LOCUS       NM_001108933            4130 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus dermatan sulfate epimerase (Dse), mRNA.
ACCESSION   NM_001108933 XM_001053297 XM_345110
VERSION     NM_001108933.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4130)
  AUTHORS   Maccarana M, Olander B, Malmstrom J, Tiedemann K, Aebersold R,
            Lindahl U, Li JP and Malmstrom A.
  TITLE     Biosynthesis of dermatan sulfate: chondroitin-glucuronate
            C5-epimerase is identical to SART2
  JOURNAL   J Biol Chem 281 (17), 11560-11568 (2006)
   PUBMED   16505484
REFERENCE   2  (bases 1 to 4130)
  AUTHORS   Nakao M, Shichijo S, Imaizumi T, Inoue Y, Matsunaga K, Yamada A,
            Kikuchi M, Tsuda N, Ohta K, Takamori S, Yamana H, Fujita H and Itoh
            K.
  TITLE     Identification of a gene coding for a new squamous cell carcinoma
            antigen recognized by the CTL
  JOURNAL   J Immunol 164 (5), 2565-2574 (2000)
   PUBMED   10679095
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474016.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_345110.3, XM_001053297.1.
            
            ##Evidence-Data-START##
            CDS exon combination :: BC168891.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA5760383, SAMEA5760386 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4130
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20q11"
     gene            1..4130
                     /gene="Dse"
                     /gene_synonym="Sart2"
                     /note="dermatan sulfate epimerase"
                     /db_xref="GeneID:365583"
                     /db_xref="RGD:1305079"
     exon            1..435
                     /gene="Dse"
                     /gene_synonym="Sart2"
                     /inference="alignment:Splign:2.1.0"
     exon            436..904
                     /gene="Dse"
                     /gene_synonym="Sart2"
                     /inference="alignment:Splign:2.1.0"
     CDS             489..3365
                     /gene="Dse"
                     /gene_synonym="Sart2"
                     /EC_number="5.1.3.19"
                     /note="squamous cell carcinoma antigen recognized by T
                     cells 2"
                     /codon_start=1
                     /product="dermatan-sulfate epimerase precursor"
                     /protein_id="NP_001102403.1"
                     /db_xref="GeneID:365583"
                     /db_xref="RGD:1305079"
                     /translation="MRTHTRGAPTVFFICLLCCVSAYITDENPEVMIPFTNANYDSHP
                     MLYFSRKDVAELQLRAASSHEHIAARLTEAVHTMLTNPLEYLPPWDHKEYSARWNEIY
                     GNNLGALAMFCVLYPENIEAREMAKDYMERMAAQPSWLVKDAPWDEVPLAHSLVGFAT
                     AYDFLYNYLSKTQQETFLEVIANASGYMYETSYRRGWGFQYLHNHQPTNCMALLTGSL
                     VLMNQGYLQEAYLWTKQVLSIMEKSLVLLREVTDGSLYEGVAYGSYTTRSLFQYMFLV
                     QRHFDINHFGHPWLKHHFAFMYRTVLPGFQRTVAIADSNYNWFYGPESQLVFLDKFVM
                     RNGSGNWLADQIRKNRVVEGPGTPSKGQRWCTLHTEFLWYDASLKSVPPLDFGTPTLH
                     YFEDWGVVTYGSALPAEINRSFLSFKSGKLGGRAIYDIVHRNKYKEWIKGWRNFNAGH
                     EHPDQNSFTFAPNGVPFITEALYGPKYTFFNNVLMFSPAVSKSCFSPWEGQVTEDCSS
                     KWSKYKHDLAASCQGRVIAAEEKDGVVFIRGEGVGAYNPMLNLKNIHRNLILLHPQLL
                     LLVDQIHLGEESPLETAASFFHNVDVPFEETVVDGVHGAFIRQRDGLYKMYWMDDTGY
                     SEKATFASVTYPRGYPYNGTNYVNVTMHLRSPITRAAYLFIGPSVDVQSFSIHGDPQR
                     LDVFVATSEHAYATYLWTGENTGQSAFAQVIADHQKILFDQSSAIKSTTVPEVKDYAA
                     IVERNLQHFKPVFQLLEKQILSRVQNTASFRKTAERLLRFSDKRQTEEAIDRIFAISQ
                     QQRQQRGKSKKSRRTGKHYKFVDAVPDIFAQIEVNEKKIRQKAQILAQKEQPIDEDEE
                     MKDLLDFADVTYEKHRNGGSMKDGFGQARMVTSHNRAPSLSASYTRLFLILNIAIFFV
                     MLAMQLTYFQRAQSLHGQRCLYAVLLIDSCVLLWLYSSCSQSQC"
     exon            905..1158
                     /gene="Dse"
                     /gene_synonym="Sart2"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1398
                     /gene="Dse"
                     /gene_synonym="Sart2"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1606
                     /gene="Dse"
                     /gene_synonym="Sart2"
                     /inference="alignment:Splign:2.1.0"
     exon            1607..4130
                     /gene="Dse"
                     /gene_synonym="Sart2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaaatcaga gctgtaggaa ctaaagcggc ggggaagggc aggctgcgtg gggtcccgtg
       61 gggtcccggc cgaagcgacg ggaaggcgga acccctcgcg tagccagggt ctggggcagc
      121 cgaggaaagc tccagcggag gtcctgatca ggcctggcgg gggtcctgct ctcccccatc
      181 cccatcctcg cctcccaggc tctgctgacg ttgcggcttc ctccgccccg ggcccagccc
      241 tgccgcggcc cgccctccct ccaccgaagg tctccgcccg gtcctcaggg ccgccagaga
      301 ctgcagcggc gcaccccggg cgcggcgccc tgagctcgga tggctcggcg cgcgcgctaa
      361 ggaacggact ccaggggtcc ggagctcctg cgccccacgg ggacgcagag agaggacgcc
      421 cgggaagacg gagcggatcg ttcaaagatg atttggctgc cttggagact tggagatctg
      481 gtgccacgat gaggactcac acacgggggg ctcccactgt gtttttcata tgtttgcttt
      541 gctgtgtgtc agcctacatc actgacgaga acccagaagt catgattccc ttcacgaatg
      601 ccaactacga cagccacccg atgttgtact tctccaggaa agatgtggca gagctccagc
      661 tgagggctgc cagctcccat gagcatatcg cggctcgtct cacagaggcc gtgcacacca
      721 tgctgactaa ccccttggag tacctccctc cttgggatca caaggagtac agtgcccgct
      781 ggaatgagat ctatggaaac aacctgggtg ccttggcgat gttctgtgtg ctgtatcctg
      841 agaacatcga agctcgagaa atggccaaag actacatgga gaggatggca gcgcagccta
      901 gttggttggt gaaagacgca ccttgggatg aagtcccact tgcgcactcc ctggtaggtt
      961 tcgccactgc gtatgacttc ttatacaact acctgagcaa gacgcagcag gagacgttcc
     1021 tggaagtgat tgccaatgcc tcgggctata tgtatgaaac ttcctacagg agaggatggg
     1081 gcttccagta cttgcacaac caccaaccca ccaactgcat ggccttactc actggaagtc
     1141 ttgttctgat gaaccaaggg taccttcagg aggcctactt gtggaccaag caagttctaa
     1201 gcatcatgga gaagtctctg gtcttgctgc gagaggtgac ggatggctcc ctctatgaag
     1261 gagttgcgta tggcagctac accactagat ccctgttcca gtacatgttt cttgttcaga
     1321 ggcactttga catcaaccac tttggccatc catggctcaa gcaccacttt gcctttatgt
     1381 ataggaccgt cttgccaggg tttcaaagaa ctgtggccat tgcagactca aattacaact
     1441 ggttttatgg tccagaaagt caattagtgt tcctggataa atttgtcatg cgtaatggga
     1501 gtggaaactg gctggctgac caaatcagaa agaatcgtgt ggtggaaggt ccaggtacac
     1561 cgtccaaagg gcaacgctgg tgtactctgc acacagaatt tctctggtat gatgccagct
     1621 tgaagtcggt tccacctctg gattttggca ccccgacatt gcattatttt gaagactggg
     1681 gtgttgtgac ttatggaagt gcactacctg cagaaatcaa cagatcattc ctttccttca
     1741 agtcaggaaa gcttgggggg cgtgcaatat atgacattgt ccacagaaat aaatataaag
     1801 aatggatcaa agggtggaga aattttaatg caggacatga gcatcctgac caaaactctt
     1861 tcacttttgc ccccaacggt gtgccattca ttaccgaggc cctctatggg ccgaagtaca
     1921 ccttctttaa caatgtacta atgttttctc cagctgtgtc aaagagttgc ttttctccct
     1981 gggagggtca ggtcacagaa gattgctcat caaaatggtc aaaatacaag catgacctgg
     2041 cagccagctg tcaggggaga gtaattgcag cagaggaaaa ggatggggtt gtttttatcc
     2101 gaggagaagg tgtaggagcg tataacccca tgctcaacct gaagaacatt catcggaatc
     2161 tcatcctcct ccacccacaa cttctcctcc ttgtagacca gatacacctg ggagaggaga
     2221 gtcccctgga gacagcagct agtttcttcc acaatgtgga tgtccccttt gaggagacag
     2281 tagtagatgg ggtccacgga gctttcatcc ggcagcgaga tggtctctat aaaatgtact
     2341 ggatggatga tactggttat agcgagaaag caacctttgc ctcagtgacg tatcctcggg
     2401 gctatcctta caatggaaca aattatgtga atgtcaccat gcatcttcga agtcccatca
     2461 ccagggcagc ttacctcttc atagggccat ctgtggatgt ccagagcttc agcatccacg
     2521 gtgaccctca gcggctggat gtgttcgtag ctaccagcga acatgcctac gcaacttacc
     2581 tgtggacagg tgagaacacg gggcagtctg cctttgcaca ggtcattgcg gatcatcaga
     2641 aaatcctgtt tgaccagagt tcagccatca aaagcaccac tgtcccggaa gtgaaagatt
     2701 acgctgctat tgtggaacgg aatctgcagc attttaagcc cgtgttccag ctgcttgaga
     2761 agcagatcct gtctcgcgtc cagaacacag ctagctttcg gaagactgct gagcgcctac
     2821 tgaggttttc ggataagaga cagacagagg aggccattga caggatcttt gctatatccc
     2881 agcaacagcg gcagcagcga ggcaagtcaa agaaaagccg aaggaccggc aagcattaca
     2941 agtttgtgga tgccgtccct gatatttttg cacagattga agtcaatgag aagaagattc
     3001 gacagaaagc tcagatttta gcacagaaag aacagcctat agatgaagat gaagaaatga
     3061 aagacctttt ggattttgct gatgtcacgt atgagaagca tagaaacggg ggctccatga
     3121 aagatggctt tggacaggcg cggatggtga caagtcacaa cagagcacct tcactgtcgg
     3181 cctcgtacac cagactcttc ttgattctga acattgccat cttctttgtc atgttggcta
     3241 tgcaactgac ttatttccag agggctcaga gcctccatgg ccaaaggtgt ctttatgcag
     3301 ttctcctaat agatagctgt gtcttattgt ggttgtattc ctcctgttct caatctcagt
     3361 gctaacacca aagcctttca tgattgtgaa atatatagga gcatttcatt atcatcctaa
     3421 tttgttatga tttctcccct aggtttattt aggcaaattc aagggaagat gttttcacac
     3481 ccagagaact ctgaactaga tacacaaagc atgtacctaa ggtataaaaa tagctttggc
     3541 tgacccctcg tgcttctttc tgggaatgtt tggcttgact gactgaccgg ttgctattag
     3601 aagagacaaa aatgcctgtt tttttgacat atttctgtta atattaagaa aaaatgaatt
     3661 ggactttatt atcattaatt taattgttag gagcttccag attctgtatt attgaacata
     3721 tggagacaca taattccaag caacacagac tgttaaaata taatgggaac cgatatctag
     3781 gacctgggaa atcacacagt aaaatggtag cagaagatca taaaggaact aaaatttttt
     3841 tagcaggaaa cagatacaaa tgaacatctt tttgatgatg ttggtcaacg cagggatgtg
     3901 atttgtggct ttttgataaa taatacaata acaaataatt ttgtattctc tttccctttt
     3961 atgtaaaatg tttatagacc caacagctaa agttttcaaa ataaactatt ttatatcttg
     4021 aaattcaata ccaaagaaca tagaactcaa gttttggtgt gattctcatg tttttaccta
     4081 gaaagttttc ttcaagttta ttttgctaaa taaaccattc ataattatga
//
