LOCUS       NM_012944               1416 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus dopamine receptor D4 (Drd4), mRNA.
ACCESSION   NM_012944
VERSION     NM_012944.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1416)
  AUTHORS   Zhang,R., Dang,W., Zhang,J., He,R., Li,G., Zhang,L., Wang,Z.,
            Zong,H., Liu,N. and Jia,W.
  TITLE     Methylation quantitative locus rs3758653 in the DRD4 gene is
            associated with duration from first heroin exposure to addiction
  JOURNAL   Brain Res 1775, 147746 (2022)
   PUBMED   34864042
REFERENCE   2  (bases 1 to 1416)
  AUTHORS   Chmielowiec,K., Chmielowiec,J., Masiak,J., Czekaj,M., Krawczyk,P.,
            Soroka,E., Smiarowska,M., Musial,W., Pawlowski,T. and Grzywacz,A.
  TITLE     DRD4 Exon 3 Gene Polymorphisms in Patients Diagnosed with
            Polysubstance Use Disorder and Co-Occurrence of a Depressive
            Episode
  JOURNAL   Genes (Basel) 12 (11), 1834 (2021)
   PUBMED   34828440
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1416)
  AUTHORS   Sonia,J.A., Kabir,T., Islam,M.M.T. and Kabir,Y.
  TITLE     Catechol-O-methyltransferase and dopamine receptor D4 gene
            variants: Possible association with substance abuse in Bangladeshi
            male
  JOURNAL   PLoS One 16 (2), e0246462 (2021)
   PUBMED   33544778
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1416)
  AUTHORS   Hui,Y., Du,C., Xu,T., Zhang,Q., Tan,H. and Liu,J.
  TITLE     Dopamine D4 receptors in the lateral habenula regulate
            depression-related behaviors via a pre-synaptic mechanism in
            experimental Parkinson's disease
  JOURNAL   Neurochem Int 140, 104844 (2020)
   PUBMED   32891683
  REMARK    GeneRIF: Dopamine D4 receptors in the lateral habenula regulate
            depression-related behaviors via a pre-synaptic mechanism in
            experimental Parkinson's disease.
REFERENCE   5  (bases 1 to 1416)
  AUTHORS   Uysal,M.A., Sever,U., Nursal,A.F. and PehlIvan,S.
  CONSRTM   Yedikule Smoking Cessation Study Group
  TITLE     Dopamine D4 Receptor Gene Exon III VNTR Variant Influences Smoking
            Status in Turkish Population
  JOURNAL   Noro Psikiyatr Ars 56 (4), 248-252 (2019)
   PUBMED   31903031
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1416)
  AUTHORS   Nothen,M.M., Cichon,S., Hemmer,S., Hebebrand,J., Remschmidt,H.,
            Lehmkuhl,G., Poustka,F., Schmidt,M., Catalano,M., Fimmers,R. et al.
  TITLE     Human dopamine D4 receptor gene: frequent occurrence of a null
            allele and observation of homozygosity
  JOURNAL   Hum Mol Genet 3 (12), 2207-2212 (1994)
   PUBMED   7881421
REFERENCE   7  (bases 1 to 1416)
  AUTHORS   Chio,C.L., Drong,R.F., Riley,D.T., Gill,G.S., Slightom,J.L. and
            Huff,R.M.
  TITLE     D4 dopamine receptor-mediated signaling events determined in
            transfected Chinese hamster ovary cells
  JOURNAL   J Biol Chem 269 (16), 11813-11819 (1994)
   PUBMED   7512953
REFERENCE   8  (bases 1 to 1416)
  AUTHORS   Van Tol,H.H., Wu,C.M., Guan,H.C., Ohara,K., Bunzow,J.R.,
            Civelli,O., Kennedy,J., Seeman,P., Niznik,H.B. and Jovanovic,V.
  TITLE     Multiple dopamine D4 receptor variants in the human population
  JOURNAL   Nature 358 (6382), 149-152 (1992)
   PUBMED   1319557
REFERENCE   9  (bases 1 to 1416)
  AUTHORS   O'Malley,K.L., Harmon,S., Tang,L. and Todd,R.D.
  TITLE     The rat dopamine D4 receptor: sequence, gene structure, and
            demonstration of expression in the cardiovascular system
  JOURNAL   New Biol 4 (2), 137-146 (1992)
   PUBMED   1554689
REFERENCE   10 (bases 1 to 1416)
  AUTHORS   Van Tol,H.H., Bunzow,J.R., Guan,H.C., Sunahara,R.K., Seeman,P.,
            Niznik,H.B. and Civelli,O.
  TITLE     Cloning of the gene for a human dopamine D4 receptor with high
            affinity for the antipsychotic clozapine
  JOURNAL   Nature 350 (6319), 610-614 (1991)
   PUBMED   1840645
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 28, 2015 this sequence version replaced NM_012944.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M84009.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-412               JAXUCZ010000001.1  205825937-205826348
            413-519             JAXUCZ010000001.1  205827836-205827942
            520-1091            JAXUCZ010000001.1  205828036-205828607
            1092-1416           JAXUCZ010000001.1  205828800-205829124
FEATURES             Location/Qualifiers
     source          1..1416
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q41"
     gene            1..1416
                     /gene="Drd4"
                     /gene_synonym="D4RA"
                     /note="dopamine receptor D4"
                     /db_xref="GeneID:25432"
                     /db_xref="RGD:2522"
     exon            1..412
                     /gene="Drd4"
                     /gene_synonym="D4RA"
                     /inference="alignment:Splign:2.1.0"
     CDS             131..1294
                     /gene="Drd4"
                     /gene_synonym="D4RA"
                     /note="dopamine D4 receptor; d(2C) dopamine receptor;
                     dopamine receptor 4"
                     /codon_start=1
                     /product="D(4) dopamine receptor"
                     /protein_id="NP_037076.2"
                     /db_xref="GeneID:25432"
                     /db_xref="RGD:2522"
                     /translation="MGNSSATGDGGLLAGRGPESLGTGTGLGGAGAGAAALVGGVLLI
                     GMVLAGNSLVCVSVASERILQTPTNYFIVSLAAADLLLAVLVLPLFVYSEGGVWLLSP
                     RLCDTLMAMDVMLCTASIFNLCAISVDRFVAVTVPLRYNQQGQCQLLLIAATWLLSAA
                     VAAPVVCGLNDVPGRDPTVCCLEDRDYVVYSSICSFFLPCPLMLLLYWATFRGLRRWE
                     AARHTKLHSRAPRRPSGPGPPVSDPTQGPLFSDCPPPSPSLRTSPTVSSRPESDLSQS
                     PCSPGCLLPDAALAQPPAPSSRRKRGAKITGRERKAMRVLPVVVGAFLMCWTPFFVVH
                     ITRALCPACFVSPRLVSAVTWLGYVNSALNPIIYTIFNAEFRSVFRKTLRLRC"
     exon            413..519
                     /gene="Drd4"
                     /gene_synonym="D4RA"
                     /inference="alignment:Splign:2.1.0"
     exon            520..1091
                     /gene="Drd4"
                     /gene_synonym="D4RA"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1416
                     /gene="Drd4"
                     /gene_synonym="D4RA"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aatttcctag agtgcagaaa ttcaagccgt ggcgggcggg gcggagctgg acgctggggg
       61 cgggattccg gatagcccct gactgcaaat ccccaggctc agcgccttgc agagtctcag
      121 ctagggcgcc atggggaaca gcagcgctac tggtgacggt gggctgttgg ccgggcgtgg
      181 gccagagtcc ttaggtactg gcaccggact tgggggcgcg ggcgcgggcg cggcggcgct
      241 ggtgggaggc gtgctgctca tcggcatggt gttggcaggg aactcgctcg tttgcgtgag
      301 cgtggcctcc gagcgcatcc tgcagacacc caccaactac ttcatcgtga gcctggcggc
      361 tgccgacctc ctcctcgcgg tgctggtgtt gcctctcttt gtctactccg agggtggcgt
      421 gtggctgctg agcccccgcc tctgtgacac cctcatggcc atggacgtca tgctgtgcac
      481 cgcctccatc ttcaacctgt gcgccatcag cgtggacagg tttgtggctg tgaccgtgcc
      541 actgcgctac aaccagcagg gtcagtgcca gctgctgctc atcgccgcca cgtggctgct
      601 gtctgccgcg gtggctgcgc ccgtcgtgtg cggcctcaat gatgtgcccg gtcgcgatcc
      661 aaccgtgtgc tgcctggagg accgcgacta cgtggtctac tcatccattt gttccttctt
      721 cctgccctgt ccgctcatgc tactgcttta ctgggccact ttccgtggct tgcggcgctg
      781 ggaggcagcc cggcacacca agcttcacag ccgcgcgccg cgccgaccca gcggcccggg
      841 cccgccggtg tcggacccta ctcagggtcc cctcttctca gattgtccgc ctccctcacc
      901 cagcctccgg acgagcccca ccgtctccag cagaccagag tcagacctct ctcagagccc
      961 ctgcagcccc gggtgtctgc tccctgatgc agcgctcgcg caaccgcctg cgccgtcttc
     1021 ccgcagaaag agaggcgcca agatcactgg aagggagcgc aaggcgatga gagtcctgcc
     1081 ggtggtagtt ggggccttcc tgatgtgttg gacgcctttc ttcgtggtgc acatcacacg
     1141 ggcgctgtgt ccggcttgtt tcgtgtcccc acgcctggtc agtgctgtca cctggctggg
     1201 ctatgtcaac agtgccctca accccatcat ctacaccatc ttcaatgccg agtttcgaag
     1261 tgtcttccgc aagactcttc gtctccgctg ctgaaagaac cgctgatgtc ttgaggtcaa
     1321 ggggttccaa gcctgtgtgc agagtgcgct ggcgcgcttt cgttcgtctg attaaatgaa
     1381 gtctttccta accatttatc aacgctgggg gctggg
//
