LOCUS       NM_001013857            1856 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus dynein regulatory complex subunit 3 (Drc3), mRNA.
ACCESSION   NM_001013857 XM_213320
VERSION     NM_001013857.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1856)
  AUTHORS   Olbrich,H., Cremers,C., Loges,N.T., Werner,C., Nielsen,K.G.,
            Marthin,J.K., Philipsen,M., Wallmeier,J., Pennekamp,P., Menchen,T.,
            Edelbusch,C., Dougherty,G.W., Schwartz,O., Thiele,H., Altmuller,J.,
            Rommelmann,F. and Omran,H.
  TITLE     Loss-of-Function GAS8 Mutations Cause Primary Ciliary Dyskinesia
            and Disrupt the Nexin-Dynein Regulatory Complex
  JOURNAL   Am J Hum Genet 97 (4), 546-554 (2015)
   PUBMED   26387594
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC083838.1.
            
            On Apr 20, 2005 this sequence version replaced XM_213320.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083838.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1856
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q22"
     gene            1..1856
                     /gene="Drc3"
                     /gene_synonym="Lrrc48; RGD1309150"
                     /note="dynein regulatory complex subunit 3"
                     /db_xref="GeneID:287371"
                     /db_xref="RGD:1309150"
     exon            1..89
                     /gene="Drc3"
                     /gene_synonym="Lrrc48; RGD1309150"
                     /inference="alignment:Splign:2.1.0"
     exon            90..288
                     /gene="Drc3"
                     /gene_synonym="Lrrc48; RGD1309150"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..1700
                     /gene="Drc3"
                     /gene_synonym="Lrrc48; RGD1309150"
                     /note="leucine-rich repeat-containing protein 48; leucine
                     rich repeat containing 48"
                     /codon_start=1
                     /product="dynein regulatory complex subunit 3"
                     /protein_id="NP_001013879.1"
                     /db_xref="GeneID:287371"
                     /db_xref="RGD:1309150"
                     /translation="MSRPYDSMEPKVMDDDMLKVAVGEQGPQEEAGQLAKQEGILFKD
                     VLALQLDFQNILRIDNLWQFENLRKLQLNNNIIERIEGLENLTHLVWLDLSFNNIEAI
                     EGLDTLVNLEDLSLSHNRISKIDSLDPLVNLQVLSLGNNQINNMMNIIYLRRFPCLRT
                     LSLSGNPVSEAEEYKVFIYAYLPDLVYLDFRRVDEQAREVAKMKHQYSIDELKHREAL
                     MQIRLEEEQAKQQKLAEHKMAFVEHLNGPFLFDSMYSDDVEGNKLSYLPGVGELLEAY
                     KDKFVIICLNIFEYGLSQQEKRKIELDTFNECIQEAIQENQDQGKLKIAKFEEKHLLN
                     LNAIREESDLFTMEQKLTECNESITELFNTLMILEMQLVEQLEETINVFERNITDLVG
                     LFIENVQSLIAQCRDLENHHHEKLLEIAINTLEKILKGEMDEDLPDDVRALFVDKDTI
                     VNAVGASHDIHLLKIDNREDELVTGVNSWCAHLVDKIHKDEIMRNRKRVKEINQFVDH
                     MQSELDNLECGDIID"
     exon            289..405
                     /gene="Drc3"
                     /gene_synonym="Lrrc48; RGD1309150"
                     /inference="alignment:Splign:2.1.0"
     exon            406..572
                     /gene="Drc3"
                     /gene_synonym="Lrrc48; RGD1309150"
                     /inference="alignment:Splign:2.1.0"
     exon            573..719
                     /gene="Drc3"
                     /gene_synonym="Lrrc48; RGD1309150"
                     /inference="alignment:Splign:2.1.0"
     exon            720..839
                     /gene="Drc3"
                     /gene_synonym="Lrrc48; RGD1309150"
                     /inference="alignment:Splign:2.1.0"
     exon            840..952
                     /gene="Drc3"
                     /gene_synonym="Lrrc48; RGD1309150"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1127
                     /gene="Drc3"
                     /gene_synonym="Lrrc48; RGD1309150"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1259
                     /gene="Drc3"
                     /gene_synonym="Lrrc48; RGD1309150"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1330
                     /gene="Drc3"
                     /gene_synonym="Lrrc48; RGD1309150"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1454
                     /gene="Drc3"
                     /gene_synonym="Lrrc48; RGD1309150"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..1586
                     /gene="Drc3"
                     /gene_synonym="Lrrc48; RGD1309150"
                     /inference="alignment:Splign:2.1.0"
     exon            1587..1825
                     /gene="Drc3"
                     /gene_synonym="Lrrc48; RGD1309150"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacgaggcta cctgggtgat ttgtttgtaa agcttttggc tgcttctcca catcctacct
       61 ctggtcttca ccaaggacat tatcatcagg aactgtatgt gaaggcggaa cccaatttct
      121 cagcaaagat gagccggccg tatgactcaa tggagcccaa agtaatggac gatgacatgc
      181 tcaaggtagc tgttggggag caagggcccc aggaagaggc tgggcagcta gccaagcagg
      241 aaggcatcct cttcaaagat gtcctggccc tgcagctgga cttccagaat atcctccgca
      301 tagataacct ctggcagttt gagaacctgc ggaagctgca gctgaacaac aacatcattg
      361 agcggatcga gggcctggaa aacctcacac acctggtctg gctggatttg tccttcaaca
      421 acattgaggc cattgagggc ctggataccc tggtcaacct ggaggacctg agcttgtccc
      481 ataaccggat ctccaagata gactctctag atcccctggt gaatctgcag gtgctgtcac
      541 tgggcaataa ccagattaac aacatgatga atatcatcta cctgcgccgg ttcccgtgcc
      601 tgcgaacact cagcctctct gggaatcccg tttctgaggc agaggagtac aaggtgttca
      661 tctatgccta ccttcctgat ctcgtgtacc tggacttccg gcgcgttgat gagcaggcga
      721 gggaggtggc gaagatgaag catcagtaca gcattgatga gctgaagcac cgggaggcac
      781 tgatgcagat ccggctggag gaggagcagg ccaagcagca gaagctggca gagcataaga
      841 tggcatttgt tgagcacctg aatggcccct tcctgtttga cagcatgtat tccgatgatg
      901 tggagggcaa caagctatcc tacctgcctg gtgttggtga gctccttgaa gcctacaagg
      961 acaaatttgt catcatctgc ctgaacattt tcgagtatgg cctgagtcag caagaaaagc
     1021 gaaagattga gttagacacc ttcaatgagt gcatacagga ggccattcag gaaaaccagg
     1081 accagggcaa gctcaagatt gccaagtttg aggaaaaaca cctgctgaac ttaaacgcca
     1141 tccgggaaga gagcgatctg ttcaccatgg agcagaagct gacggagtgc aatgagagca
     1201 tcactgagct gttcaacacg ctcatgatac tggagatgca gctggtggag cagctggagg
     1261 agaccataaa tgtatttgaa agaaacatca ctgacttggt gggactattt attgaaaatg
     1321 tccaaagtct gatcgcccag tgccgggact tggagaacca tcaccacgag aagctcctgg
     1381 agattgccat caacacccta gagaagatcc tcaagggcga gatggatgag gacttacccg
     1441 atgatgtgcg ggcacttttt gttgacaaag acacaattgt taacgccgtt ggggcatcac
     1501 atgacatcca tctcctgaag attgacaacc gggaagatga gctggtgact ggagtcaact
     1561 cttggtgtgc acatctcgta gacaagattc acaaagatga gatcatgagg aaccgtaagc
     1621 gagtgaagga gatcaatcaa ttcgtcgacc atatgcagag tgaactggac aacctggaat
     1681 gtggtgacat tatagactag gtgtcagcca tcagccagcg atcccctcta gagcatggac
     1741 ccagcccctg agagttatgg gatttctttc attcacccct gtcttaacac tgttggtaat
     1801 aattctcaat atagagaaaa ataaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa
//
