LOCUS       NM_023023               4845 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus dihydropyrimidinase-like 5 (Dpysl5), mRNA.
ACCESSION   NM_023023
VERSION     NM_023023.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4845)
  AUTHORS   Gong,X., Tan,M., Gao,Y., Chen,K. and Guo,G.
  TITLE     CRMP-5 interacts with actin to regulate neurite outgrowth
  JOURNAL   Mol Med Rep 13 (2), 1179-1185 (2016)
   PUBMED   26677106
  REMARK    GeneRIF: CRMP5 is able to interact with the actin cytoskeleton
            network in the growth cone and affect growth cone development and
            neurite outgrowth via this interaction in developing hippocampal
            neurons.
REFERENCE   2  (bases 1 to 4845)
  AUTHORS   Nozumi,M., Togano,T., Takahashi-Niki,K., Lu,J., Honda,A., Taoka,M.,
            Shinkawa,T., Koga,H., Takeuchi,K., Isobe,T. and Igarashi,M.
  TITLE     Identification of functional marker proteins in the mammalian
            growth cone
  JOURNAL   Proc Natl Acad Sci U S A 106 (40), 17211-17216 (2009)
   PUBMED   19805073
  REMARK    GeneRIF: Results provide marker proteins Gap-43 and newly
            identified candidate neuronal growth-associated proteins MAP1B,
            CRMP5, crmp5 and catenins.
REFERENCE   3  (bases 1 to 4845)
  AUTHORS   Bretin,S., Reibel,S., Charrier,E., Maus-Moatti,M., Auvergnon,N.,
            Thevenoux,A., Glowinski,J., Rogemond,V., Premont,J., Honnorat,J.
            and Gauchy,C.
  TITLE     Differential expression of CRMP1, CRMP2A, CRMP2B, and CRMP5 in
            axons or dendrites of distinct neurons in the mouse brain
  JOURNAL   J Comp Neurol 486 (1), 1-17 (2005)
   PUBMED   15834957
REFERENCE   4  (bases 1 to 4845)
  AUTHORS   Diamond,I., Owolabi,T., Marco,M., Lam,C. and Glick,A.
  TITLE     Conditional gene expression in the epidermis of transgenic mice
            using the tetracycline-regulated transactivators tTA and rTA linked
            to the keratin 5 promoter
  JOURNAL   J Invest Dermatol 115 (5), 788-794 (2000)
   PUBMED   11069615
REFERENCE   5  (bases 1 to 4845)
  AUTHORS   Horiuchi,M., El Far,O. and Betz,H.
  TITLE     Ulip6, a novel unc-33 and dihydropyrimidinase related protein
            highly expressed in developing rat brain
  JOURNAL   FEBS Lett 480 (2-3), 283-286 (2000)
   PUBMED   11034345
REFERENCE   6  (bases 1 to 4845)
  AUTHORS   Inatome,R., Tsujimura,T., Hitomi,T., Mitsui,N., Hermann,P.,
            Kuroda,S., Yamamura,H. and Yanagi,S.
  TITLE     Identification of CRAM, a novel unc-33 gene family protein that
            associates with CRMP3 and protein-tyrosine kinase(s) in the
            developing rat brain
  JOURNAL   J Biol Chem 275 (35), 27291-27302 (2000)
   PUBMED   10851247
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AJ131436.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ131436.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4845
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q14"
     gene            1..4845
                     /gene="Dpysl5"
                     /gene_synonym="Crmp5; Ulip6"
                     /note="dihydropyrimidinase-like 5"
                     /db_xref="GeneID:65208"
                     /db_xref="RGD:620467"
     exon            1..119
                     /gene="Dpysl5"
                     /gene_synonym="Crmp5; Ulip6"
                     /inference="alignment:Splign:2.1.0"
     exon            120..384
                     /gene="Dpysl5"
                     /gene_synonym="Crmp5; Ulip6"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..1818
                     /gene="Dpysl5"
                     /gene_synonym="Crmp5; Ulip6"
                     /note="DRP-5; ULIP-6; UNC33-like phosphoprotein 6;
                     dihydropyrimidinase-related protein 5-like"
                     /codon_start=1
                     /product="dihydropyrimidinase-related protein 5"
                     /protein_id="NP_075412.1"
                     /db_xref="GeneID:65208"
                     /db_xref="RGD:620467"
                     /translation="MLANSASVRILIKGGKVVNDDCTHEADVYIENGIIQQVGRELMI
                     PGGAKVIDATGKLVIPGGIDTSTHFHQTFMNATCVDDFYHGTKAALVGGTTMIIGHVL
                     PDKETSLVEAYEKCRALADPKVCCDYALHVGITWWAPKVKAEMETLVREKGVNSFQMF
                     MTYKDLYMLRDSELYQVFHACRDFGAIPRVHAENGELVAEGAKEALDLGITGPEGIEI
                     SHPEELEAEATHRVITIANRTHCPIYLVNVSSISAGDVIAAAKMQGKVVLAETTNAHA
                     TLTGLHYYHQDWSHAAAYVTVPPLRLDTNTSTYLMSLLANDTLNIVASDHRPFTTKQK
                     AMGKEDFTKIPHGVSGVQDRMSVVWERGVVGGKMDENRFVAVTSSNAAKILNLYPRKG
                     RIIPGADADVVVWDPEATKTISASTQVQGGDFNLYENMRCHGVPLVTISRGRVVYENG
                     VFMCAEGTGKFCPLRSFPDIVYKKLVQREKTLKVRGVDRTPYLGDVAVVVNPGKKEMG
                     TPLADTPTRPVTRHGGMRDLHESSFSLSGSQIDDHVPKRASARILAPPGGRSSGIW"
     exon            385..543
                     /gene="Dpysl5"
                     /gene_synonym="Crmp5; Ulip6"
                     /inference="alignment:Splign:2.1.0"
     exon            544..723
                     /gene="Dpysl5"
                     /gene_synonym="Crmp5; Ulip6"
                     /inference="alignment:Splign:2.1.0"
     exon            724..792
                     /gene="Dpysl5"
                     /gene_synonym="Crmp5; Ulip6"
                     /inference="alignment:Splign:2.1.0"
     exon            793..837
                     /gene="Dpysl5"
                     /gene_synonym="Crmp5; Ulip6"
                     /inference="alignment:Splign:2.1.0"
     exon            838..913
                     /gene="Dpysl5"
                     /gene_synonym="Crmp5; Ulip6"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1070
                     /gene="Dpysl5"
                     /gene_synonym="Crmp5; Ulip6"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1212
                     /gene="Dpysl5"
                     /gene_synonym="Crmp5; Ulip6"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1355
                     /gene="Dpysl5"
                     /gene_synonym="Crmp5; Ulip6"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1563
                     /gene="Dpysl5"
                     /gene_synonym="Crmp5; Ulip6"
                     /inference="alignment:Splign:2.1.0"
     exon            1564..1732
                     /gene="Dpysl5"
                     /gene_synonym="Crmp5; Ulip6"
                     /inference="alignment:Splign:2.1.0"
     exon            1733..4845
                     /gene="Dpysl5"
                     /gene_synonym="Crmp5; Ulip6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcagccacc gagagagcgc gctagcagcg gctcccgccc cgtgcacccg cagctaccgc
       61 gccgcggcga gacccagaga ccgaccgacg gacccgcaca atcgcagcat cctggaggag
      121 aacatgcttg ccaattcagc cagtgtgcgg attctcatca agggaggcaa ggtggtgaac
      181 gatgactgta cccacgaggc agatgtctac attgagaacg gcatcatcca gcaggtgggc
      241 cgtgaactca tgatccctgg cggggccaag gtgattgacg ccaccgggaa actggtgatc
      301 cccggaggga ttgacaccag cacccacttc caccagacct tcatgaacgc cacatgtgtg
      361 gacgacttct accacgggac caaggcagcc ctcgtcggag gcaccaccat gatcatcggt
      421 cacgtcctgc ctgacaagga gacctccctc gtggaagcct atgagaagtg cagggctcta
      481 gctgacccca aggtctgctg tgactatgcc ctccatgtgg ggatcacctg gtgggcaccc
      541 aaggtgaaag cagaaatgga gacactagtg cgagagaaag gggtcaactc cttccagatg
      601 ttcatgacct acaaggactt gtacatgctt cgagacagtg agctgtacca agtgttccat
      661 gcctgcaggg actttggggc gatcccccgg gtccacgcag aaaatgggga gcttgtggct
      721 gagggtgcta aggaggctct agatttgggt atcacaggcc cagaaggaat tgagatcagc
      781 catccagagg agctggaagc ggaagccact caccgtgtca tcaccattgc aaacaggact
      841 cactgtccca tctacctggt caatgtgtct agtatctcag ctggtgatgt cattgcagct
      901 gctaagatgc aagggaaggt ggtgctggcc gagaccacca acgcacacgc cacgctcaca
      961 ggcttacact actaccacca ggactggtcc catgcagccg cctatgtcac ggtgccgccc
     1021 ctgagactgg acaccaacac ttccacctac ctcatgagcc tgctggccaa tgacactctg
     1081 aacatcgtgg catccgatca ccggccattc accacaaagc agaaagccat gggcaaggaa
     1141 gacttcacta agatcccaca cggtgtgagc ggtgtacagg atcgaatgag cgtcgtctgg
     1201 gagaggggag tggttggagg aaagatggat gagaaccgtt tcgtagctgt caccagttct
     1261 aacgcagcca agattctcaa cctgtatcct cgcaagggcc gcatcatccc tggagccgat
     1321 gctgatgtgg tggtgtggga cccagaagcc acaaagacca tctcagccag cacccaggtg
     1381 cagggtggag acttcaatct gtacgagaac atgcgctgcc acggtgtgcc actggtcacc
     1441 atcagccggg gacgtgtggt gtatgagaat ggcgtcttca tgtgcgcgga gggcactggc
     1501 aagttctgtc ccctgcggtc tttcccagac attgtctata agaagctggt gcagagagag
     1561 aagaccttaa aagtgagggg agtggaccgt actccctacc taggggatgt cgctgtggtt
     1621 gtcaaccctg ggaaaaaaga gatgggaaca ccactggcag acactcccac acggccagtc
     1681 acccggcacg ggggcatgag ggaccttcat gaatccagtt tcagcctctc tggttctcag
     1741 attgatgacc atgttccaaa gcgggcctca gctcggatcc ttgcgccccc tggaggcagg
     1801 tcgagcggta tttggtaaag gctctgacca ggccccccaa caagtgaggc tgctccacca
     1861 ccacctgcct gcacactttc cggccacagc tgcagtgggt gggagaggtt ggcctgggca
     1921 gtgcacacca gtaagggctc caggaaccag ggagccctcc ccttgtctga acatgattca
     1981 cggggctttg atccacccct aacaaggcac tttgagctgt ccctcctgcc ctgccccttc
     2041 cttccttggc cctggggttt ctctgggccc cagaagccca cactatgcac agcacccaat
     2101 gcatagcacc tggccctacc cctcctctca ccgtgacctc ctgtgctggc tctgggaagg
     2161 cccagacttt agtgctctgc cctgctgccc aaccagacag gtgtccagag cactttagca
     2221 aatgttttat aagtataggc cttccctctt caccccctag accccatggt gacattttcc
     2281 caagtcagac aggtgtcaac tccccagtca tgcccaaggt gtcccatctc tcctgattca
     2341 ccccagctat acccacaagg gtacagtcag gacgccctgg atgtggctgt gcttgggaca
     2401 ccctgtgtcc tttgctagcc tctttcattc cctgcccaca ccctctggga gtcccagaag
     2461 ggtagctggg tgggcatatg cggctggtgc caggcgcgtg taaatggttt tgttttgcac
     2521 gtttggttta cgcagtggtt tggtttgact tgtttgtgca ccctgtggaa aatgacggtg
     2581 ctttttgtca ctagcatagc atagaatcgg gaatagattc ggtttgtagg agatgctgca
     2641 ctcgccacca accagacagt acagggcaga ggcaggggca ggctggcccc ccggcccctt
     2701 ccccccaacc cttttgcttc cagaagccct gtaccatgtc tccccgatcc cacacctcct
     2761 accaccccct tctacatccc tacattcaaa cgatcctgga tgctgaccct agaaacctta
     2821 aggcagcatc tctgctcctg gttactactc ccaggattga ctccataccc acaccctcat
     2881 accccaacat agtttccttt aacttgcctc tgctgggcaa ggcctagctg ctcctcctgt
     2941 gagactagta agaggcctca taactgctga gaaagggaga gtaggagaga gttggctagc
     3001 caaccgccag ggaaggggct tcaacccaca aggcctagct gtagaatcca cccctctgca
     3061 caagtgctgt gggatcctgc actcagcact actctcttgt tgactactgg ttggccctgc
     3121 cctgtctcag aagctcttcg gaggctctca gaggtggcta cacagtctgg gaagtggctc
     3181 agctgtctgc ctttgataag cctcacccct gcccctttgg caaatgattt cacttttgtt
     3241 tgagctccac aaacttccca gaggccccag agagtttgtc agtcacccct gcacgttttt
     3301 gtcccgcttc gagtacatca aagcacttgc ctgtgtcagc tgtcacagag taggcttgac
     3361 aggtaaactc tgaggagctt ccgaggtagg gtggggctta ccactctccc acatatcaca
     3421 gattaaaaac tgaggcccca agagtttagg ccccagaagt gtctgtgact gctcttatgg
     3481 ccttgactgt ctaacctagc tatgggaaac agttgtggat tgatgtcagg cccaccagat
     3541 agaatacttt cttcctgggg cacgttctgc cttgctttgc acaagtcaat tttatctttg
     3601 tcgtgaactg gcttctgtag tctcttggtt tgagcctgga ctagaaaagt gttgggaact
     3661 tgtgtgcagt tttagttgcg cccagtgtcc tcacttagga gctgaaggga caaataaccc
     3721 agagactgag gtagccccag gtaatgaccc tggagggtga tgacccttca caggtaacat
     3781 aagcagtgac attgacccct ggttcagttt ctatccctct ccttctctcc cactctcttc
     3841 tcattctcct cttcctcctt ctttttcttc ttcttgagac aaagccttgc ctaggtagcc
     3901 tggccttgaa ctcacagaat gcctgccttt gtttccccaa atactggaat tatacacgta
     3961 agctaccact cctagctgta cgtcatcttt gtctgtttct gcccttgctg ggtcatgggc
     4021 cttgggcaga tgccaaagat ccaaagggtg gtagagccag ctaggcaggc cacctggcat
     4081 gggccaggag tgctttaccc tctctgagtg cctccgcctg agaagtgtat gacctgaaat
     4141 ggtaggagag tacatgttca aggggccact gtgggccttc tacttcatcc accccgccct
     4201 tctacagtcc caaggccacc cttacataga ctgtgctcac ccaggagctt ctagatagga
     4261 ggcttaaaga gccaaacaaa ccatcatccc cccagtgtcc actccctgcc ccatgcagag
     4321 ctccagccac aggtccagtg gctgctggct ggagcgaaag cggtctctgg ttgcaccgaa
     4381 tgcagctctc aaactggcct tgtacttgct gaataaacac tgttgttctc gccttagctg
     4441 ctcttaggtt tgtggggtta acttaccaga aaattgtgct actgtgtgtg cgtgtgtgtg
     4501 tgtgcgcgtg tgtgtgtagt gctaggagtc cacagtaggt cgcttgtcaa gccaatgccg
     4561 tgatgagggc atctcttata ttgacccaga aaccacagaa ccacaaggaa gccaaacccc
     4621 ctccagctgc tgaggtggca ggcacagttt ggggtcagaa tggagctgcc agcaccccag
     4681 cacccaagtg accctccccc ctttctgtaa atgtcatggt gctaaggttg tatcaatcct
     4741 gagacgacac atggccctgt gctttggcca ccgtttgagg caaaacaaaa cagcccaaca
     4801 cgttgtgttc tggtgcaggt ttgtattaaa ctgtagctac ttctc
//
