LOCUS       NM_001173427            2809 bp    mRNA    linear   ROD 01-OCT-2024
DEFINITION  Rattus norvegicus DNA-damage regulated autophagy modulator 1
            (Dram1), mRNA.
ACCESSION   NM_001173427 XM_001055011 XM_002726892
VERSION     NM_001173427.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2809)
  AUTHORS   Tang,N., Zhao,H., Zhang,H. and Dong,Y.
  TITLE     Effect of autophagy gene DRAM on proliferation, cell cycle,
            apoptosis, and autophagy of osteoblast in osteoporosis rats
  JOURNAL   J Cell Physiol 234 (4), 5023-5032 (2019)
   PUBMED   30203495
  REMARK    GeneRIF: The autophagy level of ovariectomized rats was weakened,
            but overexpressed DRAM could increase the autophagy level of
            osteoblast, suppress proliferation, and induce apoptosis of
            osteoblast.
REFERENCE   2  (bases 1 to 2809)
  AUTHORS   Wu,X., Qin,Y., Zhu,X., Liu,D., Chen,F., Xu,S., Zheng,D., Zhou,Y.
            and Luo,J.
  TITLE     Increased expression of DRAM1 confers myocardial protection against
            ischemia via restoring autophagy flux
  JOURNAL   J Mol Cell Cardiol 124, 70-82 (2018)
   PUBMED   30144448
  REMARK    Erratum:[J Mol Cell Cardiol. 2019 Feb;127:277. doi:
            10.1016/j.yjmcc.2018.12.009. PMID: 30660099]
REFERENCE   3  (bases 1 to 2809)
  AUTHORS   Park,S.M., Kim,K., Lee,E.J., Kim,B.K., Lee,T.J., Seo,T., Jang,I.S.,
            Lee,S.H., Kim,S., Lee,J.H. and Park,J.
  TITLE     Reduced expression of DRAM2/TMEM77 in tumor cells interferes with
            cell death
  JOURNAL   Biochem Biophys Res Commun 390 (4), 1340-1344 (2009)
   PUBMED   19895784
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC168648.1.
            
            On or before May 13, 2010 this sequence version replaced
            XM_001055011.2, XM_002726892.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC168648.1, FQ211820.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676807, SAMN16676808
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2809
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q13"
     gene            1..2809
                     /gene="Dram1"
                     /gene_synonym="Dram"
                     /note="DNA-damage regulated autophagy modulator 1"
                     /db_xref="GeneID:679937"
                     /db_xref="RGD:1598133"
     exon            1..244
                     /gene="Dram1"
                     /gene_synonym="Dram"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..830
                     /gene="Dram1"
                     /gene_synonym="Dram"
                     /note="damage-regulated autophagy modulator"
                     /codon_start=1
                     /product="DNA damage-regulated autophagy modulator protein
                     1"
                     /protein_id="NP_001166898.1"
                     /db_xref="GeneID:679937"
                     /db_xref="RGD:1598133"
                     /translation="MLCFLRGMAFVPFLLVTWSSAAFIISYVVAVLSGHVNPFLPYIS
                     DTGTTPPESGIFGFMINFSAFLGAATMYTRYKIVEKQNETCYFGTPVFNLVSLVLGLV
                     GCIGMGIVANFQELAVPVVHDGGALLAFVCGVVYTLLQSIISYKSCPQWNSLTTCHVR
                     MAISAVSCAAVVPMIACASLISITKLEWNPKEKDYMYHVVSAICEWTVAFGFIFYFLT
                     FIQDFQSVTLRISTEINDDF"
     exon            245..312
                     /gene="Dram1"
                     /gene_synonym="Dram"
                     /inference="alignment:Splign:2.1.0"
     exon            313..455
                     /gene="Dram1"
                     /gene_synonym="Dram"
                     /inference="alignment:Splign:2.1.0"
     exon            456..633
                     /gene="Dram1"
                     /gene_synonym="Dram"
                     /inference="alignment:Splign:2.1.0"
     exon            634..692
                     /gene="Dram1"
                     /gene_synonym="Dram"
                     /inference="alignment:Splign:2.1.0"
     exon            693..785
                     /gene="Dram1"
                     /gene_synonym="Dram"
                     /inference="alignment:Splign:2.1.0"
     exon            786..2744
                     /gene="Dram1"
                     /gene_synonym="Dram"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggagcctcc gtcccgccgc gcgcgttagc tgtctgtgtc tcggccactg cctccaggca
       61 gcccgcagca agccggcttc gtggcccgac gagctcagcg tcctctcacc gcgatgctgt
      121 gctttcttag gggaatggct ttcgtcccct tcctcctggt gacttggtcg tccgcagcct
      181 tcatcatctc ctacgtggtc gcggtgctct cggggcacgt caaccccttt ctcccctata
      241 tcagtgacac aggaacaact cctccagaga gtggtatttt tggattcatg ataaacttct
      301 ctgcatttct tggcgcagct acgatgtaca caaggtataa gatcgtggag aagcagaacg
      361 agacctgcta cttcggcacc cccgttttta acttggtgtc cttggtgctc ggactggtgg
      421 gatgcatcgg aatgggcatc gtagctaact tccaggaatt agcagtgcct gtggtccacg
      481 atggcggtgc ccttctggct ttcgtctgcg gtgtggtata cacgctcctg caatcgatca
      541 tctcctacaa atcatgtccc cagtggaaca gcctcaccac gtgccatgtc aggatggcca
      601 tctccgccgt ttcctgcgca gctgtcgtcc ccatgattgc ctgtgcttca ctaatttcta
      661 taaccaagtt ggaatggaat ccaaaagaaa aggattatat gtatcatgtg gtgagcgcca
      721 tctgtgagtg gaccgttgct tttggtttta ttttctattt cctaacattc atccaagatt
      781 tccagagtgt caccctaagg atatccacag aaatcaatga tgacttttga aagagcgaga
      841 atcctgtctc tctcagggag tgtcacagac ggtttctgga agtgacagag gacggacggg
      901 cttggatgtc accctgatcg ggacatatct gtggcacatc tgggacttga atttcattaa
      961 gaattcctag tagttgttca atttacaaag gtatgtttcc cctggagaat gtatggcatt
     1021 gacaacactg taaaatattt ttatatttcc taagacaatc ttttacgaac aaagtcgtac
     1081 gcagagaaga tgaggcattg cagagagggg agaattattc ttggatatat tctttaggct
     1141 ttttatgtaa gaatgactta tgaaaataca ctaagagaaa agaatgtcaa gtttagtact
     1201 ttttattaaa gaagtcaaac ccaggggaca ttcactttaa aatctcactt tttaaatagt
     1261 cacctgcgta tattttcatc acaagagcat ttatacaatt caatccatag tgattatata
     1321 ccctgatggt atagatttag gtaataaatc aacacttaaa gcactctgaa ttttcagtgc
     1381 attaaacaaa tgcttctata gttaaggcct caaaaccatt tacagtgcac attaaccagc
     1441 gaatgtggaa gacctcggtt tgaaaacagc ctcctcaatt gctcgtccca gggacccaca
     1501 gcattactgc cgctgttaac tggtgggccc aggacctaat tccaggtagg atgggctcat
     1561 cagggccgct taggaatgat aaaactgccc ttcgctcaca agttaaactc ccttctcagt
     1621 ttccctgtaa gccagtcaaa gcgagcgcag atccaagtca gggagaaagg agagcactca
     1681 cagaaacgtc cagatgtagg ctgctgttca gtgctggtgg ccactgttct atgacactat
     1741 agaggagatg ggtcaggtgg caaggtccgg agaccacacc tttcatccag gtcaccaatg
     1801 gcaaagaaac gtcagctgct gtcgaggagg aagtggctaa aaagagtccc aagctccata
     1861 tctaagtctg ggcacgtgcc aagggcagag cagcccattt ggacagcctt ggtgaagggg
     1921 cgccgggaga tgcagggtcg tgcagccctg cctcctttgg ctgctaagcg aagggtgtgg
     1981 ctcagcagcc acttccgcca tgacaccccg tgtcttcctc agtgcgcagt ggtgaccacc
     2041 aacatccgtt tgagtcccct gtaacctttc acagtcccga acatccccct tgtaatcctg
     2101 aaacagaaag acagtggctg tcttcattcg gaagagaaag aggagcctga tatatttcct
     2161 gtggaagccg tggtggactg aatccatgtg gtcctttgct ttgagggggg acattgttga
     2221 ggctttccca gaatgcacgt ggctctctgc gcttccactg gagagccgac caagtgcctt
     2281 tacccagagt ggaacaccgt gcctcctggc acacaatagg tgcttaataa atactcaatg
     2341 tacgtctgca taaatgagtg aacaattcaa gtgatgacta gggatgtttg cggtgctaag
     2401 gggttgattt actccagttt cacggttttt ctgatgcaaa cagtctgtgc caactagtaa
     2461 cgttgtccgt tttgctttgt gaaccattct catttcaacc tgttccagtt gtgtgggctc
     2521 catgattctg tgacaactct cttctggaca gataccacag aaattgtttc atgggctaga
     2581 cctgtcttgg caaaccgaga aggccccaaa tcaccccaag tcacacactg ctgattccac
     2641 gcgacttgta acgttattcc cgttttggtg tttaatttct acaaatgtgt gtatttcctt
     2701 ggacttcgta cctgagaaaa taaaatattt ctttatttta gtaaaaaaaa aaaaaaaaaa
     2761 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa
//
