacctac agggccatgg tggattccca gcagaagtca
     4861 ccaatgaagc gtcggcggat acagagctcg gcggacctca ttattcaaga gttcatggac
     4921 ctacggacga ggtacactgc cctggtcact cttatgacgc agtacattaa attcgctggt
     4981 gattccttga aaaggctgga ggaggaggag aagtcactgg atgaagagaa gaaacagcat
     5041 gttgaaaagg ctaaagaatt gcagaaatgg gtatcaaata tcagcgagac actgggagat
     5101 ggggagagag ctgggaaacc tcacttctct aagcaacaga tttccagtaa agaaatatca
     5161 gccaagaagg agcagttctc ggaagctctt caaaacacac agattttttt ggctaaacat
     5221 ggagacaaac tgacagagga agacagaagt gacttggaga aacaggtgaa aactctgcag
     5281 gaaggttaca atttattatt cagtgaatct ctgaaacagc aagagttaca accctcagga
     5341 gaggcgaagg tcaaggtgga ggagaaggtt gtggcagagc gtcagcaaga gtacaaagag
     5401 aaactccaag ggctgtgtga cctcctcacc cagactgaaa accgcctaat tagtcaccag
     5461 gaaacctttg tgattggaga tggcacggtg gagttaaaga agtaccagtc caagcaagag
     5521 gaattacaga gggatatgca aggaagtaca caggccctgg cagaaatagt gagaaacaca
     5581 gaaatctttt tgaaagagag cggtgacgag ttgtcccaag aggataaggc tttgatcgag
     5641 cagaagctca acgaggcgaa ggtgaagtgt gagcagctga atttaaaggc cgagcagtcg
     5701 accaaggagc tggataaggt ggtgactgcg gccctcaagg aggagactga aaaggttgcg
     5761 gctgcgaggc agctggaaga gagcaaaacc aaaatagaaa accttctgaa ctggttgtca
     5821 aacgttgaga aagactcaga agggtcagga aggttgcaca cacaacccct ggagcagaat
     5881 ggaacccatt tgcatgaagg cgatggcacg tcggaagctg gtgaagagga tgaagtcaat
     5941 ggtaacctgc tggagacaga tgccgaaggg cacggtggga tgaccgaggg gaacctgaac
     6001 cagcagtacg agaaggtcaa ggcccagcat gaaaagatcg tggctcagca ccaggcggtc
     6061 atcatggcca cgcagtcggc gcaggcgctg ctggagaaac agggccacca tctgtcccct
     6121 gaagagaagg agaagctgca ggccaacgtg caggagctga aggcgcacta cgagacggtg
     6181 ctggccgagt gtgagaagaa ggtgaagctg acccactccc tgcaggagga gctggagaag
     6241 ttcgatgccg actgcggtga gtttgagcat tggctgcagc agtcggaaca ggagctggag
     6301 aacctggagg cgggcgcgga cgacctcagc gggctgacgg acaagctggc gaggcagaag
     6361 agcttctcgg aagacgtcat ttcgcacaaa ggcgacctga ggtacatcac catttccgga
     6421 aacagagtga tggaagctgc caaatcttgc agcaagagag acggtgacag gattggcaag
     6481 gacagccttg agacttccgc aacccacaga gaggttcaga ccaaactgga tcaggttaca
     6541 gaccgcttcc ggtgtctcta ctctaagtgc agtgttcttg gaaacaacct caaagatctg
     6601 gtggataaat accaacacta cgaagacgct tcctgtggac ttctctccgg gctccaggcc
     6661 tgcgaggcca aagccagcag acacttgctc gagcccatcg ctttggaccc caaaaatctg
     6721 caaaggcagt tagaagagac caaggctttg caaggacaga tatcaagtca gcaggctgct
     6781 gtagagaagc tgaagaaaac cgcagaagta ctcttggatg ccaagggctc gctacttcct
     6841 gccaagaatg acatccagaa gacgcttgat gacattgttg ggagatacga cgacctgtcc
     6901 aagtctgtga atgaacggaa cgaaaaactt cagataacgc tgacccgctc cctgagtgtg
     6961 caggacggtt tggacgagat gctggactgg atgggaagtg tggaaagctc actggtcaaa
     7021 caaggtcaag tgcccttaaa ctccacagca ctccaggacc tcatcagtaa aaacatcatg
     7081 ctggatcagg atattacggg tcgtcagagc agcataaacg ccatgaacga aaaggtgaag
     7141 acatttatag agacaacaga cccatccact gcctcctcgc tgcaggcaaa aatgaaggac
     7201 ctgtctgctc gcttttccga agcgagtcag aaacacaagg aaaagctcgc caagatggtg
     7261 gagctgaagt ccaaagtaga ggagtttgag aagctctcag acaagctcca gacattcctc
     7321 gagacacaga gccaggcgct cactgaggtg gacatgccgg gaaaggacgt gccagagctg
     7381 tctcagcata tgcaggaatc cactactaaa ttcttagaac acaggaaaga tctcgaagct
     7441 ttgcacagcc tcctgaaaga gatatccagc cacggcttac caggggacaa agctctggtg
     7501 tttgagaaaa ctaataattt gtcaaagaaa ttcaaagaac tggaggatac tatccaagaa
     7561 aaaaaagaag ctctcagttc atgtcaggag cagctgagtg ctttccacga cctcgctcag
     7621 tccctgaaaa catggataaa agaaacaacc aagcaggttc ccatcgtgaa gccttctttc
     7681 ggcacagagg acttggaaaa atctctggag gaaaccaaga aattacaaga aaagtggagt
     7741 ctgaaaaccc cagaaattca caaagcaaac aacagtgggg tctcactatg taacctgcta
     7801 agtgcactga tcagccctgc aaaggccata gcggcggcca gatcaggtgg agtaatacta
     7861 aatggtgaag gaacagacac aaatactcag gatttcttgg caaataaagg tttaacatct
     7921 attaaaacag acatgactga cataagccac agttacgaag acctgggcct cttactcaag
     7981 gacaaaatag tggagctgaa caccaagctc tcgaagctgc aaaaggctca ggaagagtcg
     8041 agcgcaatga tgcagtggtt gcagaagatg aacaagacag ccagcagatg gcgccagaca
     8101 cccaccccgg cagactccga gtccgtgaag attcaggtgg agcagaacaa gtcgtttgag
     8161 gcagaactga agcaaaacgt aaacaaagtg caagaattga aagacaaact ggcagagctt
     8221 ctgaaggaga acccggaggc tcccgaggcg ccatcctgga agcagacgat ggcagagatg
     8281 gacactaagt ggcaagaact caaccagtta accattgaca ggcaacaaaa gctggaagag
     8341 tcctccaata atctaagcca gttccagacc acagaggccc agttaaagca gtggctcgtg
     8401 gagaaggagt tgatggtcag cgtgctcggg cccttgtcca ctgacccaaa catgttgaac
     8461 actcagaagc agcaggccca gattctgcta caagaattcg acacccggaa accacagtac
     8521 gaacagctca cagcagctgg ccagggcatc ctgagcaggc ctggggaaga cccctctttg
     8581 catgggattg taaaggagca actggcagct gtgacccaga agtgggacaa cctaacaggg
     8641 caactgaggg acagatgcga ctggattgac caggctattg tcaaaagcac acagtaccag
     8701 agcctgctga gaagtctttc cggtaccctg acggagctgg atgaaaagct cagcagcagc
     8761 ctcatctcag gcacactgcc cgatgccgtg aaccagcagc tggaggcagc ccagaagctg
     8821 aagcaggaaa tcgagcagca aacaccgaag atcaaggagg cccagacgct ctgtgaggac
     8881 ctgtcggcac tggtcaaaga agagtacttg agagcagaac tgagcaggca gctggaaggc
     8941 gtcctaaagt cctttaagga tattgaacaa aagacagaga atcatgttca gcacctccag
     9001 tcagcctgcg caagctctca ccagtttcag caaatgtcta aggactttca ggcgtggctt
     9061 gacgcaaaga aagaagagca gaggaactct cccccaatat ccgccaagct ggatgtcttg
     9121 gagtcgttac tcaaagcgca gaaagacttc ggcaaaactt tcaccgagca gtctaacatt
     9181 tatgagaaaa cggttgcaga aggggaaaac ctgttgtcaa agacacaggg ggcggagaag
     9241 gcagccctgc agttgcagct taacaccatc aaaacagact gggaccgatt caggaagcag
     9301 gtgaaagaaa gggaagagaa gctgaaggag tcgttggaaa aagccctcag atacagggag
     9361 caggtggaca ctctgcagcc gtgggtagac aagtgtcagc acagcctgga gagtgtaaag
     9421 ctctccctgg atcccgctga cacagagcgc tccatcacgg agttaaagac tctgcagaag
     9481 gaaatggacc accactttgg aacgctggaa ctactgaaca attcagccaa tagcctgctc
     9541 agcgtctgcg aggtagataa agaagtggtc acggagggga ataagtcact gatccagaag
     9601 gtgaatgttg tcactgagca gctccaaagt aagaaggtct ccctggagaa catggcccag
     9661 aagtttaagg aatttcaaga agtttccaaa gacgccaaaa ggcagcttca ggatacaaag
     9721 gaacagctag aggtctatca gtccctggga ccccaggcct gcagcaacaa gcacctcacc
     9781 atgctgcagg ctcagcagaa gtcgctgcag accctgaagc atcaggtaga ctcggccaga
     9841 aggcttgctc aggacctcgt gatggaagcc acagacccaa agggaacctc tgacgtgttg
     9901 tcacaagcgg agacgttagc cgaagagcac aggggactga gccagcaggt ggacgagaag
     9961 tgttctttct tagaaaccaa gctgcagggt ctcggccact tccagaatac catccgagag
    10021 atgttctctc agtttacgga gtttgatgac gagctggata gcatggctcc agtggggaga
    10081 gacgtggaga cactgcaaaa gcaaaaggcg tccatgcaaa cctttctgaa gaagctggaa
    10141 gccctcatca cgagcaacga cagtgccaac agaacctgca agatgatgct agccaccgag
    10201 gagacctctc ctgaccttat cggagtcaaa agggacttag aagccttgag caagcagtgc
    10261 aacaagctgc tggaccgagc caagaccaga gaggagcagg tcagtggggc cacggagaag
    10321 ctcgaagagt tccaccgcaa gctggaagag ttctccaccc tgctccagaa ggctgaagaa
    10381 cacgaagagt cccagggccc cgtggggaca gagacagacg caattaacca gcagctcgac
    10441 gtgtttaaga tattccagaa agaagagatc gaacccttgc aggcgaagca gcaagatgtg
    10501 aactggttag gccaaggcct tattcagagc gcagctgcaa acacctgcac tcagggtttg
    10561 gagcatgacc tggacagcat caatgcaagg tggaagaccc tcaataagaa ggtggctcaa
    10621 cgaacatccc agctgcaaga ggccctgctc cactgtggac ggttccagga tgccctggag
    10681 tccttgctca gctggatggc agacacggaa gagcttgtgg ccaatcagaa gcctccatca
    10741 gcagagttca aagtggtgaa ggcccagata caggagcaaa agcttctgca gaggctgctg
    10801 gaagaccgga agtctaccgt ggaggcgatc aaacgagaag gagagaaaat cgctgcttca
    10861 gcagagccgg cagaccgagt gaagctctcc aggcagctga gcctcctgga cagtagatgg
    10921 gaaatgctgc ttagcagagc cgaagcaagg aaccgtcaac tggaaggtat ctctgtggta
    10981 gctcaggagt ttcatgagac cttggagccc ctgaatgagt ggctcacagc cgtagaaaaa
    11041 aagctggcca actccgaacc cataggaacc caggcaccca agctggagga acagattgca
    11101 cagcacaaag ctctacaaga agacattctc ctcaggaaac agagtgtaga tcaggcactg
    11161 ctgaacggct tagaactgct caaacaaacc acaggcgacg aagtcttaat cattcaagac
    11221 aagttggaag ccattaaagc caggtacaaa gacatcacca agttaagtgc cgacgtggcg
    11281 aagactctgg aacacgccct gcagctcgct ggacagctgc agtccaagca taaggagctg
    11341 tgcaactggc tggacagagt ggaggtggag ctgctgtcct acgagactca gggcctgaag
    11401 ggagaagctg caagccaagt gcaagagaga cagaaagaac tgaaaaatga agtcaggaac
    11461 aacaaagcct tactggattc tctcaatgag gtgagcagcg ccttgttgga actggtgccc
    11521 tggagggcaa gagaagggct tgagaagacg gtcgccgagg acaacgaacg ctaccgattg
    11581 gtgagcgaca ccatcacaca gaaagtggaa gagattgatg ctgccattct gaggtctcag
    11641 cagtttgacc aagcggcaga tgctgagtta tcctggatca ctgaaacaca gaagaaatta
    11701 atgtctctgg gttgcatcag gctggagcaa gaccagacct ctgctcagct gcaggctcaa
    11761 aaggctttca ccatggatat cttgagacac aaggatatca ttgacgaact cgttacctct
    11821 gggcataaaa tcatgaccac atccagcgaa gaggagaagc agtcaatgaa gaaaaaactg
    11881 gacaaggttc tgaagaagta cgacgccatc tgccagatca actcagagag gcacctgcag
    11941 ctggagcggg cgcagtccct cgttagccag ttctgggaga cctatgagga actttggccg
    12001 tggctaatgg aaacacaaca aatcatctct cagctaccgg ccccagccct ggagtacgag
    12061 actctgagga gacagcaaga ggagcatcgg caactgcgag agctgatagc ggaacacaag
    12121 cctcacatag ataagatgaa caagaccggg ccgcagctgc tggaactgag ccccaaggaa
    12181 ggcgtccata tccaggaaaa gtatgtggca gccgacaccc tctacagcca aattaaagaa
    12241 gatgtcaaaa agcgagccgt ggtactggat gaggccattt ctcagtccac ccagtttcac
    12301 gacaagatcg accagatcct tgagagcctg gagcgcatcg cggagcgtct acggcagccg
    12361 ccgtccatct ctgccgaggt tgaaaagatc aaggagcaga ttggtgaaaa caagagtgtg
    12421 tccgtggaca tggagaagct gcagccgctg tatgagactc tgaggcagag gggagaggag
    12481 atgatcgcca ggtctgaggg caccgaaaaa gacatatctg ccaaagctgt gcaggataag
    12541 ttggaccaaa tggttttcat ctggggaagc atccacaccc tggtggaaga cagggaagcc
    12601 aagctgctgg acgtgatgga actagcagag aaattctggt gtgatcacat gtcgctggtt
    12661 gttaccacca aagacactca agatttcatc cgggacctgg aggatcccgg aatcgatccc
    12721 tcggtagtaa agcagcagca ggaagcagca gaggcaataa gagaggagat tgatggactg
    12781 caagaggagc tcgacatggt catcacactg ggctcagagc tcattgccgc ctgtggggag
    12841 cctgataagc ccatcgtcaa gaagagtata gacgagttga actcagcgtg ggattctcta
    12901 aataaagcct ggaaagaccg gattgacaga ctgggagagg ccatgcaagc cgccgtccag
    12961 taccaggatg gattgcaggc aatattcgac tgggtcgata tcgcaggcaa taagctagcc
    13021 acaatgtctc ccatcggaac ggacttggag acggtcaagc agcagattga agagctgaag
    13081 caatttaagt cagaagctta ccaacaacag atagaaatgg aaagactgaa ccaccaagca
    13141 gaacttttgc tgaagaaagt aacagaggag gttgacaagc acaccgtcca ggacccgctg
    13201 atggagctga aattgatatg ggacagcctg gacgagcgaa ttgtcagcag acagcacaaa
    13261 cttgagggtg ctctcttggc gctgggtcag ttccagcacg ccctggacga gctcctcgca
    13321 tggctgacac acaccaaggg cttgctgagt gaacagaaac ctgttggagg agacccgaaa
    13381 gccatcgaga tcgaacttgc taagcatcac gtgctccaaa atgacgtcct agcccaccag
    13441 tccaccgtgg aggccgtcaa caaagcagga aatgacctca tcgagtcaag tgagggcgaa
    13501 gaagcaagca acctccagta caagctcaga attctgaatc agcgctggca ggatattttg
    13561 gaaaagacag atcaaaggaa gcagcagctg gacagcgcct tgcgccaggc caaagggttc
    13621 catggtgaaa ttgaggatct gcaacagtgg ctgacggaca cagagcgtca tctcctggca
    13681 tccaaacctc tgggaggtct accggagaca gccagagagc agcttaacgc acatatggaa
    13741 gtctgcaccg cctttgccat caaagaagag acatacaaga acctgatgct gaggggacag
    13801 cagatgctcg cacgatgccc caggtctgtg gaaaccaaca ttgaccaaga cataaccaac
    13861 ttgaaggaga agtgggaatc cgtgaaaagc aaactcaacg agaagaagac aaaattggaa
    13921 gaggccctgc acttggccat ggaattccac aattccctcc aggacttcat caactggctt
    13981 acccaggctg agcaaacttt gaacgtggct tcccggccaa gtcttatctt ggacaccatc
    14041 ttgttccaaa ttgatgaaca caaggtcttt gccaacgaag tgaattcaca ccgtgagcag
    14101 ataatagagc tagacaaaac tggaacccac ctgaagtatt tcagtcagaa acaagacgtc
    14161 gtgctcatta agaacctgct gatcagcgtg cagagtcggt gggaaaaggt ggttcagcgc
    14221 ttagtagaga gaggaagatc cttggacgaa gcgaggaaga gggccaagca gttccacgaa
    14281 gcttggagta agctgatgga atggctggaa gactcagaaa aatccctgga ttctgaactg
    14341 gaaatcgcca acgatccaga caaaatcaaa gcacagctgg ttcagcacaa ggagtttcag
    14401 aaatcactcg gaggcaaaca ttctgtgtac gacaccacca atcggactgg acgttctctg
    14461 aaggagaaaa cttccctggc cgacgacacc ctgaagctgg agaacatgct gagcgaactc
    14521 agggacaaat gggacaccat ctgtggaaag tccgtggaaa gacaaaacaa actggaggaa
    14581 gccctgttgt tttccgggca gttcacagat gccctgcagg ccctcattga ttggctgtat
    14641 cgggttgagc cccagctggc agaagaccaa cctgttcacg gagacattga cttggtgatg
    14701 aacctgatcg ataatcacaa ggtcttccag aaagagttgg ggaagaggac cagcagcgtg
    14761 caggccctga agcgctctgc cagggagctc atagaaggca gccgggatga ctcctcctgg
    14821 gtcagggtcc agatgcagga actaagcacc cgctgggaga cggtgtgcgc gctctcgata
    14881 tcaaagcaga cgcggctaga atcagccctg caacaggcag aggaattcca ctctgtggtc
    14941 cacacccttt tggagtggct ggcagaggca gagcaaacgc tgcgtttcca tggcgcgctc
    15001 ccagacgacg aggatgctct ccggactctt attgagcaac ataaagagtt catgaagaaa
    15061 ctggaagaga aaagagcaga actaaataag gccacaggta tgggggacgc tctcctgacc
    15121 gcctgccacc ctgactccat taccaccatt aagcactgga taaccatcat ccaggccagg
    15181 tttgaagagg tgctggcctg ggcaaagcag caccagcaga ggttagcagg ggcgctggca
    15241 gggctcatcg ctaagcagga gctgctggag aatttgctcg cctggctgca gtgggctgaa
    15301 accacactga ccgagaaaga taaggaagtc atcccccagg agatcgaaga ggtgaaaacc
    15361 ctcattgcag aacaccagac cttcatggaa gaaatgacca gaaaacagcc tgatgttgat
    15421 aaagttacca agacctataa gaggagggcc gctgaccctc catccttaca gtctcacatc
    15481 cccgtcttgg acaagggacg agccggaagg aaacgcttcc cagcctcagg cctgtatcct
    15541 tcagggtcac agacgcaaat cgaaaccaag aaccccaggg ctaacttgct ggtgagcaag
    15601 tggcagcagg tttggctcct ggccttggaa cgaaggagga agctcaacga cgccttggac
    15661 aggctggagg agctgaggga attcgctaac ttcgattttg atatctggcg gaaaaaatac
    15721 atgaggtgga tgaatcataa gaagtcgaga gtgatggatt tcttccggag aatcgataag
    15781 gaccaggatg ggaagatcac tcggcaggaa ttcattgacg gcattctgtc ctccaagttt
    15841 cctaccagtc gtctggagat gagcgccgtg gcagacatct ttgacagaga cggagatggg
    15901 tacatcgact actatgaatt cgtggccgct ctacatccaa acaaagatgc gtacaaaccc
    15961 atcacggacg ctgacaaaat cgaagatgag gtcacgaggc aggtggccaa gtgtaagtgc
    16021 gccaagcggt tccaagttga gcagatcgga gacaacaaat acaggttctt cctgggaaat
    16081 cagtttggag actcccagca gctgcgactg gttcggatcc tgcgaagcac cgtgatggtc
    16141 cgtgttggag gtggatggat ggctctggat gagttcttag tgaaaaacga tccgtgcagg
    16201 gttcatcatc acgggagtaa aatgttgcgt tcggaatcaa actcttcaat tactgctact
    16261 cagcctactc tagccaaagg aaggaccaac atggagctgc gggagaagtt catcttagcg
    16321 gacggggcca gccagggtat ggctgccttc cgaccacgag gccgccgatc tcggccttcg
    16381 tcgagaggag cttcccccaa cagatccact tccgcatcca gtcacgcctg ccaggcagcc
    16441 tccccacagg tgcctgctgc cgccagcaca cccaagggaa cgccaatcca gggaagcaag
    16501 ctgcggctgc cagggtactt gtcagggaaa ggtttccact ccggggagga caacgccttg
    16561 ataacgaccg cagcctccag agtccgaacg cagtttgctg agtccaggaa gacgcccagc
    16621 cgccctggaa gcagagccgg aagcaaagcc gggagcagag ccagcagccg ccgaggcagc
    16681 gacgcgtccg actttgacat ttcagaaatc cagtctgtgt gctcagacgt ggagaccgtc
    16741 ccacagacac acagacctgc gccccgagca ggttctcggc catccacagc caagccttct
    16801 aaaatcccca cgccccagag gaagtcaccc gccagcaaac tagacaagtc ttcgaagaga
    16861 tag
//
