LOCUS       NP_001100872             900 aa            linear   ROD 02-APR-2025
DEFINITION  desmocollin-3 [Rattus norvegicus].
ACCESSION   NP_001100872 XP_001053804 XP_226122
VERSION     NP_001100872.1
DBSOURCE    REFSEQ: accession NM_001107402.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 900)
  AUTHORS   Xu,X., Dong,C. and Vogel,B.E.
  TITLE     Hemicentins assemble on diverse epithelia in the mouse
  JOURNAL   J Histochem Cytochem 55 (2), 119-126 (2007)
   PUBMED   17015624
REFERENCE   2  (residues 1 to 900)
  AUTHORS   Den,Z., Cheng,X., Merched-Sauvage,M. and Koch,P.J.
  TITLE     Desmocollin 3 is required for pre-implantation development of the
            mouse embryo
  JOURNAL   J Cell Sci 119 (Pt 3), 482-489 (2006)
   PUBMED   16418220
REFERENCE   3  (residues 1 to 900)
  AUTHORS   Cheng,X., Mihindukulasuriya,K., Den,Z., Kowalczyk,A.P.,
            Calkins,C.C., Ishiko,A., Shimizu,A. and Koch,P.J.
  TITLE     Assessment of splice variant-specific functions of desmocollin 1 in
            the skin
  JOURNAL   Mol Cell Biol 24 (1), 154-163 (2004)
   PUBMED   14673151
REFERENCE   4  (residues 1 to 900)
  AUTHORS   Kowalczyk,A.P., Palka,H.L., Luu,H.H., Nilles,L.A., Anderson,J.E.,
            Wheelock,M.J. and Green,K.J.
  TITLE     Posttranslational regulation of plakoglobin expression. Influence
            of the desmosomal cadherins on plakoglobin metabolic stability
  JOURNAL   J Biol Chem 269 (49), 31214-31223 (1994)
   PUBMED   7983064
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473974.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XP_226122.4, XP_001053804.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760400, SAMEA5760434
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..900
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p12"
     Protein         1..900
                     /product="desmocollin-3"
                     /calculated_mol_wt=100590
     Region          33..115
                     /region_name="Cadherin_pro"
                     /note="Cadherin prodomain like; smart01055"
                     /db_xref="CDD:214999"
     Region          144..238
                     /region_name="Cadherin"
                     /note="Cadherin domain; pfam00028"
                     /db_xref="CDD:394985"
     Region          251..355
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(258..259,316,318,351,353..354)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          364..472
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(370..371,428,430,469,471..472)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          480..578
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(487..488,539,541,574,576..577)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          599..674
                     /region_name="CA_like"
                     /note="Cadherin repeat-like domain; cl46864"
                     /db_xref="CDD:481204"
     Region          851..895
                     /region_name="CADH_Y-type_LIR"
                     /note="Cadherin, Y-type LIR-motif; pfam01049"
                     /db_xref="CDD:460041"
     CDS             1..900
                     /gene="Dsc3"
                     /coded_by="NM_001107402.1:176..2878"
                     /db_xref="GeneID:307563"
                     /db_xref="RGD:1311782"
ORIGIN      
        1 mamamavpel rslpyrapft kflltlwvfs fvgeackdvt fyvpstlead kiigrvslke
       61 clssadgimp sdpdfrvldd gsvyptravv lsdekrsfti qlsdskmrkq keitvilerq
      121 kevmmkrhtn etvlrrakrr wapipcsmqe nslgpfplfl qqvqsdsaqn ynifysisgr
      181 gvdqeplnlf fierdtgnly ctrpvdreey dvfdliayas tadgysadlp lplpikvede
      241 ndnyplftea iynfevpess rlgtvvgtvc atdkdepdtm htrlkysile qsppspglfs
      301 vhpdtgvitt vshymdrevv dkyklilkvq dmngqffgli ststciitvq dsndnaptfr
      361 qnayetsvee ntynveilri pvddkdmvns anwkanftil kgnengwfki ttdpatnegv
      421 lcvvkpldye enrqvtleig vnneapfird vasriptmnr amvtvqvrdq negpeckpre
      481 qivrikensa igskingyka ydpetknsng lrykklqdpk dwvsieevsg sltiskildr
      541 eimaprndly nitvmaidqe grsctgtlav niedmndnap eiiqddivic kprmgytdis
      601 avdpdepihg ppfqfalass spevnriwtl nqvndtaarl syqktadvqi ysvpvtvtdr
      661 agqsatkilr vnlcdcthps qcllrsrrag itlgkwaila illgiallfs vlltlvcgvv
      721 taqkgkhfpe dlaqqnliis nteapgddrv csangfttht annssqgfcg tmgsgmrngg
      781 qetiemmkgh qtldscrvag hhhtldscrg ghmetdncry tysewhsftq prlgeklhvc
      841 nqnedhipsq dyvltynyeg rgspagsvgc csekqeeegl dflnnlepkf ltlaetctkr
//
