LOCUS       NM_001398556            5584 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus dihydropyrimidinase-like 3 (Dpysl3), transcript
            variant 2, mRNA.
ACCESSION   NM_001398556 XM_006254670
VERSION     NM_001398556.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5584)
  AUTHORS   Kwon,K., Song,J.H., Park,H., Kwon,O.Y. and Kim,S.W.
  TITLE     Regulation of Dihydropyrimidinase-like 3 Gene Expression by
            MicroRNAs in PC12 Cells with Induced Ischaemia and Hypothermia
  JOURNAL   Folia Biol (Praha) 69 (2), 69-73 (2023)
   PUBMED   38063003
  REMARK    GeneRIF: Regulation of Dihydropyrimidinase-like 3 Gene Expression
            by MicroRNAs in PC12 Cells with Induced Ischaemia and Hypothermia.
REFERENCE   2  (bases 1 to 5584)
  AUTHORS   Cha,C., Zhang,J., Ji,Z., Tan,M., Li,S., Wu,F., Chen,K., Gong,S.,
            Guo,G. and Lin,H.
  TITLE     CRMP4 regulates dendritic growth and maturation via the interaction
            with actin cytoskeleton in cultured hippocampal neurons
  JOURNAL   Brain Res Bull 124, 286-294 (2016)
   PUBMED   27339813
  REMARK    GeneRIF: The results of this study suggest that CRMP4 is involved
            in dendritic development via the interaction with actin
            cytoskeleton in hippocampal neurons.
REFERENCE   3  (bases 1 to 5584)
  AUTHORS   Tan,M., Cha,C., Ye,Y., Zhang,J., Li,S., Wu,F., Gong,S. and Guo,G.
  TITLE     CRMP4 and CRMP2 Interact to Coordinate Cytoskeleton Dynamics,
            Regulating Growth Cone Development and Axon Elongation
  JOURNAL   Neural Plast 2015, 947423 (2015)
   PUBMED   26064693
  REMARK    GeneRIF: Data suggest collapsin response mediator proteins (CRMP)
            CRMP2 and CRMP4 form complexes to bridge microtubules and actin and
            work cooperatively to regulate growth cone development and axonal
            elongation.
REFERENCE   4  (bases 1 to 5584)
  AUTHORS   Nakamura,F., Kumeta,K., Hida,T., Isono,T., Nakayama,Y.,
            Kuramata-Matsuoka,E., Yamashita,N., Uchida,Y., Ogura,K.,
            Gengyo-Ando,K., Mitani,S., Ogino,T. and Goshima,Y.
  TITLE     Amino- and carboxyl-terminal domains of Filamin-A interact with
            CRMP1 to mediate Sema3A signalling
  JOURNAL   Nat Commun 5, 5325 (2014)
   PUBMED   25358863
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5584)
  AUTHORS   Manivannan,J., Tay,S.S., Ling,E.A. and Dheen,S.T.
  TITLE     Dihydropyrimidinase-like 3 regulates the inflammatory response of
            activated microglia
  JOURNAL   Neuroscience 253, 40-54 (2013)
   PUBMED   23988434
  REMARK    GeneRIF: The results of this study suggested that knockdown of
            Dpysl3 can inhibit activation, migration and phagocytic capability
            of microglia and consequently reduce neuroinflammation.
REFERENCE   6  (bases 1 to 5584)
  AUTHORS   Liu,Z. and Martin,L.J.
  TITLE     Olfactory bulb core is a rich source of neural progenitor and stem
            cells in adult rodent and human
  JOURNAL   J Comp Neurol 459 (4), 368-391 (2003)
   PUBMED   12687705
REFERENCE   7  (bases 1 to 5584)
  AUTHORS   Quinn,C.C., Chen,E., Kinjo,T.G., Kelly,G., Bell,A.W., Elliott,R.C.,
            McPherson,P.S. and Hockfield,S.
  TITLE     TUC-4b, a novel TUC family variant, regulates neurite outgrowth and
            associates with vesicles in the growth cone
  JOURNAL   J Neurosci 23 (7), 2815-2823 (2003)
   PUBMED   12684468
  REMARK    GeneRIF: TUC-4b can regulate neurite extension and branching
            through a mechanism that may involve membrane transport in the
            growth cone
REFERENCE   8  (bases 1 to 5584)
  AUTHORS   Franken,S., Junghans,U., Rosslenbroich,V., Baader,S.L.,
            Hoffmann,R., Gieselmann,V., Viebahn,C. and Kappler,J.
  TITLE     Collapsin response mediator proteins of neonatal rat brain interact
            with chondroitin sulfate
  JOURNAL   J Biol Chem 278 (5), 3241-3250 (2003)
   PUBMED   12444086
  REMARK    GeneRIF: In neonatal rat brain, interacts with chondroitin sulfate
            and other glycosaminoglycans
REFERENCE   9  (bases 1 to 5584)
  AUTHORS   Fukada,M., Watakabe,I., Yuasa-Kawada,J., Kawachi,H., Kuroiwa,A.,
            Matsuda,Y. and Noda,M.
  TITLE     Molecular characterization of CRMP5, a novel member of the
            collapsin response mediator protein family
  JOURNAL   J Biol Chem 275 (48), 37957-37965 (2000)
   PUBMED   10956643
REFERENCE   10 (bases 1 to 5584)
  AUTHORS   Wang,L.H. and Strittmatter,S.M.
  TITLE     A family of rat CRMP genes is differentially expressed in the
            nervous system
  JOURNAL   J Neurosci 16 (19), 6197-6207 (1996)
   PUBMED   8815901
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000299.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001398556.2.
            
            On Dec 20, 2021 this sequence version replaced XM_006254670.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF398465.1, SRR8487231.154284.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-464               JACYVU010000299.1  24921939-24922402   c
            465-553             JACYVU010000299.1  24851228-24851316   c
            554-738             JACYVU010000299.1  24848632-24848816   c
            739-903             JACYVU010000299.1  24845940-24846104   c
            904-965             JACYVU010000299.1  24842364-24842425   c
            966-1046            JACYVU010000299.1  24841490-24841570   c
            1047-1115           JACYVU010000299.1  24833867-24833935   c
            1116-1236           JACYVU010000299.1  24831029-24831149   c
            1237-1393           JACYVU010000299.1  24828386-24828542   c
            1394-1535           JACYVU010000299.1  24827394-24827535   c
            1536-1706           JACYVU010000299.1  24825240-24825410   c
            1707-1886           JACYVU010000299.1  24823889-24824068   c
            1887-2049           JACYVU010000299.1  24821438-24821600   c
            2050-5584           JACYVU010000299.1  24816601-24820135   c
FEATURES             Location/Qualifiers
     source          1..5584
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p11-q11"
     gene            1..5584
                     /gene="Dpysl3"
                     /gene_synonym="Crmp4; TUC-4b"
                     /note="dihydropyrimidinase-like 3"
                     /db_xref="GeneID:25418"
                     /db_xref="RGD:2410"
     exon            1..464
                     /gene="Dpysl3"
                     /gene_synonym="Crmp4; TUC-4b"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..2138
                     /gene="Dpysl3"
                     /gene_synonym="Crmp4; TUC-4b"
                     /note="isoform 2 is encoded by transcript variant 2;
                     collapsin response mediator protein 4;
                     dihydropyrimidinase-related protein 3; DRP-3; CRMP-4;
                     TOAD-64/Ulip/CRMP protein 4b"
                     /codon_start=1
                     /product="dihydropyrimidinase-related protein 3 isoform 2"
                     /protein_id="NP_001385485.1"
                     /db_xref="GeneID:25418"
                     /db_xref="RGD:2410"
                     /translation="MASGRRGWDSSHEDDLPVYLARPGTTDQVPRQKYGGMFCNVEGA
                     FESKTLDFDALSVGQRGAKTPRSSQGSGRGAGNRPGVEGDTRRGPGREESREPVPESP
                     KPAGVEIRSATGKEVLQNLGPKDKSDRLLIKGGRIVNDDQSFYADIYMEDGLIKQIGD
                     NLIVPGGVKTIEANGKMVMPGGIDVHTHFQMPYKGMTTVDDFFQGTKAALAGGTTMII
                     DHVVPEPESSLTEAYEKWREWADGKSCCDYALHVDITHWNDSVKQEVQNLSKEKGVNS
                     FMVYMAYKDLYQVSNTELYEIFTCLGELGAIAQVHAENGDIIAQEQARMLEMGITGPE
                     GHVLSRPEELEAEAVFRAITVASQTNCPLYVTKVMSKSAADLISQARKKGNVVFGEPI
                     TASLGIDGTHYWSKNWAKAAAFVTSPPLSPDPTTPDYINSLLASGDLQLSGSAHCTFS
                     TAQKAIGKDNFTAIPEGTNGVEERMSVIWDKAVATGKMDENQFVAVTSTNAAKIFNLY
                     PRKGRIAVGSDSDLVIWDPDAVKIVSAKNHQSVAEYNIFEGMELRGAPLVVICQGKIM
                     LEDGNLHVTQGAGRFIPCSPFSDYVYKRIKARRKMADLHAVPRGMYDGPVFDLTTTPK
                     GGTPAGSTRGSPTRPNPPVRNLHQSGFSLSGTQVDEGVRSASKRIVAPPGGRSNITSL
                     S"
     exon            465..553
                     /gene="Dpysl3"
                     /gene_synonym="Crmp4; TUC-4b"
                     /inference="alignment:Splign:2.1.0"
     exon            554..738
                     /gene="Dpysl3"
                     /gene_synonym="Crmp4; TUC-4b"
                     /inference="alignment:Splign:2.1.0"
     exon            739..903
                     /gene="Dpysl3"
                     /gene_synonym="Crmp4; TUC-4b"
                     /inference="alignment:Splign:2.1.0"
     exon            904..965
                     /gene="Dpysl3"
                     /gene_synonym="Crmp4; TUC-4b"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1046
                     /gene="Dpysl3"
                     /gene_synonym="Crmp4; TUC-4b"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1115
                     /gene="Dpysl3"
                     /gene_synonym="Crmp4; TUC-4b"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1236
                     /gene="Dpysl3"
                     /gene_synonym="Crmp4; TUC-4b"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1393
                     /gene="Dpysl3"
                     /gene_synonym="Crmp4; TUC-4b"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1535
                     /gene="Dpysl3"
                     /gene_synonym="Crmp4; TUC-4b"
                     /inference="alignment:Splign:2.1.0"
     exon            1536..1706
                     /gene="Dpysl3"
                     /gene_synonym="Crmp4; TUC-4b"
                     /inference="alignment:Splign:2.1.0"
     exon            1707..1886
                     /gene="Dpysl3"
                     /gene_synonym="Crmp4; TUC-4b"
                     /inference="alignment:Splign:2.1.0"
     exon            1887..2049
                     /gene="Dpysl3"
                     /gene_synonym="Crmp4; TUC-4b"
                     /inference="alignment:Splign:2.1.0"
     exon            2050..5584
                     /gene="Dpysl3"
                     /gene_synonym="Crmp4; TUC-4b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actgtggctc cgtgcgcgct gccggccggc cgctgctctc ttcagcctct gaagaagaaa
       61 gcctctgagc cgctgtcgct tgaaccatgg cttcgggccg aaggggttgg gacagctccc
      121 acgaggacga cctgcctgtg tacttggccc ggccgggcac cacagatcag gtcccacggc
      181 agaagtacgg tggcatgttc tgcaacgtgg agggcgcctt cgagagcaag acattggatt
      241 ttgatgccct gagtgtggga cagcgcggcg ccaaaactcc ccggagcagc cagggcagcg
      301 gccgcggcgc ggggaaccgg cccggggtgg aaggggacac gcgcaggggc ccgggccggg
      361 aggagagcag ggagcccgtg cctgagtcgc ccaagcccgc cggggtagag atccggagcg
      421 ccactggcaa ggaggtcttg cagaacctcg gtcccaagga caagagtgac cgtcttctaa
      481 tcaagggagg gagaatcgtc aacgatgatc agtcctttta tgctgatatt tacatggagg
      541 atggcttgat aaagcaaatt ggagacaatc tgattgtccc tggaggtgtg aagaccattg
      601 aggccaatgg gaagatggtg atgcctggag gcattgatgt ccatacccac ttccagatgc
      661 cttacaaggg gatgaccaca gtggacgatt tcttccaagg gacaaaggct gccttagcgg
      721 gaggaaccac catgatcatt gaccatgtgg tacctgaacc tgagtctagc ctgaccgagg
      781 cctatgaaaa gtggcgtgag tgggctgacg ggaagagctg ctgtgactat gctttgcatg
      841 tggacatcac ccactggaat gacagcgtca agcaagaggt gcagaacctc agtaaggaaa
      901 aaggcgttaa ctccttcatg gtttacatgg catacaagga tttatatcaa gtgtccaaca
      961 cagagctcta tgagatcttc acctgcctgg gagaactggg ggccattgct caagttcatg
     1021 ccgagaatgg agacatcatt gcccaggagc aggcacgaat gctggaaatg ggaataacag
     1081 gcccagaagg tcatgttctg agcagaccgg aagagctgga agctgaggct gtgttccgtg
     1141 ccatcaccgt cgccagccag accaactgcc ccctttatgt caccaaggtc atgagcaaga
     1201 gcgcggctga tctcatctca caagccagga agaaaggaaa tgtggtcttt ggcgagccca
     1261 tcactgccag cctgggaata gatggaaccc attactggag taagaactgg gccaaggcag
     1321 ctgcatttgt gacatcccca cctctgagcc ctgacccaac cacacctgac tacatcaact
     1381 ccttgctggc cagtggagat ctgcagctct ctggaagtgc ccactgtacc ttcagcactg
     1441 cccagaaagc cattgggaag gacaacttca cggctatccc tgagggcacc aatggcgtgg
     1501 aggagcgtat gtctgtcatc tgggacaagg ctgtggccac agggaagatg gatgaaaacc
     1561 agtttgtggc tgtgacaagt accaacgctg ccaagatatt caacctgtac cctcgcaagg
     1621 ggagaatagc tgtgggttct gacagcgacc ttgtcatctg ggatccagat gccgtgaaga
     1681 tcgtctctgc caagaaccac cagtcggttg cggaatacaa catctttgaa gggatggagc
     1741 tgcgtggggc acctctggtg gttatctgcc agggcaagat catgctggaa gatggtaacc
     1801 tgcacgtgac ccagggggcc ggccgcttca ttccctgcag cccattctct gactatgtct
     1861 ataagcgcat taaagcaagg aggaagatgg cggacctgca tgcagtccca agaggcatgt
     1921 atgatggacc agtgtttgac ttgaccacca cccccaaggg gggcacccca gctggctcta
     1981 ctcgaggctc tcccactcgg ccaaacccac cagtgaggaa cctccatcag tcgggattta
     2041 gtctgtcagg cacccaagtg gatgagggtg tccgctcagc cagcaaacgc attgtggcgc
     2101 cccctggagg ccgttctaac atcacatccc tgagttaagc aagccctccc aaagagggag
     2161 gcagaagcaa gaagaagaaa aatttgaagc caaaatggta caccgataat taagaaggag
     2221 cgtggatcca aaaagttgcg atctaaagaa tcactaagcc tcaagcctta tgtttcccaa
     2281 cgttttgctt gcttgcctag ctttatgaat tgctttgatt tctgtttatg catcgcactc
     2341 tcaatttcct cccccatccc aacccccaca tacatgcatg cgatcagaca ggccactaag
     2401 gtagattctg catattatag tgttgagagc gtatatagtg ctgcatctta tgacagagga
     2461 cagacaaagc tggaatgtcg agaaaatgaa cgaaggcacg aagggtcttt gggtgattgg
     2521 gtggtgggag tccaggacaa agtggagggc acaaagggac tggggtggga cgtgtactgg
     2581 ggaggtgggt gggctgggtg agcagaaggg cattgtgtgt tgtattatga tgtgtgttaa
     2641 tttccatgga agatgggcca cataaggcag tgagattctc catcacagtc ccctggcatc
     2701 tgcagagaag gcaggaggag gtttttgggt tcaggacttt gtcatgccct ttcctagtag
     2761 atcttgtttc tttaatcatg tattgaatag cagagtccag ccatttcttc cacctgttga
     2821 tgatcccagc gtttacttgg gcctcattct ccggttgttt tctattcttc tgtttcgggc
     2881 tgtggagccc acactcggag gacaaacaaa caggtctctt cctctccatc gtctttgggg
     2941 gttcctcaaa ggctgctatg gagagtaagc cccagctctg tttgggggag aacagcgaag
     3001 cttaggcagt cttcctctca gccctgggga ggtacctctg tccccccccc ccccctctct
     3061 ctctctctct ctctctctct catctacaag ctgaggggag gcatgtgctc ttgcctgctg
     3121 agttaggccc atggcagaga caaagtcaag ggcttccttt gctcacagtg aatgcctaat
     3181 cgcttcatct cagacccaga cacattcatg ttatttcctt ctggagaact gagtttttcg
     3241 gttgttccta aactttactc ccaatagtaa tctccgattc tgtgggagta tggcagagat
     3301 tgagggaagc cagccttgag taccagaaat acactgtata accaggtttt caattctaag
     3361 ccaagtgttt cctcgtctga tagcagattc cgggggcact atttatttgg tactaattct
     3421 ccagggtgat gtgtacggag caacaggatg tggctttctt ggtgagtggt acataaggac
     3481 agtgggcagt gatgttagca tccccccccc ctttgtctgt cagagttgga agttcatgtt
     3541 cctatcacac catttccaaa accaatcgtg aaccagattc tgtgagcaag gcaagggtct
     3601 gtagaagcca ggatactttc ctgcaggaaa tatggtagta accttggctc agacttctgt
     3661 gctcccgggg cccagttagt gagaactatc acactgcgca tgaagtactc tgaagaacag
     3721 agcaggactc atgcaccttc taagtactta caagaaactg ccatctctgc ctgcaggcgt
     3781 tttgtttgtt tttgctgttt ttgctttttt gaggtggggg atttttgttt atttcatttt
     3841 gtagagctgg acaattgagt ccagggcttc tccagtgcta ggcaaaactc tgccactgtg
     3901 cttcaccctt acccccaaac cctgactgta ggctgtaata aaactgagaa ctagagaaat
     3961 atgaacagtt tagatacata agcatttgga aatagaggaa gggaatttcc ctgaggaagc
     4021 tagcttctgt tctaatcgtg gaaaaggttc tcagacctca tactaggaat attactactt
     4081 taaagctctc atggtgctct catttttaaa ggcgacttta gcagaaaaaa aacaggggaa
     4141 tgaagtcttg aattgcaaat gtcaaatttt gggatatatc caggaacaca gaatgacttt
     4201 tatatgcaaa aggagtttgc cagatctaaa gcatgtatgc taaatacctc aatagccagg
     4261 cttggcagca gcgtaggttg tagtaccatc tgtggccacc agatggagga agagatctgt
     4321 aaatgaactg taattcgggg cctccacaac tgtgtggttt cccatgcctg agacccccca
     4381 aggtctctct ggtcatgaaa aataaactcc tttgggtcat ctgcactaca cttggcactt
     4441 ccaaagtgtg tcactgtgct ggaaccttat gttccactca ggtgttccct atgccaggag
     4501 cagcttctta aagacctcaa ggtgggcagg cgccatctta ggatgcgtcg tccctgtttt
     4561 cattactagt agtgcccatg cgtagtaaat ccttcctcag aagctcccca actgttttct
     4621 taacgcaagg atttttctaa gcaacatgtt acttgagtta cgagtctaaa tgtaaattgg
     4681 ttctgtttca tagatagaca gcccgtcact gggtttcggg aaggaaagca acaatgagtt
     4741 gggcttcctc caagttcact ggcttgccat ccgagggtgg tagagcatgc tgggtactat
     4801 cttctctcaa agagctttgt catctgggct ttctaccaag cccccactaa gaataccctg
     4861 caatcttcaa accccaagtt atttctgagc cctcaatggc aatctattga cattctttct
     4921 gaaagggcca caggctcaag tggtttaaaa ggtctcactg gagcaattaa atcagctttc
     4981 ccagtggaga aatttgtttt tatgtttttt gttttgtttg gttggttttg ttttgttttt
     5041 gtttttgttt tgttttttta aactaatagg attatagtct gcttccaaaa tggctttcct
     5101 ctaacttcaa agtctagtgc ttctttgggt catttcttca tcaggatatg tagaggtctg
     5161 cctcccaagg cctgaatcct aactctggac tccattctgc tctttctaag ccccttccga
     5221 gaggtgagtg cttcccaatt ttgcttcttg ccacaagcct cccagatctt cttccctaga
     5281 cagcccagct tgagtcccga tgcagtcatg tgctggccca tgcagccagc gtttctcgta
     5341 attccccttt gagacatggt gtgtgggtgt tcagttctgt gtctggtggc tatggacaga
     5401 cagtgagtct ccttgtgacc tgtgctagct gtgaggcagc tcagatatgg aagagctgtt
     5461 tggtttgaac cgtgaagaaa actgtgtatt gagttagctg agaataaaga aacaaacaaa
     5521 caaaaaagct catcaagtga ctgttaatgt aaacctggtt attaaaataa ttataaaatt
     5581 acca
//
