LOCUS       NM_001395076            7238 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus dystrophin related protein 2 (Drp2), transcript
            variant 1, mRNA.
ACCESSION   NM_001395076 XM_039100043
VERSION     NM_001395076.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7238)
  AUTHORS   Bisgaard,C.F., Jayatissa,M.N., Enghild,J.J., Sanchez,C.,
            Artemychyn,R. and Wiborg,O.
  TITLE     Proteomic investigation of the ventral rat hippocampus links DRP-2
            to escitalopram treatment resistance and SNAP to stress resilience
            in the chronic mild stress model of depression
  JOURNAL   J Mol Neurosci 32 (2), 132-144 (2007)
   PUBMED   17873297
  REMARK    GeneRIF: DRP-2 is a potential marker for escitalopram resistance in
            an animal model of stress and depression.
REFERENCE   2  (bases 1 to 7238)
  AUTHORS   Sherman,D.L., Fabrizi,C., Gillespie,C.S. and Brophy,P.J.
  TITLE     Specific disruption of a schwann cell dystrophin-related protein
            complex in a demyelinating neuropathy
  JOURNAL   Neuron 30 (3), 677-687 (2001)
   PUBMED   11430802
REFERENCE   3  (bases 1 to 7238)
  AUTHORS   Roberts,R.G. and Sheng,M.
  TITLE     Association of dystrophin-related protein 2 (DRP2) with
            postsynaptic densities in rat brain
  JOURNAL   Mol Cell Neurosci 16 (5), 674-685 (2000)
   PUBMED   11083927
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Jun 3, 2021 this sequence version replaced XM_039100043.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF195788.1, SRR26360194.401305.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-122               JAXUCZ010000021.1  101901286-101901407
            123-300             JAXUCZ010000021.1  101918014-101918191
            301-464             JAXUCZ010000021.1  101923069-101923232
            465-621             JAXUCZ010000021.1  101925154-101925310
            622-742             JAXUCZ010000021.1  101926291-101926411
            743-1011            JAXUCZ010000021.1  101928419-101928687
            1012-1158           JAXUCZ010000021.1  101929054-101929200
            1159-1237           JAXUCZ010000021.1  101929602-101929680
            1238-1298           JAXUCZ010000021.1  101931654-101931714
            1299-1360           JAXUCZ010000021.1  101932051-101932112
            1361-1435           JAXUCZ010000021.1  101933359-101933433
            1436-1637           JAXUCZ010000021.1  101934453-101934654
            1638-1723           JAXUCZ010000021.1  101934865-101934950
            1724-1881           JAXUCZ010000021.1  101935840-101935997
            1882-2048           JAXUCZ010000021.1  101936272-101936438
            2049-2160           JAXUCZ010000021.1  101938395-101938506
            2161-2297           JAXUCZ010000021.1  101940971-101941107
            2298-2363           JAXUCZ010000021.1  101941374-101941439
            2364-2429           JAXUCZ010000021.1  101941709-101941774
            2430-2573           JAXUCZ010000021.1  101942568-101942711
            2574-2811           JAXUCZ010000021.1  101944305-101944542
            2812-2932           JAXUCZ010000021.1  101946700-101946820
            2933-7238           JAXUCZ010000021.1  101947098-101951403
FEATURES             Location/Qualifiers
     source          1..7238
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq32"
     gene            1..7238
                     /gene="Drp2"
                     /gene_synonym="DRP-2"
                     /note="dystrophin related protein 2"
                     /db_xref="GeneID:66027"
                     /db_xref="RGD:621750"
     exon            1..122
                     /gene="Drp2"
                     /gene_synonym="DRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            123..300
                     /gene="Drp2"
                     /gene_synonym="DRP-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             184..3057
                     /gene="Drp2"
                     /gene_synonym="DRP-2"
                     /note="dystrophin-related protein 2 A-form"
                     /codon_start=1
                     /product="dystrophin-related protein 2"
                     /protein_id="NP_001382005.1"
                     /db_xref="GeneID:66027"
                     /db_xref="RGD:621750"
                     /translation="MQPLVMQGCPYTLPRCHEWHAADRFHHSSSLRNTCPQPQVRAAV
                     TIPAPPWDGAGDPCLSPKLLNGSVGAVGPLEPSAMNLCWNEIKKKSHNLRARLEAFSD
                     HSGKLQLPLQEIIDWLSQKDEELSAQLPLQGDVALVQQEKETHAAFMEEVKSKGPYIY
                     SVLESAQAFLSQHPFEELEESHSESKDTSPRQRIQNLSRFVWKQATVASELWEKLTAR
                     CVDQHRHIEHTLEHLLEIQGAMEELSSTLTQAEGVRATWEPIGDLFIDSLPEHIQAIK
                     LFKEEFSPVKDGVKLVNDLAHQLAISDVHLSMENSRALEQINVRWKQLQVSVAERLKQ
                     LQDAHRDFGPGSQHFLSTSVQVPWERAISPNKVPYYINHQAQTTCWDHPKMTELYQTL
                     ADLNNIKFSAYRTAMKLRRVQKALRLDLVTLTTALEIFNEHDLQASEHVMDVVEVIHC
                     LTALYERLEEERGILVNVPLCVDMSLNWLLNVFDSGRSGKMRALSFKTGIACLCGTEV
                     KEKLQYLFSQVANSGSQCDQRHLGALLHEAIQVPRQLGEVAAFGGSNVEPSVRSCFRF
                     STGKPVIEASQFLEWVNLEPQSMVWLAVLHRVTVAEQVKHQTKCSICRQCPIKGFRYR
                     SLKQFNVDICQTCFLTGKASKGNKLHYPIMEYYTPTTSSENMRDFATTLKNKFRSKQY
                     FSKHPQRGYLPVQSVLESDCSETPASSPMLPHADTHSRIEHFASRLAEMESQNCSFFN
                     DSLSPDDSIDEDQYLLRHSSPITDREPAFGQQAPCSMATESKGELEKILAHLEDENRI
                     LQGELRRLKWQHEEAVEAPTLAEGSAEATPDHRNEELLAEARILRQHKSRLETRMQIL
                     EDHNKQLESQLQRLRELLLQPPTESDGNGSAGSSLASSPRQSEGSHPREKGQTTPDTE
                     AADDVGSKSQDVSLCLEDIMEKLRHAFPSVRSSDVTANTLLAS"
     exon            301..464
                     /gene="Drp2"
                     /gene_synonym="DRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            465..621
                     /gene="Drp2"
                     /gene_synonym="DRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            622..742
                     /gene="Drp2"
                     /gene_synonym="DRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            743..1011
                     /gene="Drp2"
                     /gene_synonym="DRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1158
                     /gene="Drp2"
                     /gene_synonym="DRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1237
                     /gene="Drp2"
                     /gene_synonym="DRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1298
                     /gene="Drp2"
                     /gene_synonym="DRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1360
                     /gene="Drp2"
                     /gene_synonym="DRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1435
                     /gene="Drp2"
                     /gene_synonym="DRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..1637
                     /gene="Drp2"
                     /gene_synonym="DRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1638..1723
                     /gene="Drp2"
                     /gene_synonym="DRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1724..1881
                     /gene="Drp2"
                     /gene_synonym="DRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1882..2048
                     /gene="Drp2"
                     /gene_synonym="DRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2049..2160
                     /gene="Drp2"
                     /gene_synonym="DRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2161..2297
                     /gene="Drp2"
                     /gene_synonym="DRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2298..2363
                     /gene="Drp2"
                     /gene_synonym="DRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2364..2429
                     /gene="Drp2"
                     /gene_synonym="DRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2430..2573
                     /gene="Drp2"
                     /gene_synonym="DRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2574..2811
                     /gene="Drp2"
                     /gene_synonym="DRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2812..2932
                     /gene="Drp2"
                     /gene_synonym="DRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2933..7238
                     /gene="Drp2"
                     /gene_synonym="DRP-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcacacagca gctgtcggca tccctgtctg agggacttct ttgctgattc acagagacag
       61 cctagcctgg gcctcccggc ttccagctac cgcctgcttc gcagacctga cggaatcaga
      121 aggtgtttga tgctccacag ttggtctact gccaatcctc accctccatg agccttggtt
      181 ctgatgcaac ctttggtcat gcagggatgc ccttacaccc tcccacgatg tcatgagtgg
      241 catgctgctg acaggtttca tcacagcagc agcctccgaa acacctgtcc ccagcctcag
      301 gttagagctg cggtcaccat ccctgcacca ccttgggatg gtgccgggga tccctgccta
      361 agtccaaagc tcttgaacgg gtctgttgga gccgttggcc ccctggaacc atcagccatg
      421 aatctgtgtt ggaatgaaat aaaaaagaag tctcacaacc tccgcgctcg cctagaggcc
      481 ttctcagacc acagtggaaa acttcagctc ccactccaag agattattga ctggctcagc
      541 caaaaggatg aagaattgtc agctcagctg cccttgcaag gggatgtggc cctggtacaa
      601 caggagaagg agacacatgc tgcctttatg gaagaagtga agtctaaagg cccctatatc
      661 tactctgtgc tggaatcggc acaggctttc ctgtctcagc acccatttga ggaattagag
      721 gagtctcatt ctgagagcaa agatacctcc ccaagacagc ggattcaaaa cctcagtcgc
      781 tttgtgtgga agcaggcaac agtggccagt gaactgtggg agaagctgac agcccgctgt
      841 gtggatcagc atcgccacat tgagcacacc ctggaacatc tattggagat ccaaggggca
      901 atggaggaac tgagcagtac tttgacccaa gcagagggag tccgagccac atgggagccc
      961 ataggagatc tctttatcga ttccctccca gagcatatcc aagccatcaa gttattcaaa
     1021 gaagaattct ctcctgtgaa agacggggtg aagttagtga atgacctggc ccaccagctt
     1081 gctatttctg atgtgcactt gtcaatggag aattcaaggg ctctggaaca gatcaacgtc
     1141 cgctggaaac agctccaggt gtcagttgct gagaggctta aacagctcca ggatgcccac
     1201 cgggactttg ggcctgggtc acagcacttc ctctccactt ctgttcaagt tccctgggaa
     1261 agagcaattt ctcccaataa agtcccctac tacatcaacc accaggctca gaccacatgc
     1321 tgggaccatc ccaagatgac cgagttatac caaaccctag ctgacctgaa caacatcaag
     1381 ttctcagctt accgcactgc catgaagctc cgccgagtcc agaaggccct gcgcttggat
     1441 ctggtaactt taactacagc tctggagatc ttcaatgagc acgacttgca ggccagtgaa
     1501 catgtaatgg atgtggtgga ggtcattcac tgcttgactg ccttgtatga acgactggag
     1561 gaggaaagag gcatcctggt caacgtgccg ctgtgtgtag acatgagcct caactggctc
     1621 ctcaacgttt ttgatagtgg ccgcagtgga aagatgcgag cattgtcctt taagactggc
     1681 atcgcatgcc tgtgtggcac tgaagtgaaa gaaaaacttc agtatctctt cagccaagtg
     1741 gccaattcag gcagccagtg tgaccagcgc cacctcggtg ccctgcttca tgaagccatc
     1801 caagtgcccc gtcagctggg tgaagtggca gcatttgggg gcagcaatgt ggagcccagt
     1861 gtccgtagtt gctttcgctt cagcactggc aagccagtca ttgaagcttc ccaattcctg
     1921 gagtgggtca acctggagcc ccagtctatg gtgtggctgg ctgttcttca tcgggtcacc
     1981 gttgctgagc aagtgaagca tcagaccaag tgttctatct gtagacagtg ccccatcaaa
     2041 gggttcaggt accggagtct gaaacaattt aacgtggata tctgccagac ctgcttcttg
     2101 acaggcaagg ccagcaaagg caacaagctc cactatccca tcatggagta ttacacaccg
     2161 accacatcta gtgaaaacat gagggacttt gccacaacct taaagaataa atttcgctcc
     2221 aagcagtatt tcagcaaaca ccctcagcga ggttatctgc ctgtgcagtc agtactggag
     2281 agcgactgca gtgagacacc tgcttcttcc ccgatgttgc cacacgctga cacacactct
     2341 cgaattgagc attttgccag caggcttgct gagatggaaa gtcaaaattg ttcctttttt
     2401 aatgacagcc tgtccccgga tgacagcatc gacgaggacc agtacctgtt gaggcactcc
     2461 agccccatca cagaccgaga gccggccttt ggacagcagg ctccgtgcag catggccaca
     2521 gaaagcaagg gggaactcga gaagatcctg gcccatttag aagatgagaa ccggattctt
     2581 cagggagagc tgaggcgcct gaaatggcag cacgaagaag cagtcgaggc acctacccta
     2641 gctgagggct ctgctgaagc aaccccagac caccgcaatg aagagcttct agctgaagcc
     2701 aggatcctgc ggcagcacaa gagccgcctg gagacacgca tgcagatcct tgaagaccac
     2761 aacaagcagt tagagtctca gctgcaacgc ctgagagagc tgctcctgca gccacccact
     2821 gaatcagatg gcaatggctc tgcaggctca tccctagcct cctccccacg ccagtcagaa
     2881 ggcagtcatc cccgggagaa gggacagact actccagaca ctgaggctgc agatgatgtg
     2941 ggttcaaaga gtcaggatgt cagcctatgc ttagaagaca tcatggagaa gctccgccac
     3001 gccttcccca gtgtgcgaag ctctgatgtg actgcgaaca ctctgctggc ctcttgatgg
     3061 agtcataccc ccatcctgta gttcatagtc ctttcctgat tctcgtcaat gccgtccctt
     3121 aacctttgcc caacctttcc agtagccact ggccccacat tcctcagcca gagatatttg
     3181 ggcctggggc agcagcaggg atctaatggc ttgtgagatg tggtggagga agagaggaga
     3241 gctgtgttac ctctgactct agaaatgtac ccattaatcc ttaagactga acctgtccct
     3301 tatgttattc tgctgttgca gcccaggcaa aggcacttgt cacccagata aggagcagaa
     3361 agttaccttg cagagctaag cagtgcccac tggtcccttt cgcttctcca tggaatcaaa
     3421 gaagggaaag cctaatggcc tcgaggttct gcgttattga tctcctacta tctggcccaa
     3481 ctgaaagaga caaatgggta tccctgagac attcctccaa agggcgcctt aggaagtcta
     3541 ggcagtttat gtcctattag ttcagctcca gagcatagtt cttgaggatt ctatctacat
     3601 gttttttcct ccaatatctt taattcatcc tgccacagta cctagcagag cttctctgat
     3661 ggaggagcat tttcattgta gacacgcttc caccctatat ttggaaacat taacataaaa
     3721 aatacttgtt tctttaaata ccccccccat gatcctattt tctggtggcc ttggcatccc
     3781 aagagactcg ttgagatgct ctggaaagcc atccgaagtc actctggttt tctgagtctg
     3841 tcctcactga gctgctggca ggagtggcat cttcttcaac aaagaggcct ttactttctc
     3901 tttgtgtgtg tgagagagag agaaagagaa aggaaaagag accctctatc ctagaggagt
     3961 ataaacgagg atataaccaa ttgatagcat aggttagact gggtaagatg gcggattgcc
     4021 cccaaatact cactggaaaa gttccaactg accagcctga atggtgattc ctgctttaaa
     4081 gctactaaac ttgaatcaga aaactggcca cattccacgc aaagtggaat agcagcgagg
     4141 tcttcctgta tatcaaactg ttgctaacaa tgaaagatga actcggtcct caaaatgaac
     4201 taacttctcc tcggctgtat acactctgac tcctttggct agcaactgtt cagaacagaa
     4261 tgtggatgtg gaaagagtgg gttggagaac ttgaagcaga ggcagagccc actttgacta
     4321 ctttctacag aggagagctt tcaccccaga gtcttgcaat ggactcaatt ttgagtttat
     4381 atatacatat ctatactaca tttctactgt acatcagtgt tctcccagcc ttactcaaat
     4441 attaaattct aatagttctt aaagaattag tgtcctgcct tgctctttgt tagcctcagt
     4501 ctctagcagg aagggaaggg aaggcatcct ggctgggccc ttaaggacgt ttttctctat
     4561 actgatattt gaggtacatt gacctttaga ccaatccaaa gaaagtctgt ggccacagag
     4621 taatctaaca ggaagaggca ttctgttctc ttcactattt caaactttgt tccactgaga
     4681 cttgagcctt aggtaaaatt ttcttaccac ccttaaaaag tgatttggga accaaagtag
     4741 aacacatcca agctctaccc actccacaca gaaagaataa ataaggcata tgttagtctc
     4801 tgccaggcta agacagaata catcctatcc cattagggcc taaggtctgc atcatggcct
     4861 tatagaatgc agtggttgtc atcacagtca ggagaaagtg agatatttac agttctgtat
     4921 tataatccaa gccacagcac acacatggac ctgctaggaa cctagcttga tctgttccag
     4981 ggaggtagag tagtagcttg gctccagaaa tcaagattgc attctcccca accaagccac
     5041 agattcaagg gtcaaatctc ctgcctggag atctctcaga agaactgggt atctgcttgt
     5101 attgtgagca tttggtaggc aagcatcaaa cacagaacca ggtcatagtc agaatgaggc
     5161 atctttgtag gagcctagat tgtgggcagg attcaaataa atttgttgtg gaatagggga
     5221 ctcagaaact atgaactgca tgcctcccta aggcttaggg acatggatac tatgaaacaa
     5281 tctaagagtc cttttgtaag ccccatccaa gagttcttag gccaccgagg gtctgtgaca
     5341 acttcaatgg actggacttg gtagagaaga tgttgatctt gttatgtaga atttgtgctg
     5401 gatgtagacc gaagcagcag gtcaaggttg aagtctcact aggagagtca ctggcacttt
     5461 gccatcttgt gtttacctgc cataccccag acgagtacat tgctcaggga tccagtagca
     5521 gtcactgctg cctatgtagg caagttgcct gcagtgatga aaatgactcc tcggacagtg
     5581 tgagtccata ctggggttga atttagcaaa atgtgctcta tgttattggg tatgttgtgt
     5641 gttgaaggtc ctaaaggagc cctgtgtaat gtataaccct gcagttgaag gtagtgaaag
     5701 agttgctgga ttagtaacct gcgttatgag atagcatcag tgacggggaa tgtgtttact
     5761 ggatttttta tcaaataatg taggcaattt attctggaca gaatttgata gagagcaata
     5821 agccattggg agggtagctg tgctttcggc tcagagtagc ttcacactgg ttggcaattg
     5881 taagggaagg ctgactggct agaagacaca agactgtggt atatagttcc atagttttct
     5941 acccaggagg ccatgtgccc ttctcttcag aatgcaaggg tgagaatcaa ggttctcaat
     6001 gttcctcaca aggccgagac tctggcagga cttcactatg gagaaatctg attgggattc
     6061 aggtgttttg tgaactggtc tggcaggtca caatagtgaa aaacaaacca aggggcaagg
     6121 cagaggcaaa gcctgggaaa tttcttacca ccagattaat gttaaagact actattcctt
     6181 cctggggtgt gtgtttttaa agggtttggg ggttcagtcc ccagcttcag gctagagcat
     6241 ttgctgaact cacattttca atggcagaat tgtggcctct gggactattt tctgttatta
     6301 atcccatcca gtttcccttg gtactttgac aaataaccaa caaactgagg gacagtcctg
     6361 gaggagaacc tagaggcatt cccctaaggc tgtggaaatt cagctcctca gctgggtagt
     6421 ccaatctgtg ggcctccctg caaaatcctg ggacttggaa gaaaaatact tcagcaattc
     6481 ctcgctgttt taactcctcc tttagctgcc atttttggaa ggagacctgc caaatgccct
     6541 tgctgttccc aaggcagtat aaaaggcaga ctgaagttga ctatgctgct tgctggctgc
     6601 aagaattgat cacaaggatg aaaattaggg gataggggag gtgtcaaggg tggcatgcaa
     6661 atgtattaaa gttcggggtg aagggggcta ggagcaaatg ggttaatgtc agttgccact
     6721 cactgtggtg cttttcccat tttatccttg aattccgctt tgaagaataa atttgtattt
     6781 gtttactttg gtccctctgg ttattttctc cgctcatggc cttccaccgt cctctagtat
     6841 tttagggtgg acagaaaaga gtagaggtga agaagccaca ggcatactga cagacgggca
     6901 gttgcctgga ctggtggccc ctcaagttcc ccctttcaaa aggaagagct tgcctcacag
     6961 aaaaagtaat ggtttctaaa ttttctcatc aatctgagtt tttcaagcag ctgaagcagt
     7021 atgagaaaaa tcagggtcac tgctgtgagt ttccatgaaa gtgcatttac tctgttaagc
     7081 tctgtccttt attctgagat tgtagaatga atatatatat gcatatatat atgtgcatat
     7141 atatggagag agtgtgtgtt aaaatgtccc catgaactga tgataatcat tttgcttact
     7201 gccatttcat gccaaaataa agctttgtta gtccttca
//
