LOCUS       NM_001105717            4370 bp    mRNA    linear   ROD 12-AUG-2024
DEFINITION  Rattus norvegicus dihydropyrimidinase-like 2 (Dpysl2), mRNA.
ACCESSION   NM_001105717 XM_001067745 XM_573810
VERSION     NM_001105717.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4370)
  AUTHORS   Rahamim,N., Liran,M., Aronovici,C., Flumin,H., Gordon,T.,
            Urshansky,N. and Barak,S.
  TITLE     Inhibition of ERK1/2 or CRMP2 Disrupts Alcohol Memory
            Reconsolidation and Prevents Relapse in Rats
  JOURNAL   Int J Mol Sci 25 (10), 5478 (2024)
   PUBMED   38791516
  REMARK    GeneRIF: Inhibition of ERK1/2 or CRMP2 Disrupts Alcohol Memory
            Reconsolidation and Prevents Relapse in Rats.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4370)
  AUTHORS   Martinez-Alonso,E., Escobar-Peso,A., Guerra-Perez,N., Roca,M.,
            Masjuan,J. and Alcazar,A.
  TITLE     Dihydropyrimidinase-Related Protein 2 Is a New Partner in the
            Binding between 4E-BP2 and eIF4E Related to Neuronal Death after
            Cerebral Ischemia
  JOURNAL   Int J Mol Sci 24 (9), 8246 (2023)
   PUBMED   37175950
  REMARK    GeneRIF: Dihydropyrimidinase-Related Protein 2 Is a New Partner in
            the Binding between 4E-BP2 and eIF4E Related to Neuronal Death
            after Cerebral Ischemia.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4370)
  AUTHORS   Li,Y., Tong,F., Zhang,Y., Cai,Y., Ding,J., Wang,Q. and Wang,X.
  TITLE     Neuropilin-2 Signaling Modulates Mossy Fiber Sprouting by
            Regulating Axon Collateral Formation Through CRMP2 in a Rat Model
            of Epilepsy
  JOURNAL   Mol Neurobiol 59 (11), 6817-6833 (2022)
   PUBMED   36044155
  REMARK    GeneRIF: Neuropilin-2 Signaling Modulates Mossy Fiber Sprouting by
            Regulating Axon Collateral Formation Through CRMP2 in a Rat Model
            of Epilepsy.
REFERENCE   4  (bases 1 to 4370)
  AUTHORS   Li,Y., Tong,F., Liu,L., Su,Z., Ding,J., Wang,Q. and Wang,X.
  TITLE     CRMP2 modulates mossy fiber sprouting in dentate gyrus of
            pilocarpine induced rat model of epilepsy
  JOURNAL   Biochem Biophys Res Commun 605, 141-147 (2022)
   PUBMED   35334412
  REMARK    GeneRIF: CRMP2 modulates mossy fiber sprouting in dentate gyrus of
            pilocarpine induced rat model of epilepsy.
REFERENCE   5  (bases 1 to 4370)
  AUTHORS   Fazil,M.H.U.T., Prasannan,P., Wong,B.H.S., Kottaiswamy,A.,
            Salim,N.S.B.M., Sze,S.K. and Verma,N.K.
  TITLE     GSK3beta Interacts With CRMP2 and Notch1 and Controls T-Cell
            Motility
  JOURNAL   Front Immunol 12, 680071 (2021)
   PUBMED   34975828
  REMARK    GeneRIF: GSK3beta Interacts With CRMP2 and Notch1 and Controls
            T-Cell Motility.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4370)
  AUTHORS   Wong,C.C. and Leung,M.S.
  TITLE     Effects of neonatal hypothyroidism on the expressions of growth
            cone proteins and axon guidance molecules related genes in the
            hippocampus
  JOURNAL   Mol Cell Endocrinol 184 (1-2), 143-150 (2001)
   PUBMED   11694350
REFERENCE   7  (bases 1 to 4370)
  AUTHORS   Gu,Y., Hamajima,N. and Ihara,Y.
  TITLE     Neurofibrillary tangle-associated collapsin response mediator
            protein-2 (CRMP-2) is highly phosphorylated on Thr-509, Ser-518,
            and Ser-522
  JOURNAL   Biochemistry 39 (15), 4267-4275 (2000)
   PUBMED   10757975
REFERENCE   8  (bases 1 to 4370)
  AUTHORS   Wang,L.H. and Strittmatter,S.M.
  TITLE     Brain CRMP forms heterotetramers similar to liver
            dihydropyrimidinase
  JOURNAL   J Neurochem 69 (6), 2261-2269 (1997)
   PUBMED   9375656
REFERENCE   9  (bases 1 to 4370)
  AUTHORS   Geschwind,D.H., Kelly,G.M., Fryer,H., Feeser-Bhatt,H. and
            Hockfield,S.
  TITLE     Identification and characterization of novel developmentally
            regulated proteins in rat spinal cord
  JOURNAL   Brain Res Dev Brain Res 97 (1), 62-75 (1996)
   PUBMED   8946055
REFERENCE   10 (bases 1 to 4370)
  AUTHORS   Minturn,J.E., Fryer,H.J., Geschwind,D.H. and Hockfield,S.
  TITLE     TOAD-64, a gene expressed early in neuronal differentiation in the
            rat, is related to unc-33, a C. elegans gene involved in axon
            outgrowth
  JOURNAL   J Neurosci 15 (10), 6757-6766 (1995)
   PUBMED   7472434
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB749736.1, JAXUCZ010000015.1, CB729753.1, CA510768.1 and
            CB577285.1.
            
            On Oct 24, 2007 this sequence version replaced NM_001105717.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643294.52343.1,
                                           SRR26643291.37161.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-147               CB749736.1         57-203
            148-383             CB749736.1         205-440
            384-537             JAXUCZ010000015.1  45242356-45242509   c
            538-702             JAXUCZ010000015.1  45211861-45212025   c
            703-1033            CB729753.1         109-439
            1034-1551           CA510768.1         151-668
            1552-1884           CB577285.1         300-632
            1885-4370           JAXUCZ010000015.1  45181041-45183526   c
FEATURES             Location/Qualifiers
     source          1..4370
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p12"
     gene            1..4370
                     /gene="Dpysl2"
                     /gene_synonym="Crmp2; TOAD-64"
                     /note="dihydropyrimidinase-like 2"
                     /db_xref="GeneID:25416"
                     /db_xref="RGD:2517"
     exon            1..263
                     /gene="Dpysl2"
                     /gene_synonym="Crmp2; TOAD-64"
                     /inference="alignment:Splign:2.1.0"
     CDS             225..1943
                     /gene="Dpysl2"
                     /gene_synonym="Crmp2; TOAD-64"
                     /note="DRP-2; CRMP-2; turned on after division, 64 kDa
                     protein; collapsin response mediator protein 2"
                     /codon_start=1
                     /product="dihydropyrimidinase-related protein 2"
                     /protein_id="NP_001099187.1"
                     /db_xref="GeneID:25416"
                     /db_xref="RGD:2517"
                     /translation="MSYQGKKNIPRITSDRLLIKGGKIVNDDQSFYADIYMEDGLIKQ
                     IGENLIVPGGVKTIEAHSRMVIPGGIDVHTRFQMPDQGMTSADDFFQGTKAALAGGTT
                     MIIDHVVPEPGTSLLAAFDQWREWADSKSCCDYSLHVDITEWHKGIQEEMEALVKDHG
                     VNSFLVYMAFKDRFQLTDSQIYEVLSVIRDIGAIAQVHAENGDIIAEEQQRILDLGIT
                     GPEGHVLSRPEEVEAEAVNRSITIANQTNCPLYVTKVMSKSAAEVIAQARKKGTVVYG
                     EPITASLGTDGSHYWSKNWAKAAAFVTSPPLSPDPTTPDFLNSLLSCGDLQVTGSAHC
                     TFNTAQKAVGKDNFTLIPEGTNGTEERMSVIWDKAVVTGKMDENQFVAVTSTNAAKVF
                     NLYPRKGRISVGSDADLVIWDPDSVKTISAKTHNSALEYNIFEGMECRGSPLVVISQG
                     KIVLEDGTLHVTEGSGRYIPRKPFPDFVYKRIKARSRLAELRGVPRGLYDGPVCEVSV
                     TPKTVTPASSAKTSPAKQQAPPVRNLHQSGFSLSGAQIDDNIPRRTTQRIVAPPGGRA
                     NITSLG"
     exon            264..352
                     /gene="Dpysl2"
                     /gene_synonym="Crmp2; TOAD-64"
                     /inference="alignment:Splign:2.1.0"
     exon            353..537
                     /gene="Dpysl2"
                     /gene_synonym="Crmp2; TOAD-64"
                     /inference="alignment:Splign:2.1.0"
     exon            538..702
                     /gene="Dpysl2"
                     /gene_synonym="Crmp2; TOAD-64"
                     /inference="alignment:Splign:2.1.0"
     exon            703..764
                     /gene="Dpysl2"
                     /gene_synonym="Crmp2; TOAD-64"
                     /inference="alignment:Splign:2.1.0"
     exon            765..845
                     /gene="Dpysl2"
                     /gene_synonym="Crmp2; TOAD-64"
                     /inference="alignment:Splign:2.1.0"
     exon            846..914
                     /gene="Dpysl2"
                     /gene_synonym="Crmp2; TOAD-64"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1035
                     /gene="Dpysl2"
                     /gene_synonym="Crmp2; TOAD-64"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1192
                     /gene="Dpysl2"
                     /gene_synonym="Crmp2; TOAD-64"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1334
                     /gene="Dpysl2"
                     /gene_synonym="Crmp2; TOAD-64"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1505
                     /gene="Dpysl2"
                     /gene_synonym="Crmp2; TOAD-64"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..1685
                     /gene="Dpysl2"
                     /gene_synonym="Crmp2; TOAD-64"
                     /inference="alignment:Splign:2.1.0"
     exon            1686..1851
                     /gene="Dpysl2"
                     /gene_synonym="Crmp2; TOAD-64"
                     /inference="alignment:Splign:2.1.0"
     exon            1852..4370
                     /gene="Dpysl2"
                     /gene_synonym="Crmp2; TOAD-64"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tttttccgcc ctagctggat ctgtgttgga ggagagaaaa agagacagag gattgcatct
       61 gtctcttata gttttgaaat ctcctaatag caagaccagc taagggattg tacctttttc
      121 ctacaaatat aaatatatat atattttaaa ccaagtcttt ttttccggct ctctttgctt
      181 taaagctgtc ctcttgaaat tacttccccc cgccccccgg agagatgtct tatcagggga
      241 agaaaaatat tccacgcatc acgagcgatc gtcttctgat caaaggtggc aagattgtga
      301 atgatgacca gtccttctat gcagacatat acatggaaga tgggttgatc aagcaaatag
      361 gagaaaacct gattgtgcca ggaggggtga agaccatcga agcccactcc agaatggtga
      421 tccctggagg aattgacgtg cacactcgct tccagatgcc agaccaggga atgacatcag
      481 ctgatgactt cttccaggga accaaggcag ccctggccgg aggaaccacc atgatcatcg
      541 accatgttgt tcctgagccc gggacaagcc tattggcagc ctttgatcag tggagggagt
      601 gggcggacag caagtcctgc tgtgactatt cgctgcacgt ggacatcacg gagtggcaca
      661 agggcatcca ggaggagatg gaagctctgg tgaaggacca cggggtaaac tccttcctcg
      721 tgtacatggc tttcaaagat cggttccagc tgacggattc ccagatctat gaagtactga
      781 gcgtgatccg ggatattggt gccatagctc aagtccatgc agagaatggt gacatcattg
      841 cagaggaaca gcagaggatc ctggatctgg gcatcacagg ccccgaggga cacgtgctga
      901 gccggccaga ggaggtcgag gctgaagctg tgaaccggtc catcaccatt gccaatcaga
      961 ccaactgccc gctgtatgtc accaaggtga tgagcaagag tgctgctgaa gtcatcgccc
     1021 aggcacggaa gaagggaact gtggtgtatg gtgagcccat cactgccagc ctggggactg
     1081 atggctctca ttattggagc aagaactggg ccaaggccgc tgcctttgtc acctctccac
     1141 ccttgagccc cgacccaacc actccagact ttctcaactc gttgctgtcc tgtggagacc
     1201 tccaggtcac tggcagtgcc cactgtacct tcaacactgc ccagaaggct gtggggaagg
     1261 ataacttcac cttgattcca gagggcacca atggcactga ggagcggatg tctgtcattt
     1321 gggataaagc tgtggtcact gggaagatgg acgagaacca gtttgtggct gtgactagca
     1381 ccaacgcagc caaagtcttc aatctttacc cacggaaagg tcgtatctcc gtgggatctg
     1441 acgcagactt ggtcatctgg gaccctgaca gtgtgaagac catctctgcc aagacgcaca
     1501 acagtgctct tgagtacaac atctttgaag gcatggagtg tcggggctcc ccactggtgg
     1561 tcatcagcca gggcaagatt gtcctggagg acggcacgtt gcatgtcacg gaaggctcag
     1621 gacgctacat tccccggaag cccttccctg actttgtgta caaacgcatc aaggcaagga
     1681 gcaggctggc tgagctgagg ggggtccctc gtggcctgta tgatggaccc gtatgcgagg
     1741 tgtctgtgac gcccaagacg gtcactccgg cctcatcagc taagacatcc cctgccaagc
     1801 agcaggcgcc acctgttcgg aacctgcacc agtctggttt cagcttgtct ggtgctcaga
     1861 ttgacgacaa cattccccgc cgcaccaccc agcgcattgt ggcaccccct ggtggccgcg
     1921 ccaacatcac cagcctgggc taaagctcct aggcctgcag gccacgtggg gatgggggat
     1981 gggacacctg aggacattct gagacttcct tccttccaat ttttttttcc tttttttgag
     2041 agagcctgtg atagttgctg tgggcagcca gttcctgggg cttcctcttg ggccccctgc
     2101 actcggtctc ccctggagtt tctgaattcg ctcacccaag tccctacaca gtcatgaaca
     2161 ccacacccaa gcccagccac ccaccccaca ctgagctgca tccaacatgc agacatgcgc
     2221 caccatgcag atcccagcaa gggtgccctt atcacatcct tggctgtgca gtcagcacct
     2281 tcctgtcacg gggaagattt agtgaattac cctgagctgc cttcttttct tttgaaaaat
     2341 ttttaaaaat ggttttcttt gtgggactgg ggagggatgg gggggtggga gtgttttttt
     2401 ttttaatact aaattgaaag tctgattcaa tattaatcct tgggtcttga actggacatc
     2461 ctaatgatgc aattacttaa ccattaagct gattccgagg ctggcaggct accgccgccc
     2521 ctctggaaag gttccatgtg tctgtatcac ccatccctta ctcttccggg tcagctgttg
     2581 agaagagact ggttttcttc tttggcctag attttgcaac agattagacc ttttgaaggt
     2641 tctctaccat ttttctgtgt ctccggtctg ttctggcttt ttcttctgca ctcttggaga
     2701 gatttagatg ttggtctcct ggtttgtgtt tcttcgagac aatgtgcttt tttccctggc
     2761 tttttgtttg ttctcaaagc caggcatctg aatttggcct cagacacagc ctgagcggac
     2821 cctagttttg acccccactc catagttttg tgctagcctg gtgtctgttt aagattggtg
     2881 ctagctgatt cccgtcacta ggaggtggct gagcttgagg cttgccagac acagggatgg
     2941 tcctgattat gtcaccaata ttgtcacatg tgggcccaga atagagtcac ttgtggtgga
     3001 aagagatggg gggaagaatt agactgtagg agtaacagtc tccagttaaa tctgtaaacc
     3061 cagttcccaa gctcacatga gacaaccaaa ctgggaccag tctctctgtg gaggagccct
     3121 gcccagcctt cgccaggaag cgtttttggg gattctagaa tgttgggatt tctcattgtg
     3181 tgagtgtggt ggtcggagga acattttctt tacagttttt ttttcaaaag gtctaacatg
     3241 atgggggaag gctttgcaaa ggtagaaatc tttgggataa ttagacttca agtcttttta
     3301 caagaggggc aaccctattt taggaaataa tatgttgtgg gaagaaaact atacaaatgg
     3361 aaccgcatga cccgctttag agatcatgtc gcctcttaga gaccatgtca cctcatatct
     3421 atcacccttc ctcttcctgt tatagtgaca ggctttcact agctggcttc tttctgtatt
     3481 tgctgatgtc tgtcatactc ctttccagat gtgtttacag gtccctgtaa gcagtgttag
     3541 gtctgtaggc ttttatgaat ccaatctgct tgtgtaaaac agagcatcaa aaattagcga
     3601 tactttgagt gtccacacat tttgtctttg gggttaaggg tcggtatttt gggtttgttg
     3661 ttaattttca ttgttataaa ggtaaattgc acttttaaaa attggttgac ttaatatatt
     3721 tgctcttttt tttcttacct gcgcttagag aggaaatttg aacattggaa aacacatttt
     3781 tttattttat tttatttttt attttttttt tggttcattc ctttggattt tgagaaactt
     3841 gcagctcttc agtattcact cccgatgttt cttgtacggg gccgcgggcc tcttggttgt
     3901 tttcgagcat tttcttaaaa aaaaagaaac aagacaaaca caacagtttt aaaccggaag
     3961 atttccgcag tccgtgtaag catgtttacc tgttggtttg ctttctgtgt ctgtgaaatg
     4021 aatgtcatgt gtaaatgcta acctaaggca acagcgtctc agaactgagt gactgcagtg
     4081 acttgatgct ctacatcatt gtagaattta ctgctagacg gttttaaccc ttgaacctgt
     4141 gattgtgacc cacgaggggg gacctttcag tgctaaagct gatcatgtgt gtagccagaa
     4201 aggtacttct ttcttttttc tttttcaaat ttttgtttta tattttgtaa ccactgtctt
     4261 aatggcaaga taattatggt aaaatacaag tctcgtgttt attattcctt aagaagtctg
     4321 tgttatatga ccacggaaca cccaataaag cagagtgtgg ttgtttcaga
//
