LOCUS       NM_001107655            4479 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus drosha ribonuclease III (Drosha), mRNA.
ACCESSION   NM_001107655 XM_001058381 XM_226843
VERSION     NM_001107655.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4479)
  AUTHORS   Pidikova,P., Chovancova,B., Mravec,B. and Herichova,I.
  TITLE     The 24-h pattern of dgcr8, drosha, and dicer expression in the rat
            suprachiasmatic nuclei and peripheral tissues and its modulation by
            angiotensin II
  JOURNAL   Gen Physiol Biophys 41 (5), 417-430 (2022)
   PUBMED   36222340
  REMARK    GeneRIF: The 24-h pattern of dgcr8, drosha, and dicer expression in
            the rat suprachiasmatic nuclei and peripheral tissues and its
            modulation by angiotensin II.
REFERENCE   2  (bases 1 to 4479)
  AUTHORS   Yang,Y., Wang,W., Chang,H., Han,Z., Yu,X. and Zhang,T.
  TITLE     Reciprocal regulation of miR-206 and IL-6/STAT3 pathway mediates
            IL6-induced gefitinib resistance in EGFR-mutant lung cancer cells
  JOURNAL   J Cell Mol Med 23 (11), 7331-7341 (2019)
   PUBMED   31507089
REFERENCE   3  (bases 1 to 4479)
  AUTHORS   Ushakov,K., Koffler-Brill,T., Rom,A., Perl,K., Ulitsky,I. and
            Avraham,K.B.
  TITLE     Genome-wide identification and expression profiling of long
            non-coding RNAs in auditory and vestibular systems
  JOURNAL   Sci Rep 7 (1), 8637 (2017)
   PUBMED   28819115
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4479)
  AUTHORS   Lugli,G., Larson,J., Demars,M.P. and Smalheiser,N.R.
  TITLE     Primary microRNA precursor transcripts are localized at
            post-synaptic densities in adult mouse forebrain
  JOURNAL   J Neurochem 123 (4), 459-466 (2012)
   PUBMED   22897173
REFERENCE   5  (bases 1 to 4479)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   6  (bases 1 to 4479)
  AUTHORS   Rybak,A., Fuchs,H., Smirnova,L., Brandt,C., Pohl,E.E., Nitsch,R.
            and Wulczyn,F.G.
  TITLE     A feedback loop comprising lin-28 and let-7 controls pre-let-7
            maturation during neural stem-cell commitment
  JOURNAL   Nat Cell Biol 10 (8), 987-993 (2008)
   PUBMED   18604195
REFERENCE   7  (bases 1 to 4479)
  AUTHORS   Davis,B.N., Hilyard,A.C., Lagna,G. and Hata,A.
  TITLE     SMAD proteins control DROSHA-mediated microRNA maturation
  JOURNAL   Nature 454 (7200), 56-61 (2008)
   PUBMED   18548003
REFERENCE   8  (bases 1 to 4479)
  AUTHORS   Han,J., Lee,Y., Yeom,K.H., Kim,Y.K., Jin,H. and Kim,V.N.
  TITLE     The Drosha-DGCR8 complex in primary microRNA processing
  JOURNAL   Genes Dev 18 (24), 3016-3027 (2004)
   PUBMED   15574589
REFERENCE   9  (bases 1 to 4479)
  AUTHORS   Bhogal,R.K., Mitchell,A.L. and Coen,C.W.
  TITLE     Identification of putative rat ribonuclease III by differential
            display: a novel rat mRNA expressed in a circadian manner in the
            rat suprachiasmatic nucleus
  JOURNAL   Brain Res Mol Brain Res 131 (1-2), 51-57 (2004)
   PUBMED   15530651
REFERENCE   10 (bases 1 to 4479)
  AUTHORS   Lee,Y., Ahn,C., Han,J., Choi,H., Kim,J., Yim,J., Lee,J.,
            Provost,P., Radmark,O., Kim,S. and Kim,V.N.
  TITLE     The nuclear RNase III Drosha initiates microRNA processing
  JOURNAL   Nature 425 (6956), 415-419 (2003)
   PUBMED   14508493
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Sep 15, 2012 this sequence version replaced NM_001107655.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643285.7580.1,
                                           SRR26643296.5601.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                JAXUCZ010000002.1  63591978-63592050
            74-184              JAXUCZ010000002.1  63593102-63593212
            185-250             JAXUCZ010000002.1  63594774-63594839
            251-1084            JAXUCZ010000002.1  63600360-63601193
            1085-1177           JAXUCZ010000002.1  63603845-63603937
            1178-1288           JAXUCZ010000002.1  63608514-63608624
            1289-1520           JAXUCZ010000002.1  63608843-63609074
            1521-1662           JAXUCZ010000002.1  63611831-63611972
            1663-1817           JAXUCZ010000002.1  63613899-63614053
            1818-1898           JAXUCZ010000002.1  63617453-63617533
            1899-1985           JAXUCZ010000002.1  63624273-63624359
            1986-2072           JAXUCZ010000002.1  63626944-63627030
            2073-2144           JAXUCZ010000002.1  63633296-63633367
            2145-2226           JAXUCZ010000002.1  63634883-63634964
            2227-2301           JAXUCZ010000002.1  63635878-63635952
            2302-2471           JAXUCZ010000002.1  63648148-63648317
            2472-2596           JAXUCZ010000002.1  63651209-63651333
            2597-2696           JAXUCZ010000002.1  63652774-63652873
            2697-2804           JAXUCZ010000002.1  63654816-63654923
            2805-2912           JAXUCZ010000002.1  63659803-63659910
            2913-3051           JAXUCZ010000002.1  63660345-63660483
            3052-3112           JAXUCZ010000002.1  63661006-63661066
            3113-3172           JAXUCZ010000002.1  63671118-63671177
            3173-3272           JAXUCZ010000002.1  63672554-63672653
            3273-3375           JAXUCZ010000002.1  63675487-63675589
            3376-3446           JAXUCZ010000002.1  63677411-63677481
            3447-3491           JAXUCZ010000002.1  63682586-63682630
            3492-3649           JAXUCZ010000002.1  63684020-63684177
            3650-3755           JAXUCZ010000002.1  63685341-63685446
            3756-3897           JAXUCZ010000002.1  63694462-63694603
            3898-3980           JAXUCZ010000002.1  63696447-63696529
            3981-4084           JAXUCZ010000002.1  63696608-63696711
            4085-4177           JAXUCZ010000002.1  63699199-63699291
            4178-4224           JAXUCZ010000002.1  63700022-63700068
            4225-4479           JAXUCZ010000002.1  63703434-63703688
FEATURES             Location/Qualifiers
     source          1..4479
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q16"
     gene            1..4479
                     /gene="Drosha"
                     /gene_synonym="Etohi2; RGD1307626; Rn3; Rnasen"
                     /note="drosha ribonuclease III"
                     /db_xref="GeneID:310159"
                     /db_xref="RGD:1307626"
     exon            1..73
                     /gene="Drosha"
                     /gene_synonym="Etohi2; RGD1307626; Rn3; Rnasen"
                     /inference="alignment:Splign:2.1.0"
     exon            74..184
                     /gene="Drosha"
                     /gene_synonym="Etohi2; RGD1307626; Rn3; Rnasen"
                     /inference="alignment:Splign:2.1.0"
     exon            185..250
                     /gene="Drosha"
                     /gene_synonym="Etohi2; RGD1307626; Rn3; Rnasen"
                     /inference="alignment:Splign:2.1.0"
     CDS             234..4355
                     /gene="Drosha"
                     /gene_synonym="Etohi2; RGD1307626; Rn3; Rnasen"
                     /EC_number="3.1.26.3"
                     /note="ribonuclease III, nuclear; ethanol induced 2;
                     ribonuclease type III, nuclear; drosha, ribonuclease type
                     III"
                     /codon_start=1
                     /product="ribonuclease 3"
                     /protein_id="NP_001101125.2"
                     /db_xref="GeneID:310159"
                     /db_xref="RGD:1307626"
                     /translation="MQGNTCHRMSYHPGRGCPRGRGGHGARPSAPTYRPQNLRLLHPQ
                     QPPAQYQYEPPSAPSSSFSNSQAPNFMPPRPDFVPYPPPVAPSAQGPLPPCPVRPPYP
                     NHQMRHPFPVPPCFPPMPPPMPCPNNPPVSGAPPGQGTFPFMVPPPSMPHPPPPPVMP
                     QQVNYQYPPGYSHSFPPPNFNSFQNNSSSFPPSANNSSTPHFRHLPPYSLPKAQSERR
                     SPERLKHYDDHRHRDHSHGRGERHRSLERRERGRSPERRRPESRYRSEYDRGRTPPPR
                     HRSYERSRERERERHRHRENRRSPSLERAYKKEYKRSGRSYGLPVTPEPAGCTAELPG
                     EIIKNTDSWAPPQENVNHRSPSREKKRARWEEEKDRWSDSQSSGKEKSYTSIKEKEPE
                     EAPPEKTEEEDEELLKPVWIRCTHSESYYSSDPMDQVGDSTVVGTSRLRDLYDKFEEE
                     LGNRQEKAKAARPPWEPPKTKLDEDLESSSESECETDEDSTCSSSSDSEVFDVIAEIK
                     RKKAHPDRLHDELWYNDPGQMNDGPLCKCSAKARRTGIRHSIYPGEEAIKPCRPMTNN
                     AGRLFHYRITVSPPTNFLTDRPTVIEYDDHEYIFEGFSMFAHAPLTNIPLCKVIRFNI
                     DYTIHFIEEMMPENFCVKGLELFSLFLFRDILELYDWNLKGPLFEDSPPCCPRFHFMP
                     RFVRFLPDGGKEVLSMHQILLYLLRCSKALVPEEEIANMLQWEELEWQKYAEECKGMI
                     VTNPGTKPSSVRIDQLDREQFNPEVITFPIIVHFGIRPAQLSYAGDPQYQKLWKSYVK
                     LRHLLANSPKVKQTDKQKLAQREEALQKIRQKNTMRREVTVELSSQGFWKTGIRSDVC
                     QHAMMLPVLTHHIRYHQCLMHLDKLIGYTFQDRCLLQLAMTHPSHHLNFGMNPDHARN
                     SLSNCGIRQPKYGDRKVHHMHMRKKGINTLINIMSRLGQDDPTPSRINHNERLEFLGD
                     AVVEFLTSVHLYYLFPSLEEGGLATYRTAIVQNQHLAMLAKKLELDRFMLYAHGPDLC
                     RESDLRHAMANCFEALIGAVYLEGTLEEAKQLFGRLLFNDPDLREVWLNYPLHPLQLQ
                     EPNTDRQLIETSPVLQKLTEFEEAIGVIFTHVRLLARAFTLRTVGFNHLTLGHNQRME
                     FLGDSIMQLVATEYLFIHFPDHHEGHLTLLRSSLVNNRTQAKVAEELGMQEYAITNDK
                     TKRPVALRTKTLADLLESFIAALYIDKDLEYVHTFMNVCFFPRLKEFILNQDWNDPKS
                     QLQQCCLTLRTEGKEPDIPLYKTLQTVGPSHARTYTVAVYFKGERIGCGKGPSIQQAE
                     MGAAMDALEKYNFPQMAHQKRFIERKYRQELKEMRWEREHQEREPDEAEDIKK"
     exon            251..1084
                     /gene="Drosha"
                     /gene_synonym="Etohi2; RGD1307626; Rn3; Rnasen"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1177
                     /gene="Drosha"
                     /gene_synonym="Etohi2; RGD1307626; Rn3; Rnasen"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1288
                     /gene="Drosha"
                     /gene_synonym="Etohi2; RGD1307626; Rn3; Rnasen"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1520
                     /gene="Drosha"
                     /gene_synonym="Etohi2; RGD1307626; Rn3; Rnasen"
                     /inference="alignment:Splign:2.1.0"
     exon            1521..1662
                     /gene="Drosha"
                     /gene_synonym="Etohi2; RGD1307626; Rn3; Rnasen"
                     /inference="alignment:Splign:2.1.0"
     exon            1663..1817
                     /gene="Drosha"
                     /gene_synonym="Etohi2; RGD1307626; Rn3; Rnasen"
                     /inference="alignment:Splign:2.1.0"
     exon            1818..1898
                     /gene="Drosha"
                     /gene_synonym="Etohi2; RGD1307626; Rn3; Rnasen"
                     /inference="alignment:Splign:2.1.0"
     exon            1899..1985
                     /gene="Drosha"
                     /gene_synonym="Etohi2; RGD1307626; Rn3; Rnasen"
                     /inference="alignment:Splign:2.1.0"
     exon            1986..2072
                     /gene="Drosha"
                     /gene_synonym="Etohi2; RGD1307626; Rn3; Rnasen"
                     /inference="alignment:Splign:2.1.0"
     exon            2073..2144
                     /gene="Drosha"
                     /gene_synonym="Etohi2; RGD1307626; Rn3; Rnasen"
                     /inference="alignment:Splign:2.1.0"
     exon            2145..2226
                     /gene="Drosha"
                     /gene_synonym="Etohi2; RGD1307626; Rn3; Rnasen"
                     /inference="alignment:Splign:2.1.0"
     exon            2227..2301
                     /gene="Drosha"
                     /gene_synonym="Etohi2; RGD1307626; Rn3; Rnasen"
                     /inference="alignment:Splign:2.1.0"
     exon            2302..2471
                     /gene="Drosha"
                     /gene_synonym="Etohi2; RGD1307626; Rn3; Rnasen"
                     /inference="alignment:Splign:2.1.0"
     exon            2472..2596
                     /gene="Drosha"
                     /gene_synonym="Etohi2; RGD1307626; Rn3; Rnasen"
                     /inference="alignment:Splign:2.1.0"
     exon            2597..2696
                     /gene="Drosha"
                     /gene_synonym="Etohi2; RGD1307626; Rn3; Rnasen"
                     /inference="alignment:Splign:2.1.0"
     exon            2697..2804
                     /gene="Drosha"
                     /gene_synonym="Etohi2; RGD1307626; Rn3; Rnasen"
                     /inference="alignment:Splign:2.1.0"
     exon            2805..2912
                     /gene="Drosha"
                     /gene_synonym="Etohi2; RGD1307626; Rn3; Rnasen"
                     /inference="alignment:Splign:2.1.0"
     exon            2913..3051
                     /gene="Drosha"
                     /gene_synonym="Etohi2; RGD1307626; Rn3; Rnasen"
                     /inference="alignment:Splign:2.1.0"
     exon            3052..3112
                     /gene="Drosha"
                     /gene_synonym="Etohi2; RGD1307626; Rn3; Rnasen"
                     /inference="alignment:Splign:2.1.0"
     exon            3113..3172
                     /gene="Drosha"
                     /gene_synonym="Etohi2; RGD1307626; Rn3; Rnasen"
                     /inference="alignment:Splign:2.1.0"
     exon            3173..3272
                     /gene="Drosha"
                     /gene_synonym="Etohi2; RGD1307626; Rn3; Rnasen"
                     /inference="alignment:Splign:2.1.0"
     exon            3273..3375
                     /gene="Drosha"
                     /gene_synonym="Etohi2; RGD1307626; Rn3; Rnasen"
                     /inference="alignment:Splign:2.1.0"
     exon            3376..3446
                     /gene="Drosha"
                     /gene_synonym="Etohi2; RGD1307626; Rn3; Rnasen"
                     /inference="alignment:Splign:2.1.0"
     exon            3447..3491
                     /gene="Drosha"
                     /gene_synonym="Etohi2; RGD1307626; Rn3; Rnasen"
                     /inference="alignment:Splign:2.1.0"
     exon            3492..3649
                     /gene="Drosha"
                     /gene_synonym="Etohi2; RGD1307626; Rn3; Rnasen"
                     /inference="alignment:Splign:2.1.0"
     exon            3650..3755
                     /gene="Drosha"
                     /gene_synonym="Etohi2; RGD1307626; Rn3; Rnasen"
                     /inference="alignment:Splign:2.1.0"
     exon            3756..3897
                     /gene="Drosha"
                     /gene_synonym="Etohi2; RGD1307626; Rn3; Rnasen"
                     /inference="alignment:Splign:2.1.0"
     exon            3898..3980
                     /gene="Drosha"
                     /gene_synonym="Etohi2; RGD1307626; Rn3; Rnasen"
                     /inference="alignment:Splign:2.1.0"
     exon            3981..4084
                     /gene="Drosha"
                     /gene_synonym="Etohi2; RGD1307626; Rn3; Rnasen"
                     /inference="alignment:Splign:2.1.0"
     exon            4085..4177
                     /gene="Drosha"
                     /gene_synonym="Etohi2; RGD1307626; Rn3; Rnasen"
                     /inference="alignment:Splign:2.1.0"
     exon            4178..4224
                     /gene="Drosha"
                     /gene_synonym="Etohi2; RGD1307626; Rn3; Rnasen"
                     /inference="alignment:Splign:2.1.0"
     exon            4225..4479
                     /gene="Drosha"
                     /gene_synonym="Etohi2; RGD1307626; Rn3; Rnasen"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtggcgcct ctgccgtgga ggctgttata gtaaccaggc tgggctttga tggcggcgac
       61 ctcggtacta tctaggctgt gaaggatgca ggaatgactg aatgagcgca tgatttcaag
      121 gatctagtaa atgctggagg agttcaccat gggcacacgt gactgtcaca tacagcagat
      181 tctgaactta cattgtgagc ggaagatgta gcttatctac agtgtacctc gagatgcaag
      241 gcaatacgtg tcatagaatg tcttaccacc caggacgagg gtgtccccgg ggacgaggag
      301 gacatggagc cagaccctca gcaccgactt acaggcccca aaatctgaga cttcttcacc
      361 ctcagcagcc tcctgcgcag tatcaatatg agcctcccag tgccccctct tcctcgttct
      421 cgaactctca agcccccaac tttatgcccc cacggcctga ctttgtccct taccctccac
      481 cagttgcacc gtcagcacag ggccctctcc caccctgccc agttaggccc ccttacccca
      541 accaccagat gagacaccct ttccctgtgc ctccctgttt tccacccatg ccccctccaa
      601 tgccttgtcc caacaacccc ccagtctccg gagcacctcc cggccaaggc actttcccct
      661 tcatggtccc ccctccttcc atgccccacc ccccaccccc tcccgtcatg ccgcagcagg
      721 ttaattatca gtaccctcct ggatactcgc acagtttccc gcctcccaat ttcaacagtt
      781 ttcagaacaa ctccagttct ttcccaccca gtgctaataa cagcagcacc cctcatttta
      841 gacacctccc tccatactca cttcccaagg ctcagagtga gagaaggtcc ccagagaggc
      901 ttaagcacta cgatgaccac aggcaccgag atcacagtca cgggcgaggt gagaggcatc
      961 ggtccctgga gcgcagagag cgcggccgca gcccggagag gagaagacct gagagccgct
     1021 accgctcgga atatgatcgg gggaggacgc caccgccgcg ccatcgcagc tacgaaagga
     1081 gcagagagcg ggaacgagag agacacaggc accgggaaaa ccgcagatca ccgtctctgg
     1141 aaagggccta caaaaaggaa tataagagat ctggaaggag ctatggctta ccagtcactc
     1201 ctgagccggc tggatgcaca gcagaattac ctggggagat tattaaaaat acagattctt
     1261 gggccccacc ccaggagaat gtgaatcatc gttctccaag cagggagaag aagagagcac
     1321 gttgggagga ggaaaaagac aggtggagtg acagccagag ctctggcaaa gagaagagct
     1381 atacgtccat caaagaaaag gaaccagagg aggcgccgcc tgagaaaacc gaggaagagg
     1441 acgaagagct cctcaagccc gtgtggatcc gatgcacaca ctcggaaagt tactactcca
     1501 gtgaccccat ggatcaggtg ggagactcta ctgtcgtagg aacaagcagg ctccgggatc
     1561 tgtatgacaa atttgaggaa gagttgggga acaggcaaga gaaggccaaa gctgcccggc
     1621 ctccatggga gcccccaaag acaaagctgg atgaagattt agagagctcc agtgagtctg
     1681 aatgcgagac ggacgaggac agcacctgct caagcagctc ggactcggag gtgttcgatg
     1741 tcattgcaga gattaaacgc aaaaaggctc accctgaccg acttcatgat gaactttggt
     1801 acaacgaccc aggccagatg aacgacggac cactttgcaa atgcagtgca aaagcaagac
     1861 gcacaggaat tcggcacagc atttatcccg gagaagaggc aatcaagccc tgtcgtccta
     1921 tgaccaacaa cgctggacga cttttccact accggattac cgtctccccg cctaccaact
     1981 ttttaacgga caggccaaca gtcatagaat acgatgatca tgagtatatc tttgaaggat
     2041 tttctatgtt tgcacatgcc cctctgacca atattccact gtgtaaagta attcgattca
     2101 acatagacta cacgattcat tttattgaag agatgatgcc tgagaatttt tgtgtgaaag
     2161 gacttgaact gttttcattg ttcctattca gagatatttt ggagttatac gactggaatc
     2221 ttaaaggtcc tttgtttgaa gacagccctc cctgctgtcc aagatttcat ttcatgccac
     2281 gttttgtaag atttcttcca gatggcggca aagaagtgtt atcaatgcac cagattcttc
     2341 tctacctgct tcgctgtagc aaggctttgg tccctgagga ggagattgcc aatatgctcc
     2401 aatgggagga gctcgagtgg cagaaatatg cggaagagtg caaaggcatg atagttacca
     2461 accctgggac gaaaccaagc tctgtccgca tcgatcaact ggatcgtgag cagttcaacc
     2521 ctgaagtgat cacttttccg attatcgttc actttgggat acgccctgca cagttgagtt
     2581 atgcaggaga cccacaatac caaaaattat ggaaaagtta cgtgaaactt cgccacctct
     2641 tagcaaatag tcccaaggtc aaacagactg acaaacagaa gctggcgcag agggaggaag
     2701 cgctccagaa gatacggcag aagaacacaa tgcgtcgaga agtcaccgtg gagctgagta
     2761 gccaaggatt ctggaaaact ggcattcgtt ctgatgtctg tcagcacgcg atgatgctgc
     2821 ctgttctgac ccatcacatc cgataccatc aatgcttaat gcacttggac aagttgatag
     2881 ggtatacttt tcaggatcgt tgtctgctcc agctggccat gactcatccg agtcatcatt
     2941 taaattttgg aatgaatcct gatcatgcca ggaattctct gtctaactgt ggaattcgac
     3001 agcccaaata tggagacaga aaagttcatc acatgcacat gcggaaaaaa ggaattaaca
     3061 ccctaataaa tatcatgtca cgcctcggcc aagatgatcc aactccttca aggattaatc
     3121 acaatgaaag gttggagttc ctgggagatg ctgttgttga gtttctgacc agtgtccacc
     3181 tgtactattt gtttcctagc ttggaggaag gaggcttggc aacctatcgg acagccattg
     3241 ttcagaatca gcacctcgcc atgctcgcaa agaaacttga actggatcga tttatgctgt
     3301 atgcccatgg gcccgaccta tgtagagaat cagacctccg gcatgcgatg gccaattgtt
     3361 tcgaagcatt gataggagct gtttacttgg aggggaccct ggaggaagcc aaacagttgt
     3421 ttggacgctt actctttaat gatccggacc tgagagaagt ctggctcaat tatcctctcc
     3481 acccactcca actacaagag ccaaatacag atcgacaact tattgaaact tccccagttc
     3541 tacagaaact gaccgagttt gaagaagcaa ttggggtgat cttcactcac gtccggcttc
     3601 tggcacgggc attcacacta agaactgtgg gctttaacca cctgacccta ggccacaatc
     3661 agaggatgga attcctgggt gactccataa tgcagctggt agccacggag tacttgttca
     3721 tccacttccc cgaccaccac gaaggacact tgacgttgtt acgaagttct ttagtgaaca
     3781 acagaactca agccaaggta gcagaggaac tgggcatgca agagtatgcc atcaccaacg
     3841 acaaaaccaa gagacccgtg gccctaagaa ccaagacttt ggcagacctt ttggaatcat
     3901 ttattgcagc cctgtacatc gacaaggact tggaatacgt ccatactttc atgaacgtct
     3961 gcttctttcc acgtctgaag gagttcattc tgaaccagga ctggaatgac cccaagtcgc
     4021 agctgcagca gtgctgcctg accctgagga ctgaagggaa agaaccagac atccccttgt
     4081 acaagactct gcagacagtg gggccgtccc acgctagaac ctacacggtg gccgtttact
     4141 tcaaaggaga gaggataggc tgtgggaaag gaccaagtat tcagcaggcc gaaatgggag
     4201 cagcaatgga cgcacttgag aaatataact ttccccagat ggctcatcag aagcggttca
     4261 ttgaacggaa atacagacaa gagttaaagg aaatgaggtg ggaaagagag catcaggaga
     4321 gagagccgga tgaggctgaa gacataaaga agtaaagggg gacacgaagt ggtggagcac
     4381 tgacttcctg agaatgagac tgtggcccct cgagacctag cctgcttttc ctccaatgaa
     4441 tgaagcgtgc ccatcgaaat aaaactcaaa gtcaaactg
//
