LOCUS       NM_001025768            2002 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus DSN1 component of MIS12 kinetochore complex
            (Dsn1), mRNA.
ACCESSION   NM_001025768 XM_575278
VERSION     NM_001025768.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2002)
  AUTHORS   Sun C, Huang S, Ju W, Hou Y, Wang Z, Liu Y, Wu L and He X.
  TITLE     Elevated DSN1 expression is associated with poor survival in
            patients with hepatocellular carcinoma
  JOURNAL   Hum Pathol 81, 113-120 (2018)
   PUBMED   30136646
REFERENCE   2  (bases 1 to 2002)
  AUTHORS   Chuang TP, Wang JY, Jao SW, Wu CC, Chen JH, Hsiao KH, Lin CY, Chen
            SH, Su SY, Chen YJ, Chen YT, Wu DC and Li LH.
  TITLE     Over-expression of AURKA, SKA3 and DSN1 contributes to colorectal
            adenoma to carcinoma progression
  JOURNAL   Oncotarget 7 (29), 45803-45818 (2016)
   PUBMED   27329586
REFERENCE   3  (bases 1 to 2002)
  AUTHORS   Kline SL, Cheeseman IM, Hori T, Fukagawa T and Desai A.
  TITLE     The human Mis12 complex is required for kinetochore assembly and
            proper chromosome segregation
  JOURNAL   J Cell Biol 173 (1), 9-17 (2006)
   PUBMED   16585270
REFERENCE   4  (bases 1 to 2002)
  AUTHORS   Cheeseman IM, Niessen S, Anderson S, Hyndman F, Yates JR 3rd,
            Oegema K and Desai A.
  TITLE     A conserved protein network controls assembly of the outer
            kinetochore and its ability to sustain tension
  JOURNAL   Genes Dev 18 (18), 2255-2268 (2004)
   PUBMED   15371340
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC098027.1.
            
            [WARNING] On Mar 20, 2024 this sequence was replaced by
            NM_001025768.2.
            
            On Jul 22, 2005 this sequence version replaced XM_575278.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098027.1, SRR8487227.286026.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2002
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..2002
                     /gene="Dsn1"
                     /note="DSN1 component of MIS12 kinetochore complex"
                     /db_xref="GeneID:499933"
                     /db_xref="RGD:1565179"
     exon            1..67
                     /gene="Dsn1"
                     /inference="alignment:Splign:2.1.0"
     exon            68..93
                     /gene="Dsn1"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..1115
                     /gene="Dsn1"
                     /note="DSN1, MIND kinetochore complex component, homolog;
                     DSN1, MIS12 kinetochore complex component; DSN1 homolog,
                     MIS12 kinetochore complex component"
                     /codon_start=1
                     /product="kinetochore-associated protein DSN1 homolog"
                     /protein_id="NP_001020939.1"
                     /db_xref="GeneID:499933"
                     /db_xref="RGD:1565179"
                     /translation="MTSVTKSEDQGPTMSETQDRPLQPSLEPLEALPRSSAYQEMMAQ
                     GTSEEQNHLGRSPREGEGCGADPQEGPQLRSFHLSPQEQSARHRDRRQSWRRASMKEI
                     NRRKSLAPFHPGITELSRSISMKLAQSQRLGALLLSSFQFSVEKLEPFLKNTKDFSLE
                     CFRAKASSLSEELKHFTDRLGNDGTLQKCFVEDSKEKAPDFSLEASVAEVKEYITKFS
                     LERQAWDRLLLQYQNEVPPEEMPRGSTETKINEVNVDPAAYLRSSQKEVLNTKPDYQR
                     IVQSQNEVFAYMELVMDELQGAVKQLQAFMDESTQYLQKVSVQLKKRSMEQLDSSPAR
                     KLLKLHLQSSSTTQ"
     exon            94..417
                     /gene="Dsn1"
                     /inference="alignment:Splign:2.1.0"
     exon            418..491
                     /gene="Dsn1"
                     /inference="alignment:Splign:2.1.0"
     exon            492..564
                     /gene="Dsn1"
                     /inference="alignment:Splign:2.1.0"
     exon            565..655
                     /gene="Dsn1"
                     /inference="alignment:Splign:2.1.0"
     exon            656..715
                     /gene="Dsn1"
                     /inference="alignment:Splign:2.1.0"
     exon            716..793
                     /gene="Dsn1"
                     /inference="alignment:Splign:2.1.0"
     exon            794..941
                     /gene="Dsn1"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1029
                     /gene="Dsn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1975
                     /gene="Dsn1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagcgcggaa cctggaacta gactaacggg gaagaccacc ctctgtggtg acgcccagtc
       61 tgcagaggat gacttcggtg accaaatcag aagaccaggg accaacgatg tcggagactc
      121 aggatcgtcc attgcaacca agtctcgagc ctttggaagc attgcctcga tcctctgcct
      181 accaggaaat gatggcacaa ggcacttcag aggaacaaaa ccaccttggc cggagcccca
      241 gagaggggga aggttgtggt gctgaccccc aggagggacc tcagttgagg tcctttcatt
      301 tgtctcctca agaacagtct gcccgtcaca gagacagaag gcagtcctgg aggcgagcaa
      361 gcatgaaaga gataaaccgg cggaagtcgt tggctccttt tcacccgggc atcacagagc
      421 tcagcaggtc aatcagtatg aagttagcac agagccaacg gcttggcgcc ctcctgctct
      481 ccagcttcca gttctctgtt gaaaaacttg aacctttctt aaagaacact aaggacttca
      541 gccttgaatg ttttagagcc aaagcatctt ctctctctga agaattgaaa cattttacag
      601 acaggctggg aaatgatgga actctacaaa aatgttttgt tgaagattca aaagaaaaag
      661 caccagattt ctcactggaa gcatcagtag ctgaggtgaa agaatatata acaaagtttt
      721 ctttagagcg tcaggcctgg gatcggctct tactgcagta ccagaacgag gttccacctg
      781 aagagatgcc cagaggatca actgaaacca aaatcaatga agtgaatgtg gacccggcag
      841 cctacctcag gtcttcccag aaggaagttc tgaacacgaa acccgactat cagagaatag
      901 tgcagagtca gaatgaagtc tttgcctata tggaattagt gatggatgag ctacaaggag
      961 cagtgaagca gctgcaagcc ttcatggatg aaagtactca gtacctccag aaggtgtcag
     1021 tacagctcaa gaagagaagt atggagcagt tagattcttc acctgctcga aaactgctca
     1081 agctccatct acagagctca tctaccaccc agtgatcagg atcctgtcag ggatcttacc
     1141 tcacagcact cagctgggaa gtcctggccc tgcagcactt tcactgttcc tgagtgactg
     1201 catatctgta tccagaagag agtgttaagg acacttttgt aatagtgtgc aagatgctta
     1261 aaatgacctt cagaaccatt gctctaaata tcttcatggt cagcgctttt catcccataa
     1321 aacgatccaa agacatctag aactaacctt aaggcaatgt tttaggggcc acggtagatt
     1381 gtcggcataa aagactgatg ctaaagtttg agtgtgggac taaaggcaga ttataggagg
     1441 ttgtcacata acgggtgtgc gtggacactt ttaaaatgtc cattttctga agtgtcctaa
     1501 tgtctgtaga gtgctttagt ttttaatatt gaattgaatt cctttgggaa ttcccctgcc
     1561 tccctaagaa ttgagcccag ggctttgtga gtactaggga aacactctca tgaagctgca
     1621 tcttcagtcc ccatggtttt tgtcttttta agttctagtt cctgagtggc acctggacca
     1681 taatagccct gtgagctgta ttttaaaaac catgtgttgt catttcctgt gactgagata
     1741 tagtcacttg acctcttatc tagaacatta gaagggtgtt agaagctatg ctgtaaggac
     1801 actgtaagga ttcgtttaaa gagtaaaagc ctagaacaat gttgttgaag atttaaaaat
     1861 gagtagacag tagttaatga ggtgaaaaag ctaatatcta atttggaata ccacatggag
     1921 agctcaagca gatacatata aagtctggat tagaaataaa tttaagttat gtctaaaaaa
     1981 aaaaaaaaaa aaaaaaaaaa aa
//
