LOCUS       NM_012933               2628 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus dihydropyrimidinase-like 4 (Dpysl4), mRNA.
ACCESSION   NM_012933 XM_001057768 XM_341953
VERSION     NM_012933.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2628)
  AUTHORS   Nakamura,F., Kumeta,K., Hida,T., Isono,T., Nakayama,Y.,
            Kuramata-Matsuoka,E., Yamashita,N., Uchida,Y., Ogura,K.,
            Gengyo-Ando,K., Mitani,S., Ogino,T. and Goshima,Y.
  TITLE     Amino- and carboxyl-terminal domains of Filamin-A interact with
            CRMP1 to mediate Sema3A signalling
  JOURNAL   Nat Commun 5, 5325 (2014)
   PUBMED   25358863
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2628)
  AUTHORS   Liu,W., Zhou,X.W., Liu,S., Hu,K., Wang,C., He,Q. and Li,M.
  TITLE     Calpain-truncated CRMP-3 and -4 contribute to potassium
            deprivation-induced apoptosis of cerebellar granule neurons
  JOURNAL   Proteomics 9 (14), 3712-3728 (2009)
   PUBMED   19639589
  REMARK    GeneRIF: The findings demonstrated that calpain-truncated CRMP-3
            and -4 act as pro-apoptotic players when CGNs undergo apoptosis.
REFERENCE   3  (bases 1 to 2628)
  AUTHORS   Fukada,M., Watakabe,I., Yuasa-Kawada,J., Kawachi,H., Kuroiwa,A.,
            Matsuda,Y. and Noda,M.
  TITLE     Molecular characterization of CRMP5, a novel member of the
            collapsin response mediator protein family
  JOURNAL   J Biol Chem 275 (48), 37957-37965 (2000)
   PUBMED   10956643
REFERENCE   4  (bases 1 to 2628)
  AUTHORS   Inatome,R., Tsujimura,T., Hitomi,T., Mitsui,N., Hermann,P.,
            Kuroda,S., Yamamura,H. and Yanagi,S.
  TITLE     Identification of CRAM, a novel unc-33 gene family protein that
            associates with CRMP3 and protein-tyrosine kinase(s) in the
            developing rat brain
  JOURNAL   J Biol Chem 275 (35), 27291-27302 (2000)
   PUBMED   10851247
REFERENCE   5  (bases 1 to 2628)
  AUTHORS   Wang,L.H. and Strittmatter,S.M.
  TITLE     Brain CRMP forms heterotetramers similar to liver
            dihydropyrimidinase
  JOURNAL   J Neurochem 69 (6), 2261-2269 (1997)
   PUBMED   9375656
REFERENCE   6  (bases 1 to 2628)
  AUTHORS   Wang,L.H. and Strittmatter,S.M.
  TITLE     A family of rat CRMP genes is differentially expressed in the
            nervous system
  JOURNAL   J Neurosci 16 (19), 6197-6207 (1996)
   PUBMED   8815901
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Jun 3, 2021 this sequence version replaced NM_012933.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U52103.1, SRR26360176.62861.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-153               JAXUCZ010000001.1  203312713-203312865
            154-242             JAXUCZ010000001.1  203316202-203316290
            243-427             JAXUCZ010000001.1  203316852-203317036
            428-592             JAXUCZ010000001.1  203318545-203318709
            593-654             JAXUCZ010000001.1  203320286-203320347
            655-735             JAXUCZ010000001.1  203320432-203320512
            736-804             JAXUCZ010000001.1  203321029-203321097
            805-925             JAXUCZ010000001.1  203321485-203321605
            926-1082            JAXUCZ010000001.1  203322809-203322965
            1083-1224           JAXUCZ010000001.1  203323312-203323453
            1225-1395           JAXUCZ010000001.1  203324624-203324794
            1396-1575           JAXUCZ010000001.1  203325297-203325476
            1576-1741           JAXUCZ010000001.1  203326500-203326665
            1742-2628           JAXUCZ010000001.1  203327637-203328523
FEATURES             Location/Qualifiers
     source          1..2628
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q41"
     gene            1..2628
                     /gene="Dpysl4"
                     /gene_synonym="Crmp3; Dpys4"
                     /note="dihydropyrimidinase-like 4"
                     /db_xref="GeneID:25417"
                     /db_xref="RGD:2409"
     exon            1..153
                     /gene="Dpysl4"
                     /gene_synonym="Crmp3; Dpys4"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..1833
                     /gene="Dpysl4"
                     /gene_synonym="Crmp3; Dpys4"
                     /note="DRP-4; CRMP-3; ULIP4 protein; UNC33-like
                     phosphoprotein 4; ULIP-4; Collapsin response mediator
                     protein 3"
                     /codon_start=1
                     /product="dihydropyrimidinase-related protein 4"
                     /protein_id="NP_037065.1"
                     /db_xref="GeneID:25417"
                     /db_xref="RGD:2409"
                     /translation="MSFQGKKSIPRITSDRLLIKGGKIVNDDQSFHADLYVEDGLIKQ
                     IGENLIVPGGIKTIDAHGLMVLPGGVDVHTRLQMPVLGMTPADDFCQGTKAALAGGTT
                     MILDHVFPDAGVSLLAAYEQWRERADSAACCDYSLHVDIPRWHESTKEELEALVRDKG
                     VNSFLVFMAYKDRCQCTDGQIYEIFSLIRDLGAVAQVHAENGDIVEEEQKRLLEQGIT
                     GPEGHVLSHPEEVEAEAVYRAVTIAKQANCPLYITKVMSKGAADMVAQAKRRGVVVFG
                     EPITASLGTDGSHYWSKNWAKAAAFVTSPPINPDPTTADHLTSLLSSGDLQVTGSAHC
                     TFTTAQKAVGKDNFTLIPEGINGIEERMSVVWEKCVASGKMDENEFVAVTSTNAAKIF
                     NFYPRKGRVAVGSDADLVIWNPRATKVISAKSHNLNVEYNIFEGVECRGMPTVVISQG
                     RVVLEDGNLLVTPGAGRFIPRKTFPDFVYKRIKARNRLAEIHGVPRGLYDGPVHEVML
                     PAKPGSGTQARASCPGKISVPPVRNLHQSGFSLSGSQADDHIARRTAQKIMAPPGGRS
                     NITSLS"
     exon            154..242
                     /gene="Dpysl4"
                     /gene_synonym="Crmp3; Dpys4"
                     /inference="alignment:Splign:2.1.0"
     exon            243..427
                     /gene="Dpysl4"
                     /gene_synonym="Crmp3; Dpys4"
                     /inference="alignment:Splign:2.1.0"
     exon            428..592
                     /gene="Dpysl4"
                     /gene_synonym="Crmp3; Dpys4"
                     /inference="alignment:Splign:2.1.0"
     exon            593..654
                     /gene="Dpysl4"
                     /gene_synonym="Crmp3; Dpys4"
                     /inference="alignment:Splign:2.1.0"
     exon            655..735
                     /gene="Dpysl4"
                     /gene_synonym="Crmp3; Dpys4"
                     /inference="alignment:Splign:2.1.0"
     exon            736..804
                     /gene="Dpysl4"
                     /gene_synonym="Crmp3; Dpys4"
                     /inference="alignment:Splign:2.1.0"
     exon            805..925
                     /gene="Dpysl4"
                     /gene_synonym="Crmp3; Dpys4"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1082
                     /gene="Dpysl4"
                     /gene_synonym="Crmp3; Dpys4"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1224
                     /gene="Dpysl4"
                     /gene_synonym="Crmp3; Dpys4"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1395
                     /gene="Dpysl4"
                     /gene_synonym="Crmp3; Dpys4"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1575
                     /gene="Dpysl4"
                     /gene_synonym="Crmp3; Dpys4"
                     /inference="alignment:Splign:2.1.0"
     exon            1576..1741
                     /gene="Dpysl4"
                     /gene_synonym="Crmp3; Dpys4"
                     /inference="alignment:Splign:2.1.0"
     exon            1742..2628
                     /gene="Dpysl4"
                     /gene_synonym="Crmp3; Dpys4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccagcgctg ggctagctca cactcggact tcctaagctc cgcgcgtgtc cccgccggca
       61 cgtccacgcc cgcgcagccc ctaccgagga cacccagccc gcccgtggat caggatgtcc
      121 ttccaaggca agaagagcat tccccggata acgagtgacc gccttctcat caaaggtggg
      181 aagattgtga atgatgacca gtcctttcat gcggatctct acgtggagga cggtctgatt
      241 aaacaaattg gagaaaatct tatcgtccct gggggaatca aaaccatcga tgctcatggt
      301 ctgatggtac tgcctggggg agttgacgtc cacacccggc tgcagatgcc tgtgctgggc
      361 atgaccccag ccgatgattt ctgtcagggc accaaggctg ccctagcagg cgggaccacg
      421 atgatattgg accatgtgtt tcctgatgct ggcgtgagcc tgctggcggc ctatgagcag
      481 tggcgggagc gagcagacag tgcagcctgc tgtgactact ccttacacgt ggacattccc
      541 cgctggcatg agagcaccaa agaggagctg gaggccctag tcagggacaa aggtgtgaac
      601 tccttcctgg tcttcatggc ttacaaggac aggtgccagt gtactgatgg ccagatatat
      661 gaaatcttca gcctcatccg ggacctggga gctgtggccc aggtgcatgc agaaaacggg
      721 gacatcgtgg aggaggaaca gaagcgcctg ctggagcagg gcatcactgg tcctgagggc
      781 catgtgctca gccacccaga agaggtagag gccgaagctg tgtacagagc tgtgaccatt
      841 gccaagcagg ccaactgccc actgtatatc accaaggtga tgagcaaggg tgcggctgat
      901 atggttgccc aagccaagcg caggggggtg gtcgtctttg gggaacctat cactgccagc
      961 ctgggcactg atggctcaca ctactggagc aagaactggg ccaaggctgc agccttcgtc
     1021 acatcacccc ctatcaaccc ggaccctact actgcagacc acctcacctc tctgctgtcc
     1081 agtggggacc tccaggtgac aggcagtgca cactgcacct tcactactgc ccagaaggct
     1141 gttggcaaag ataacttcac gctgatcccc gagggcatca acggtataga agaacgcatg
     1201 tctgtggtct gggagaaatg tgtggcttca gggaaaatgg acgagaatga gttcgttgcc
     1261 gtgaccagca caaatgctgc caaaatcttc aatttctacc ccaggaaggg gcgtgtggct
     1321 gtgggctctg atgctgacct ggtcatctgg aaccccaggg ccacaaaagt catctctgcc
     1381 aagagccata acctgaatgt agagtacaac atcttcgaag gagtggagtg cagaggcatg
     1441 cccacggtgg tcataagtca gggcagagtg gtgctggagg acggaaacct gcttgtcact
     1501 ccaggggctg gccgcttcat tccccggaag acattcccag actttgtcta taagaggata
     1561 aaggctcgta acaggctagc agagatccac ggtgtgcccc gaggcctgta tgatgggcct
     1621 gtccacgaag tgatgttacc tgccaagcca gggagcggca cacaagcccg tgcatcctgt
     1681 ccaggcaaga tctcagtgcc acccgtgcgc aacctgcacc agtcagggtt cagcctatct
     1741 ggctctcagg ctgacgatca cattgccaga cgcacagctc agaagatcat ggcacccccc
     1801 ggaggacgct ccaacatcac ttcactttct tagacttggg gtctggcaat gcaggtgctg
     1861 tccccactgg cagggtgtgg ggactactct cttcagttag ctccttcctt tgtagatcat
     1921 tattgtgaaa ggtgctcagc cttgccctcc ccctccccat aaactctctt ttggaagttc
     1981 ccagccccca gtctgaggca ccccctccag agggctgaat ccagggaggg ttcactgcca
     2041 gagtgagagg attaggcagg gcagtgagct ggtgcctctt gccccacccc tgaccttacc
     2101 atgaaggccg tccacgagag ctctcagcct ccagcctgtg aactttccag ggcctggtgg
     2161 taggcagggt gggtgtttgc tgctgccacc ccctcagaaa tcactgccct gtggaagccc
     2221 ccaagcttcc accagttcca tgttgctaaa ggtgcagcga ccccttgggg gcctgtcccc
     2281 tctggctgcc ctggtgtagg gaggagagca ggtgagcgga gcctccgctt ggcagagctg
     2341 ctgtgacttc agggatccac cagttactca gtgcagggtc gctccctccc acatagtccc
     2401 ttgcaaggac caaacctgag ctcctatagc agccgccctc tagggagttt gatgatccct
     2461 tagctaagac actttccttt tcctacaaag tgtgttttca taggtttatt agagtagctg
     2521 ttttggactg tgaggaaacc atagccaggg atctgcatgc tgctgtacca gacaccggcc
     2581 accggccaag ctgatttgag tcaggtcaat aaaaagtctg ggttcgaa
//
