LOCUS       NM_012546               3426 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus dopamine receptor D1 (Drd1), mRNA.
ACCESSION   NM_012546
VERSION     NM_012546.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3426)
  AUTHORS   Andreska,T., Luningschror,P., Wolf,D., McFleder,R.L.,
            Ayon-Olivas,M., Rattka,M., Drechsler,C., Perschin,V., Blum,R.,
            Aufmkolk,S., Granado,N., Moratalla,R., Sauer,M., Monoranu,C.,
            Volkmann,J., Ip,C.W., Stigloher,C. and Sendtner,M.
  TITLE     DRD1 signaling modulates TrkB turnover and BDNF sensitivity in
            direct pathway striatal medium spiny neurons
  JOURNAL   Cell Rep 42 (6), 112575 (2023)
   PUBMED   37252844
  REMARK    GeneRIF: DRD1 signaling modulates TrkB turnover and BDNF
            sensitivity in direct pathway striatal medium spiny neurons.
REFERENCE   2  (bases 1 to 3426)
  AUTHORS   Witt,K.M., Harper,D.N. and Ellenbroek,B.A.
  TITLE     Dopamine D1 receptor and effort-based decision making in rats: The
            moderating effect of sex
  JOURNAL   Prog Neuropsychopharmacol Biol Psychiatry 120, 110651 (2023)
   PUBMED   36191805
  REMARK    GeneRIF: Dopamine D1 receptor and effort-based decision making in
            rats: The moderating effect of sex.
REFERENCE   3  (bases 1 to 3426)
  AUTHORS   Babushkina,N. and Manahan-Vaughan,D.
  TITLE     Frequency-dependency of the involvement of dopamine D1/D5 and
            beta-adrenergic receptors in hippocampal LTD triggered by locus
            coeruleus stimulation
  JOURNAL   Hippocampus 32 (6), 449-465 (2022)
   PUBMED   35478421
  REMARK    GeneRIF: Frequency-dependency of the involvement of dopamine D1/D5
            and beta-adrenergic receptors in hippocampal LTD triggered by locus
            coeruleus stimulation.
REFERENCE   4  (bases 1 to 3426)
  AUTHORS   Mesgar,S., Jameie,S.B., Aliaghaei,A., Parvardeh,S., Torabi,A. and
            Haghparast,A.
  TITLE     Dopamine D1 Receptor-Mediated Regulation of Per1, Per2, CLOCK, and
            BMAL1 Expression in the Suprachiasmatic Nucleus in Adult Male Rats
  JOURNAL   J Mol Neurosci 72 (3), 618-625 (2022)
   PUBMED   34751875
  REMARK    GeneRIF: Dopamine D1 Receptor-Mediated Regulation of Per1, Per2,
            CLOCK, and BMAL1 Expression in the Suprachiasmatic Nucleus in Adult
            Male Rats.
REFERENCE   5  (bases 1 to 3426)
  AUTHORS   Ramires Lima,K., de Souza da Rosa,A.C., Severo Picua,S., Souza E
            Silva,S., Marks Soares,N. and Billig Mello-Carpes,P.
  TITLE     One single physical exercise session improves memory persistence by
            hippocampal activation of D1 dopamine receptors and PKA signaling
            in rats
  JOURNAL   Brain Res 1762, 147439 (2021)
   PUBMED   33753064
  REMARK    GeneRIF: One single physical exercise session improves memory
            persistence by hippocampal activation of D1 dopamine receptors and
            PKA signaling in rats.
REFERENCE   6  (bases 1 to 3426)
  AUTHORS   Zhou,Q.Y., Li,C. and Civelli,O.
  TITLE     Characterization of gene organization and promoter region of the
            rat dopamine D1 receptor gene
  JOURNAL   J Neurochem 59 (5), 1875-1883 (1992)
   PUBMED   1402930
REFERENCE   7  (bases 1 to 3426)
  AUTHORS   Liu,Y.F., Civelli,O., Zhou,Q.Y. and Albert,P.R.
  TITLE     Cholera toxin-sensitive 3',5'-cyclic adenosine monophosphate and
            calcium signals of the human dopamine-D1 receptor: selective
            potentiation by protein kinase A
  JOURNAL   Mol Endocrinol 6 (11), 1815-1824 (1992)
   PUBMED   1282671
REFERENCE   8  (bases 1 to 3426)
  AUTHORS   Salkovic,M. and Lackovic,Z.
  TITLE     Brain D1 dopamine receptor in alloxan-induced diabetes
  JOURNAL   Diabetes 41 (9), 1119-1121 (1992)
   PUBMED   1386820
REFERENCE   9  (bases 1 to 3426)
  AUTHORS   Tiberi,M., Jarvie,K.R., Silvia,C., Falardeau,P., Gingrich,J.A.,
            Godinot,N., Bertrand,L., Yang-Feng,T.L., Fremeau,R.T. Jr. and
            Caron,M.G.
  TITLE     Cloning, molecular characterization, and chromosomal assignment of
            a gene encoding a second D1 dopamine receptor subtype: differential
            expression pattern in rat brain compared with the D1A receptor
  JOURNAL   Proc Natl Acad Sci U S A 88 (17), 7491-7495 (1991)
   PUBMED   1831904
REFERENCE   10 (bases 1 to 3426)
  AUTHORS   O'Dowd,B.F., Nguyen,T., Tirpak,A., Jarvie,K.R., Israel,Y.,
            Seeman,P. and Niznik,H.B.
  TITLE     Cloning of two additional catecholamine receptors from rat brain
  JOURNAL   FEBS Lett 262 (1), 8-12 (1990)
   PUBMED   2138567
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On Feb 3, 2015 this sequence version replaced NM_012546.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: M35077.1, SRR21887623.1696807.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3426              JAXUCZ010000017.1  10546604-10550029
FEATURES             Location/Qualifiers
     source          1..3426
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p14"
     gene            1..3426
                     /gene="Drd1"
                     /gene_synonym="D1a; Drd-1; Drd1a"
                     /note="dopamine receptor D1"
                     /db_xref="GeneID:24316"
                     /db_xref="RGD:2518"
     exon            1..3426
                     /gene="Drd1"
                     /gene_synonym="D1a; Drd-1; Drd1a"
                     /inference="alignment:Splign:2.1.0"
     CDS             439..1779
                     /gene="Drd1"
                     /gene_synonym="D1a; Drd-1; Drd1a"
                     /note="Dopamine-1A receptor; dopamine receptor D1A"
                     /codon_start=1
                     /product="D(1A) dopamine receptor"
                     /protein_id="NP_036678.3"
                     /db_xref="GeneID:24316"
                     /db_xref="RGD:2518"
                     /translation="MAPNTSTMDEAGLPAERDFSFRILTACFLSLLILSTLLGNTLVC
                     AAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFD
                     IMCSTASILNLCVISVDRYWAISSPFQYERKMTPKAAFILISVAWTLSVLISFIPVQL
                     SWHKAKPTWPLDGNFTSLEDTEDDNCDTRLSRTYAISSSLISFYIPVAIMIVTYTSIY
                     RIAQKQIRRISALERAAVHAKNCQTTAGNGNPVECAQSESSFKMSFKRETKVLKTLSV
                     IMGVFVCCWLPFFISNCMVPFCGSEETQPFCIDSITFDVFVWFGWANSSLNPIIYAFN
                     ADFQKAFSTLLGCYRLCPTTNNAIETVSINNNGAVVFSSHHEPRGSISKDCNLVYLIP
                     HAVGSSEDLKKEEAGGIAKPLEKLSPALSVILDYDTDVSLEKIQPVTHSGQHST"
ORIGIN      
        1 ggcatttgga gagatgcggt gccaggggct tggaggagaa atgcatgtat tttaggccgt
       61 gtctcagaaa aagaggcagc atccctgaaa agtgactaga attgacctgg aagaggccat
      121 ggactcagag tgtgcttaaa agccaatgct ctccttgggg aatgtaggga ccagccgatg
      181 tcacagggac acactgtcac agggacagtg acctggagca ccaagcccag aagacagatg
      241 ggaagcagga gagtctttac cccggcatgg cttggattgc tacggggaag ctcctgatgg
      301 aaccctacca tcctttagtc caggcagcaa ctggggctga acaagaaggg gctgggtggt
      361 gagtggttgg gggaagtctg gctaagcctg gtcaagaact tgaggggcaa gtccccggaa
      421 gtgtgttcct tctggaagat ggctcctaac acttctacca tggatgaggc cgggctgcca
      481 gcggagaggg atttctcctt tcgcatcctc acggcctgtt tcctgtcact gctcatcctg
      541 tccactctcc tgggcaatac ccttgtctgt gcggccgtca tccggtttcg acacctgagg
      601 tccaaggtga ccaacttctt tgtcatctct ttagctgtgt cagatctctt ggtggctgtc
      661 ctggtcatgc cctggaaagc tgtggccgag attgctggct tttggccctt tgggtccttt
      721 tgtaacatct gggtagcctt tgacatcatg tgctctacgg cgtccattct gaacctctgc
      781 gtgatcagcg tggacaggta ctgggctatc tccagccctt tccagtatga gaggaagatg
      841 acccccaaag cagccttcat cctgattagc gtagcatgga ctctgtctgt ccttatatcc
      901 ttcatcccag tacagctaag ctggcacaag gcaaagccca catggccctt ggatggcaat
      961 tttacctccc tggaggacac cgaggatgac aactgtgaca caaggttgag caggacgtat
     1021 gccatttcat cgtccctcat cagcttttac atccccgtag ccattatgat cgtcacctac
     1081 accagtatct acaggattgc ccagaagcaa atccggcgca tctcagcctt ggagagggca
     1141 gcagtccatg ccaagaattg ccagaccacc gcaggtaacg ggaaccccgt cgaatgcgcc
     1201 cagtctgaaa gttcctttaa gatgtccttc aagagggaga cgaaagttct aaagacgctg
     1261 tctgtgatca tgggggtgtt tgtgtgctgc tggctccctt tcttcatctc gaactgtatg
     1321 gtgcccttct gtggctctga ggagacccag ccattctgca tcgattccat caccttcgat
     1381 gtgtttgtgt ggtttgggtg ggcgaattct tccctgaacc ccattattta tgcttttaat
     1441 gctgacttcc agaaggcgtt ctcaaccctc ttaggatgct acagactctg ccctactacg
     1501 aataatgcca tagagacggt gagcattaac aacaatgggg ctgtggtgtt ttccagccac
     1561 catgagcccc gaggctccat ctccaaggac tgtaatctgg tttacctgat ccctcatgcc
     1621 gtgggctcct ctgaggacct gaagaaggaa gaggctggtg gaatagctaa gccactggag
     1681 aagctgtccc cagccttatc ggtcatattg gactatgaca ccgatgtctc tctagaaaag
     1741 atccaacctg tcacacacag tggacagcat tccacttgaa tattgggtcc tcatctctga
     1801 ggccacgagt tcccttgggc ttgctgttaa ggaattaaca ggagatccct ctgctgcttt
     1861 tggacaatta cgaagcttct caaactcact gattccagtg tattctctag cttcaaggga
     1921 aatgacttcg gctctgaaat cagtttggga gtattatctt aggacattat aaaacaacaa
     1981 caaacaaaca aacaaacaaa caaatagggc caagagtcaa ctgtaaacag cttcacttaa
     2041 aaatcgaact ttccagaaag gaagggtagg agttgagttt gctgtccaaa caggtgctaa
     2101 aactgtccga gcagttttca gattggaaag gtaggtgcat gcctttgtta attaacttct
     2161 ccaataataa ttgagcctta cagcaggagt gggattcctt tttctcagaa ttgacagatg
     2221 cattgttgat gacggtttta tttatttatt tattgtacta tatgaatatt ttaaatttat
     2281 catagtgaat ctatatttaa catatttaac agagcaaacc aatgtgttat ctgagactga
     2341 cctctccatt tgtactagca ctttatgagc caatgaaaca tacgcgtaga ctctgagatt
     2401 ctgaattgtg agttacttct gggaacacag caaagactga tgtggtggct ccttaactcg
     2461 acaaggacac aaagaaacgc aagaggagaa gtgactaatg ccaccaatgc tccccctaaa
     2521 aagattttga aaagattagt tttttttttt tttaaaagaa gctactattg tgttctgaat
     2581 gttttaaatg gcagaggctt tccccggggc gaatttgcac ttctgtaaat atctatgtaa
     2641 gaaccagctc aagaggaata caactttata tttccgcttt tggatggcga ggaagagcat
     2701 atgccacttt gtatttatgt aaaataattg gccctccttg tcatttctca tttcatgctt
     2761 gaaatagctt tctgaaacaa acaaatgact gtccaggctg gagatctgca gggtggagaa
     2821 tgagttgtaa attcacaggt cacagcagcc cctccgatag ctgggctcat cattggtcct
     2881 ttatctgccc aggtctaacc aagtcggctg cttaaggggc tacttttgta gtgctttaat
     2941 ccgaatttag tatcctctct ttaaaaaaaa aaagctcttt aatgttagtg gtaaactagc
     3001 taatgaacgg tacctcatcg ctgcataata cacttctgtt ggtgggggcg tagacgagcc
     3061 ccttcccggt gcgagcacca caaagccatc tgcatagcta gtcacaaatg ctgtttttct
     3121 ttctctgtgg gtttgaatct agtttccttg ttatcatagc ctggactgca aaaagaacca
     3181 tcgagtcccc tcttgtgggg gcattgcaac agtgtttctt tttgtttttg ttttgttttt
     3241 gaaatgttta caaggtgttc tttggaagca gttgcaacac gtggatggaa ctgaagaaaa
     3301 ggctgactgg cttgctaacg gtatctcctg cagggggttt gtactgcgga ctttgaatgt
     3361 tttctcagct ctaaggcttg tatgctttct tacatacaat aaacttattt tgtgaattca
     3421 aatcaa
//
