LOCUS       NM_012790               4398 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus dentin sialophosphoprotein (Dspp), mRNA.
ACCESSION   NM_012790 XM_577305
VERSION     NM_012790.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4398)
  AUTHORS   Gao,H., Fan,S., Xie,L., Hu,S. and Zhang,Y.
  TITLE     Overexpression of DSPP promotes the proliferation and migration of
            astrocytes
  JOURNAL   Neurosci Lett 754, 135775 (2021)
   PUBMED   33647395
  REMARK    GeneRIF: Overexpression of DSPP promotes the proliferation and
            migration of astrocytes.
REFERENCE   2  (bases 1 to 4398)
  AUTHORS   Zhu,Y.Q., Song,R.M. and Ritchie,H.H.
  TITLE     Differential expression between 'DSP-only' and DSP-PP523
            transcripts in rat molar teeth
  JOURNAL   Arch Oral Biol 82, 33-37 (2017)
   PUBMED   28595095
REFERENCE   3  (bases 1 to 4398)
  AUTHORS   Zhang,H., Liu,P., Wang,S., Liu,C., Jani,P., Lu,Y. and Qin,C.
  TITLE     Transgenic expression of dentin phosphoprotein inhibits skeletal
            development
  JOURNAL   Eur J Histochem 60 (1), 2587 (2016)
   PUBMED   26972716
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4398)
  AUTHORS   Martin-Gonzalez,J., Perez-Perez,A., Sanchez-Jimenez,F.,
            Diaz-Parrado,E.M., de Miguel,M., Sanchez-Margalet,V. and
            Segura-Egea,J.J.
  TITLE     Leptin promotes dentin sialophosphoprotein expression in human
            dental pulp
  JOURNAL   J Endod 41 (4), 487-492 (2015)
   PUBMED   25583546
  REMARK    GeneRIF: the effect of leptin on Dentin sialophosphoprotein
            expression in human dental pulp
REFERENCE   5  (bases 1 to 4398)
  AUTHORS   Lee,H.K., Lee,D.S., Park,S.J., Cho,K.H., Bae,H.S. and Park,J.C.
  TITLE     Nuclear factor I-C (NFIC) regulates dentin sialophosphoprotein
            (DSPP) and E-cadherin via control of Kruppel-like factor 4 (KLF4)
            during dentinogenesis
  JOURNAL   J Biol Chem 289 (41), 28225-28236 (2014)
   PUBMED   25138274
  REMARK    GeneRIF: NFIC regulates DSPP and E-cadherin via control of KLF4
            during dentinogenesis.
REFERENCE   6  (bases 1 to 4398)
  AUTHORS   Ritchie,H.H. and Wang,L.
  TITLE     The presence of multiple rat DSP-PP transcripts
  JOURNAL   Biochim Biophys Acta 1493 (1-2), 27-32 (2000)
   PUBMED   10978503
REFERENCE   7  (bases 1 to 4398)
  AUTHORS   Yamazaki,H., Kunisada,T., Miyamoto,A., Tagaya,H. and Hayashi,S.
  TITLE     Tooth-specific expression conferred by the regulatory sequences of
            rat dentin sialoprotein gene in transgenic mice
  JOURNAL   Biochem Biophys Res Commun 260 (2), 433-440 (1999)
   PUBMED   10403786
REFERENCE   8  (bases 1 to 4398)
  AUTHORS   Ritchie,H.H., Berry,J.E., Somerman,M.J., Hanks,C.T.,
            Bronckers,A.L., Hotton,D., Papagerakis,P., Berdal,A. and
            Butler,W.T.
  TITLE     Dentin sialoprotein (DSP) transcripts: developmentally-sustained
            expression in odontoblasts and transient expression in
            pre-ameloblasts
  JOURNAL   Eur J Oral Sci 105 (5 Pt 1), 405-413 (1997)
   PUBMED   9395101
REFERENCE   9  (bases 1 to 4398)
  AUTHORS   Ritchie,H.H. and Wang,L.H.
  TITLE     Sequence determination of an extremely acidic rat dentin
            phosphoprotein
  JOURNAL   J Biol Chem 271 (36), 21695-21698 (1996)
   PUBMED   8702961
REFERENCE   10 (bases 1 to 4398)
  AUTHORS   Ritchie,H.H., Hou,H., Veis,A. and Butler,W.T.
  TITLE     Cloning and sequence determination of rat dentin sialoprotein, a
            novel dentin protein
  JOURNAL   J Biol Chem 269 (5), 3698-3702 (1994)
   PUBMED   8106414
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Dec 5, 2020 this sequence version replaced NM_012790.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ403971.1, AF250374.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMEA5760433 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-66                JAXUCZ010000014.1  5876274-5876339     c
            67-153              JAXUCZ010000014.1  5875348-5875434     c
            154-1092            JAXUCZ010000014.1  5874256-5875194     c
            1093-4398           JAXUCZ010000014.1  5870232-5873537     c
FEATURES             Location/Qualifiers
     source          1..4398
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..4398
                     /gene="Dspp"
                     /gene_synonym="Dsp; RDSP2"
                     /note="dentin sialophosphoprotein"
                     /db_xref="GeneID:25254"
                     /db_xref="RGD:2525"
     exon            1..66
                     /gene="Dspp"
                     /gene_synonym="Dsp; RDSP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             10..2868
                     /gene="Dspp"
                     /gene_synonym="Dsp; RDSP2"
                     /note="dentin sailophosphoprotein; Dentin sialoprotein;
                     Dentine sialoprotein"
                     /codon_start=1
                     /product="dentin sialophosphoprotein precursor"
                     /protein_id="NP_036922.3"
                     /db_xref="GeneID:25254"
                     /db_xref="RGD:2525"
                     /translation="MKTKIIIYICIWATAWAIPVPQLVPLERDIVEKSADVPFLAHPG
                     TAAQNELHINKATNDSDSDDSPKGSELGRQVHSNGGYERDRNGSESIAVGGKSSPTQP
                     ILANAQGNSAKEREDVETYGHDGIHAGENSTANGIRGQLGIAENAEEAKESKVHEQPH
                     QDTKTGLASDTSQNGDATLVQENEPQVAGSKNSTNHEVGTHGSGVAAQETTPQREGEG
                     SENQGAEVTPSIGEGAGLDNTEGSPSGNGIEEDEDTGSGDGVGADAGDGRESHDGTEG
                     HEGQSSGGNNDNRGQGSVSTEDDDSKEQEGSPNGRGGDNTSSSEETGIEEGDGTQTTQ
                     DNQNLSPTEGGIISQAEACPSGQSQNQGLETEGSSTGNKSSITKESGKLSGSKDSNGH
                     HGMELDKRNSPKQGAAEKSDTHNNMGHSRIGSSSNSDGHDSYDFDDESMQGDDPNSSD
                     ESNGSDGSDDANSESANENGNHGDASYTSDESSDNGGDSDSYAGEDDSSDDTSDTDDS
                     DSNGDDDSESEDKDESDNSNHDNDSDSESKSDSSDSDSDSSDSSDSSDSSDSSDSSDS
                     SESSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSDSNDSSDSSDSSDSSDSSDSSESSD
                     SSDSSDSSDSSESSESSESSDSSDSSDSSDSSDSSESSESSDSSDSSDSSDSDSSDSS
                     DSSDSSDSSDSSDSSDSSDSSDSSDSSDSDSSDSDSSDSSDSSDSSDSSDSSDSSDSS
                     DSSNSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDS
                     SDSSDSSDSSDSSDSSDSSDSSDSSDSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSD
                     SSDSSNSSDSSDSSDGDSSDGDSSDSDSSDSDSSNSSDSDSSDSSDSSSSDSSDSDSD
                     SKDSTSDSSDDDSKSGNGNSDSDSDSEGSDSNHSTSDD"
     exon            67..153
                     /gene="Dspp"
                     /gene_synonym="Dsp; RDSP2"
                     /inference="alignment:Splign:2.1.0"
     exon            154..1092
                     /gene="Dspp"
                     /gene_synonym="Dsp; RDSP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..4398
                     /gene="Dspp"
                     /gene_synonym="Dsp; RDSP2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttattcataa tgaaaacgaa gataattata tatatttgca tttgggcaac cgcatgggcc
       61 attccggttc ctcagttagt gccgctggag agagacattg ttgaaaaatc tgccgacgta
      121 ccctttctag cacatccagg aaccgcagca cagaatgagt tgcatatcaa caaggccact
      181 aacgacagcg acagcgacga ttccccaaag ggcagtgagc taggaaggca ggtacactct
      241 aatgggggtt acgaaagaga caggaatggc tccgagtcga tagccgtagg agggaagagt
      301 tctcctactc agcccatttt agcaaacgca caggggaaca gtgctaaaga acgcgaagac
      361 gtagaaacat acggtcacga tgggatacac gcaggagaga acagcacagc aaacggcatc
      421 aggggccaat taggcatcgc tgaaaatgcc gaggaagcaa aggagagtaa ggtacacgag
      481 cagcctcatc aggatacaaa aactggcctt gccagtgaca cgagccagaa tggagacgcc
      541 acccttgtcc aggaaaatga gcctcaggta gccggaagca agaatagcac aaaccatgag
      601 gttggaacac acgggagtgg agttgctgca caggaaacga cgccgcagag agaaggggag
      661 gggagtgaga accagggggc tgaggtgaca ccaagcattg gggaaggtgc tggtttggat
      721 aatactgaag ggagtcctag cgggaacggg atagaggagg atgaagacac gggttctggt
      781 gatggtgtgg gtgcagacgc aggagatgga agggagagtc acgatggcac ggagggccac
      841 gagggccagt ctagtggggg aaacaatgac aacagaggtc agggttcagt tagtactgaa
      901 gacgatgact ctaaagaaca agaaggctcc ccaaatggac gtggtgggga caacacctcc
      961 agcagtgagg aaaccggtat tgaagaaggc gatggtaccc aaacaacaca ggacaaccag
     1021 aatctcagtc ccacagaggg tgggattatc agccaggcag aagcatgtcc ttctgggcag
     1081 agccaaaatc agggattaga aaccgaaggt tccagcacgg gcaacaaaag tagtattacc
     1141 aaagaatctg ggaagctcag tggaagtaaa gacagcaacg gacaccatgg aatggagctg
     1201 gacaaaagga atagcccaaa gcaaggggct gccgagaagt cagacaccca taataacatg
     1261 ggacacagca ggataggcag cagcagcaat agtgacgggc atgacagtta tgattttgac
     1321 gatgagtcca tgcaaggaga cgatcccaac agcagtgacg agtctaacgg aagtgacgga
     1381 agtgatgatg ctaactccga aagcgccaat gagaatggca accatggaga tgcttcttac
     1441 acctctgatg aatcaagcga taatggcggc gacagtgact catatgctgg agaggatgac
     1501 agcagtgatg acacatctga taccgatgac agtgacagta acggtgatga tgacagtgag
     1561 agtgaggaca aggacgaatc agacaacagt aaccacgaca atgacagtga cagtgagagc
     1621 aaatcagaca gcagcgacag tgacagtgac agcagtgaca gcagtgacag cagtgacagc
     1681 agtgacagca gtgacagtag cgacagcagc gaaagcagtg acagtagcga cagtagcgac
     1741 agcagcgaca gcagtgacag cagtgacagc agtgacagca gtgacagtag cgacagcagc
     1801 gacagtgaca gcaatgacag cagtgacagt agtgacagca gtgacagcag tgacagtagt
     1861 gacagcagtg aaagcagtga cagtagcgac agcagtgaca gcagtgacag cagcgaaagt
     1921 agcgaaagca gtgaaagcag tgacagtagt gacagcagtg acagtagcga cagcagtgac
     1981 agtagtgaga gcagcgaaag cagtgacagc agtgacagta gcgacagcag cgacagtgac
     2041 agcagtgaca gcagtgacag tagtgacagc agtgacagca gtgatagcag cgacagtagt
     2101 gatagcagtg acagcagtga cagcagtgac agcagcgaca gtgacagcag cgacagtgac
     2161 agcagtgaca gtagtgacag cagtgacagt agtgacagca gtgacagcag cgacagtagt
     2221 gacagtagtg acagcagcaa cagtgacagt agcgacagca gtgacagtag cgacagcagt
     2281 gacagtagtg acagcagtga cagcagtgac agcagtgaca gtagcgacag cagtgacagt
     2341 agtgacagca gtgacagcag cgacagcagt gatagcagtg acagcagtga cagcagtgac
     2401 agcagtgaca gtagtgacag cagtgacagc agtgacagca gtgatagcag tgacagcagt
     2461 gacagtagcg acagcagcga tagcaacagc agtgacagca gtgacagcag tgacagtagt
     2521 gacagcagcg acagcagtga cagtagtgac agtagtgaca gcagtgacag tagtgacagc
     2581 agtgacagca gcaacagcag tgacagcagt gacagcagcg atggtgacag cagtgacggt
     2641 gacagcagcg atagtgacag cagtgatagt gacagtagta acagcagtga tagtgacagc
     2701 agtgacagta gtgacagcag cagcagtgac agcagcgata gtgatagtga cagcaaggac
     2761 agcacttctg acagcagtga tgacgacagc aagtctggta atggcaacag tgacagcgac
     2821 agtgacagcg aaggcagtga cagtaaccac tcaaccagtg atgattagag cagagaaccc
     2881 cttgagatcc tctgtgtgac ctctggtgag tgataggaag gcagtgaagg ttcctaactc
     2941 aatgacaaga ggagagacga aaagattgtg tgaaacccac ggagctccca gggaatggag
     3001 ccgagctcca gctccctcag agagaatctg ggtgctccac ctttggtaca catgtgttag
     3061 aatatattca tgttcagaag atacttttaa aaaggataaa tctaaacata atacttaaac
     3121 aggaactgaa gtaatcactt accctgacac atagcttcga tttgaatggc gggtgcttta
     3181 gagagcagag caggcaacat cacaaccttc tgcagcctcc tccctcagtg ctccaggccc
     3241 cagagagcta gtcttcatgt tgtgcagtga gcaacgctgt tctgtgacac tctactcatc
     3301 tactctgtca tttactaatt ctggggaaaa atacatttaa gacatgagca aaacactgca
     3361 gcaactactg gtgctgggat aatctttgtg atgataaaat agctataatt tatgaaaatt
     3421 ctgaagaatg aatgagaaaa gagctcgagg atggcccgga cgagatctga cacatgctgt
     3481 taagtttctg tataggatgg aaatgtacta agcccccaac ccctgcattt tgaagtgtct
     3541 cgcttccagc aacggctctc gaatcttaaa taaatgagca acacggatgg atgatttcgg
     3601 gagtttggga tcatattctg agctctccac ataccactgt gttattagtt ttcttcaaat
     3661 cagtttcaca ggtcaaatag gctcacagtt taatcaagaa ttgtaaggct gtgcaggaga
     3721 agagagggac cctctttggg ctctagggct cttctgaaag caagagaggc ggtgagaaca
     3781 aaccacacca agacaggagg tgtgaactga gattgtcgca agaaaacctt aacccccaag
     3841 ccttaagaat atttttgaag atttaaggtt ttccctttgt catttcccta ttttctcacg
     3901 tcggcggtta tgccagattt gggttaaaac gaaaccatca acgacattat aacgatagtt
     3961 gtctctcttc tcacttcagg cttattttac tcagagtttc agaagagatt cctttcccct
     4021 gggtgctcac ctcccattct gagggtttct gagttaagga atattgctga ggctttcaca
     4081 cgctgctacc tgtaaacgca tctgtaaccc ccgacactgt aaagcgccag gtttctgcac
     4141 tgccacaggt gcgacctgac cccagaccac tcaccagaaa gcgatggttc aggctctgcc
     4201 ttctcttagg tggcaaactc tccttcgttt gcttcaactt gtgaagcacc tgcctgtagc
     4261 aacccccccc cccatcacac ccactcatca aagttgtgat caccaaaccc tgggtggaaa
     4321 actcattgta aactgtatgt gaaatctaaa ggaagagata atgaacttca gtattataat
     4381 aaacatctat ttatacaa
//
