LOCUS       NM_001011914            3035 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus down-regulator of transcription 1 (Dr1), mRNA.
ACCESSION   NM_001011914 XM_214124
VERSION     NM_001011914.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3035)
  AUTHORS   Li,H., Wei,Y., Xi,Y., Jiao,L., Wen,X., Wu,R., Chang,G., Sun,F. and
            Hao,J.
  TITLE     DR1-CSE/H2S pathway upregulates autophagy and inhibits H9C2 cells
            damage induced by high glucose
  JOURNAL   Acta Cardiol 78 (5), 594-606 (2023)
   PUBMED   36197015
  REMARK    GeneRIF: DR1-CSE/H2S pathway upregulates autophagy and inhibits
            H9C2 cells damage induced by high glucose.
REFERENCE   2  (bases 1 to 3035)
  AUTHORS   Spedale,G., Timmers,H.T. and Pijnappel,W.W.
  TITLE     ATAC-king the complexity of SAGA during evolution
  JOURNAL   Genes Dev 26 (6), 527-541 (2012)
   PUBMED   22426530
  REMARK    Review article
REFERENCE   3  (bases 1 to 3035)
  AUTHORS   Krebs,A.R., Demmers,J., Karmodiya,K., Chang,N.C., Chang,A.C. and
            Tora,L.
  TITLE     ATAC and Mediator coactivators form a stable complex and regulate a
            set of non-coding RNA genes
  JOURNAL   EMBO Rep 11 (7), 541-547 (2010)
   PUBMED   20508642
REFERENCE   4  (bases 1 to 3035)
  AUTHORS   Guelman,S., Kozuka,K., Mao,Y., Pham,V., Solloway,M.J., Wang,J.,
            Wu,J., Lill,J.R. and Zha,J.
  TITLE     The double-histone-acetyltransferase complex ATAC is essential for
            mammalian development
  JOURNAL   Mol Cell Biol 29 (5), 1176-1188 (2009)
   PUBMED   19103755
REFERENCE   5  (bases 1 to 3035)
  AUTHORS   Wang,Y.L., Faiola,F., Xu,M., Pan,S. and Martinez,E.
  TITLE     Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel
            NC2-like histone fold module that interacts with the TATA-binding
            protein
  JOURNAL   J Biol Chem 283 (49), 33808-33815 (2008)
   PUBMED   18838386
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC083822.1.
            
            On Feb 11, 2005 this sequence version replaced XM_214124.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083822.1, EV768811.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840115, SAMN16676784
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3035
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..3035
                     /gene="Dr1"
                     /note="down-regulator of transcription 1"
                     /db_xref="GeneID:289881"
                     /db_xref="RGD:1305201"
     exon            1..841
                     /gene="Dr1"
                     /inference="alignment:Splign:2.1.0"
     CDS             622..1152
                     /gene="Dr1"
                     /note="NC2-beta; negative cofactor 2-beta; TATA-binding
                     protein-associated phosphoprotein; down-regulator of
                     transcription 1, TBP-binding (negative cofactor 2);
                     protein Dr1-like"
                     /codon_start=1
                     /product="protein Dr1"
                     /protein_id="NP_001011914.1"
                     /db_xref="GeneID:289881"
                     /db_xref="RGD:1305201"
                     /translation="MASSSGNDDDLTIPRAAINKMIKETLPNVRVANDARELVVNCCT
                     EFIHLISSEANEICNKSEKKTISPEHVIQALESLGFGSYISEVKEVLQECKTVALKRR
                     KASSRLENLGIPEEELLRQQQELFAKARQQQAELAQQEWLQMQQAAQQAQLAAASASA
                     SNQAGSSQDEDDDDDI"
     exon            842..1005
                     /gene="Dr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..3008
                     /gene="Dr1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccgcttctg ctcccacagc ctgctctcgg ccaaacgctc ggtcgcggcg actgccgctg
       61 cggctcccgc tgttttcggc cctgtccact tggttcccag gcagccagcg tgcgttcagc
      121 tgcggcttcg gcagacatgt tgtgaggcgg cggcgcgggt gcctgaagga tggtttggcc
      181 gaggcggctg caaccgctgc tagtggcggt ggccgcgggg gctccggctc tgtagagccg
      241 accctgctgt ggtgcgtccg cccggtactg cggccgggcg ggtactcctc ggtcttgcgt
      301 gcgcccccga gccgtttagg ttcggttagg cgacagcgcc agtccgtttg aggcgacacg
      361 caaggtggtt cttgagccct gggagtggtg tccccagagc gagccctcag ccccctgacc
      421 tctccttcat atccgcacta aaatctctca cacagtgggt gttccctgcc ctcgagcccg
      481 ctccttcctg gtttctgctg cactctgagc ctcccggacc ccgacatctc tctccaggga
      541 cagcctgttg agaaatcttc gtggagtggt ggactagagg gaggacttta aaagttaggg
      601 cttgaaagac aggaaggcac gatggcttcc tcgtctggca acgacgatga tctcactatc
      661 ccgagagctg ctataaataa gatgatcaaa gagactctcc ctaatgtcag ggtggccaac
      721 gatgcccgag agctcgtagt gaactgctgc actgaattca ttcaccttat atcttccgaa
      781 gccaacgaga tttgtaacaa gtcagaaaag aagacaatct caccagagca tgtcatccaa
      841 gcactagaaa gtttgggctt tggctcttac atcagtgaag taaaagaagt cttacaagaa
      901 tgcaagacag tagcattaaa aagaagaaag gccagttctc gtttggaaaa ccttggcatt
      961 cctgaagaag aattattgag acagcaacag gaattatttg caaaagctag acagcaacaa
     1021 gcagaattgg cccaacagga gtggcttcag atgcagcaag cagctcagca ggcccagttg
     1081 gctgctgcct cagccagtgc atccaatcag gccgggtctt cacaggacga agacgacgac
     1141 gacgacatct gaacttcacc ttccgggctt ctgcttcctc tgtaaggaaa cagtgaaaga
     1201 agtgcatctt gatgaactta ccgttggtgt tttagagatg tctgctgtca ggcttcaact
     1261 actgtgctat acatgtaaaa ctgtctcttt gaactattga aaatttaagg ttaagtatca
     1321 tattaccttt gaatttgtaa tggtgtttct ggaatcttag accagtgtga accctttatt
     1381 tggtcaataa acagtgttac agaaaacttc aggtttataa aaatacagtg aaatttatag
     1441 aaatctctta atctgtattt gtattttctc tgccctttta actgaactaa aattgagaat
     1501 ttatattgag atggggcatg gcgtaatgca gaatacattg aatcaggttg gtgaaaagtt
     1561 cagttctata tagtatctaa attttttgtc ttttaaagtg agtatatatg caggcaacaa
     1621 ttatatgctc agataaatat acttgtttag aggaaatctc aaataagaca ttcattaact
     1681 aggaaggaaa tgtattcttt agtagttgtg taaatttggt gagttacgtt ttttattttg
     1741 tttctgtttt gtgtagcagt gaagactagt ttattatagt ataatttatc ttgagctaca
     1801 ctatgccatt tcagagactg gctaatcttg aagattgtca cgattcttac tgtttcactc
     1861 cagttgggta gttgttcata gcattagttg ctcagtccat tttttgatat gtaggtggga
     1921 cttaggagac agtcgcttgg gttctgttgg tttacctgag gttcctggat gttgaagcct
     1981 gtgctggagg acataaacaa aagctagtga gcatgcttgc taggaaaagg ccttaagtcc
     2041 ttatttgact tgcagtctcc ttactgcttg gtgttagtgt agcattcaca ttttcttgtg
     2101 aattttcttc taggaggcct caagaatcca atgctaactt ttgatatgac atcattgtcc
     2161 ccgtcatcat agtttagtga tagctttaaa agttttgtgt ttgcttaaag agtgtcataa
     2221 ctgaccagcc ctatacaaag tgttaacttg cttgttaaaa gggagcagct ttaattcggt
     2281 ttcagtgcat aagatgtagt agtgtttgtg agagggatct aatgtatttg gtgaaatggc
     2341 atattactta tattttggaa agagaaaaat gccacctaag ataagtcatt aagttcccat
     2401 gtcagttgcc aagccattta aatatctgta ttcaccaagc cccagaggag attctagctg
     2461 ctaggatttc aatttcgaga gctaagaaat gtttataagt attagatttc ttaatattca
     2521 tatttttcag ttttagaagg gaaatttata tgcatattat tatgcattta tcagatattc
     2581 ttccccctat aacaaaaagg gtagcaaaaa gggtagtaat tttgctgaat gttttatgtt
     2641 gaagttattt caaggcattt catgggtctg cccatggtgt gtttggaaaa catagaagga
     2701 accgtttcct tcagaaaggt tgagcaccaa aggccggtgg tttagtcttt ggaaatgagc
     2761 tagtcgcttt tggcttttct aatttgtact gtaacagtct tttgttttgt tttaagtata
     2821 cgtttctcaa gtaaacaatt tggataattt tccatacctt tttttttccg atgcagactt
     2881 caggttaatt aatattttgc tgcatctgat aatgtattat atgttggaag cctagtgact
     2941 tttaattttg atgttcttgt gatttcatat gctgtattct tcaagcaata aaattctgat
     3001 gtgttttaaa aaaaaaaaaa aaaaaaaaaa aaaaa
//
