LOCUS       XM_006254474            5649 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus desmoglein 2 (Dsg2), mRNA.
ACCESSION   XM_006254474
VERSION     XM_006254474.4
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051353.1) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            [WARNING] On Jan 17, 2024 this sequence was replaced by
            NM_001427278.1.
            
            On Jan 21, 2021 this sequence version replaced XM_006254474.3.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5649
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /sex="male"
                     /tissue_type="kidney"
                     /geo_loc_name="USA: Wisconsin, Milwaukee, Medical College
                     of Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..5649
                     /gene="Dsg2"
                     /note="desmoglein 2; Derived by automated computational
                     analysis using gene prediction method: Gnomon. Supporting
                     evidence includes similarity to: 16 ESTs, 5 Proteins, and
                     100% coverage of the annotated genomic feature by RNAseq
                     alignments, including 18 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:307562"
                     /db_xref="RGD:1311143"
     CDS             240..3626
                     /gene="Dsg2"
                     /codon_start=1
                     /product="desmoglein-2"
                     /protein_id="XP_006254536.1"
                     /db_xref="GeneID:307562"
                     /db_xref="RGD:1311143"
                     /translation="MARSPSGRCTLLLLLQLLAVVCLDFGDGLHLEVFSTRGEDRLFT
                     KRTHLVRQKRAWITAPVALREGEDLSKKNPIAKIHSDLAEERGIKITYKYTGKGITEP
                     PFGIFVFDRNTGDLNITSILDREETPFFLLTGYALDSRGNNLEKPLELRIKVLDINDN
                     EPVFTQEVFVGSIEELSAAHTLVMKITATDADDPQTLNSKISYRIVSQEPANTPVFYL
                     NKDTGEIYTTSFALDREEHSSYSLTVEARDGNGQITDKPVQQAQVQIRILDVNDNIPV
                     VEYGTYEGVVEENQVNVEVMRIKVTDADEVGSDNWLANFTFASGNEGGYFHIETDTQT
                     NEGIVTLVKELDYEEMKKLDLSILVTNKAAFHKSVVSKYKATPIPITVKVKNVVEGIH
                     FKSSTVTFRASEAMDRSSLSRSIGKFQVFDEDTGKAADVTYVKVQDTDNWVSVDSETS
                     EIKLVKIPDFESRHVQNGTYTVKVVAISKGHPQKTVTGTILINVEDVNDNCPVLVDSV
                     RSVCADAPYVNVTAEDLDGPRNSGPFTFSIIDQPPGTAQKWKITHQESTSVLLQPSER
                     KLGRSEIPFLISDSQGFSCLERQVLQLTVCECLEGGGCVAALYDNYVGLGPAAIALMI
                     LALLLLLLVPLLLLMCHCGEGAKGFAPIPGTIEMLHPWNNEGAPPEDKVVPSLLVTDH
                     VENSGVRGGGGGGGGGVGGVKLKEGVSSSASITKGQHELIEVDGRWEEHRSLLTSGLT
                     HHVATAGSIAANDTTIRTTRATGASRDMSGARGAVAMNEELLRSYFTEKAASYAGEDD
                     FHLAKDCLLVYSQEDTDSLRGSVGCCSFIEGELDDLFLDDLGPKFKTLAEVCLGRKID
                     MDVDIEQRQKPVRETSVNAAPGSHYTQVTASSESTYSSNSGFQAPKPLHGAHTEKVTQ
                     EVVTESSVSSRQSQKVVPPPNPVASGNIIVTETSYAAGSAVPPSTVILAPRQPQSLIV
                     TERVYAPASTLVDQHYANEENVLVTERVIQPNGGIPKPLEVTQHLNDAQYVMVRERES
                     ILAPSSGVQPTLAMPSVAAGGQNVTVTERVLTPASTLQSSYQIPSEASIKARKTVLSS
                     VGGMGPLPNLDLEESGPPNSTVTTSSTRVTKHSTVQHSYS"
ORIGIN      
        1 caccggcccc aggtgcggag ggcgggaact gcctcgcacc tcctggcaga gcgagcgctt
       61 tcccctcctc catccagact gcggcccggc tcccggctac cctttctgac ccggccacac
      121 ctggaaccgc accccgggcc gggcggaggc ggagaagggc ggccccggga gagacctggc
      181 ccggaggatc ggcgggactc tggcaaggcc cggcggcaag ggcgcggcga agcgaggcga
      241 tggcgcggag cccgagcggc cggtgcaccc tactgctgct gttgcagctg ctggcggtgg
      301 tctgcttgga ctttggagat ggacttcact tagaggtctt cagcacgaga ggtgaagaca
      361 gactgttcac taagcgcact cacttggttc gtcaaaagag agcctggatc actgcccctg
      421 tggctcttcg ggagggagaa gacctttcca aaaagaaccc aatcgccaag atacactctg
      481 accttgcaga agaaagggga ataaagatca cctacaagta cactgggaag ggaattacag
      541 agccaccctt cggtatattc gtgtttgata ggaacacagg agacctgaac atcaccagta
      601 ttcttgaccg ggaagaaacg ccatttttcc tgctgacagg ctatgccttg gactccagag
      661 gaaacaacct ggagaagccc ttagaactcc gcatcaaagt tctggacatc aatgacaacg
      721 agccagtgtt cacacaggag gtctttgttg ggtccattga ggaactgagt gcagcacata
      781 cactagtgat gaaaatcacc gcgacggatg cagacgatcc tcagaccctg aactctaaaa
      841 tctcctacag aattgtctct caggagcctg caaacactcc tgtgttctac ctaaataaag
      901 acacggggga gatctacaca accagctttg ctttggacag agaggaacac agcagctatt
      961 ccttgacagt ggaagcgaga gacggtaacg ggcagataac agacaaaccc gtgcaacaag
     1021 cccaagttca gattcgcatt ttggatgtca atgacaatat acctgtggtg gaatacggaa
     1081 cgtacgaggg ggtagtggaa gaaaaccagg tcaatgtaga agtcatgcgg atcaaagtga
     1141 ccgacgcgga tgaagtgggc tcggataact ggctagcaaa ctttacgttc gcatcaggaa
     1201 atgaaggggg ctatttccac atcgagactg acacacagac taacgaaggc atcgtgaccc
     1261 ttgtcaagga attggactat gaagaaatga agaagctgga cttgagcatc cttgtcacga
     1321 acaaagcagc tttccacaag tccgttgtga gcaagtacaa ggccacgccc attcccatca
     1381 ctgtcaaggt caagaacgtg gtcgaaggca ttcatttcaa gagcagcaca gtcaccttcc
     1441 gagctagtga ggcgatggat cgatccagcc tcagccggtc gattggaaaa tttcaagttt
     1501 tcgatgaaga cactggaaag gcagctgatg taacgtacgt aaaagtgcaa gacaccgaca
     1561 actgggtctc tgtggactct gaaacttcag agattaagct ggtaaagatt cccgactttg
     1621 aatctcgaca cgtccagaat ggcacctaca ctgtaaaggt tgtcgctata tccaaaggtc
     1681 accctcaaaa aaccgtcact ggcaccatcc ttatcaatgt tgaagacgtc aatgacaact
     1741 gtcccgtact ggtggactca gtacggagtg tctgtgcgga tgcaccgtat gtgaacgtca
     1801 ctgcggaaga cttggatgga ccccggaaca gtgggccatt caccttctcc atcattgacc
     1861 agcctcccgg aacggcacag aagtggaaaa tcacgcacca agaaagtacc agtgtgctgc
     1921 tgcagccaag cgagcggaag cttgggagaa gtgagattcc cttcctcatc tccgacagcc
     1981 agggtttcag ctgcctggag aggcaagtcc tccagctcac cgtgtgcgag tgtctggagg
     2041 gcggtggctg tgtggctgcg ctgtatgaca actacgtcgg tttgggcccc gccgcgatcg
     2101 ccctcatgat tctggctctc ctgcttctgc tgctggtgcc gctcttgttg ttgatgtgcc
     2161 actgtggaga gggcgccaaa ggcttcgccc ccattcccgg gaccatagag atgctgcatc
     2221 cttggaacaa tgaaggggca ccacccgagg acaaggtggt gccatcgctt ctggtgactg
     2281 atcacgtgga gaactcggga gtgagaggcg gcggcggcgg cggcggcggc ggcgtaggag
     2341 gggtgaagct caaggaaggc gtgagtagct cagcctccat taccaaaggg cagcatgagc
     2401 taattgaggt tgacggaaga tgggaagaac acagaagcct cctcactagt gggctcactc
     2461 accatgtagc caccgcagga tccatcgctg ccaatgacac cacaataagg acaacaagag
     2521 ccactggggc gtccagagac atgagcgggg ctcgaggagc cgttgccatg aatgaggaac
     2581 tcttgagaag ttacttcaca gagaaagcag cttcctacgc cggggaagac gactttcacc
     2641 tggccaaaga ctgccttctc gtttactccc aggaagacac ggactctctc cgaggctccg
     2701 tcgggtgctg cagttttatc gagggagagc tcgacgatct gttcttagat gacctggggc
     2761 cgaaattcaa gaccctagcc gaagtttgcc taggtcgaaa gatcgatatg gatgtggaca
     2821 ttgaacagag gcaaaagccg gtcagagaaa caagtgtgaa tgcagctccc ggctctcact
     2881 acacacaagt gacagccagc tcagagagca cgtattcctc taacagtggc ttccaagccc
     2941 ccaaacctct gcatggagca cacacagaga aagtcacaca ggaagttgtc actgaaagct
     3001 ctgtgtcttc caggcagagt caaaaggtag taccaccacc caatcctgtg gcttcaggta
     3061 acattatagt gacggaaact tcctatgccg cgggatcagc ggtgccaccc agcactgtga
     3121 tcctggctcc tagacagcca cagagcctta ttgtaacaga gagggtgtac gcaccagcct
     3181 ccaccttggt ggaccagcac tatgccaatg aagaaaatgt ccttgttacc gaacgagtga
     3241 tccagcctaa tggaggcatc cctaagcccc ttgaggtcac ccagcatctg aacgatgctc
     3301 agtatgtcat ggtgagggaa agagagagca tcctggctcc cagctcaggc gtgcagccca
     3361 ctctggcaat gcccagtgtg gcagcaggag ggcagaatgt cactgtcaca gaaagagtac
     3421 tgactcctgc ttccactctg cagtccagtt accagattcc cagtgaagcc tccatcaagg
     3481 ctaggaagac ggtgctgtcc agtgtgggag gcatgggccc gctgcccaat ttagatttag
     3541 aggagtctgg tcctcccaac tctactgtaa ccacgtcttc caccagggtc accaagcata
     3601 gcaccgtgca gcattcttac tcctaaagag aagccagccg cagtctgatt cggagcttaa
     3661 ccaggttcca ctgggtgtgt ttttccttcc gtgtccctaa tgtcatatga gccgcacaaa
     3721 gacttgcacg ttgggaaagc tcatcggcat gccaaagaca cggtgtctca ggcagggtcg
     3781 tatttcagaa atgctctgtg attactgggg ggggtggagt taagatgcta gttcctaagt
     3841 gccttctagt gcattctgca agcaatactc acctacagga catggaaaat tggcttctaa
     3901 gaacttacca aattaaagca cagtttctaa ttaatctggt ccagaaggat ggctctctgc
     3961 acaatgcatt gatattcagc agggacagtt ccaaccctaa tattatagaa ccacacaggt
     4021 tctgggtacc aaatagcaca tccatccaga gacacgtctc cattctgccg ttctgggcct
     4081 tcaacttcag tttctgcttc actttaacgc tggaaccctg agtgcactgg agaaaacaga
     4141 aaggaagaaa cgctggagcc ctttttaatg taaagttgac agaacttcag agcgctagag
     4201 ggataaggac acatattgtg tacttctctg cacataacat gtcctgtaag cttaaaaaat
     4261 gacttcatat ttctcctcgc ttatcagagg ttgtgaaaat gttgagcatt tcaaattagt
     4321 tttataatcc atgacagcca aacgtgacgg tgcatgccca gaactcaaga ggcaggcaaa
     4381 tctctccggg ttcaaggtca gcctggtcta tataaagagt tccagaacag ccagggctac
     4441 atagaaaaac cctgtttcaa agaacaaaca acaacaaaag caatactagt cataacccag
     4501 gataaaactc atagtcaact tttccgtgac aatatagtag tctactaaga aaaacctcat
     4561 catatatttg tttcctggct acaagttagt gcccttaggg cgggacaaat gagcacatta
     4621 ctactcttgc agacaagcct acttcagttt ctgatgtcca cacactgtgc ctcacaacca
     4681 cctctaattc caactcaggg gatgccctct gatggactcc aaagacgtca cactcacgca
     4741 gttgagtgtt agtgacctgc catatctccc tcttgccatt gactgcctta catcctcagt
     4801 gcctctcaca gggcccaagc cgggatctat gggtcaagat aagttccaca aaccactctt
     4861 ttacatttag tcagacatca agaagactca atagttccat aattctgaat cacggtatct
     4921 gaaagtaatt gtctggtcat gacttgatat atataaagta aatgttttat cataaattgg
     4981 cccaatttca tccagcttcc ttgccttgtt tctttaagga agttgttgtt tgggttttac
     5041 agaacatcaa tggaaagtat tatatagtaa aacttggctt ctaaaaagta atgtttcaaa
     5101 acatatcagt catatttcta tccatatttc tcatccaaaa ataaatgttg aaaaccatca
     5161 aatttctgga tattttgcta ggagaataaa attctacact tacattttgt aggccttttt
     5221 aaaatgttgt ttacatgaat tgtgttgtga aaaaagttgt accgtgcacc ctaactgatt
     5281 cgggaggtgt tcttatttgc atgatctgct ctgtggggca gaggtcacct tattcctctg
     5341 atctggaatt gtttactttc tacagagtaa gctttgtggg gattttgctt tctttttcat
     5401 tgtagctgat gtcattttgc caagtgtgca caggaattgt cctactgtgt gaagttatag
     5461 attcatgcta aaaacaaaac ctaaaactca atcttggact cccacggtgg gtaggtttaa
     5521 ggccccactc ctcttttgta cagagtataa tcttccttgt gatttccatt agtttttaat
     5581 gtttgttcct tgagagggtt gcatttgtgt gtgtgatata ttgtaataaa aaggccatct
     5641 tccttcaga
//
