LOCUS       NM_145767               2403 bp    mRNA    linear   ROD 23-MAR-2025
DEFINITION  Rattus norvegicus dorsal root ganglia homeobox (Drgx), transcript
            variant 2, mRNA.
ACCESSION   NM_145767
VERSION     NM_145767.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2403)
  AUTHORS   Ito,T., Sakai,A., Maruyama,M., Miyagawa,Y., Okada,T., Fukayama,H.
            and Suzuki,H.
  TITLE     Dorsal Root Ganglia Homeobox downregulation in primary sensory
            neurons contributes to neuropathic pain in rats
  JOURNAL   Mol Pain 16, 1744806920904462 (2020)
   PUBMED   32000573
  REMARK    GeneRIF: Dorsal Root Ganglia Homeobox downregulation in primary
            sensory neurons contributes to neuropathic pain in rats.
REFERENCE   2  (bases 1 to 2403)
  AUTHORS   Rebelo,S., Chen,Z.F., Anderson,D.J. and Lima,D.
  TITLE     Involvement of DRG11 in the development of the primary afferent
            nociceptive system
  JOURNAL   Mol Cell Neurosci 33 (3), 236-246 (2006)
   PUBMED   16978876
REFERENCE   3  (bases 1 to 2403)
  AUTHORS   Ding,Y.Q., Yin,J., Kania,A., Zhao,Z.Q., Johnson,R.L. and Chen,Z.F.
  TITLE     Lmx1b controls the differentiation and migration of the superficial
            dorsal horn neurons of the spinal cord
  JOURNAL   Development 131 (15), 3693-3703 (2004)
   PUBMED   15229182
  REMARK    Erratum:[Development. 2009 Jun;136(11):1961]
REFERENCE   4  (bases 1 to 2403)
  AUTHORS   Samad,T.A., Srinivasan,A., Karchewski,L.A., Jeong,S.J.,
            Campagna,J.A., Ji,R.R., Fabrizio,D.A., Zhang,Y., Lin,H.Y., Bell,E.
            and Woolf,C.J.
  TITLE     DRAGON: a member of the repulsive guidance molecule-related family
            of neuronal- and muscle-expressed membrane proteins is regulated by
            DRG11 and has neuronal adhesive properties
  JOURNAL   J Neurosci 24 (8), 2027-2036 (2004)
   PUBMED   14985445
REFERENCE   5  (bases 1 to 2403)
  AUTHORS   Ding,Y.Q., Yin,J., Xu,H.M., Jacquin,M.F. and Chen,Z.F.
  TITLE     Formation of whisker-related principal sensory nucleus-based
            lemniscal pathway requires a paired homeodomain transcription
            factor, Drg11
  JOURNAL   J Neurosci 23 (19), 7246-7254 (2003)
   PUBMED   12917357
REFERENCE   6  (bases 1 to 2403)
  AUTHORS   Chen,Z.F., Rebelo,S., White,F., Malmberg,A.B., Baba,H., Lima,D.,
            Woolf,C.J., Basbaum,A.I. and Anderson,D.J.
  TITLE     The paired homeodomain protein DRG11 is required for the projection
            of cutaneous sensory afferent fibers to the dorsal spinal cord
  JOURNAL   Neuron 31 (1), 59-73 (2001)
   PUBMED   11498051
REFERENCE   7  (bases 1 to 2403)
  AUTHORS   Saito,T., Greenwood,A., Sun,Q. and Anderson,D.J.
  TITLE     Identification by differential RT-PCR of a novel paired homeodomain
            protein specifically expressed in sensory neurons and a subset of
            their CNS targets
  JOURNAL   Mol Cell Neurosci 6 (3), 280-292 (1995)
   PUBMED   7496632
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Nov 27, 2020 this sequence version replaced NM_145767.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U29174.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN17050747, SAMN17050756
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-193               JAXUCZ010000016.1  7861157-7861349
            194-312             JAXUCZ010000016.1  7861578-7861696
            313-410             JAXUCZ010000016.1  7865563-7865660
            411-512             JAXUCZ010000016.1  7866794-7866895
            513-691             JAXUCZ010000016.1  7869636-7869814
            692-804             JAXUCZ010000016.1  7869900-7870012
            805-2403            JAXUCZ010000016.1  7889111-7890709
FEATURES             Location/Qualifiers
     source          1..2403
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..2403
                     /gene="Drgx"
                     /gene_synonym="Drg11; Prrxl1"
                     /note="dorsal root ganglia homeobox"
                     /db_xref="GeneID:252880"
                     /db_xref="RGD:628616"
     exon            1..193
                     /gene="Drgx"
                     /gene_synonym="Drg11; Prrxl1"
                     /inference="alignment:Splign:2.1.0"
     exon            194..312
                     /gene="Drgx"
                     /gene_synonym="Drg11; Prrxl1"
                     /inference="alignment:Splign:2.1.0"
     CDS             279..1070
                     /gene="Drgx"
                     /gene_synonym="Drg11; Prrxl1"
                     /note="homeobox protein DRG11; dorsal root ganglion 11;
                     paired-related homeobox protein-like 1; paired-like
                     homeodomain trancription factor Drg11"
                     /codon_start=1
                     /product="dorsal root ganglia homeobox protein"
                     /protein_id="NP_665710.2"
                     /db_xref="GeneID:252880"
                     /db_xref="RGD:628616"
                     /translation="MFYFHCPPQLEGTAPFGNHSTGDFDDGFLRRKQRRNRTTFTLQQ
                     LEALEAVFAQTHYPDVFTREELAMKINLTEARVQVWFQNRRAKWRKTERGASDQEPGA
                     KEPMAEVTPPPVRNINSPPPGDQARGKKEALEAQQSLGRTVGPAGPFFPSCLPGTLLN
                     TATYAQALSHVASLKGGPLCSCCVPDPMGLSFLPTYGCQSNRTASVAALRMKAREHSE
                     AVLQSANLLPSTSSSPGPASKQVPPEGSQDKPSPTKEQSEGEKSV"
     exon            313..410
                     /gene="Drgx"
                     /gene_synonym="Drg11; Prrxl1"
                     /inference="alignment:Splign:2.1.0"
     exon            411..512
                     /gene="Drgx"
                     /gene_synonym="Drg11; Prrxl1"
                     /inference="alignment:Splign:2.1.0"
     exon            513..691
                     /gene="Drgx"
                     /gene_synonym="Drg11; Prrxl1"
                     /inference="alignment:Splign:2.1.0"
     exon            692..804
                     /gene="Drgx"
                     /gene_synonym="Drg11; Prrxl1"
                     /inference="alignment:Splign:2.1.0"
     exon            805..2403
                     /gene="Drgx"
                     /gene_synonym="Drg11; Prrxl1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagaggtag gcagggttcc cgagccgctc tcccggctcc ctgctctggg ccttggggct
       61 ccaccggctt cttggcccga gctgctgcgc gtgcagatgg ccttgcgcga tcgccggacc
      121 ccgctgcggt ggccaagtgc agggcttgtg gctgggaccc ctgagaacca ggagccagac
      181 tgtgctcagc ttgccaggcc ggagccacgc acgggcacaa gtctgtcagg ccgccatcag
      241 tcctggtcca gccgtcaggg cccatccgac cgtcggcgat gttttatttc cactgcccgc
      301 cacagctaga gggcacagcg ccttttggta accactctac gggggatttt gatgatgggt
      361 ttcttagaag aaaacagcgc agaaatcgga caaccttcac tcttcagcag ttggaagctc
      421 tggaggcagt ctttgcccaa acacactacc cagatgtctt caccagagaa gagctagcca
      481 tgaaaataaa cctcacagaa gccagagtgc aggtttggtt ccagaaccga agagccaagt
      541 ggaggaagac agagagaggg gcctctgacc aggaaccagg ggctaaggaa cccatggcag
      601 aggtgacacc acccccagtg aggaacatca actctccacc cccaggggac caggcccggg
      661 gcaagaagga ggccctggag gcccagcaga gcctgggacg cacagtgggc cccgccgggc
      721 ctttcttccc ctcctgcttg ccagggaccc tcctgaacac agccacttat gcccaggccc
      781 tgtcccatgt ggcatctctg aaagggggcc cactgtgctc ttgctgcgtc ccagacccta
      841 tggggctctc cttcctcccc acttacggtt gccagagtaa ccgcacagcc agcgtggctg
      901 ccctgcgcat gaaggcccgc gagcattcag aagcggtcct gcagtctgcc aaccttctgc
      961 cgtccaccag cagcagcccc ggccctgcct ccaagcaggt gcctccagaa ggcagccagg
     1021 acaagccctc cccaacgaag gaacagagcg agggagagaa gagcgtatga gggtccggag
     1081 aacccagctg ggagccctgc ccacccctgc ttctctcagc ctcagccctg ccagcctctg
     1141 aaccacaagg agtagccacc tcctcatgga tctgacaggg caaacgggac ctgcaagctg
     1201 gttgagacct gaagagtccc tctagaattc tgctggtagg ctgtgttgtt ctcgcttttc
     1261 ctttggtgac attttccgat ggctcttagt gactctggac actgctctgt gatgaggtcc
     1321 ctgttttttg ctttttgttt tgtctctttt ttttttttgt tttgttttgt tttattttcc
     1381 aggccaagca gccttggagc aaagcagatt agtttattcc accatccttc ttgagatatc
     1441 tgggaaggtc ttgtcaattc caaggactgt ggcaaggatc atccgtgaaa gatgccaaga
     1501 agtgacatct catgacagga aatgagacgg gcactcccat attgcttaag aaccacagaa
     1561 ctggtggact atcagccagt tctcactccc ttcagccagg actggcatcg gcctcctttg
     1621 tcttgtttaa aggaattagc tgaggttttg gctaggaagt gacaagatat gggctgaaga
     1681 cattgtggtc ctgaccctag cagatctccc tgggcacatc tgacctggtc cagtcaggca
     1741 ggttgtcagt tcggggatgg gggctgctct gctgattctg tgtgtgggtt ccctgcaatt
     1801 agagtgttca cttgcaggcc ccgcctctct tcagaagagt gatgggaagt tcaccaatca
     1861 gaatgtagct ttgtggccca ggaaaggacc agagtccttg aagcggtagg aaatccctag
     1921 gaaggtccct taaatactta tgcccagatg agctgccctt cttcctatcc ccgtatgtcg
     1981 agaggttgac gagacaggaa agccaggaag atgactccgt gtggcagaag agaatggagt
     2041 ccaaagggcc aactttcaca gagatttctg ccgcagtcta gcgtggctgt gttctttcac
     2101 gcgatggtga cttcggagag atcagaggga gatgtgcaat agcatgagcc ccgctcctgg
     2161 cccgggtcct ggaaaggttg tggttgtttg gtggctttgg ctgataatgt ttccacgcaa
     2221 acagatattg ctttcatgat ggctgttctc atttcagttc tgataatcga gacgctgtgc
     2281 tcccaggcgc tctgcctccc cttaactctt caggagcacc ccctcccctg taatactcct
     2341 aagtgtatcg tgcctcactt acggttactg caacacattt gatggaacac actgtctcct
     2401 tta
//
