LOCUS       NM_012768               3101 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus dopamine receptor D5 (Drd5), mRNA.
ACCESSION   NM_012768
VERSION     NM_012768.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3101)
  AUTHORS   Babushkina,N. and Manahan-Vaughan,D.
  TITLE     Frequency-dependency of the involvement of dopamine D1/D5 and
            beta-adrenergic receptors in hippocampal LTD triggered by locus
            coeruleus stimulation
  JOURNAL   Hippocampus 32 (6), 449-465 (2022)
   PUBMED   35478421
  REMARK    GeneRIF: Frequency-dependency of the involvement of dopamine D1/D5
            and beta-adrenergic receptors in hippocampal LTD triggered by locus
            coeruleus stimulation.
REFERENCE   2  (bases 1 to 3101)
  AUTHORS   Prosilis,A., Mesiakaris,V. and Stamatakis,A.
  TITLE     Expression of D5 dopamine receptors in the lateral ventricle walls
            during post-weaning rat development
  JOURNAL   Int J Dev Biol 66 (1-2-3), 263-267 (2022)
   PUBMED   34881789
  REMARK    GeneRIF: Expression of D5 dopamine receptors in the lateral
            ventricle walls during post-weaning rat development.
REFERENCE   3  (bases 1 to 3101)
  AUTHORS   Maingret,F. and Groc,L.
  TITLE     Characterization of the Functional Cross-Talk between Surface GABAA
            and Dopamine D5 Receptors
  JOURNAL   Int J Mol Sci 22 (9), 4867 (2021)
   PUBMED   34064454
  REMARK    GeneRIF: Characterization of the Functional Cross-Talk between
            Surface GABAA and Dopamine D5 Receptors.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3101)
  AUTHORS   Papaleonidopoulos,V., Kouvaros,S. and Papatheodoropoulos,C.
  TITLE     Effects of endogenous and exogenous D1/D5 dopamine receptor
            activation on LTP in ventral and dorsal CA1 hippocampal synapses
  JOURNAL   Synapse 72 (8), e22033 (2018)
   PUBMED   29537707
  REMARK    GeneRIF: Results suggest that the dynamic range of D1/D5
            receptor-mediated dopamine effects on LTP may be higher in ventral
            hippocampus than dorsal hippocampus and that ventral hippocampus
            may be specialized to acquire information about behaviorally
            relevant strong stimuli signaled by the dopamine system.
REFERENCE   5  (bases 1 to 3101)
  AUTHORS   Ke,Y., Li,W., Tan,Z. and Yang,Z.
  TITLE     Induction of dopamine D1 and D5 receptors in R28 cells by light
            exposures
  JOURNAL   Biochem Biophys Res Commun 486 (3), 686-692 (2017)
   PUBMED   28336436
  REMARK    GeneRIF: The results suggest that dopamine receptors in the retinal
            cells might actively respond to the environmental lighting to act
            as an important player in the activation of the dopaminergic system
            in the ocular structures relevant to the lighting-induced
            pathogenic development of myopia.
REFERENCE   6  (bases 1 to 3101)
  AUTHORS   Barr,C.L., Wigg,K.G., Feng,Y., Zai,G., Malone,M., Roberts,W.,
            Schachar,R., Tannock,R. and Kennedy,J.L.
  TITLE     Attention-deficit hyperactivity disorder and the gene for the
            dopamine D5 receptor
  JOURNAL   Mol Psychiatry 5 (5), 548-551 (2000)
   PUBMED   11032390
REFERENCE   7  (bases 1 to 3101)
  AUTHORS   Karpa,K.D., Lidow,M.S., Pickering,M.T., Levenson,R. and Bergson,C.
  TITLE     N-linked glycosylation is required for plasma membrane localization
            of D5, but not D1, dopamine receptors in transfected mammalian
            cells
  JOURNAL   Mol Pharmacol 56 (5), 1071-1078 (1999)
   PUBMED   10531415
REFERENCE   8  (bases 1 to 3101)
  AUTHORS   Barbanti,P., Fabbrini,G., Ricci,A., Cerbo,R., Bronzetti,E.,
            Caronti,B., Calderaro,C., Felici,L., Stocchi,F., Meco,G., Amenta,F.
            and Lenzi,G.L.
  TITLE     Increased expression of dopamine receptors on lymphocytes in
            Parkinson's disease
  JOURNAL   Mov Disord 14 (5), 764-771 (1999)
   PUBMED   10495037
REFERENCE   9  (bases 1 to 3101)
  AUTHORS   Tiberi,M., Jarvie,K.R., Silvia,C., Falardeau,P., Gingrich,J.A.,
            Godinot,N., Bertrand,L., Yang-Feng,T.L., Fremeau,R.T. Jr. and
            Caron,M.G.
  TITLE     Cloning, molecular characterization, and chromosomal assignment of
            a gene encoding a second D1 dopamine receptor subtype: differential
            expression pattern in rat brain compared with the D1A receptor
  JOURNAL   Proc Natl Acad Sci U S A 88 (17), 7491-7495 (1991)
   PUBMED   1831904
REFERENCE   10 (bases 1 to 3101)
  AUTHORS   Sunahara,R.K., Guan,H.C., O'Dowd,B.F., Seeman,P., Laurier,L.G.,
            Ng,G., George,S.R., Torchia,J., Van Tol,H.H. and Niznik,H.B.
  TITLE     Cloning of the gene for a human dopamine D5 receptor with higher
            affinity for dopamine than D1
  JOURNAL   Nature 350 (6319), 614-619 (1991)
   PUBMED   1826762
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Sep 29, 2022 this sequence version replaced NM_012768.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR26360176.1685557.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3101              JAXUCZ010000014.1  76700244-76703344   c
FEATURES             Location/Qualifiers
     source          1..3101
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..3101
                     /gene="Drd5"
                     /gene_synonym="D1B"
                     /note="dopamine receptor D5"
                     /db_xref="GeneID:25195"
                     /db_xref="RGD:2523"
     exon            1..3101
                     /gene="Drd5"
                     /gene_synonym="D1B"
                     /inference="alignment:Splign:2.1.0"
     CDS             277..1704
                     /gene="Drd5"
                     /gene_synonym="D1B"
                     /note="d(5) dopamine receptor; dopamine D5 receptor;
                     dopamine receptor 5"
                     /codon_start=1
                     /product="D(1B) dopamine receptor"
                     /protein_id="NP_036900.2"
                     /db_xref="GeneID:25195"
                     /db_xref="RGD:2523"
                     /translation="MLPPGRNRTAQPARLGLQRQLAQVDAPAGSATPLGPAQVVTAGL
                     LTLLIVWTLLGNVLVCAAIVRSRHLRAKMTNIFIVSLAVSDLFVALLVMPWKAVAEVA
                     GYWPFGTFCDIWVAFDIMCSTASILNLCIISVDRYWAISRPFRYERKMTQRVALVMVG
                     LAWTLSILISFIPVQLNWHRDKAGSQGQEGLLSNGTPWEEGWELEGRTENCDSSLNRT
                     YAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRRISSLERAAEHAQSCRSRGAYEPDP
                     SLRASIKKETKVFKTLSMIMGVFVCCWLPFFILNCMVPFCSSGDAEGPKTGFPCVSET
                     TFDIFVWFGWANSSLNPIIYAFNADFRKVFAQLLGCSHFCFRTPVQTVNISNELISYN
                     QDTVFHKEIAAAYVHMIPNAVSSGDREVGEEEEEGPFDHMSQISPTTPDGDLAAESVW
                     ELDCEEEVSLGKISPLTPNCFDKTA"
ORIGIN      
        1 agacacagcg gcagcctccg gtgtgctgcc gacacaggat ctcagacccg gcggcccgcg
       61 ggcatcggtc gtttctggtc ccatcttggg gaccagaggt gcgcaagagt gttaccatta
      121 caggatccta agcggtgcac ggtgagcgct cctcgggtcc ggggacggtc agctgcaggg
      181 cccggagcac cctctggggt gcccgatggg gccttccacg gggcgcaggg gcgaagttgg
      241 gaccgcaagc agagagcccg agctactcag cgcgacatgc tgcctcctgg gcgcaaccgc
      301 acggctcaac cggcaaggct gggattacag aggcaactgg ctcaggtgga cgccccagcg
      361 ggctctgcaa ccccactggg acccgcgcag gtggtcaccg caggcctcct gactctccta
      421 atcgtctgga ccttgctcgg gaacgtgcta gtgtgtgctg ccatcgtccg cagccgccat
      481 ctgcgcgcca agatgaccaa catcttcatc gtatccctag ctgtctcaga cctcttcgtg
      541 gcattgctgg tcatgccctg gaaggctgtg gctgaggtgg ctgggtactg gccctttggg
      601 acattctgcg acatctgggt ggcctttgac atcatgtgct ccactgcctc catcctgaat
      661 ctgtgtatca tcagcgtgga ccgttactgg gctatttcca gacccttccg ctacgagcgc
      721 aagatgaccc agcgagtagc cctggtcatg gtgggcctgg cctggacctt gtccatcctc
      781 atctccttca tcccggtcca actcaattgg cacagagaca aggcaggctc ccagggccaa
      841 gagggcctgc tgtccaatgg gacaccctgg gaggaaggct gggagctaga agggaggacg
      901 gagaactgtg actccagcct gaaccgaacc tacgccatct cctcgtcact catcagcttc
      961 tacatcccgg tggccatcat gatcgtgacc tatacgcgta tctaccgcat tgcgcaggtg
     1021 cagatccggc ggatctcctc cctagagagg gcagctgagc atgctcagag ttgccggagt
     1081 cgtggagcct atgaacctga ccccagcctg cgagcgtcca tcaagaagga gaccaaggtc
     1141 ttcaaaaccc tgtcaatgat catgggggtc ttcgtgtgtt gctggttgcc tttcttcatc
     1201 ctgaactgta tggttccttt ctgcagtagt ggggatgccg agggcccaaa gactggcttc
     1261 ccttgtgtca gcgagaccac cttcgacata ttcgtctggt ttggctgggc caactcctct
     1321 ctcaatccca tcatctatgc ctttaatgca gacttccgga aggtgtttgc ccagctgctg
     1381 gggtgcagcc acttctgctt ccggacccca gtgcagacgg taaacatcag taatgagctc
     1441 atctcctaca accaagacac ggtcttccac aaggagatcg ctgctgccta tgtccacatg
     1501 ataccgaatg cagtatcctc cggagacagg gaggtgggag aggaggagga ggaggggcct
     1561 ttcgatcaca tgtctcaaat ctctccaacg acgccagacg gtgacctggc tgctgagtct
     1621 gtctgggagc ttgactgtga ggaagaggtt tccttaggca aaatctcacc tctcaccccc
     1681 aattgtttcg ataaaactgc ttagaaacat tctcatgggc atatacaatg gtggccatat
     1741 ttccaagcat gcacaaatac ccacgtgcgt acacacacac acacacacac acacacacac
     1801 acacacactc ccagtgtgca tatgctttct gtagtcctgc tgcatagaaa ccaaactatt
     1861 cttagctgag aaaatgaacc gaggctgttg gaataaactc agacattctg gacaaagaat
     1921 gttccgttta gagatgagaa agtggagcct ggacctttaa gagtatatac ttcaacttac
     1981 cctttctaac aaagatttgt tctgtgactt gcacctgggt tgctttttaa atgacaggtc
     2041 tgagtggcaa ttgttggtgt gggctgtgac tttctaaaga tgtaggtctg tagccctgtg
     2101 ctctggcagc tgctttagtg cagttgaggg gtctttcctg tgactggggt ttctttctga
     2161 tttgttctga ttttttgtaa gctcacagta cattcgttta aggctggggg ggggcagtca
     2221 cctttgcttt gccagttggt gctgcgtgtt gctcctggag aaaccacaag tgcaagtgct
     2281 cttgaaagac acatttattt tctgggcagc tttgcttagg gaacacacag gacaaagggc
     2341 cttgaggaac ttctgacttc ttagcttccc tttccttagt cacaccttca gaacacactc
     2401 aaggctagtt tctccttcac acatgagatg cgggatttcc ctcaagcctg aaactcgatg
     2461 agttttgttt tgtcttttgg aactgtcttc tggaattaca ggagacaatg gttctgcttg
     2521 ctagacagat agtcagggtt catcggaaag accacctagc atagcaaccc ctcttctcca
     2581 tctctcatct ggggggttcc agagtgacat gggttctgga aaccacattt tctagggtct
     2641 tttagatgtg atgtgctccg aaatgcttca aaaccaaaat cctgctttga agccgatgat
     2701 tttctttgca gccaatagca aatggaatga acttcagcct ctatggggaa agccagaggt
     2761 aacacatgac tggatgaact tatagggtga ggggctcacg gaggagccca cgtgtctttt
     2821 tgctttccca acctgcactg agtacagcaa agtgttcttt attccgttat gatttcatta
     2881 gacacaaatg taaaaaaaaa aaaaagtagc aaaggaaacg aaatgtgcat atgttagttc
     2941 ctacacgccc ctgctccaaa gacgggttct caaggacagt tcaatcaatt ttggtttcct
     3001 tatggatgac tgtattatga gtcttctgaa cagccgtgtc ttgttccctg taaactgtgt
     3061 agtgcctgcc acatcgtgct taataaatgt tggttgaatg a
//
