LOCUS       NM_001033688            4508 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus desmocollin 2 (Dsc2), mRNA.
ACCESSION   NM_001033688 XM_226120
VERSION     NM_001033688.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4508)
  AUTHORS   Ren,Y.S., Li,H.H., Yao,J.C., Tan,Y.J., Pan,L.H., Peng,T.,
            Zhao,L.L., Zhang,G.M., Yue,J., Hu,X.M., Liu,Z. and Li,J.
  TITLE     Application quantitative proteomics approach to identify
            differentially expressed proteins associated with cardiac
            protection mediated by cycloastragenol in acute myocardial
            infarction rats
  JOURNAL   J Proteomics 222, 103691 (2020)
   PUBMED   32068187
REFERENCE   2  (bases 1 to 4508)
  AUTHORS   Mazurek,S.R., Calway,T., Harmon,C., Farrell,P. and Kim,G.H.
  TITLE     MicroRNA-130a Regulation of Desmocollin 2 in a Novel Model of
            Arrhythmogenic Cardiomyopathy
  JOURNAL   Microrna 6 (2), 143-150 (2017)
   PUBMED   27834139
REFERENCE   3  (bases 1 to 4508)
  AUTHORS   Moncayo-Arlandi,J., Guasch,E., Sanz-de la Garza,M., Casado,M.,
            Garcia,N.A., Mont,L., Sitges,M., Knoll,R., Buyandelger,B.,
            Campuzano,O., Diez-Juan,A. and Brugada,R.
  TITLE     Molecular disturbance underlies to arrhythmogenic cardiomyopathy
            induced by transgene content, age and exercise in a truncated PKP2
            mouse model
  JOURNAL   Hum Mol Genet 25 (17), 3676-3688 (2016)
   PUBMED   27412010
REFERENCE   4  (bases 1 to 4508)
  AUTHORS   dos Santos,D.O., Blefari,V., Prado,F.P., Silva,C.A., Fazan,R. Jr.,
            Salgado,H.C., Ramos,S.G. and Prado,C.M.
  TITLE     Reduced expression of adherens and gap junction proteins can have a
            fundamental role in the development of heart failure following
            cardiac hypertrophy in rats
  JOURNAL   Exp Mol Pathol 100 (1), 167-176 (2016)
   PUBMED   26708424
REFERENCE   5  (bases 1 to 4508)
  AUTHORS   Wong,J.A., Duff,H.J., Yuen,T., Kolman,L., Exner,D.V., Weeks,S.G.
            and Gerull,B.
  TITLE     Phenotypic analysis of arrhythmogenic cardiomyopathy in the
            Hutterite population: role of electrocardiogram in identifying
            high-risk desmocollin-2 carriers
  JOURNAL   J Am Heart Assoc 3 (6), e001407 (2014)
   PUBMED   25497880
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4508)
  AUTHORS   Gehmlich,K., Syrris,P., Peskett,E., Evans,A., Ehler,E., Asimaki,A.,
            Anastasakis,A., Tsatsopoulou,A., Vouliotis,A.I., Stefanadis,C.,
            Saffitz,J.E., Protonotarios,N. and McKenna,W.J.
  TITLE     Mechanistic insights into arrhythmogenic right ventricular
            cardiomyopathy caused by desmocollin-2 mutations
  JOURNAL   Cardiovasc Res 90 (1), 77-87 (2011)
   PUBMED   21062920
REFERENCE   7  (bases 1 to 4508)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   8  (bases 1 to 4508)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   9  (bases 1 to 4508)
  AUTHORS   Tunggal,J.A., Helfrich,I., Schmitz,A., Schwarz,H., Gunzel,D.,
            Fromm,M., Kemler,R., Krieg,T. and Niessen,C.M.
  TITLE     E-cadherin is essential for in vivo epidermal barrier function by
            regulating tight junctions
  JOURNAL   EMBO J 24 (6), 1146-1156 (2005)
   PUBMED   15775979
REFERENCE   10 (bases 1 to 4508)
  AUTHORS   Gallicano,G.I., Kouklis,P., Bauer,C., Yin,M., Vasioukhin,V.,
            Degenstein,L. and Fuchs,E.
  TITLE     Desmoplakin is required early in development for assembly of
            desmosomes and cytoskeletal linkage
  JOURNAL   J Cell Biol 143 (7), 2009-2022 (1998)
   PUBMED   9864371
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001033688.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC101864.1, SRR26360194.2294284.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-293               JAXUCZ010000018.1  11757174-11757466   c
            294-378             JAXUCZ010000018.1  11749505-11749589   c
            379-578             JAXUCZ010000018.1  11748216-11748415   c
            579-698             JAXUCZ010000018.1  11746601-11746720   c
            699-854             JAXUCZ010000018.1  11745399-11745554   c
            855-999             JAXUCZ010000018.1  11744570-11744714   c
            1000-1166           JAXUCZ010000018.1  11742917-11743083   c
            1167-1301           JAXUCZ010000018.1  11740036-11740170   c
            1302-1487           JAXUCZ010000018.1  11739604-11739789   c
            1488-1744           JAXUCZ010000018.1  11736428-11736684   c
            1745-1887           JAXUCZ010000018.1  11736172-11736314   c
            1888-2112           JAXUCZ010000018.1  11732807-11733031   c
            2113-2349           JAXUCZ010000018.1  11730046-11730282   c
            2350-2474           JAXUCZ010000018.1  11729345-11729469   c
            2475-2735           JAXUCZ010000018.1  11727877-11728137   c
            2736-4508           JAXUCZ010000018.1  11725466-11727238   c
FEATURES             Location/Qualifiers
     source          1..4508
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p12"
     gene            1..4508
                     /gene="Dsc2"
                     /note="desmocollin 2"
                     /db_xref="GeneID:291760"
                     /db_xref="RGD:1309426"
     exon            1..293
                     /gene="Dsc2"
                     /inference="alignment:Splign:2.1.0"
     CDS             225..2933
                     /gene="Dsc2"
                     /codon_start=1
                     /product="desmocollin-2 precursor"
                     /protein_id="NP_001028860.2"
                     /db_xref="GeneID:291760"
                     /db_xref="RGD:1309426"
                     /translation="MAAAGSSRSGSPALGLGHLLTLAILALACDACKEVVLQVPSELP
                     AGKFVGRVNLMECLKSANVIHLSDPDFQVFEDGSVYTTNSVVLSSGQRSFTIWLFNTD
                     SQEERELSVHLEGPVEVLNQRLHTEKVLRRAKRRWAPIPCSMMENSLGPFPLFLQQIQ
                     SDKAQNYTIYYSISGPGVDKEPVGLFRIDRDTGNLYCTDRVDREQYDSFELTALAMTP
                     DGYMVENLLTLLIKVEDENDNYPIFTQKVYSFTVLENSPFGSHVGEVCATDKDEPDTM
                     HTRLKYSILEQSPSPPMLFTMHPRTGVITTTSTQLDRELIDKYQLIIKVQDMDGQYFG
                     LQTTATCVITIGDVNDNLPTFTRTTYVTSVEENTVNVELLRLSVQDKDLVNSPNWRAN
                     YTILKGNENGNFKIKTDPQTNEGILCVIMPLDYEERQRVTLEIGVVNEAPYTRQAGSK
                     SSMSTATVTVNVKNQDEGPECIPQTQTVRIRENVPIGTRNDGYKAYDPETKNSIGIRY
                     RKLSDPKGWITVNEDSGSITIFRTLDREAETIRNGIYNITVLALDADGRSCTGTLGIL
                     LEDVNDNGPFIPKQTVVICRATMSSAEIVAVDPDEPANGPPFDFSLESSDSEVRRRWK
                     LTRINDTAASLSYQNDPAFDSYVIPVRVTDRFGLSSVTSLNVVVCDCITESDCTYRTG
                     ERTGYADVRLGPWAILAILLGVALLLCILFTLVCSVSRASKQQKILPDDLAQQNLIVS
                     NTEAPGDDKVYSANGFTAQTAGASGQTTFTTLGAGVKSTGQETIEMVKGGQRTLDSRR
                     ATGYHHHTMDPGRGGHVEVDNYRYTYSEWHNFTQPRLGEKVQFCHEDDNQKLAQDYVL
                     TYNYEGKGSAAGSVGCCSDLQEEDGLEFLDHLEPKFRTLAEVCAKR"
     exon            294..378
                     /gene="Dsc2"
                     /inference="alignment:Splign:2.1.0"
     exon            379..578
                     /gene="Dsc2"
                     /inference="alignment:Splign:2.1.0"
     exon            579..698
                     /gene="Dsc2"
                     /inference="alignment:Splign:2.1.0"
     exon            699..854
                     /gene="Dsc2"
                     /inference="alignment:Splign:2.1.0"
     exon            855..999
                     /gene="Dsc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1166
                     /gene="Dsc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1301
                     /gene="Dsc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1487
                     /gene="Dsc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1744
                     /gene="Dsc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1745..1887
                     /gene="Dsc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1888..2112
                     /gene="Dsc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2113..2349
                     /gene="Dsc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2350..2474
                     /gene="Dsc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2475..2735
                     /gene="Dsc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2736..4508
                     /gene="Dsc2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggagttccc accggttgag ttcttaaagt catgaagact caagaaaaat aacaaggagt
       61 ggccgattgg agtcttttgg acttgcccgg agctccaccc tcggccagag gaaaagcccc
      121 tggggaccga ggcgggagca tcagacaagc gcgagaaaag tgcctgtgcg cgctccacct
      181 ctgcgcagcg ggtgcggggc ggtgacctgt cccttgagtt agccatggcg gcagcgggat
      241 cctcgcgctc cgggagccct gccctcggcc tgggacacct gttgaccctc gcgatccttg
      301 cacttgcctg tgatgcttgt aaagaagtcg tcctccaggt cccctctgaa ctacctgctg
      361 ggaaatttgt tggcagagtg aacctgatgg agtgccttaa atcagcaaat gtaattcact
      421 tgagtgatcc tgatttccaa gtcttcgaag atggttctgt gtacacaacc aattctgttg
      481 ttttgtcttc ggggcaaaga agctttacta tttggctttt caacacagac agccaggaag
      541 agagggagtt gtctgtccat ttagagggcc ctgtagaggt cctaaatcaa agactgcata
      601 cagaaaaagt tctccgccgc gccaagagaa gatgggctcc catcccttgt tccatgatgg
      661 agaattcatt gggtcccttc ccacttttcc ttcaacagat ccaatccgac aaagctcaaa
      721 actacaccat atactattcc atcagcggtc caggagttga taaagaaccc gtaggcttat
      781 ttcgtattga tagagatact ggaaacctgt attgcactga tcgtgtagat cgagaacagt
      841 atgactcctt tgagctgact gcattagcaa tgactccaga tgggtatatg gtagagaacc
      901 tgctgacgct cctcattaaa gtagaggatg agaacgataa ttacccgatc tttacccaga
      961 aagtgtacag cttcacagtt ttggaaaaca gtccatttgg ttctcacgtc ggggaggtct
     1021 gtgcaacaga caaggatgag ccggacacaa tgcacactcg tctgaagtac tccatcctgg
     1081 agcagtcgcc ttctcccccc atgttattca ccatgcatcc caggactggt gtcatcacta
     1141 ccacctccac ccagctggac agagagttaa ttgacaagta ccagttgata ataaaagttc
     1201 aggacatgga tggccagtat tttggtttgc agacaacagc gacctgcgtc attactattg
     1261 gagatgtgaa tgacaacttg ccaacattca cgcgtactac gtacgtgaca tcagtggaag
     1321 aaaatacggt caatgtggaa ctcttacgtc tttctgttca agataaagat ttagttaact
     1381 ctcctaattg gagagctaat tacaccattt taaagggcaa cgaaaatgga aattttaaaa
     1441 tcaaaacaga tccccaaacc aatgaaggca ttctgtgcgt gattatgcct ctggactatg
     1501 aagaacggca acgggtgacc ctggaaattg gcgtagttaa tgaagccccg tacactagac
     1561 aggctggttc aaagtcatcc atgagcacag ctacagtgac tgtcaacgtg aaaaatcagg
     1621 atgagggccc tgagtgtatc cctcaaacgc aaactgtgag gattcgagaa aatgtaccaa
     1681 ttggtactag aaacgatggg tataaagcat atgacccaga gaccaaaaac agcattggca
     1741 taaggtacag gaagttaagt gacccaaaag gatggatcac tgttaatgaa gattcaggat
     1801 caatcaccat tttccgaact ctggatcggg aggctgagac catcagaaac ggcatctaca
     1861 atattacagt ccttgcatta gatgcagacg ggagaagctg tacgggaact ctgggaatct
     1921 tacttgaaga tgtgaatgac aacggcccat tcatacccaa gcagacagtg gtgatatgca
     1981 gggctaccat gtcctctgct gaaattgttg cggttgaccc tgatgagcca gcaaatggtc
     2041 caccatttga ttttagtttg gagagttctg attcagaagt acggaggagg tggaagttga
     2101 caagaatcaa tgatacagct gctagtcttt cctatcagaa tgaccctgcg tttgattcct
     2161 acgtaattcc cgtccgagtt acagacaggt ttggtctgtc ctcagtcacg tcactgaatg
     2221 tcgttgtatg tgactgcatc actgaaagtg actgcacata ccgcactgga gaaaggactg
     2281 gctatgctga cgtgagactt ggaccatggg ctatccttgc tatactgctg ggcgtagcct
     2341 tgctactttg tatcctgttt accttagtct gtagtgtttc ccgggcatca aaacaacaga
     2401 aaattcttcc cgatgactta gctcagcaga acctaattgt atcaaacacc gaggctcctg
     2461 gagatgacaa agtctattcc gcaaatggct tcacagctca aactgcggga gcttctgggc
     2521 agacaacatt cacaaccttg ggagctggag tcaaaagtac agggcaagag accattgaga
     2581 tggtaaaagg aggacagcgc acactggact cccgcagggc gaccggctat caccaccata
     2641 ccatggatcc tggcagggga gggcatgtgg aggtggacaa ttacagatac acctactctg
     2701 agtggcacaa tttcactcag ccccgacttg gtgagaaggt gcagttttgc catgaggatg
     2761 acaaccagaa gcttgcccaa gactatgtcc tcacatacaa ctatgaggga aaaggctcgg
     2821 ctgctggctc tgtgggttgc tgtagcgacc tacaggaaga agacgggctt gagtttttgg
     2881 accatctgga gcctaaattt aggacattag cagaagtatg tgcaaagagg tgaacgactt
     2941 ctaacaggat aacgaaaact aatggattta ctgccttgtc ctccctgctt ttaactgtaa
     3001 accaggagtt ttcaaaaaca gaagatgtta tatttggggc tccctccgcc atctacagag
     3061 tctccatgga tatacacatt tacagagaaa cgttgtatat tagtgctcgg aaaccattgc
     3121 tctcgagttt cagtcacttc tcttttacgg gtgtcctctc acatggaaac ttaaggaatt
     3181 ctcattactg tttacattgg gtgtaatgac agcagccaac ttagagtgca atgacgttga
     3241 atggatttca gtccgtttct agactattga ctgtaaccca attggagact gtagacacca
     3301 tcatctccag ttaacgaatt aactgattgt ttgtatggtg cttggaaaca gttgttttcc
     3361 tcaacattct aaactgtgta tactgtgtct tacttttgtt atagtcttgt aacatggcct
     3421 ggctttgtag tgcaaaggta gacggccagg cagccatcga atgtgctgaa gttctaatcc
     3481 agtgggtttt agcttctgtt ctatgtaaaa gcctgcactg aatctcagtc tcttttgtac
     3541 tgactttgtc agttaaattt agatttcaaa actcctgttt tttcctccta aaatttttgg
     3601 tctgtgaata ccaaatggtc taccctccca tcctctcttc atttttaatt ttgtttttgt
     3661 tttctttcct gttgactttg aaaggtctac ttgggttgaa gaaatccaag atgtccctat
     3721 aagttgtctc ataaaatagt ttttctctgg tgtgtatgca tgtgccttgt tagttttctt
     3781 aagctcaatg taacagcaac attattgttt tggatttttg gtaattgctt catttctgtc
     3841 cttagtgaag aactttcagt ttttccaatg aaactatagg actctttcat gatcttttag
     3901 aagcaacgtt ctgtgtaaca gaagcaatag tgtacttaga agtaggttgt gtcaatctga
     3961 tgtagaatag catagttaca atttctgttc ttaattcaag gacactggaa gtaggaagta
     4021 gtgataagag tttgaagtaa gcttctcagc agaataatct cagacaatct ctaggacaat
     4081 gacttcactt actttttaga tgatatggtt agtcataatt acatggttgt aaaattattt
     4141 ttagaaagtt tgtaattata gttattttat gaaatataga aatgggccaa acaatttaat
     4201 ctttttaagg aatttacaca tgagtaaact tcatagccag ctacgttcta gaacacaggt
     4261 catgtttcct tcagtcagtg agctcagcac tttgactgga tggatggaga ttctaggatg
     4321 gacattctag gtgcagttct catgtgtgcg attgttcatt gtgtggaaca atgtcttgaa
     4381 ttcaccgagt tggcttataa caattgtgtc cagaacaaac attggggaaa tttttgaaca
     4441 ccaactatgt atgcagtgga gtcattattt gtgtcagaga catttttaat aaattatgta
     4501 caaaatga
//
