LOCUS       NM_001419598            9491 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus desmoplakin (Dsp), mRNA.
ACCESSION   NM_001419598 XM_225259
VERSION     NM_001419598.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 9491)
  AUTHORS   Kam,C.Y., Dubash,A.D., Magistrati,E., Polo,S., Satchell,K.J.F.,
            Sheikh,F., Lampe,P.D. and Green,K.J.
  TITLE     Desmoplakin maintains gap junctions by inhibiting Ras/MAPK and
            lysosomal degradation of connexin-43
  JOURNAL   J Cell Biol 217 (9), 3219-3235 (2018)
   PUBMED   29959233
  REMARK    GeneRIF: Desmoplakin prevents lysosomal-mediated degradation of
            Cx43. Desmoplakin loss triggered robust activation of ERK1/2-MAPK
            and increased phosphorylation of S279/282 of Cx43, which signals
            clathrin-mediated internalization and subsequent lysosomal
            degradation of Cx43.
REFERENCE   2  (bases 1 to 9491)
  AUTHORS   Samuelov,L., Li,Q., Bochner,R., Najor,N.A., Albrecht,L.,
            Malchin,N., Goldsmith,T., Grafi-Cohen,M., Vodo,D., Fainberg,G.,
            Meilik,B., Goldberg,I., Warshauer,E., Rogers,T., Edie,S.,
            Ishida-Yamamoto,A., Burzenski,L., Erez,N., Murray,S.A.,
            Irvine,A.D., Shultz,L., Green,K.J., Uitto,J., Sprecher,E. and
            Sarig,O.
  TITLE     SVEP1 plays a crucial role in epidermal differentiation
  JOURNAL   Exp Dermatol 26 (5), 423-430 (2017)
   PUBMED   27892606
REFERENCE   3  (bases 1 to 9491)
  AUTHORS   Sharma,P., Abbasi,C., Lazic,S., Teng,A.C.T., Wang,D., Dubois,N.,
            Ignatchenko,V., Wong,V., Liu,J., Araki,T., Tiburcy,M., Ackerley,C.,
            Zimmermann,W.H., Hamilton,R., Sun,Y., Liu,P.P., Keller,G.,
            Stagljar,I., Scott,I.C., Kislinger,T. and Gramolini,A.O.
  TITLE     Evolutionarily conserved intercalated disc protein Tmem65 regulates
            cardiac conduction and connexin 43 function
  JOURNAL   Nat Commun 6, 8391 (2015)
   PUBMED   26403541
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9491)
  AUTHORS   Szabo,S., Wogenstein,K.L., Osterreicher,C.H., Guldiken,N., Chen,Y.,
            Doler,C., Wiche,G., Boor,P., Haybaeck,J., Strnad,P. and Fuchs,P.
  TITLE     Epiplakin attenuates experimental mouse liver injury by chaperoning
            keratin reorganization
  JOURNAL   J Hepatol 62 (6), 1357-1366 (2015)
   PUBMED   25617501
REFERENCE   5  (bases 1 to 9491)
  AUTHORS   Zanivan,S., Maione,F., Hein,M.Y., Hernandez-Fernaud,J.R.,
            Ostasiewicz,P., Giraudo,E. and Mann,M.
  TITLE     SILAC-based proteomics of human primary endothelial cell
            morphogenesis unveils tumor angiogenic markers
  JOURNAL   Mol Cell Proteomics 12 (12), 3599-3611 (2013)
   PUBMED   23979707
REFERENCE   6  (bases 1 to 9491)
  AUTHORS   Green,K.J., Stappenbeck,T.S., Noguchi,S., Oyasu,R. and Nilles,L.A.
  TITLE     Desmoplakin expression and distribution in cultured rat bladder
            epithelial cells of varying tumorigenic potential
  JOURNAL   Exp Cell Res 193 (1), 134-143 (1991)
   PUBMED   1995289
REFERENCE   7  (bases 1 to 9491)
  AUTHORS   Tsukita,S. and Tsukita,S.
  TITLE     Isolation of cell-to-cell adherens junctions from rat liver
  JOURNAL   J Cell Biol 108 (1), 31-41 (1989)
   PUBMED   2463257
REFERENCE   8  (bases 1 to 9491)
  AUTHORS   Nishikawa,S., Fujiwara,K. and Kitamura,H.
  TITLE     Formation of the tooth enamel rod pattern and the cytoskeletal
            organization in secretory ameloblasts of the rat incisor
  JOURNAL   Eur J Cell Biol 47 (2), 222-232 (1988)
   PUBMED   3149586
REFERENCE   9  (bases 1 to 9491)
  AUTHORS   Owaribe,K., Kartenbeck,J., Rungger-Brandle,E. and Franke,W.W.
  TITLE     Cytoskeletons of retinal pigment epithelial cells: interspecies
            differences of expression patterns indicate independence of cell
            function from the specific complement of cytoskeletal proteins
  JOURNAL   Cell Tissue Res 254 (2), 301-315 (1988)
   PUBMED   3058315
REFERENCE   10 (bases 1 to 9491)
  AUTHORS   Cowin,P., Kapprell,H.P. and Franke,W.W.
  TITLE     The complement of desmosomal plaque proteins in different cell
            types
  JOURNAL   J Cell Biol 101 (4), 1442-1454 (1985)
   PUBMED   2413044
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On Apr 12, 2023 this sequence version replaced XM_225259.10.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.54125.1,
                                           SRR26643287.33680.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-407               JAXUCZ010000017.1  26876715-26877121   c
            408-510             JAXUCZ010000017.1  26863024-26863126   c
            511-659             JAXUCZ010000017.1  26860331-26860479   c
            660-828             JAXUCZ010000017.1  26859222-26859390   c
            829-957             JAXUCZ010000017.1  26854622-26854750   c
            958-1008            JAXUCZ010000017.1  26853700-26853750   c
            1009-1170           JAXUCZ010000017.1  26852270-26852431   c
            1171-1275           JAXUCZ010000017.1  26850911-26851015   c
            1276-1371           JAXUCZ010000017.1  26850076-26850171   c
            1372-1497           JAXUCZ010000017.1  26848988-26849113   c
            1498-1650           JAXUCZ010000017.1  26848383-26848535   c
            1651-1805           JAXUCZ010000017.1  26846350-26846504   c
            1806-1932           JAXUCZ010000017.1  26845498-26845624   c
            1933-2134           JAXUCZ010000017.1  26844410-26844611   c
            2135-2361           JAXUCZ010000017.1  26843334-26843560   c
            2362-2528           JAXUCZ010000017.1  26842157-26842323   c
            2529-2667           JAXUCZ010000017.1  26841706-26841844   c
            2668-2861           JAXUCZ010000017.1  26840612-26840805   c
            2862-3024           JAXUCZ010000017.1  26839386-26839548   c
            3025-3108           JAXUCZ010000017.1  26838735-26838818   c
            3109-3216           JAXUCZ010000017.1  26837894-26838001   c
            3217-3315           JAXUCZ010000017.1  26837242-26837340   c
            3316-5610           JAXUCZ010000017.1  26834099-26836393   c
            5611-9491           JAXUCZ010000017.1  26829153-26833033   c
FEATURES             Location/Qualifiers
     source          1..9491
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p12"
     gene            1..9491
                     /gene="Dsp"
                     /gene_synonym="DP"
                     /note="desmoplakin"
                     /db_xref="GeneID:306871"
                     /db_xref="RGD:1305794"
     exon            1..407
                     /gene="Dsp"
                     /gene_synonym="DP"
                     /inference="alignment:Splign:2.1.0"
     CDS             211..8844
                     /gene="Dsp"
                     /gene_synonym="DP"
                     /codon_start=1
                     /product="desmoplakin"
                     /protein_id="NP_001406527.1"
                     /db_xref="GeneID:306871"
                     /db_xref="RGD:1305794"
                     /translation="MSCNGGSHPRINTLGRMTRAESGPDLRYEMTYSGGGGGGGGGGG
                     GTSRMYYSRRCTVNDQNSDGYCQTGTMSRHQNQNTIQELLQNCADCLMRAELIAQPEL
                     KFGEGIQLAWNRELDEYFTQANDQMEIIDGLIREMRQMGQPCDAYQKRLLQLQEQMRA
                     LYKAISAPRVRRASSKGGYTCQSGSGWDEFTKRLTGECLGWMRQQRAEMDLMAWGVDS
                     GSVEQHINSHRSIHNAIGDYRWQLDKIKADLREKSAIYQLEEEYENLLKASFERMDHL
                     RQLQNIIQATSREIMWINDCEEEELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELN
                     KLKQESDQLVLNQHPASDKIEAYMDTLQTQWSWILQITKCIDVHLKENAAYFQFFEEA
                     QSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQIKELEKEREKILEYKRQVQNLVNKSK
                     KIVQLKPRNPDYRSNKPIILRALCDYKQDQKIVHKGDECILKDNNERSKWYVTGPGGV
                     DMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILALWNQLYINMKSLVSWHYCMIDIEK
                     IRAMTIAKLKTMRQEDYMKTIEDLELHYQDFIKNSQGSEMFGDDDKRRMQSQFTDAQK
                     HYQTLVIQLPGHPQHQTVTKTEITHVGTCQDVNHNKVIETNRENDKQETWLLMELQKI
                     RRQMEHCEARMTLKNLLLTDQGSTHNITVKINELKSVQNDSQALAEVLNQLKDMLANF
                     RGSEKYCYLQNEIFGLFQKLENINGVTDGYLNSLCSVRALLQAILQTEDMLKVYEARL
                     TEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQKAQQIHSQSSQQYPLY
                     DLDLGKFTEKVTQLTDRWQKIDKQIDFRLWDLEKQIKQLRNYRDNYQSFCKWLYDAKR
                     RQDSLESMKFGDSNTVMRFLNEQKNLHNEISGKRDKSEEVHKIAELCANSIKDYELQL
                     ASYTSGLETLLNIPIKRTMVQSPSGVILQEAADIHARYIELLTRSGDYYRFLSEMLKS
                     LEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLVSLEE
                     LKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKTVEDRFDQQKNDY
                     DQLQKARQCEKESLGWQKLESEKAIKEKEYEIERLRVLLQEEGARKREYENELAKVRN
                     HYNEEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVR
                     LNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEVELKQVIQQRSEDNARHKQSL
                     EEAAKTIQDKNKEIERLKAEYQEEAKRRWEYENELSKVRNSYDEEIISLRNKFETEIN
                     ITKTTIHQLTMQKEEDTSGYRAQIDNLTRENRSLSEEVKRLKNTLAQTTENLRRVEEN
                     VQQQKASGSEMSQRKQQLEIELRQVSQMRTEESMRYKQSLDDAAKTIQDKNKEIERLK
                     QLVDKETNERKCLEDENSKLQRVQYDLQKANNSATEAMSKLKVQEQELTRLRIDYERV
                     SQERTVKDQDITRIQSSLKDLQLQKQKAEEELSRLKRTASDESSKRKMLEEELEAMRR
                     SLKEQAVKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHVREKQRTQEELRRLSLDV
                     EALRRQLVQEQENVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLM
                     LEEELRNLRLEYDDLRRGRSEADNDKNSTISELRSQLQISNNRTLELQGLINDLQRER
                     ENLRQEIEKFQKQALEASNRIQESKSQCTQVVQERESLLVKIKVLEQDKARLQRLEDE
                     LNRAKATLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEETIRKIESEREKSEREKN
                     SLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERCRLQKEIDKLRQRPYGSHR
                     ETQTEYEWTVDSSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQ
                     PFLRGAGAIAGASASPKEKYSLVEAKRKKFITPESTVMLLEAQAATGGIIDPHRNEKL
                     TVDNAIARDLIDFDDRQQIYTAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLL
                     EAQLASGGVVDPVNSVFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPITKKKVSY
                     MQLRERCRIEPHTGLLLLSVQKRSMSFQGIRQPVTVTELVDSGILRPSTVNELESGQI
                     SYDEVGERIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATG
                     FIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKE
                     LIEKGHGIRLLEAQIATGGIIDPKESHRLPVDMAYKRGYFNEELSEILSDPSDDTKGF
                     FDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVVIVDPET
                     NKEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQYDIQ
                     DAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSGLSGSVNDDVFSSSRHES
                     VSKISTISSVRNLTIRSSSLSDPLEESSPIAAIFDTENLEKISITEGIERGIVDSITG
                     QRLLEAQACTGGIIHPTTGQKLSLQDAVSQGLIDQDMATRLKPAQKAFIGFEGVKGKK
                     KMSAAEAVKEKWLPYEAGQRFLEFQFLTGGLVDPEVHGRISTEEAIRKGFIDGRAAQR
                     LQDISSYAKILTCPKTKLKISYKDAMNRSMVEDITGLRLLEAASVSSKGLPSPYNMSA
                     PGSRSGSRSGSRSGSRSGSRSGSRRGSFDATGNSSYSYSYSFSSSSIGY"
     exon            408..510
                     /gene="Dsp"
                     /gene_synonym="DP"
                     /inference="alignment:Splign:2.1.0"
     exon            511..659
                     /gene="Dsp"
                     /gene_synonym="DP"
                     /inference="alignment:Splign:2.1.0"
     exon            660..828
                     /gene="Dsp"
                     /gene_synonym="DP"
                     /inference="alignment:Splign:2.1.0"
     exon            829..957
                     /gene="Dsp"
                     /gene_synonym="DP"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1008
                     /gene="Dsp"
                     /gene_synonym="DP"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1170
                     /gene="Dsp"
                     /gene_synonym="DP"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1275
                     /gene="Dsp"
                     /gene_synonym="DP"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1371
                     /gene="Dsp"
                     /gene_synonym="DP"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..1497
                     /gene="Dsp"
                     /gene_synonym="DP"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..1650
                     /gene="Dsp"
                     /gene_synonym="DP"
                     /inference="alignment:Splign:2.1.0"
     exon            1651..1805
                     /gene="Dsp"
                     /gene_synonym="DP"
                     /inference="alignment:Splign:2.1.0"
     exon            1806..1932
                     /gene="Dsp"
                     /gene_synonym="DP"
                     /inference="alignment:Splign:2.1.0"
     exon            1933..2134
                     /gene="Dsp"
                     /gene_synonym="DP"
                     /inference="alignment:Splign:2.1.0"
     exon            2135..2361
                     /gene="Dsp"
                     /gene_synonym="DP"
                     /inference="alignment:Splign:2.1.0"
     exon            2362..2528
                     /gene="Dsp"
                     /gene_synonym="DP"
                     /inference="alignment:Splign:2.1.0"
     exon            2529..2667
                     /gene="Dsp"
                     /gene_synonym="DP"
                     /inference="alignment:Splign:2.1.0"
     exon            2668..2861
                     /gene="Dsp"
                     /gene_synonym="DP"
                     /inference="alignment:Splign:2.1.0"
     exon            2862..3024
                     /gene="Dsp"
                     /gene_synonym="DP"
                     /inference="alignment:Splign:2.1.0"
     exon            3025..3108
                     /gene="Dsp"
                     /gene_synonym="DP"
                     /inference="alignment:Splign:2.1.0"
     exon            3109..3216
                     /gene="Dsp"
                     /gene_synonym="DP"
                     /inference="alignment:Splign:2.1.0"
     exon            3217..3315
                     /gene="Dsp"
                     /gene_synonym="DP"
                     /inference="alignment:Splign:2.1.0"
     exon            3316..5610
                     /gene="Dsp"
                     /gene_synonym="DP"
                     /inference="alignment:Splign:2.1.0"
     exon            5611..9491
                     /gene="Dsp"
                     /gene_synonym="DP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctctgagccc tcgctgccct ccgagccaca gctccgctcc ggttcccgcg ctcagacgcc
       61 agtcgccgtc cccgtctccg ccctgctgga gcgctgctcc ccggccagtc ctccgcgtcc
      121 cgcgctcctc tccgggagtc cctcgcgtgc tccgaggcga cgcctcgcgt atgccgcggc
      181 gctgagcggc tctcttgagt gaccgcagac atgagctgca acggcggctc ccacccgcgg
      241 atcaacacgc tgggtcgcat gacccgcgcg gagtccggcc ccgacctgcg ctacgagatg
      301 acctacagcg gaggcggcgg cgggggcggc ggcggcggcg gtggcaccag caggatgtac
      361 tactcccggc gctgcactgt caacgaccag aactccgacg gctactgtca aaccggcacc
      421 atgtccaggc atcagaacca gaacactatc caagaacttc tgcaaaactg cgcagactgt
      481 ctgatgcggg cagagctgat cgcacagccg gaactgaagt tcggagaagg aatccagctg
      541 gcgtggaaca gagaactgga tgagtatttc actcaagcca atgatcagat ggaaatcata
      601 gatggcttga tccgggagat gaggcagatg ggccagccct gtgatgcgta tcagaaaaga
      661 ctgcttcagc tccaggaaca gatgcgagcc ctgtacaagg ccatcagtgc ccctcgagtg
      721 cgaagggcca gctccaaggg agggtacact tgtcagagtg gctccgggtg ggatgaattc
      781 accaaacgcc tgacgggcga gtgcctgggc tggatgaggc agcagagggc ggaaatggac
      841 ctgatggcct ggggtgtgga ctctggttca gtggagcagc acatcaacag ccacaggagt
      901 atccacaatg ccatcggaga ctaccgctgg caactggaca agatcaaagc agacctgcgt
      961 gagaagtccg caatctatca attggaggag gaatatgaaa acctgctgaa agcctccttc
     1021 gagaggatgg accacctgcg ccagttgcaa aacatcatcc aggccacctc gagagagatc
     1081 atgtggatca atgactgtga ggaggaggag ctgctgtatg actggagcga caagaacaca
     1141 aacatcgctc agaagcagga ggccttctct atccgcatga gtcaactgga agtcaaggaa
     1201 aaggagctca acaagcttaa acaagaaagt gaccaacttg tcctcaatca gcatccagcg
     1261 tcagacaaaa tcgaggcata tatggatact cttcagacac agtggagttg gattctgcaa
     1321 atcaccaagt gcatcgatgt ccacctcaaa gaaaatgctg cctactttca gttttttgaa
     1381 gaggcccagt caactgaagc ctacctgaag ggactgcagg actccatcag gaagaaatac
     1441 ccctgtgaca agaacatgcc cctccagcac ctgctggagc agatcaaaga gctggagaaa
     1501 gaacgggaga agatcctgga atacaagcgt caggtgcaga acttggtgaa caagtccaag
     1561 aagatcgtgc agctgaagcc tcggaaccca gactacagaa gcaacaaacc cattattctc
     1621 agggccctct gcgactacaa acaagaccag aaaatcgtcc acaaggggga tgaatgcatc
     1681 ctcaaggaca acaatgagcg cagcaagtgg tacgtgaccg gccccggagg cgttgacatg
     1741 cttgtccctt ctgtgggcct gatcatccct cctccaaacc cactggctgt ggacctttct
     1801 tgcaagattg agcagtacta tgaagccatc ttggctctgt ggaaccagct ctacatcaac
     1861 atgaagagcc tggtgtcttg gcattactgt atgattgaca tcgagaagat cagagccatg
     1921 actattgcca agctgaaaac catgagacag gaagattaca tgaagaccat tgaagacctg
     1981 gagctccatt accaagactt catcaaaaac agccaaggct cggagatgtt cggagacgat
     2041 gacaaacgga ggatgcagtc tcagttcact gatgcccaga agcattacca gaccctggtc
     2101 attcagcttc ctggccaccc ccagcaccag acagtcacca aaactgaaat cactcacgtg
     2161 ggtacctgcc aggatgtcaa ccacaataaa gtaattgaga ctaacagaga gaacgacaaa
     2221 caggagacgt ggctgctgat ggagctgcag aagatccgca ggcagatgga gcactgcgag
     2281 gccagaatga cactcaaaaa tctgctgctc acagaccagg gctctacaca caacatcacc
     2341 gtgaaaatca acgagctcaa gagtgtacag aacgactcac aagctctggc cgaggttctc
     2401 aatcagctta aagacatgct tgccaacttc cgagggtctg aaaagtactg ctatttacag
     2461 aatgagatat ttggactatt tcagaagctg gaaaatatca atggtgtcac agatggctac
     2521 ttaaacagcc tgtgctctgt gagagccctt ctccaggcaa ttctgcaaac ggaagacatg
     2581 ttgaaggtct acgaagcgag gctgacggag gaggaaactg tctgtctgga cctggataaa
     2641 gtggaggctt accgctgcgg gctgaagaaa ataaaaaatg acttgaactt gaaaaagtca
     2701 ctgttggcca ccatgaagac ggagctgcag aaggcacagc agattcactc ccagtcttca
     2761 cagcagtacc cgctctatga cctggacctg ggcaaattca ctgagaaagt gacacagctg
     2821 acggatcgct ggcaaaagat agataagcag atagacttta gattgtggga cctggagaaa
     2881 caaatcaaac aactgaggaa ttatcgtgac aactatcaga gcttctgcaa gtggctgtat
     2941 gatgccaaac gccgccagga ctctttggag tccatgaagt tcggagattc caacacagtc
     3001 atgcggtttt tgaatgagca gaagaacctg cacaatgaaa tatctggcaa acgggataaa
     3061 tcagaagaag tacataaaat tgctgagctt tgcgcaaact caattaagga ttatgaactc
     3121 cagctggcgt catacacctc agggctggaa actctactga acatacctat taagaggacc
     3181 atggttcagt ccccatctgg ggtaattctg caagaggctg cggacatcca tgcaaggtac
     3241 atcgagctac ttacaaggtc tggagactac tacagattct taagtgagat gctgaagagc
     3301 ctagaagatc tgaagctgaa aaacaccaag attgaagttt tggaagagga gctaagactg
     3361 gcccgggatg ccaactcgga aaattgcaat aagaataagt tcctagatca gaacctgcag
     3421 aaataccagg ccgagtgttc ccagttcaaa gcaaagcttg tgagcctgga ggagctgaag
     3481 agacaagctg agctggatgg gaagtcagcc aagcaaaacc tagacaagtg ctacggtcag
     3541 atcaaagagc tcaatgaaaa gatcacccgg ctgacctatg agatcgaaga cgagaagcgc
     3601 aggagaaaga ccgtggagga caggttcgac caacagaaga atgactatga tcagctgcag
     3661 aaggcaaggc agtgtgaaaa ggagagcctt ggctggcaga agctggagtc tgagaaagcc
     3721 atcaaggaga aggagtacga gatagagagg ttgagggttc tgctgcagga agagggcgcc
     3781 cggaagagag aatatgaaaa tgagctggca aaggtaagaa accactataa tgaggagatg
     3841 agtaatttaa ggaacaagta tgaaacagag attaacatca ccaagaccac catcaaggag
     3901 atatccatgc agaaggaaga tgattccaag aatctcagaa accagcttga cagactgtcc
     3961 cgggagaaca gagatcttaa agacgagata gtcaggctca atgacagcat cttgcaggcc
     4021 acagagcagc gaaggcgagc tgaggaaaac gcccttcagc agaaagcctg tggctcagaa
     4081 atcatgcaga agaagcaaca cctggaggtt gaactgaagc aggtcatcca gcagcgctca
     4141 gaggacaatg ccaggcacaa gcagtccctg gaggaggctg ccaagacaat tcaggacaaa
     4201 aataaagaga tcgaaagact caaagctgag tatcaggagg aggccaagcg tcgctgggaa
     4261 tacgaaaatg aactgagtaa ggtaaggaac agttacgatg aggagatcat tagcttaaga
     4321 aacaagttcg agactgagat caacatcacc aagaccacca tccaccagct gaccatgcaa
     4381 aaggaagagg ataccagcgg ctaccgagct cagatagaca acctcacccg ggagaacagg
     4441 agcctgtctg aggaggtaaa gaggctaaag aacactctag cccagaccac cgagaacctc
     4501 aggagggttg aagagaatgt ccagcagcaa aaggccagtg gctcagagat gtctcagagg
     4561 aaacagcagt tggagatcga gctccgacag gtcagtcaga tgcggaccga agagagcatg
     4621 aggtacaagc agtccctcga tgatgctgcc aagacgatcc aagataaaaa caaggagatt
     4681 gaaaggctca aacagctggt agacaaagag accaatgaga ggaaatgcct ggaggacgaa
     4741 aattccaagt tgcagagagt gcagtatgac ctgcagaaag ccaacaacag cgccacggag
     4801 gccatgagca agctgaaggt tcaggaacag gaactgacac gcctgcggat tgactatgag
     4861 agggtttccc aggagaggac cgtgaaggat caggacatca cgaggatcca aagctccctg
     4921 aaggatctgc agctgcagaa gcagaaagca gaagaggagc tgagtaggct gaagagaacg
     4981 gcctccgacg agtcctccaa gaggaagatg ctggaggagg agctggaggc catgaggagg
     5041 tctttgaaag agcaagcggt caagatcacc aacctgaccc agcagctgga gcaggcatcc
     5101 attgttaaga agaggagcga ggatgatctc aggcagcaga gggatgtgct ggatggccat
     5161 gtgagggaga agcagaggac ccaggaggag ctgaggaggc tctccttgga tgtagaggcc
     5221 cttcggcggc agctcgtgca ggaacaggaa aatgtcaagc aggctcactt gaggaatgag
     5281 catttccaga aggccataga agacaaaagc aggagcctca atgaaagtaa aatagagatt
     5341 gaaaggctac agtctctcac ggagaacctg accaaggagc atttgatgct ggaggaggag
     5401 ctgcggaacc tgaggctgga atacgacgac ctacggaggg gccgaagcga agcagataac
     5461 gataaaaact caaccatttc ggagctaagg agccagctgc agatcagcaa caatcgaacc
     5521 ctggaactgc aggggctgat taatgattta cagagagaga gggaaaattt gagacaggaa
     5581 attgagaaat tccaaaagca ggctttagag gcatctaata ggattcagga gtcaaagagt
     5641 cagtgcactc aagtcgttca ggagagagag agcctgctgg tgaagattaa ggtcctggag
     5701 caagacaagg caaggctgca gcggctggag gacgagctga accgtgccaa agcaacgctg
     5761 gaggcagaaa cccgggtgaa acagcgccta gagtgtgaga agcagcagat ccagaacgac
     5821 ctgaaccagt ggaaaactca atactcccgc aaggaggaga ccattaggaa gatagagtcg
     5881 gaaagagaga agagtgagag agagaagaac agtcttagga gtgagattga gagactccag
     5941 gcagagatca agaggattga agagaggtgc aggcggaagc tagaggattc taccagggag
     6001 actcagtccc agctggaaac ggaacgctgc aggcttcaga aggagattga caaactcagg
     6061 cagcgcccct atgggtccca tcgggagacc cagacagagt acgagtggac cgttgattcc
     6121 tccaagctgg tatttgacgg actgaggaag aaggtgacag caatgcagct ctatgagtgc
     6181 cagttgattg acaagacaac actggacaag ctattgaagg ggaagaagtc agtggaggag
     6241 gtggcttcag agatccagcc tttcctgcgg ggtgcggggg ccatcgctgg tgcttctgct
     6301 tctcccaagg aaaaatactc tttggtggag gccaagagaa agaaattcat caccccagaa
     6361 tccacagtca tgcttctgga ggcccaggcg gccactggtg gtatcatcga tccccatcgg
     6421 aatgagaagc tcacggtgga caatgccata gctcgggacc tcattgactt tgatgaccgc
     6481 caacagatct acacagccga gaaagccatc actggttttg atgacccgtt ttcaggcaag
     6541 accgtatctg tttcagaagc catcaagaag aatttgattg acagagaaac cggaatgcgc
     6601 ctgctggaag cccagcttgc ttcagggggt gtagttgatc cagtcaacag tgtctttttg
     6661 ccaaaagatg tagccttggc ccgtgggctg attgataggg atttgtatcg ctccttgaat
     6721 gacccccgag atagccagaa gaacttcgtg gatccaatca ccaagaagaa ggtcagctac
     6781 atgcagctga gagaacggtg cagaatcgaa ccccacacgg gtctgctcct gctgtcagta
     6841 cagaagagaa gcatgtcctt ccaaggaatc agacagccag tgaccgtcac cgaactggtt
     6901 gattctggca tattgagacc atccaccgta aatgaactgg aatctggtca gatttcttat
     6961 gacgaggttg gcgagagaat taaggacttc ctccaggggt caagctgcat agcaggtatt
     7021 tataatgaga ccacgaaaca gaagcttggc atctacgagg ctatgaaaat tggcttagtt
     7081 cgacctggta ccgctctgga gttgctggaa gcccaagcag ctactggttt tatagtagat
     7141 cctgtcagca atttaaggtt acctgtggag gaagcctaca aaagaggtct ggtgggcatt
     7201 gagttcaaag agaagcttct ctctgcagaa cgagctgtca ctggctataa cgatcctgaa
     7261 accggaaaca tcatctcttt gttccaagcg atgaacaagg aactcatcga aaagggccac
     7321 ggaattcgct tactggaggc tcagatcgca accggcggta tcattgatcc aaaggagagt
     7381 catcggttac cggttgacat ggcttataag aggggctatt ttaacgagga gcttagcgaa
     7441 atcctctcag acccaagtga tgataccaaa ggctttttcg atcccaacac tgaagaaaac
     7501 ctcacctatt tgcaactgaa agaaaggtgc atcaaagatg aggagacggg gctctgcctg
     7561 ctgcctctga aagaaaagaa gaaacaggtg cagacttcac agaagaacac cctcagaaag
     7621 cggcgggtgg taatagttga cccagaaacc aacaaagaga tgtctgttca ggaggcgtac
     7681 aagaaaggcc ttattgatta tgaaaccttc aaagagctgt gtgagcagga gtgtgaatgg
     7741 gaagaaataa ccatcacggg ttcggatggc tccaccaggg tagtcctagt agacaggaag
     7801 acgggcagtc agtatgacat tcaagatgct attgacaaag gcctcgtcga caggaagttc
     7861 ttcgatcaat accgatccgg cagcctcagc ctcacgcagt ttgcggacat gatctccttg
     7921 aagaatggcg ttggcaccag cagcggcttg agcgggagtg tcaacgatga tgtgtttagc
     7981 agctctcgac acgaatccgt gagtaagatt tccaccatat ccagcgtcag aaatttaacc
     8041 atccgaagca gctctctgtc tgaccccctg gaggagtcaa gccccattgc ggccatcttt
     8101 gacacagaaa acctggagaa aatctccatt acagaaggta tagagcgggg cattgtggat
     8161 agcatcactg gtcagaggct tctggaagct caggcctgca cgggtggcat catccaccct
     8221 accaccggtc agaagctgtc ccttcaagac gcagtctccc agggtctcat tgaccaagac
     8281 atggccacca ggctgaagcc cgcccagaag gccttcattg gctttgaagg tgtcaaagga
     8341 aagaagaaga tgtcagcagc agaggcagtg aaagaaaaat ggctgcccta cgaggcaggc
     8401 cagcgcttcc tggagttcca gttcctcacc ggaggccttg ttgacccgga agtacatggg
     8461 aggatcagca ccgaagaagc catccgcaaa ggtttcatcg atggccgtgc agctcagagg
     8521 ttgcaggaca tcagcagcta tgccaaaatc ctcacctgcc ccaaaaccaa attaaaaatc
     8581 tcctacaagg atgccatgaa tcgctccatg gtggaagaca tcactgggct gcgccttctg
     8641 gaagccgcct ccgtgtcctc gaagggtttg cctagccctt ataacatgtc ggccccaggc
     8701 tcccgctctg gctcgaggtc cggatctcgc tcaggctccc gctctggttc ccgtagtggg
     8761 tctcgaagag gaagcttcga tgcgaccggg aattcctcct actcctattc ctattcattt
     8821 agcagtagct ccattgggta ctagttggtc agaagtagtt gccatgcctt agaatcattt
     8881 gtatgaattt ctactttatc ttaaaaaaaa caaagaaaac ctggtgcttg aggtatagcc
     8941 gtagaaccct ctgtgcttaa aacatagctg caagagaatt ccgatagtaa aggttcgctt
     9001 agctctgtag ttttcagctc aaccaatgga cttccatata gtgaatgaga agtggtgagg
     9061 atagcacacg ttgaattggg aatttacttc ctccatattt tgatcaattc tctgtaactt
     9121 ttcttggcct ataaggtcca atttctgtgt ctggagatat aagagattac actgactact
     9181 ggtgtcttgg tccttatgtt gcctctcact taaatagttc cactttctgc cttaggagca
     9241 aactggcccc tccccactcc aagtagtttg gcccaagttt cctttagttt gcggacatag
     9301 attgaatcac ccatatattc ttgaatacac ttgtttggtt tggtattact ctgactaggt
     9361 tcataatagc gcagtctttg ccttttgtta gccaaggttt tctgtttatt tggcttgtca
     9421 ttttccatgt gctttaaaaa ggtgtcttta tgaagtttgc tgttctgaca ataaactttt
     9481 agactttgga a
//
