LOCUS       NM_199490               4947 bp    mRNA    linear   ROD 18-FEB-2024
DEFINITION  Rattus norvegicus desmoglein 4 (Dsg4), mRNA.
ACCESSION   NM_199490 XM_226115
VERSION     NM_199490.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4947)
  AUTHORS   Moreno-Sosa,T., Sanchez,M.B., Pietrobon,E.O., Fernandez-Munoz,J.M.,
            Zoppino,F.C.M., Neira,F.J., Germano,M.J., Cargnelutti,D.E.,
            Innocenti,A.C., Jahn,G.A., Valdez,S.R. and Mackern-Oberti,J.P.
  TITLE     Desmoglein-4 Deficiency Exacerbates Psoriasiform Dermatitis in Rats
            While Psoriasis Patients Displayed a Decreased Gene Expression of
            DSG4
  JOURNAL   Front Immunol 12, 625617 (2021)
   PUBMED   33995349
  REMARK    GeneRIF: Desmoglein-4 Deficiency Exacerbates Psoriasiform
            Dermatitis in Rats While Psoriasis Patients Displayed a Decreased
            Gene Expression of DSG4.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4947)
  AUTHORS   Bazzi,H., Demehri,S., Potter,C.S., Barber,A.G., Awgulewitsch,A.,
            Kopan,R. and Christiano,A.M.
  TITLE     Desmoglein 4 is regulated by transcription factors implicated in
            hair shaft differentiation
  JOURNAL   Differentiation 78 (5), 292-300 (2009)
   PUBMED   19683850
  REMARK    GeneRIF: show that HOXC13, LEF1 and FOXN1 repress DSG4
            transcription and provide in vitro and in vivo evidence correlating
            the Notch pathway with the activation and/or maintenance of DSG4
            expression in the hair follicle.
REFERENCE   3  (bases 1 to 4947)
  AUTHORS   Owens,P., Bazzi,H., Engelking,E., Han,G., Christiano,A.M. and
            Wang,X.J.
  TITLE     Smad4-dependent desmoglein-4 expression contributes to hair
            follicle integrity
  JOURNAL   Dev Biol 322 (1), 156-166 (2008)
   PUBMED   18692037
REFERENCE   4  (bases 1 to 4947)
  AUTHORS   Bazzi,H., Martinez-Mir,A., Kljuic,A. and Christiano,A.M.
  TITLE     Desmoglein 4 mutations underlie localized autosomal recessive
            hypotrichosis in humans, mice, and rats
  JOURNAL   J Investig Dermatol Symp Proc 10 (3), 222-224 (2005)
   PUBMED   16382669
  REMARK    GeneRIF: We identified a homozygous missense mutation in the
            lanceolate (lah/lah) rat.
REFERENCE   5  (bases 1 to 4947)
  AUTHORS   Meyer,B., Bazzi,H., Zidek,V., Musilova,A., Pravenec,M., Kurtz,T.W.,
            Nurnberg,P. and Christiano,A.M.
  TITLE     A spontaneous mutation in the desmoglein 4 gene underlies
            hypotrichosis in a new lanceolate hair rat model
  JOURNAL   Differentiation 72 (9-10), 541-547 (2004)
   PUBMED   15617564
  REMARK    GeneRIF: A spontaneous mutation in dsg4 underlies hypotrichosis in
            a new lanceolate hair rat model.
REFERENCE   6  (bases 1 to 4947)
  AUTHORS   Bazzi,H., Kljuic,A., Christiano,A.M., Christiano,A.M. and
            Panteleyev,A.A.
  TITLE     Intragenic deletion in the Desmoglein 4 gene underlies the skin
            phenotype in the Iffa Credo 'hairless' rat
  JOURNAL   Differentiation 72 (8), 450-464 (2004)
   PUBMED   15606503
  REMARK    GeneRIF: A large intragenic deletion encompassing nine exons of the
            desmoglein 4 gene underlies the skin phenotype in the Iffa Credo
            'hairless' rat.
REFERENCE   7  (bases 1 to 4947)
  AUTHORS   Rafiq,M.A., Ansar,M., Mahmood,S., Haque,S., Faiyaz-ul-Haque,M.,
            Leal,S.M. and Ahmad,W.
  TITLE     A recurrent intragenic deletion mutation in DSG4 gene in three
            Pakistani families with autosomal recessive hypotrichosis
  JOURNAL   J Invest Dermatol 123 (1), 247-248 (2004)
   PUBMED   15191570
REFERENCE   8  (bases 1 to 4947)
  AUTHORS   Jahoda,C.A., Kljuic,A., O'Shaughnessy,R., Crossley,N.,
            Whitehouse,C.J., Robinson,M., Reynolds,A.J., Demarchez,M.,
            Porter,R.M., Shapiro,L. and Christiano,A.M.
  TITLE     The lanceolate hair rat phenotype results from a missense mutation
            in a calcium coordinating site of the desmoglein 4 gene
  JOURNAL   Genomics 83 (5), 747-756 (2004)
   PUBMED   15081105
  REMARK    GeneRIF: cloning and identification of the rat Dsg4 gene, and
            identification of a missense mutation in a naturally occurring
            lanceolate hair (lah) rat mutant
REFERENCE   9  (bases 1 to 4947)
  AUTHORS   Kljuic,A., Bazzi,H., Sundberg,J.P., Martinez-Mir,A.,
            O'Shaughnessy,R., Mahoney,M.G., Levy,M., Montagutelli,X., Ahmad,W.,
            Aita,V.M., Gordon,D., Uitto,J., Whiting,D., Ott,J., Fischer,S.,
            Gilliam,T.C., Jahoda,C.A., Morris,R.J., Panteleyev,A.A.,
            Nguyen,V.T. and Christiano,A.M.
  TITLE     Desmoglein 4 in hair follicle differentiation and epidermal
            adhesion: evidence from inherited hypotrichosis and acquired
            pemphigus vulgaris
  JOURNAL   Cell 113 (2), 249-260 (2003)
   PUBMED   12705872
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000299.1 and AY314982.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by NM_199490.3.
            
            On Oct 25, 2022 this sequence version replaced NM_199490.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY314982.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-131               JACYVU010000299.1  1163018-1163148
            132-179             AY314982.1         1-48
            180-215             JACYVU010000299.1  1173579-1173614
            216-347             JACYVU010000299.1  1174136-1174267
            348-503             JACYVU010000299.1  1176510-1176665
            504-648             JACYVU010000299.1  1177008-1177152
            649-815             JACYVU010000299.1  1179324-1179490
            816-950             JACYVU010000299.1  1179724-1179858
            951-970             JACYVU010000299.1  1181488-1181507
            971-1117            AY314982.1         840-986
            1118-1136           JACYVU010000299.1  1181656-1181674
            1137-1408           JACYVU010000299.1  1183609-1183880
            1409-1548           JACYVU010000299.1  1185249-1185388
            1549-1767           JACYVU010000299.1  1187926-1188144
            1768-2070           JACYVU010000299.1  1189384-1189686
            2071-2210           JACYVU010000299.1  1191851-1191990
            2211-2274           JACYVU010000299.1  1192139-1192202
            2275-2483           JACYVU010000299.1  1193362-1193570
            2484-4947           JACYVU010000299.1  1197638-1200101
FEATURES             Location/Qualifiers
     source          1..4947
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p12"
     gene            1..4947
                     /gene="Dsg4"
                     /note="desmoglein 4"
                     /db_xref="GeneID:291754"
                     /db_xref="RGD:735015"
     exon            1..179
                     /gene="Dsg4"
                     /inference="alignment:Splign:2.1.0"
     CDS             132..3254
                     /gene="Dsg4"
                     /codon_start=1
                     /product="desmoglein-4 precursor"
                     /protein_id="NP_955784.1"
                     /db_xref="GeneID:291754"
                     /db_xref="RGD:735015"
                     /translation="MDWLLFRNICLLILFMVVLGVNSEFIVEVKELDIENGTTTWQTV
                     RRQKREWIKFAAACREGEDNSKRNPIARIRSDCEVSQRITYRISGAGIDRPPYGVFTI
                     NPRTGEINITSVVDREITPLFLIHCRALNSRGEDLERPLELRVKVMDVNDNPPVFTQN
                     VYTANIEENSDANALVVKLSATDADEDNHLNSKIAYKIISQEPAGAPMFMVNRYTGEV
                     RTMSNFLDREQHSMYNLLVRGSDRDGATDGLSSECDCRIKILDVNDNFPILEKTSYSA
                     SIEENCLSSELIRLQAIDLDEEGTDNWLAQYSILSGNDGNWFEIQTDPKTNEGILKLV
                     KMLDYEQEPNIYLSIGVRNQAEFHHSVASQFQMHSTPVRIQVINVREGPTFRPSSMTF
                     SLRGGMRGDSLMNYVLGTYTAIDMDTGSPATNVRYVIGHDAGSWLKVDSRTGEIQFSR
                     EFDTKSKYITDGMYAAEILAIDDGSGRTATGTICIEVPDANDYCPVIYAESRSVCTHA
                     SSVRIYVNDHSFGAPFTFCVVDESPDTADIWDIRSINGTSAILMTEQTLSPGPYQIPI
                     LVKDSHNRACELPQTVLLDACLCDDYHVCLHSSTTGIYTGDTIWVTDDMGTVTDDGLR
                     QSNVGLGPAGIGMIILGLLLLFLSPLLLLMCCCKRRQPEGLGTRFAPVPEGGEGVMQP
                     WRIEGAHPEDRDVSNICVPMTASNTQDRIDSSEIYTNTYAGGGTVEGGVSGVELNTGV
                     GTAAGIAAGGATGTLRKRSSTIGTLREYQDTGMNMAFLDSYFSEKAYAYADEDEGRPA
                     NDCLLIYDHEGTGSPVGSIGCCSWIVDDLDESYMETLDPKFRTLAEICLDTEIEPFPS
                     HQACIPISTDLPLLGPNYFVNESSGMTLSEAEFQAEMAAASEPMIHGDIIVTETYTAT
                     DPCVQPTTIVFDSQLPPNVVVTETVMAPVYDVQGNICVPAEIANTHNVYYAERVVASP
                     GVPDMGNGNIGDTCIGPVMSGGILVGPEIQVTQMMSPDIHISQTTRSTSPMTSQHRVT
                     RYSNIHYSRQ"
     exon            180..215
                     /gene="Dsg4"
                     /inference="alignment:Splign:2.1.0"
     exon            216..347
                     /gene="Dsg4"
                     /inference="alignment:Splign:2.1.0"
     exon            348..503
                     /gene="Dsg4"
                     /inference="alignment:Splign:2.1.0"
     exon            504..648
                     /gene="Dsg4"
                     /inference="alignment:Splign:2.1.0"
     exon            649..815
                     /gene="Dsg4"
                     /inference="alignment:Splign:2.1.0"
     exon            816..950
                     /gene="Dsg4"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1136
                     /gene="Dsg4"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1408
                     /gene="Dsg4"
                     /inference="alignment:Splign:2.1.0"
     exon            1409..1548
                     /gene="Dsg4"
                     /inference="alignment:Splign:2.1.0"
     exon            1549..1767
                     /gene="Dsg4"
                     /inference="alignment:Splign:2.1.0"
     exon            1768..2070
                     /gene="Dsg4"
                     /inference="alignment:Splign:2.1.0"
     exon            2071..2210
                     /gene="Dsg4"
                     /inference="alignment:Splign:2.1.0"
     exon            2211..2274
                     /gene="Dsg4"
                     /inference="alignment:Splign:2.1.0"
     exon            2275..2483
                     /gene="Dsg4"
                     /inference="alignment:Splign:2.1.0"
     exon            2484..4947
                     /gene="Dsg4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagttatca tccatgccct cctgacagaa catctcctag cacatcctgc tgcgaagact
       61 aatttgggat ctggaagacc aggactagaa ctgattctca ctgggttcga agccaagaga
      121 gactctacgc aatggactgg cttctcttca gaaatatttg ccttctgatc ctatttatgg
      181 tggtcctagg agtgaacagt gaatttatcg ttgaggtaaa agaattagac atagaaaacg
      241 gcaccacaac ctggcagact gtcaggaggc agaagcgaga gtggatcaag tttgcagcgg
      301 cctgtcggga gggcgaggac aactccaaga ggaatccgat tgccagaatt agatcagact
      361 gtgaagtgag ccagaggatc acttatcgaa tctctggagc ggggattgat cggccgcctt
      421 atggagtgtt caccatcaac cctcggactg gagaaatcaa cattacctca gtagtggaca
      481 gagagataac cccactgttc ctgatccatt gccgagctct caactcgaga ggagaagacc
      541 tggagagacc gctggagctc agagtgaaag tcatggatgt aaatgacaac cctccagtct
      601 tcactcagaa cgtgtacaca gccaacattg aagaaaacag tgatgcaaat gcactggtgg
      661 tgaagttaag tgccacggat gcagatgaag acaatcactt gaattctaaa attgcttaca
      721 agatcatctc ccaggagcct gctggtgcac ccatgttcat ggtgaacagg tacactggag
      781 aagtccgcac gatgtccaac ttccttgaca gagagcaaca cagtatgtac aatctcctgg
      841 tgaggggctc agatcgggat ggagccacag atgggctgtc ctctgaatgt gactgcagaa
      901 tcaagatttt ggatgtcaat gataatttcc ccatcttgga gaaaacctca tactcagcaa
      961 gtattgaaga aaactgtttg agctcagaac tgatacgact gcaagcaatc gatctcgatg
     1021 aggaaggcac tgataactgg ctggcccaat actccatcct ctctggcaat gatgggaact
     1081 ggtttgaaat ccaaacagat ccaaaaacca acgaaggcat tttgaaattg gtcaagatgc
     1141 tggactatga acaggaacct aacatttacc tcagcattgg agttagaaac caagctgagt
     1201 ttcaccattc agtggcatct caattccaaa tgcactccac tcccgtgaga atccaggtta
     1261 ttaacgtgcg ggaaggacca acctttcgcc caagttccat gacatttagt ctacgaggag
     1321 gaatgagggg agactcctta atgaactatg tgcttggcac atacacagcc atagatatgg
     1381 acacggggag ccctgcaaca aacgtcaggt atgtcatagg gcacgatgca ggcagctggc
     1441 taaaagttga ttcaaggact ggtgagatac agttttctag ggaatttgac acgaagtcaa
     1501 aatatattac ggatgggatg tatgcagcag agatcctggc tatagatgat ggctctggga
     1561 gaacagctac gggaaccata tgcattgagg ttcctgatgc caatgattac tgtcccgtca
     1621 tttatgccga aagtagaagt gtctgcaccc atgcttcgtc tgtcaggatc tacgtcaacg
     1681 accattcttt cggggctccc tttacctttt gtgtggttga cgagtcgcca gacacagctg
     1741 acatatggga tatcaggtcc atcaatggaa cttctgcaat ccttatgact gagcagacct
     1801 tgtctccagg accctaccaa atccccatcc tcgtgaagga cagtcacaac agagcatgtg
     1861 aattgccaca gactgtactg ttagacgcct gcttgtgtga cgactaccat gtgtgcttgc
     1921 actccagcac cacaggcatc tacactgggg acaccatctg ggtgaccgat gacatgggga
     1981 cggtcactga tgatggactt aggcagtcaa acgtcggact tggcccagcg gggattggca
     2041 tgattatttt gggtctcttg ctgctgttct tgtcacccct tttactgctc atgtgctgct
     2101 gcaagaggag acagccagaa ggcctgggga caaggtttgc ccctgtgcct gagggaggcg
     2161 aaggagtgat gcagccctgg agaatcgagg gggctcatcc ggaagacagg gatgtatcaa
     2221 atatatgtgt gcccatgaca gcctctaaca cccaagatcg cattgattcc tctgaaatct
     2281 acaccaacac ttatgctggt ggaggaacag tggaaggggg tgtgtcagga gtggagctca
     2341 atacaggtgt tgggacagct gcaggcatag cagctggagg agcaacaggg accctgagaa
     2401 agaggagttc aactataggg actcttcggg aataccaaga caccggcatg aacatggcct
     2461 tcctggacag ctacttctct gagaaagcgt atgcgtatgc agatgaagat gaaggccgtc
     2521 cagccaatga ttgcctgctc atttatgacc atgaaggaac tggctcaccc gtgggctcca
     2581 ttggctgctg cagttggatt gtggatgact tagatgagag ctacatggag actttagatc
     2641 caaagttcag gactctagct gaaatctgct tggacacaga gattgaacca ttcccctcac
     2701 accaggcctg tataccaata agcactgacc tccctctgct ggggcctaat tactttgtca
     2761 atgaatcttc aggaatgact ctctcggagg ctgaattcca agcagaaatg gcagcagcct
     2821 ctgaacccat gattcatggg gacatcatag tgactgaaac ttacactgcc actgacccat
     2881 gtgtacaacc cacgacgatt gtctttgact ctcagcttcc acccaatgta gtcgtgaccg
     2941 aaaccgtgat ggcacctgtc tatgatgttc aagggaacat ctgtgtgcct gccgagatag
     3001 ccaacacaca caatgtatac tacgctgaga gagtggtggc tagccctggt gtgcctgaca
     3061 tgggcaacgg taacataggt gatacatgta taggaccagt gatgagtggt ggtattttgg
     3121 tagggccaga aattcaagtg acacaaatga tgagcccaga cattcacata agccaaacca
     3181 cacgctctac ctccccaatg acgtctcaac accgagtaac cagatacagc aacatacact
     3241 actcccgaca gtaagccctc catggagact ttgtgttcca atgcccacca acatcccatc
     3301 aaaggcatat aaggtgctgg agtcaactct ttaacactca gcaaacgtta acacgttcta
     3361 agttcagcgg ggctctttga tgacagcttt gggaggataa aaatgactct gcattttaga
     3421 taagcctcct tccacttctt tctgtttctc aataacgggc caaaaaatac accatagcgc
     3481 atcagtcatg attccaaacc tgaaagtccc ggggctgaat caacaaccca ggaaagatgg
     3541 tgtgcacaga agttgcaaat gaactttcat ctgcatcttc tatccatatt tttctttcga
     3601 gaaatatttt gatcagtttt taattcaggc cagagctaca tagtgaaacc ctgtctcaaa
     3661 aaaaaaaaag aaagaaagaa agaaaagaaa agaaaagtca gttacttcaa gactgcaagt
     3721 gcagctcaat ggtagcgttt gtccagaatg catgaagtcc tatgctcagt cctcagcacc
     3781 agagaaaaat taactgaaac aagtgaaatg caaatttctg aaaggaaggt gacacatttg
     3841 taagatcata ggaattgtgt tttcaaagag ttttgcaaga cacgcaacat taagcattat
     3901 tgtaacacta agcatgcctt atatgagaaa aggttggagg ctagagagac agctgagtgt
     3961 caagagtact taccactctt gcactggacc caggttcact tcctggcatc cacactgtgg
     4021 ctcacggtca tgtttaactc cattctaggg gatctgatgc cctcttctag ccgcattggg
     4081 cactaagcat gaacatgaaa cacatacata catgcagtca aacactcaga cacataaacc
     4141 tgagagagag ggggggggag agagagagag agagagaggg aggaagagga agaaagggtt
     4201 gaagaaaagg agagaggaag agaaagagga agaaagggag agaggaagag agagaaagag
     4261 aagtttgtta actagaaatc cttcctccaa aggatatata catacatata tctataaata
     4321 catatagtta tattttattg atttatatta acttaaaatc acaaaaagaa actgatcttg
     4381 gaagatgtat tagtattttc cctattacaa ggattttttt ccttttgcta attatgtcaa
     4441 aaatatgaca tattgtttaa tcagtttctt tggcctgagt catggaggtt tcacttggcc
     4501 accagaagtt ttcctgatat acatacacaa ttattatatt tttaagcaac atttacttgg
     4561 aaactaccag gttttgagca ttggtgctaa ccttatgaat atggaaggga agagaccaga
     4621 tgtgcctgcc tcaagctttg cgctcatttc tagatgtaaa aagaaaacat ggaggtatga
     4681 ctttgcatgc atccaagaac agttagggaa cagctcaagg ccattacaga gctgtgcttc
     4741 tctttctgat actgcgtgtg atgctgagtg tgcgaaatgc aaacagtgac acagacttcc
     4801 cgttttcagc aggcatacat ctggctcagg aaacagaaac tatctaattc tgtaaaatat
     4861 gtaaactgtg cagtacaaac tctaatatga ctggaaaaac aatgtaaatg aaataaaaat
     4921 cttttcaggg ctgattcctt ttaaaag
//
