LOCUS       NM_001305281            5717 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus dermatan sulfate epimerase-like (Dsel), mRNA.
ACCESSION   NM_001305281
VERSION     NM_001305281.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5717)
  AUTHORS   Bartolini,B., Thelin,M.A., Rauch,U., Feinstein,R., Oldberg,A.,
            Malmstrom,A. and Maccarana,M.
  TITLE     Mouse development is not obviously affected by the absence of
            dermatan sulfate epimerase 2 in spite of a modified brain dermatan
            sulfate composition
  JOURNAL   Glycobiology 22 (7), 1007-1016 (2012)
   PUBMED   22496542
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments and orthologous data.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-785               JAXUCZ010000013.1  200133-200917       c
            786-5717            JAXUCZ010000013.1  194745-199676       c
FEATURES             Location/Qualifiers
     source          1..5717
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13p13"
     gene            1..5717
                     /gene="Dsel"
                     /gene_synonym="RGD1307724"
                     /note="dermatan sulfate epimerase-like"
                     /db_xref="GeneID:297865"
                     /db_xref="RGD:1307724"
     exon            1..785
                     /gene="Dsel"
                     /gene_synonym="RGD1307724"
                     /inference="alignment:Splign:2.1.0"
     exon            786..5717
                     /gene="Dsel"
                     /gene_synonym="RGD1307724"
                     /inference="alignment:Splign:2.1.0"
     CDS             1623..5249
                     /gene="Dsel"
                     /gene_synonym="RGD1307724"
                     /EC_number="5.1.3.19"
                     /note="dermatan-sulfate epimerase-like protein"
                     /codon_start=1
                     /product="dermatan-sulfate epimerase-like protein
                     precursor"
                     /protein_id="NP_001292210.1"
                     /db_xref="GeneID:297865"
                     /db_xref="RGD:1307724"
                     /translation="MALMFTGHLLFLTLMMCSFTTCEESVSNYSEWAVFTDDVQWFKT
                     QKIQDFKLNQKLYPNLYFDAGDIQTMKQQSRTSHLHIFRAIKSAVTIMLSNPSYYLPP
                     PKHAEFAAKWNEIYGNNLPPLALYCLLCPEDKVAFEFVMEYMDRMVSYKDWLVQNAPG
                     DEVPLGHSLTGFATAFDFLYNLLGKQRKQKYLEKIWIVTEEMYEYSKIRSWGKQLLHN
                     HQATNMIALLIGALVTGVDKGSKANIWKRVAVDEMEKTMFILNHIVDGSLDEGVAYGS
                     YTSKSVTQYVFLAQRHFNISNFDNNWLKMHFWFYYATLLPGYQRTVGIADSNYNWFYG
                     PESQLIFLDKFILRNGAGNWLAQQIRKHRPKDGPMVPSTAQRWSTLHTEYIWYDPTLP
                     PQPPVDFGTAKMHTFPNWGVVTYGGGLPNTQTNTFVSFKSGKLGGRAVYDIVHFQPYS
                     WIDGWKSFNPGHEHPDQNSFTFAPNGQVFVSEALYGPKLSHLNNVLVFAPSPSSQCNQ
                     PWEGQLGECAQWLKWTGEEVGDAAGEVIAAAQHGERMFVSGEAVSAYSSAMRLKSVYR
                     ALILLNSQTLLVVDHIERQETSPINSVSAFFHNLDIDFKYIPYRFMNRYNGAMMDVWD
                     AHYKMFWFDHHGNSPVASIQEAEQAAEFKKRWTQFVNVTFHMESTITRIAYVFYGPYV
                     NVSSCRFIDSSSSGLQISLYVNSTEHSVSVVTDYQNLKSRFRYLGFGGFASVANQGQI
                     TRFGLGTQAILNPVRHERVINFPFGFKFNIAVGFILCISLVILTFQWRFYLSFRKLMR
                     CVLILVIALWLIELLDVWSTCTQPICAKWTRTEAKANEKVIISEGHHVDLPNVVITSL
                     PGSGAEILKQLFFNSSDFLYIRIPTTYMDIPETEFEIDSFVDACEWKVSDIHSGQFHL
                     LRGWLQSLVQDTKLHLQNIHLHETSRNKLVQYFTTNKDKKRKLKRRESLPDQRSRIKG
                     SFDIDAEYIRALRRHLVYYPSARPVLSLSSGSWTLKLHFFQEVLGTSMRALYIVRDPR
                     AWVYSMLYGSKPSLYSLKNVPDHLAKLFKIEEGKSKCNSNSGYAFEYESLKKELEIPQ
                     LNAVSLLSHLWVANTAAALRINTDLLPTNYHLVKFEDIVHFPQKTTERIFAFLGIPLS
                     PASLNQILFATSTNLFYLPYEREISPSNTNIWKTNLPRNEIKLIENICWTLMDRLGYP
                     KFMD"
ORIGIN      
        1 ttttcctgcc atcagtgggc tagtcagcaa cagctagctg ggcacagcgt cggtccaggc
       61 ggcatcgggc ctcgggttac ggtcgctctc ttcaaggcag cgcctggaga tcaccgccgc
      121 ccgcggtttg cctcctacca acgaagcagt ccccgccagc gcctggcgtt cctcccggcg
      181 ggcgtgtctg ggtctccatc gcggagactc ggccctgagg agactcggca cctaggagag
      241 cagcggagac tgtggtgctg agaaaaacca cacgctttag agaacctccc cgcccccgaa
      301 atgtagggcc gctgaggaga acaagcctgg cggctgcctg tgctctcccg ggcctcacac
      361 gggcggaggc ttgtcgagct cttgatgtcc gtaggcccgc ctccaaagaa acctcaattg
      421 cttgagctgc cacccttcgc ctgtgttggg gcccagctct gcttgaagat cctgttgcag
      481 gcggcctgag gtaagccaac ttggtcattt agaagtctct agtccccaca ttgcaggcac
      541 aggtcaggca gtaggtactg gagcaaaagg atgttgcgtt ctgaagaaag gacttaaaat
      601 atgcaacagg cgggtcaaat caggaactac tagacgtgtt tatttcctga agaaaggaga
      661 cttgtctaag atagaaactt agtgagtttc ttccaaatcc aagatgggca aaagagaggc
      721 ctgctcctta aacccgggga tgagcgccct ctggcggctt atggggagga tgttaacagc
      781 tatagagagg agtgacacga aaaaagaaca aaagacagac ttcagtgttg tgaaagtgga
      841 ttttttttac ccacttggtg gatgtgttca tgattggaag aacatctaga cattgaagag
      901 attagactct tttagaggta cagataaaca aacttgatat aagaatattt ggaaatgctt
      961 taaaaagacg tttgaaatga aggcagaaag ttcaatgtcc tttgacaacc atgtaggaat
     1021 ttctacactt gttcagaata ttttattttc caaaatggaa gaagaaacaa ttgacaaacc
     1081 attgtgcttc agactctgag aaaaaaacat aatgaaatct gctcactctg tgaaggacaa
     1141 tactttatca tcttttgggg gacagacaga aatgtaccat atgtgtgtgg taagttaatc
     1201 aggaaggatg ctttcttgtg ctcgaaatga cttcatttga attttggaat tttttaaatt
     1261 ttctcttttt cacatgttag ttagatttat atacagagaa taaatgctgg attccttgta
     1321 ttttctgact acaacactga tttttgtgca ttatggagac actggaggca ttaatattcc
     1381 ttgaaatatt ttattggaag caaatgtgtg ccaagcacac aaacatgcta tataatttcc
     1441 tctttacatc aactttcctt gctttgaatg agctgaatgt cacctggatt tcacagccta
     1501 tgaagtatat agtctgtttt tttgctacac ctttaatata taatttatag taaccagatg
     1561 ggaaacacat taaacactgt gcttaacata tatgcctaag taaaagatct tccccatgga
     1621 tcatggcgtt aatgtttaca ggacatttat tatttttaac attgatgatg tgtagtttta
     1681 ctacttgtga agaatctgtg agcaattatt ctgaatgggc agttttcact gatgatgtac
     1741 aatggtttaa gacacagaaa atacaagatt tcaaactcaa ccaaaaactt tatccaaatt
     1801 tatactttga tgccggagat atacaaacaa tgaaacaaca gtctcgtaca agccatttgc
     1861 atatttttag agctatcaaa agtgcagtga caattatgct gtccaaccca tcatactacc
     1921 tacctccacc caagcatgct gagtttgctg ccaagtggaa cgaaatatat ggtaataacc
     1981 ttcctccttt agcattgtat tgtttattat gcccagaaga caaggttgcc tttgaatttg
     2041 tcatggaata tatggacagg atggttagct acaaagactg gctagttcag aatgcaccag
     2101 gggatgaggt tccacttggc cattctttaa caggttttgc tactgccttt gactttttat
     2161 ataatctatt aggtaagcag cggaaacaaa aataccttga aaaaatttgg attgttactg
     2221 aggaaatgta tgaatattcc aagattcgct catggggcaa acaacttctt cataatcacc
     2281 aagctacaaa tatgatcgca ttactcatag gggccttggt tactggagta gataaaggat
     2341 ctaaagcaaa catatggaaa cgggttgctg ttgatgagat ggaaaaaact atgtttatct
     2401 tgaaccatat tgtagacggc tctttggatg aaggtgttgc ctatggcagc tatacctcca
     2461 aatcagttac acagtatgtt ttcttggcac agcgccattt taacatcagt aactttgata
     2521 ataactggct aaaaatgcac ttttggtttt attatgctac acttttgcca ggctatcaaa
     2581 gaactgtagg catagcagat tctaattata attggtttta cggtccagaa agccagttaa
     2641 tttttttgga taagttcatt ttacggaatg gagctggaaa ttggttagct cagcaaatta
     2701 gaaagcatcg acctaaggat ggaccaatgg ttccttccac tgctcagcgg tggagtactc
     2761 ttcatactga atacatctgg tatgatccaa cgctcccccc acagcctcct gttgattttg
     2821 gcactgcaaa aatgcacaca tttcctaact ggggtgttgt gacttatggg ggtggcttac
     2881 caaacacaca gaccaatacc tttgtgtctt ttaaatctgg gaaactggga ggacgagctg
     2941 tatatgacat agttcacttt cagccatatt cctggattga tggatggaaa agctttaacc
     3001 caggacatga acatccagat caaaattcat ttacttttgc ccctaatgga caagtatttg
     3061 tttctgaggc tctttatgga ccaaagttga gccaccttaa caatgtattg gtgttcgccc
     3121 catcaccatc aagccaatgt aatcagccct gggaaggtca actgggagaa tgtgcacaat
     3181 ggctcaagtg gactggtgaa gaggttggtg atgcagctgg ggaagttatt gctgctgctc
     3241 aacatggaga aaggatgttt gtgagtgggg aagcagtgtc tgcttattct tctgcaatga
     3301 gactgaaaag tgtctatcgt gctttaattc ttttaaattc gcaaactctg cttgttgtgg
     3361 atcatattga aaggcaagag acttccccaa taaattctgt cagtgccttc tttcataatt
     3421 tggatattga ttttaaatac atcccataca ggtttatgaa tcggtataat ggtgccatga
     3481 tggatgtgtg ggatgcacac tataaaatgt tttggtttga tcaccatggc aacagtcctg
     3541 tggccagtat acaagaagca gaacaggctg cagaatttaa gaaacggtgg actcagttcg
     3601 ttaatgttac atttcatatg gaatccacaa tcacacgaat tgcttatgta ttttatggtc
     3661 catatgtcaa tgtttccagc tgcagattta ttgatagttc cagttctgga cttcagattt
     3721 ctttatatgt caatagtact gaacatagtg tttctgttgt aactgactac caaaacctga
     3781 aaagcagatt cagatacctg ggatttggtg gttttgccag tgtggctaat caaggacaaa
     3841 taactcgatt tggtttgggt actcaagcaa tattaaaccc tgtaagacat gaaagagtta
     3901 ttaatttccc cttcgggttt aaatttaata tagcagttgg attcattttg tgtattagtt
     3961 tggttatttt aacttttcag tggcggtttt acctttcctt tagaaagcta atgcgctgtg
     4021 tattaatact tgttattgcc ttgtggttaa ttgagcttct ggatgtatgg agcacttgca
     4081 ctcagcccat ctgtgcaaag tggacaagga cagaagctaa ggcaaatgag aaggtcatta
     4141 tttccgaagg gcatcatgtg gatcttccta atgttgttat tacctcactc cctggttcag
     4201 gagctgaaat tctcaaacag ctttttttca atagtagtga ttttctctac attagaattc
     4261 ctacgaccta catggatatc cctgaaactg aatttgaaat tgactcattt gtagatgctt
     4321 gtgaatggaa agtatcagat atccacagtg ggcaatttca tcttcttcga gggtggctgc
     4381 agtctttggt ccaggataca aaacttcatt tacaaaacat ccatctacat gaaaccagta
     4441 ggaataaact ggtccaatat tttacaacta ataaggacaa aaaacggaaa ttgaaaagaa
     4501 gggagtcttt gccagatcaa agaagtagaa taaaaggatc atttgatatt gatgctgaat
     4561 atattagggc tttaagaaga cacctagttt attacccaag tgcacgtcct gtgctcagct
     4621 taagtagtgg tagctggaca ttgaagcttc atttttttca agaagtttta ggaacttcaa
     4681 tgcgggcatt gtacatagta agagaccccc gagcttgggt ctattcaatg ctatatggta
     4741 gtaaaccaag tctttattct ttgaagaatg tgccagacca cttagcaaaa ttgtttaaaa
     4801 tagaggaagg taaaagcaag tgtaactcga attctggcta tgcttttgaa tatgaatcac
     4861 tgaagaaaga attagaaata ccccaattaa atgctgtctc attattatct catttgtggg
     4921 tagcaaacac tgcagcagcc ttgagaataa atacggattt gctgcctacc aattaccatc
     4981 tggtcaagtt tgaagatatt gttcattttc ctcagaagac tactgaaagg atttttgctt
     5041 ttcttggcat tcctttgtct cccgctagtt taaaccaaat actatttgcc acttccacaa
     5101 acctttttta tcttccatat gagagggaaa tatcaccatc taatactaat atttggaaaa
     5161 caaatttgcc tagaaatgaa ataaagctaa ttgaaaacat ttgctggaca ctgatggatc
     5221 gtctaggata tccaaagttt atggactaaa tgctgcaggt cagcaaaatt tgcactaata
     5281 tgtcccaacc tactttgtgg atatgaacta taaaactgtt tattcttgta catgtatgta
     5341 tgtgtgtaga gagaatgtgt gttttcagtc tgttatttca cagagatatt ttcaaaatag
     5401 gcactatagt tggcctagca ggatttattt ttatgttacc acttttttgc ctttgtttct
     5461 gaattttttt ctgctaaaat gtttctgcta cagaggtata tattctgggg gtctgaaaat
     5521 atgggaagat tttaatgaac tttaactcac ctttcgaaac tagttatcta tcttgggacc
     5581 tcaaacactg caaaaggcct tgcaattgct gctctatcca gtcatctctt gctcataaga
     5641 tggactacaa aactttatgt tttgaaaaga tctaatgttt accttgcaca caaaaaagaa
     5701 ataaaaagaa ggaaaaa
//
