LOCUS       XM_039103214            1712 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus dihydropyrimidine dehydrogenase
            (Dpyd), transcript variant X2, mRNA.
ACCESSION   XM_039103214
VERSION     XM_039103214.1
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051337.1) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            [WARNING] On Feb 22, 2024 this sequence was replaced by
            XM_039103214.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1712
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /sex="male"
                     /tissue_type="kidney"
                     /geo_loc_name="USA: Wisconsin, Milwaukee, Medical College
                     of Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..1712
                     /gene="Dpyd"
                     /note="dihydropyrimidine dehydrogenase; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 7 ESTs, 1 Protein, and 100% coverage of the annotated
                     genomic feature by RNAseq alignments, including 6 samples
                     with support for all annotated introns"
                     /db_xref="GeneID:81656"
                     /db_xref="RGD:621218"
     CDS             133..1704
                     /gene="Dpyd"
                     /codon_start=1
                     /product="dihydropyrimidine dehydrogenase [NADP(+)]
                     isoform X2"
                     /protein_id="XP_038959142.1"
                     /db_xref="GeneID:81656"
                     /db_xref="RGD:621218"
                     /translation="MAGVLSRDAPDIESILALNPRIQAHATLRSTMAKKLDKKHWKRN
                     TDKNCFTCEKLENNFDDIKHTTLGERGALREAVRCLKCADAPCQKSCPTSLDIKSFIT
                     SIANKNYYGAAKLIFSDNPLGLTCGMVCPTSDLCVGGCNLHATEEGPINIGGLQQFAT
                     EVFKAMNIPQIRSPLLPPPEHMPEAYSAKIALFGAGPASISCASFLARLGYSDITIFE
                     KQEYVGGLSTSEIPQFRLPYDVVNFEIELMKDLGVKIICGKSISTDEMTLSTLKENGY
                     KAAFIGIGLPEPKKDHIFQGLTQVQGFYTSKDFLPLVAKGSKPGMCACHSPLPSVRGA
                     VIVLGAGDTAFDCATSALRCGARRVFIVFRKGFANIRAVPEEMELAKEEKCEFLPFLS
                     PRKVIVKDGKIVGMQFVRTEQDETGNWVEDEEQIVRLKADVVISAFGSVLDDPKVIEA
                     LSPIKFNRWGLPEVNPETMQTSEPWVFAGGDVVGMANTTVESVNDGKQASWYIHKYIQ
                     SNEAEMELVAQRPYF"
ORIGIN      
        1 ctgccatact gccttagctc gggcagtcag tgcaccagcg ctagggcaag ctgaggcttc
       61 cgtgcggggc tggaggctgc cgcagtggag ggagggtcag tgtgcgggag actgaggcca
      121 gaaagcgttg ccatggcggg tgtgctgagc agggacgcgc ctgacatcga gagtatcctg
      181 gctttaaatc ctcgaataca agctcatgcg actcttcgtt ccaccatggc caagaaacta
      241 gacaagaaac attggaaaag gaacactgat aagaactgct ttacctgtga gaagctggag
      301 aataattttg atgacatcaa gcacacgact cttggtgagc gaggggctct ccgagaagca
      361 gtgagatgct tgaaatgtgc agatgctccc tgccagaaga gttgtcccac gtctcttgac
      421 attaagtcat tcatcacaag tatcgccaac aagaactact atggtgcagc taagctgatt
      481 ttttccgata atcctcttgg tcttacttgc ggaatggttt gtccaacatc tgacctctgt
      541 gtcggaggat gcaacttaca tgctactgaa gaggggccaa ttaatattgg tggactgcag
      601 cagtttgcta ccgaggtgtt caaagcgatg aacatcccac agatcagaag cccgttgctg
      661 cctcctccgg aacatatgcc ggaagcttac tcagcaaaaa ttgcgctgtt tggagctggg
      721 cctgcgagta taagctgtgc ctcctttctg gctcgactgg gctattccga catcaccata
      781 tttgaaaagc aagaatacgt tggtggctta agcacttctg aaatccctca gtttcggctc
      841 ccatatgatg tcgtgaattt tgagattgag ctcatgaagg accttggtgt caagataatt
      901 tgtggtaaaa gcatttccac agatgaaatg actcttagta ctttgaaaga aaatggctac
      961 aaagctgctt ttattggaat aggtttgcca gaacccaaaa aggaccatat tttccaaggc
     1021 ttgacacaag tccagggatt ttacacatcc aaagactttt tgccacttgt cgccaaaggt
     1081 agcaaaccag gaatgtgcgc ctgtcactct ccattgccat ccgtgagggg agccgtgatt
     1141 gtactcggag ctggggacac tgcgtttgac tgtgcaacat ccgctctgcg ctgcggagca
     1201 cgtcgcgtgt tcatcgtctt cagaaagggc tttgctaata ttcgagctgt tccagaggag
     1261 atggagcttg ctaaggaaga gaaatgtgaa tttttgcctt tcctttcccc acggaaggtt
     1321 atagtcaaag atggaaagat tgtaggaatg cagtttgttc gaactgagca ggatgaaacc
     1381 ggaaactggg tcgaagatga agagcagata gtgcgtttga aggctgatgt ggttattagc
     1441 gcctttggat ctgtcttgga tgatcccaaa gtgatagaag cattgagtcc catcaagttt
     1501 aacagatggg gtctccctga agtaaaccca gaaaccatgc aaaccagtga gccatgggta
     1561 tttgcaggtg gtgatgttgt gggtatggct aacaccacag tggaatctgt caatgatgga
     1621 aaacaggctt catggtacat tcacaagtac atacagagca atgaggctga gatggaactg
     1681 gtggcccaaa gaccttactt ttagaatccc tg
//
