LOCUS       NM_031027               4348 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus dihydropyrimidine dehydrogenase (Dpyd), mRNA.
ACCESSION   NM_031027 XM_346632
VERSION     NM_031027.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4348)
  AUTHORS   Pellicer,M., Garcia-Gonzalez,X., Garcia,M.I., Robles,L.,
            Gravalos,C., Garcia-Alfonso,P., Pachon,V., Longo,F., Martinez,V.,
            Blanco,C., Iglesias,I., Sanjurjo,M. and Lopez-Fernandez,L.A.
  TITLE     Identification of new SNPs associated with severe toxicity to
            capecitabine
  JOURNAL   Pharmacol Res 120, 133-137 (2017)
   PUBMED   28347776
REFERENCE   2  (bases 1 to 4348)
  AUTHORS   Zhao,X.Q., Cao,W.J., Yang,H.P., Yang,X.W., Tang,P., Sun,L. and
            Gao,X.
  TITLE     DPYD gene polymorphisms are associated with risk and chemotherapy
            prognosis in pediatric patients with acute lymphoblastic leukemia
  JOURNAL   Tumour Biol 37 (8), 10393-10402 (2016)
   PUBMED   26846104
REFERENCE   3  (bases 1 to 4348)
  AUTHORS   Teh,L.K., Hamzah,S., Hashim,H., Bannur,Z., Zakaria,Z.A.,
            Hasbullani,Z., Shia,J.K., Fijeraid,H., Md Nor,A., Zailani,M.,
            Ramasamy,P., Ngow,H., Sood,S. and Salleh,M.Z.
  TITLE     Potential of dihydropyrimidine dehydrogenase genotypes in
            personalizing 5-fluorouracil therapy among colorectal cancer
            patients
  JOURNAL   Ther Drug Monit 35 (5), 624-630 (2013)
   PUBMED   23942539
REFERENCE   4  (bases 1 to 4348)
  AUTHORS   Kobuchi,S., Ito,Y., Okada,K., Imoto,K. and Takada,K.
  TITLE     Pharmacokinetics of 5-fluorouracil and increased hepatic
            dihydropyrimidine dehydrogenase activity levels in
            1,2-dimethylhydrazine-induced colorectal cancer model rats
  JOURNAL   Eur J Drug Metab Pharmacokinet 38 (3), 171-181 (2013)
   PUBMED   23197286
REFERENCE   5  (bases 1 to 4348)
  AUTHORS   Cui,Y., Li,Q., Yu,Y., Chen,Y., Feng,Y., Wang,Y. and Liu,T.
  TITLE     Combination of low-dose docetaxel and standard-dose S-1 for the
            treatment of advanced gastric cancer: efficacy, toxicity, and
            potential predictive factor
  JOURNAL   Cancer Chemother Pharmacol 71 (1), 145-152 (2013)
   PUBMED   23064955
REFERENCE   6  (bases 1 to 4348)
  AUTHORS   Lu,Z.H., Zhang,R. and Diasio,R.B.
  TITLE     Purification and characterization of dihydropyrimidine
            dehydrogenase from human liver
  JOURNAL   J Biol Chem 267 (24), 17102-17109 (1992)
   PUBMED   1512248
REFERENCE   7  (bases 1 to 4348)
  AUTHORS   Porter,D.J., Chestnut,W.G., Merrill,B.M. and Spector,T.
  TITLE     Mechanism-based inactivation of dihydropyrimidine dehydrogenase by
            5-ethynyluracil
  JOURNAL   J Biol Chem 267 (8), 5236-5242 (1992)
   PUBMED   1544906
REFERENCE   8  (bases 1 to 4348)
  AUTHORS   Fujimoto,S., Kikugawa,M., Kaneko,M. and Tamaki,N.
  TITLE     Role of dihydropyrimidine dehydrogenase in the uridine nucleotide
            metabolism in the rat liver
  JOURNAL   J Nutr Sci Vitaminol (Tokyo) 38 (1), 39-48 (1992)
   PUBMED   1629785
REFERENCE   9  (bases 1 to 4348)
  AUTHORS   Harris,B.E., Song,R.L., He,Y.J., Soong,S.J. and Diasio,R.B.
  TITLE     Circadian rhythm of rat liver dihydropyrimidine dehydrogenase.
            Possible relevance to fluoropyrimidine chemotherapy
  JOURNAL   Biochem Pharmacol 37 (24), 4759-4762 (1988)
   PUBMED   3202908
REFERENCE   10 (bases 1 to 4348)
  AUTHORS   Hallock,R.O. and Yamada,E.W.
  TITLE     Visualization of dihydrouracil dehydrogenase activity after disc
            gel electrophoresis
  JOURNAL   Anal Biochem 56 (1), 84-90 (1973)
   PUBMED   4128676
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Nov 27, 2020 this sequence version replaced NM_031027.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D85035.1, SRR26643295.11035.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-92                JAXUCZ010000002.1  209293980-209294071
            93-203              JAXUCZ010000002.1  209329914-209330024
            204-286             JAXUCZ010000002.1  209400899-209400981
            287-374             JAXUCZ010000002.1  209476660-209476747
            375-536             JAXUCZ010000002.1  209493938-209494099
            537-733             JAXUCZ010000002.1  209516453-209516649
            734-815             JAXUCZ010000002.1  209525465-209525546
            816-903             JAXUCZ010000002.1  209532727-209532814
            904-1011            JAXUCZ010000002.1  209620699-209620806
            1012-1181           JAXUCZ010000002.1  209622807-209622976
            1182-1392           JAXUCZ010000002.1  209641560-209641770
            1393-1577           JAXUCZ010000002.1  209672865-209673049
            1578-1793           JAXUCZ010000002.1  209710443-209710658
            1794-1958           JAXUCZ010000002.1  209776777-209776941
            1959-2027           JAXUCZ010000002.1  209847428-209847496
            2028-2111           JAXUCZ010000002.1  209860483-209860566
            2112-2232           JAXUCZ010000002.1  209920529-209920649
            2233-2352           JAXUCZ010000002.1  209921373-209921492
            2353-2495           JAXUCZ010000002.1  209983954-209984096
            2496-2675           JAXUCZ010000002.1  210040364-210040543
            2676-2819           JAXUCZ010000002.1  210132776-210132919
            2820-2960           JAXUCZ010000002.1  210153236-210153376
            2961-4348           JAXUCZ010000002.1  210158390-210159777
FEATURES             Location/Qualifiers
     source          1..4348
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q42"
     gene            1..4348
                     /gene="Dpyd"
                     /note="dihydropyrimidine dehydrogenase"
                     /db_xref="GeneID:81656"
                     /db_xref="RGD:621218"
     exon            1..92
                     /gene="Dpyd"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..3131
                     /gene="Dpyd"
                     /EC_number="1.3.1.2"
                     /note="DPD; DHPDHase; dihydrouracil dehydrogenase;
                     dihydrothymine dehydrogenase"
                     /codon_start=1
                     /product="dihydropyrimidine dehydrogenase [NADP(+)]"
                     /protein_id="NP_112289.2"
                     /db_xref="GeneID:81656"
                     /db_xref="RGD:621218"
                     /translation="MAGVLSRDAPDIESILALNPRIQAHATLRSTMAKKLDKKHWKRN
                     TDKNCFTCEKLENNFDDIKHTTLGERGALREAVRCLKCADAPCQKSCPTSLDIKSFIT
                     SIANKNYYGAAKLIFSDNPLGLTCGMVCPTSDLCVGGCNLHATEEGPINIGGLQQFAT
                     EVFKAMNIPQIRSPLLPPPEHMPEAYSAKIALFGAGPASISCASFLARLGYSDITIFE
                     KQEYVGGLSTSEIPQFRLPYDVVNFEIELMKDLGVKIICGKSISTDEMTLSTLKENGY
                     KAAFIGIGLPEPKKDHIFQGLTQVQGFYTSKDFLPLVAKGSKPGMCACHSPLPSVRGA
                     VIVLGAGDTAFDCATSALRCGARRVFIVFRKGFANIRAVPEEMELAKEEKCEFLPFLS
                     PRKVIVKDGKIVGMQFVRTEQDETGNWVEDEEQIVRLKADVVISAFGSVLDDPKVIEA
                     LSPIKFNRWGLPEVNPETMQTSEPWVFAGGDVVGMANTTVESVNDGKQASWYIHKYIQ
                     AQYGALVPSQPTLPLFYTPVDLVDISVEMAGLRFPNPFGLASATPATSTPMIRRAFEA
                     GWGFALTKTFSLDKDIVTNVSPRIIRGTTSGPLYGPGQSSFLNIELISEKTAAYWCHS
                     VTELKADFPDNILIASIMCSYNKNDWMELSKMAEASGADALELNLSCPHGMGERGMGL
                     ACGQDPELVRNICRWVRQSVRVPFFAKLTPNVTDIVSIARAAKEGGADGVTATNTVSG
                     LMGLKADGSPWPSVGSGKRTTYGGVSGTAIRPIALRAVTAIARALPGFPILATGGIDS
                     AESGLQFLHSGASVLQVCSAIQNQDFTVIEDYCTGLKALLYLKSIEELSDWDGQSPPT
                     MSHQKGKPVPHIAELMGQKLPSFGPYLERRKKILAASKIREKDQNRACSPLQRKHFNS
                     QKPIPAIKDVIGKSLQYLGTFGELNVMEQVVALIDEEMCINCGKCYMTCNDSGYQAIQ
                     FDPETHLPTVSDTCTGCTLCLSVCPIMDCIRMVSRATPYEPKRGLPLAVKPVC"
     exon            93..203
                     /gene="Dpyd"
                     /inference="alignment:Splign:2.1.0"
     exon            204..286
                     /gene="Dpyd"
                     /inference="alignment:Splign:2.1.0"
     exon            287..374
                     /gene="Dpyd"
                     /inference="alignment:Splign:2.1.0"
     exon            375..536
                     /gene="Dpyd"
                     /inference="alignment:Splign:2.1.0"
     exon            537..733
                     /gene="Dpyd"
                     /inference="alignment:Splign:2.1.0"
     exon            734..815
                     /gene="Dpyd"
                     /inference="alignment:Splign:2.1.0"
     exon            816..903
                     /gene="Dpyd"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1011
                     /gene="Dpyd"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1181
                     /gene="Dpyd"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1392
                     /gene="Dpyd"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..1577
                     /gene="Dpyd"
                     /inference="alignment:Splign:2.1.0"
     exon            1578..1793
                     /gene="Dpyd"
                     /inference="alignment:Splign:2.1.0"
     exon            1794..1958
                     /gene="Dpyd"
                     /inference="alignment:Splign:2.1.0"
     exon            1959..2027
                     /gene="Dpyd"
                     /inference="alignment:Splign:2.1.0"
     exon            2028..2111
                     /gene="Dpyd"
                     /inference="alignment:Splign:2.1.0"
     exon            2112..2232
                     /gene="Dpyd"
                     /inference="alignment:Splign:2.1.0"
     exon            2233..2352
                     /gene="Dpyd"
                     /inference="alignment:Splign:2.1.0"
     exon            2353..2495
                     /gene="Dpyd"
                     /inference="alignment:Splign:2.1.0"
     exon            2496..2675
                     /gene="Dpyd"
                     /inference="alignment:Splign:2.1.0"
     exon            2676..2819
                     /gene="Dpyd"
                     /inference="alignment:Splign:2.1.0"
     exon            2820..2960
                     /gene="Dpyd"
                     /inference="alignment:Splign:2.1.0"
     exon            2961..4348
                     /gene="Dpyd"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgcagtgga gggagggtca gtgtgcggga gactgaggcc agaaagcgtt gccatggcgg
       61 gtgtgctgag cagggacgcg cctgacatcg agagtatcct ggctttaaat cctcgaatac
      121 aagctcatgc gactcttcgt tccaccatgg ccaagaaact agacaagaaa cattggaaaa
      181 ggaacactga taagaactgc tttacctgtg agaagctgga gaataatttt gatgacatca
      241 agcacacgac tcttggtgag cgaggggctc tccgagaagc agtgagatgc ttgaaatgtg
      301 cagatgctcc ctgccagaag agttgtccca cgtctcttga cattaagtca ttcatcacaa
      361 gtatcgccaa caagaactac tatggtgcag ctaagctgat tttttccgat aatcctcttg
      421 gtcttacttg cggaatggtt tgtccaacat ctgacctctg tgtcggagga tgcaacttac
      481 atgctactga agaggggcca attaatattg gtggactgca gcagtttgct accgaggtgt
      541 tcaaagcgat gaacatccca cagatcagaa gcccgttgct gcctcctccg gaacatatgc
      601 cggaagctta ctcagcaaaa attgcgctgt ttggagctgg gcctgcgagt ataagctgtg
      661 cctcctttct ggctcgactg ggctattccg acatcaccat atttgaaaag caagaatacg
      721 ttggtggctt aagcacttct gaaatccctc agtttcggct cccatatgat gtcgtgaatt
      781 ttgagattga gctcatgaag gaccttggtg tcaagataat ttgtggtaaa agcatttcca
      841 cagatgaaat gactcttagt actttgaaag aaaatggcta caaagctgct tttattggaa
      901 taggtttgcc agaacccaaa aaggaccata ttttccaagg cttgacacaa gtccagggat
      961 tttacacatc caaagacttt ttgccacttg tcgccaaagg tagcaaacca ggaatgtgcg
     1021 cctgtcactc tccattgcca tccgtgaggg gagccgtgat tgtactcgga gctggggaca
     1081 ctgcgtttga ctgtgcaaca tccgctctgc gctgcggagc acgtcgcgtg ttcatcgtct
     1141 tcagaaaggg ctttgctaat attcgagctg ttccagagga gatggagctt gctaaggaag
     1201 agaaatgtga atttttgcct ttcctttccc cacggaaggt tatagtcaaa gatggaaaga
     1261 ttgtaggaat gcagtttgtt cgaactgagc aggatgaaac cggaaactgg gtcgaagatg
     1321 aagagcagat agtgcgtttg aaggctgatg tggttattag cgcctttgga tctgtcttgg
     1381 atgatcccaa agtgatagaa gcattgagtc ccatcaagtt taacagatgg ggtctccctg
     1441 aagtaaaccc agaaaccatg caaaccagtg agccatgggt atttgcaggt ggtgatgttg
     1501 tgggtatggc taacaccaca gtggaatctg tcaatgatgg aaaacaggct tcatggtaca
     1561 ttcacaagta catacaggca caatatggag ccttggtgcc ttcccagcct acactgcccc
     1621 tgttttacac tcctgttgac ctcgtggaca tcagtgtgga aatggcaggg ttgaggttcc
     1681 ccaatccctt tggccttgcc agtgcgacac cagccactag cacaccaatg attcgaaggg
     1741 cctttgaagc aggatggggt tttgctttga ccaaaacttt ctctcttgat aaggacatcg
     1801 tgacaaacgt ctcacccaga atcatccgag ggaccacttc tggccccttg tatggccctg
     1861 gacaaagctc tttcctcaac attgagctca tcagtgagaa aacagctgca tattggtgtc
     1921 acagtgtcac cgaactaaag gctgacttcc cggacaacat cctgatcgcc agcatcatgt
     1981 gcagttacaa caaaaatgac tggatggaac tctccaaaat ggctgaggct tctggagcag
     2041 atgccctgga gttaaattta tcctgtccac atggcatggg ggagagagga atgggtttgg
     2101 cttgtgggca ggatccagag ctggtgagga acatctgtcg ctgggtgaga caatctgttc
     2161 gggttccatt ttttgccaag ttgaccccaa atgtcactga tattgtaagc atcgcaagag
     2221 cagcaaagga aggtggtgca gatggcgtta cagccaccaa cactgtctca ggcctgatgg
     2281 gactgaaagc tgatggttca ccctggcctt cggtgggcag tggaaagagg actacatatg
     2341 gaggagtatc aggaactgcc atcaggccta ttgctttgag agctgtgacc gccattgccc
     2401 gcgctttgcc tgggtttcct atactggcca caggtggaat tgactcagct gaaagtggac
     2461 ttcagtttct tcatagtggt gcttcagttc tccaggtatg cagtgctatt cagaatcagg
     2521 acttcactgt gattgaagat tactgcactg gcctcaaagc tctgctttat ctgaagagta
     2581 ttgaagagtt atcagactgg gatgggcaga gtccacccac tatgagtcat cagaaaggga
     2641 aaccagttcc acacattgct gagctcatgg gacagaaact tccaagcttt ggaccgtacc
     2701 ttgaacggcg caagaaaatc ctagcagcaa gtaaaatcag agagaaagat caaaacagag
     2761 cttgctcacc tctccagaga aagcacttta actcccaaaa gccgattcct gccatcaagg
     2821 atgtaattgg aaaatcactg caatacctgg ggacgtttgg tgagctgaac gtcatggagc
     2881 aagttgtggc cctgatcgat gaggaaatgt gtatcaattg cggcaaatgt tacatgacct
     2941 gtaatgactc tggctaccag gctatacagt tcgatccaga aactcacctg cctactgtta
     3001 gcgacacatg tacaggctgc actctctgcc tcagcgtctg ccctattatg gactgtatca
     3061 ggatggtttc cagggcaaca ccttatgaac caaagagagg cctaccatta gccgtgaagc
     3121 cggtgtgtta aggtgatttg taagacagct gctgtgaact ttgatgttac caacacaggc
     3181 tgatctttaa aaacaataac aattgtaatc attatgatca gttctttcca aatttgatag
     3241 ctatgcatat ataatttcta aataagtgtc taaattggaa aacaatgtct aatgccagtg
     3301 accaattaat ggtcataaaa tggaataatt cttctctgaa gtagctggtg agtaactgtg
     3361 gaccagttaa ttggatatgc tcggtcagtt gtctgctgtg aaaaattaac tttttcatgg
     3421 caattagtgt gacaatttct aaattgccct atgccgtgct cactctttga tttctaattg
     3481 taagcgaaat gaactatttt ggaacggagt gcgctttcat atacaggaaa ctgtttccaa
     3541 ggaaacactt tgtaattaaa aattacctgt aattttaaca ctgcttctaa ggacatgcaa
     3601 ttagccccat taagaacaat tgaagagagt cacgtcatta tttactatga caaggggaac
     3661 acaacctggc agagggtttt ctagagtttt cttacatccc cctttgctga agtaactcac
     3721 tctttggtgc tggacactgg aagggagatt atttcctgac taaaatactg ttcaccactc
     3781 atccctgaaa caggtgtcag actgcccagg aatggagcac aggtcatttt tatttgaata
     3841 gcaaagctgt gctcctgatg aaataagata tcaagatgga tatctagtga aggccacact
     3901 gtcactgggc acagaccact cagtctgctt ctcatagtca ccttcattat gagagcaatt
     3961 aacgttcaaa caagggctag attacacagc actgagccat aggcttcacg ctacaacagc
     4021 aaaaacatcg tatctgaaat ttatacataa tgagacaaat gggtctgacg acgcttgaat
     4081 gctcgtatga tttcaaaatt gttgaaatcg acgtgtactt ttaaatattg ataaatattt
     4141 tctgtctctt tatttttata atcaataaat agcatcatat gaactcattt attccttctt
     4201 tatgacatac tttaaaatga atctatagga aataagtgag aaataacagt ctgtggcata
     4261 tttctatgat aaatgcacga tatctgcaag tgcactttaa aaatgtgtat gactaaataa
     4321 tcacaaataa aattttatga tttattgt
//
