LOCUS       NM_012547               2747 bp    mRNA    linear   ROD 20-MAY-2024
DEFINITION  Rattus norvegicus dopamine receptor D2 (Drd2), transcript variant
            1, mRNA.
ACCESSION   NM_012547 XM_346830
VERSION     NM_012547.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2747)
  AUTHORS   Mansour,H.M., Mohamed,A.F., Khattab,M.M. and El-Khatib,A.S.
  TITLE     Unveiling the therapeutic prospects of EGFR inhibition in
            rotenone-mediated parkinsonism in rats: Modulation of dopamine D3
            receptor
  JOURNAL   Brain Res 1834, 148893 (2024)
   PUBMED   38554797
  REMARK    GeneRIF: Unveiling the therapeutic prospects of EGFR inhibition in
            rotenone-mediated parkinsonism in rats: Modulation of dopamine D3
            receptor.
REFERENCE   2  (bases 1 to 2747)
  AUTHORS   Raut,S., Khambata,K., Singh,D. and Balasinor,N.H.
  TITLE     Dopamine receptor D2 regulates genes involved in germ cell movement
            and sperm motility in rat testesdagger
  JOURNAL   Biol Reprod 110 (2), 377-390 (2024)
   PUBMED   37956402
  REMARK    GeneRIF: Dopamine receptor D2 regulates genes involved in germ cell
            movement and sperm motility in rat testesdagger.
REFERENCE   3  (bases 1 to 2747)
  AUTHORS   Tsyba,E.T., Birioukova,L.M., Midzyanovskaya,I.S., Surina,N.M. and
            Abbasova,K.R.
  TITLE     Brain D2-Like Dopamine Receptor Distribution in Rats with Different
            Types of Genetic Epilepsy
  JOURNAL   Dokl Biol Sci 509 (1), 140-144 (2023)
   PUBMED   37208583
  REMARK    GeneRIF: Brain D2-Like Dopamine Receptor Distribution in Rats with
            Different Types of Genetic Epilepsy.
REFERENCE   4  (bases 1 to 2747)
  AUTHORS   Chen,B., Xu,J., Chen,S., Mou,T., Wang,Y., Wang,H., Zhang,Z.,
            Ren,F., Wang,Z., Jin,K. and Lu,J.
  TITLE     Dysregulation of striatal dopamine D2/D3 receptor-mediated by
            hypocretin induces depressive behaviors in rats
  JOURNAL   J Affect Disord 325, 256-263 (2023)
   PUBMED   36638964
  REMARK    GeneRIF: Dysregulation of striatal dopamine D2/D3 receptor-mediated
            by hypocretin induces depressive behaviors in rats.
REFERENCE   5  (bases 1 to 2747)
  AUTHORS   Mattioni,J., Vansteene,C., Poupon,D., Gorwood,P. and Ramoz,N.
  TITLE     Associated and intermediate factors between genetic variants of the
            dopaminergic D2 receptor gene and harmful alcohol use in young
            adults
  JOURNAL   Addict Biol 28 (3), e13269 (2023)
   PUBMED   36825486
REFERENCE   6  (bases 1 to 2747)
  AUTHORS   Liu,Y.F., Civelli,O., Grandy,D.K. and Albert,P.R.
  TITLE     Differential sensitivity of the short and long human dopamine D2
            receptor subtypes to protein kinase C
  JOURNAL   J Neurochem 59 (6), 2311-2317 (1992)
   PUBMED   1331329
REFERENCE   7  (bases 1 to 2747)
  AUTHORS   Livingstone,C.D., Strange,P.G. and Naylor,L.H.
  TITLE     Molecular modelling of D2-like dopamine receptors
  JOURNAL   Biochem J 287 (Pt 1) (Pt 1), 277-282 (1992)
   PUBMED   1358063
REFERENCE   8  (bases 1 to 2747)
  AUTHORS   Minowa,T., Minowa,M.T. and Mouradian,M.M.
  TITLE     Analysis of the promoter region of the rat D2 dopamine receptor
            gene
  JOURNAL   Biochemistry 31 (36), 8389-8396 (1992)
   PUBMED   1390623
REFERENCE   9  (bases 1 to 2747)
  AUTHORS   Cox,B.A., Henningsen,R.A., Spanoyannis,A., Neve,R.L. and Neve,K.A.
  TITLE     Contributions of conserved serine residues to the interactions of
            ligands with dopamine D2 receptors
  JOURNAL   J Neurochem 59 (2), 627-635 (1992)
   PUBMED   1321233
REFERENCE   10 (bases 1 to 2747)
  AUTHORS   Sokoloff,P., Giros,B., Martres,M.P., Bouthenet,M.L. and
            Schwartz,J.C.
  TITLE     Molecular cloning and characterization of a novel dopamine receptor
            (D3) as a target for neuroleptics
  JOURNAL   Nature 347 (6289), 146-151 (1990)
   PUBMED   1975644
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Jul 15, 2022 this sequence version replaced NM_012547.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X56065.1, X53278.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-312               JAXUCZ010000008.1  58605403-58605714
            313-628             JAXUCZ010000008.1  58656393-58656708
            629-738             JAXUCZ010000008.1  58660765-58660874
            739-875             JAXUCZ010000008.1  58661800-58661936
            876-1066            JAXUCZ010000008.1  58663119-58663309
            1067-1153           JAXUCZ010000008.1  58664264-58664350
            1154-1484           JAXUCZ010000008.1  58665823-58666153
            1485-2747           JAXUCZ010000008.1  58668077-58669339
FEATURES             Location/Qualifiers
     source          1..2747
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q23"
     gene            1..2747
                     /gene="Drd2"
                     /note="dopamine receptor D2"
                     /db_xref="GeneID:24318"
                     /db_xref="RGD:2520"
     exon            1..312
                     /gene="Drd2"
                     /inference="alignment:Splign:2.1.0"
     exon            313..628
                     /gene="Drd2"
                     /inference="alignment:Splign:2.1.0"
     CDS             344..1678
                     /gene="Drd2"
                     /note="isoform 1 is encoded by transcript variant 1; d(2)
                     dopamine receptor; dopamine receptor 2"
                     /codon_start=1
                     /product="D(2) dopamine receptor isoform 1"
                     /protein_id="NP_036679.1"
                     /db_xref="GeneID:24318"
                     /db_xref="RGD:2520"
                     /translation="MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLL
                     IFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKF
                     SRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVW
                     VLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRK
                     RRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRA
                     QELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIV
                     NPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFI
                     THILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC"
     exon            629..738
                     /gene="Drd2"
                     /inference="alignment:Splign:2.1.0"
     exon            739..875
                     /gene="Drd2"
                     /inference="alignment:Splign:2.1.0"
     exon            876..1066
                     /gene="Drd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1153
                     /gene="Drd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1484
                     /gene="Drd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..2747
                     /gene="Drd2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctggtcgcct cttgtgcgca gcgcctcctg cccgccttcc cgcctggtcc ccgcgctgcg
       61 ctcccgtcct cccgccccgc ctcgtcctgc cccgccgcgg ccggtctact gctccccgcg
      121 ggcccgagcc ggccgagcgg ctgcccgccg gggatctgaa cggcgcggcg gggccggaag
      181 ccgagggacc cgcggagggg accggcggcc ccggacggct gccggagggg cggccgtgcg
      241 tggatgcggc gggagctgga agcctcgagc agccggcgcc ttctctggcc ccgggcgcca
      301 tatggcttga agagccgtgc cacccagtgg ccccactgcc ccaatggatc cactgaacct
      361 gtcctggtac gatgacgatc tggagaggca gaactggagc cggcccttca atgggtcaga
      421 agggaaggca gacaggcccc actacaacta ctatgccatg ctgctcaccc tcctcatctt
      481 tatcatcgtc tttggcaatg tgctggtgtg catggctgta tcccgagaga aggctttgca
      541 gaccaccacc aactacttga tagtcagcct tgctgtggct gatcttctgg tggccacact
      601 ggtaatgccg tgggttgtct acctggaggt ggtgggtgag tggaaattca gcaggattca
      661 ctgtgacatc tttgtcactc tggatgtcat gatgtgcaca gcaagcatcc tgaacctgtg
      721 tgccatcagc attgacaggt acacagctgt ggcaatgccc atgctgtata acacacgcta
      781 cagctccaag cgccgagtta ctgtcatgat tgccattgtc tgggtcctgt ccttcaccat
      841 ctcctgccca ctgctcttcg gactcaacaa tacagaccag aatgagtgta tcattgccaa
      901 ccctgccttt gtggtctact cctccattgt ctcattctac gtgcccttca tcgtcactct
      961 gctggtctat atcaaaatct acatcgtcct ccggaagcgc cggaagcggg tcaacaccaa
     1021 gcgcagcagt cgagctttca gagccaacct gaagacacca ctcaagggca actgtaccca
     1081 ccctgaggac atgaaactct gcaccgttat catgaagtct aatgggagtt tcccagtgaa
     1141 caggcggaga atggatgctg cccgccgagc tcaggagctg gaaatggaga tgctgtcaag
     1201 caccagcccc ccagagagga cccggtatag ccccatccct cccagtcacc accagctcac
     1261 tctccctgat ccatcccacc acggcctaca tagcaaccct gacagtcctg ccaaaccaga
     1321 gaagaatggg cacgccaaga ttgtcaatcc caggattgcc aagttctttg agatccagac
     1381 catgcccaat ggcaaaaccc ggacctccct taagacgatg agccgcagaa agctctccca
     1441 gcagaaggag aagaaagcca ctcagatgct tgccattgtt ctcggtgtgt tcatcatctg
     1501 ctggctgccc ttcttcatca cgcacatcct gaatatacac tgtgattgca acatcccacc
     1561 agtcctctac agcgccttca catggctggg ctatgtcaac agtgccgtca accccatcat
     1621 ctacaccacc ttcaacatcg agttccgcaa ggccttcatg aagatcttgc actgctgagt
     1681 ctgccccttg cctgcacagc agctgcttcc cacctccctg cctatgcagg ccagacctca
     1741 tccctgcaag ctgtgggcag aaaggcccag atgaacttgg ccttctctcg accctgcagg
     1801 ccctgcagtg ttagcttggc tcgatgcccc tctctgccca cacaccctca tcctgccagg
     1861 gtagggccag ggagactggt atcttaccag ctctggggtt ggacccatgg ctcagggcag
     1921 ctcacagagt gcccctctca tatccagacc ctgtctcctt ggcaccaaag atgcagcggc
     1981 cttccttgac cttcctcttg ggcacagaaa ctagctcagt ggtcgagcac accctgatcg
     2041 ctggcttggc ctggcccttg cttgcctgtg ccggatcagg tggtgggagg gagcgacagt
     2101 tcttacttta taggaaccac ataggaaagc agggaacacg ccaagtcctc caggcaacat
     2161 cagtgtcagg agacacacat aaacaccagg tagctccatg gaccccagag aaactgaggc
     2221 tgaaaaatct gttttccact ccaactctag tgtgagtccc tacttttcat agccatgggt
     2281 attactatgt cctaccttgt tatagtatcc catggggttt ctgtaccatt tgggggaaaa
     2341 caactctaat cctcaagggc cccaagagaa tctgtaagga gaaaaatagc tgatctccct
     2401 ctactctcca atccactcca ccacttcttg atataccttg gatgtatcca ttcctcacag
     2461 caaatgctgg ccagtcaggc cttggaccag tgttggagtt gaagctggat gtggtaactt
     2521 ggggctcttt ggggctgggg gggttgttaa catcgtctct cttccatatc tcttccttcc
     2581 cagtgcctct gccttagaag aggctgtgga tggggtgctg ggactgctga taccattggg
     2641 cctggccctg aatgaggagg ggaagctgca gtttggaggg ttctgggatc caactctgta
     2701 acatcactat acctgcacca aaactaataa aaccttgaca agagtca
//
