LOCUS       NM_001025018            1435 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus DNA damage regulated autophagy modulator 2
            (Dram2), mRNA.
ACCESSION   NM_001025018 XM_342310
VERSION     NM_001025018.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1435)
  AUTHORS   El-Asrag,M.E., Sergouniotis,P.I., McKibbin,M., Plagnol,V.,
            Sheridan,E., Waseem,N., Abdelhamed,Z., McKeefry,D., Van Schil,K.,
            Poulter,J.A., Johnson,C.A., Carr,I.M., Leroy,B.P., De Baere,E.,
            Inglehearn,C.F., Webster,A.R., Toomes,C. and Ali,M.
  CONSRTM   UK Inherited Retinal Disease Consortium
  TITLE     Biallelic mutations in the autophagy regulator DRAM2 cause retinal
            dystrophy with early macular involvement
  JOURNAL   Am J Hum Genet 96 (6), 948-954 (2015)
   PUBMED   25983245
REFERENCE   2  (bases 1 to 1435)
  AUTHORS   Park,S.M., Kim,K., Lee,E.J., Kim,B.K., Lee,T.J., Seo,T., Jang,I.S.,
            Lee,S.H., Kim,S., Lee,J.H. and Park,J.
  TITLE     Reduced expression of DRAM2/TMEM77 in tumor cells interferes with
            cell death
  JOURNAL   Biochem Biophys Res Commun 390 (4), 1340-1344 (2009)
   PUBMED   19895784
REFERENCE   3  (bases 1 to 1435)
  AUTHORS   O'Prey,J., Skommer,J., Wilkinson,S. and Ryan,K.M.
  TITLE     Analysis of DRAM-related proteins reveals evolutionarily conserved
            and divergent roles in the control of autophagy
  JOURNAL   Cell Cycle 8 (14), 2260-2265 (2009)
   PUBMED   19556885
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC091251.1.
            
            On Jun 25, 2005 this sequence version replaced XM_342310.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC091251.1, FQ218349.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132264, SAMD00132265
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1435
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..1435
                     /gene="Dram2"
                     /gene_synonym="Tmem77"
                     /note="DNA damage regulated autophagy modulator 2"
                     /db_xref="GeneID:362011"
                     /db_xref="RGD:1564099"
     exon            1..141
                     /gene="Dram2"
                     /gene_synonym="Tmem77"
                     /inference="alignment:Splign:2.1.0"
     exon            142..203
                     /gene="Dram2"
                     /gene_synonym="Tmem77"
                     /inference="alignment:Splign:2.1.0"
     exon            204..334
                     /gene="Dram2"
                     /gene_synonym="Tmem77"
                     /inference="alignment:Splign:2.1.0"
     exon            335..479
                     /gene="Dram2"
                     /gene_synonym="Tmem77"
                     /inference="alignment:Splign:2.1.0"
     CDS             349..1152
                     /gene="Dram2"
                     /gene_synonym="Tmem77"
                     /note="transmembrane protein 77"
                     /codon_start=1
                     /product="DNA damage-regulated autophagy modulator protein
                     2"
                     /protein_id="NP_001020189.1"
                     /db_xref="GeneID:362011"
                     /db_xref="RGD:1564099"
                     /translation="MWWFQQGLSFLPSALVIWTFATFIFSYITAITLHHVDPALPYIS
                     DTGTMPPERCLFGVMLNIAAVLGIATIYVRYKQVHALNPEENLIIKLNKAGLVLGILS
                     CLGLSLVANFQKSALFIVHVCGAVLAFSMGSFYMFVQTILSYQMQPKIHSKQVFWVRL
                     LLVIWCGVSALSMMTCSSILYSSDFGADIVQKLHWNPEDKGYVLHIVTTAAEWSMSFS
                     FFGFFLTYIRDFQKITLRVEANLHGLTLYDTVPCPVTNERTPLLSRDFQ"
     exon            480..547
                     /gene="Dram2"
                     /gene_synonym="Tmem77"
                     /inference="alignment:Splign:2.1.0"
     exon            548..687
                     /gene="Dram2"
                     /gene_synonym="Tmem77"
                     /inference="alignment:Splign:2.1.0"
     exon            688..865
                     /gene="Dram2"
                     /gene_synonym="Tmem77"
                     /inference="alignment:Splign:2.1.0"
     exon            866..948
                     /gene="Dram2"
                     /gene_synonym="Tmem77"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1041
                     /gene="Dram2"
                     /gene_synonym="Tmem77"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1404
                     /gene="Dram2"
                     /gene_synonym="Tmem77"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgtatcga agggtggttc acaagcttag agcgaaggcg caacgcgagt ccccttagtc
       61 ccaccggcgc gcgaaccacg cgaaccgcgg cagcctcacc tggcttcgtg agcttcttga
      121 tgcacaggat ctgagtcgcc ggatttaaaa gggaaccggt ttggacagtt ctgaagattg
      181 acattttggg actcagaaca caggtggtaa aataaagata ccatcaagaa ctggactcta
      241 tttaaagtct tccatcacta attcaaagtt cagactcaca gtctacatgc tctgagaaac
      301 tagaagccaa ggaattaacc tgaagttcac ccagaagacc tgtctgaaat gtggtggttt
      361 cagcaaggcc ttagcttcct tccgtcggcc cttgtaattt ggacatttgc tacctttata
      421 ttctcatata tcactgcaat aacactccac catgttgacc ctgcattgcc ttacatcagc
      481 gacactggga caatgcctcc tgaaaggtgc ctctttggag taatgctgaa tatcgctgcc
      541 gttttaggca ttgctactat ctatgttcgt tacaagcaag ttcatgcact gaaccctgaa
      601 gagaacctta tcatcaaatt aaacaaggct ggccttgtac ttgggatact gagttgttta
      661 ggactttctc ttgtggcaaa tttccagaaa tcagcactat ttattgttca tgtatgtgga
      721 gctgtccttg cctttagtat gggctcattt tacatgtttg ttcagaccat cctttcctac
      781 caaatgcagc ccaaaattca cagcaaacaa gtcttctggg tccgactact attggttatc
      841 tggtgtggag taagtgcact tagcatgatg acttgctcat caattttgta cagtagtgac
      901 tttggtgctg atatagtaca gaaactacac tggaacccag aggacaaagg ttatgtgctt
      961 cacatagtta ctactgcagc agaatggtct atgtcatttt ccttctttgg atttttcctg
     1021 acttatattc gtgattttca gaaaattact ttacgggtgg aagccaattt acatggatta
     1081 accctctatg acactgttcc ttgccctgtt accaatgaaa gaacaccatt gctttccaga
     1141 gattttcaat gaatggataa acatcttctg tgatgattgt gattctcagg gactgagaaa
     1201 agatgcataa aagttgctta ttatactgtg aaaatttgaa tcagttaatc aaggttgaca
     1261 gtgatataat aatgaaagat gatatcaaaa gaagtgtaat aagccatctg ataagttttc
     1321 ttaaaggatg ttgttaagaa gactatctaa aaacattatg tatagacttt tttataatcc
     1381 agaaaataaa accaaaggat aacaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa
//
