LOCUS       NM_001170545             680 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus dpy-30 histone methyltransferase complex
            regulatory subunit (Dpy30), transcript variant 2, mRNA.
ACCESSION   NM_001170545
VERSION     NM_001170545.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 680)
  AUTHORS   Shilatifard,A.
  TITLE     The COMPASS family of histone H3K4 methylases: mechanisms of
            regulation in development and disease pathogenesis
  JOURNAL   Annu Rev Biochem 81, 65-95 (2012)
   PUBMED   22663077
  REMARK    Review article
REFERENCE   2  (bases 1 to 680)
  AUTHORS   Patel,A., Dharmarajan,V., Vought,V.E. and Cosgrove,M.S.
  TITLE     On the mechanism of multiple lysine methylation by the human mixed
            lineage leukemia protein-1 (MLL1) core complex
  JOURNAL   J Biol Chem 284 (36), 24242-24256 (2009)
   PUBMED   19556245
REFERENCE   3  (bases 1 to 680)
  AUTHORS   Xu,Z., Gong,Q., Xia,B., Groves,B., Zimmermann,M., Mugler,C., Mu,D.,
            Matsumoto,B., Seaman,M. and Ma,D.
  TITLE     A role of histone H3 lysine 4 methyltransferase components in
            endosomal trafficking
  JOURNAL   J Cell Biol 186 (3), 343-353 (2009)
   PUBMED   19651892
  REMARK    GeneRIF: The mDpy-30 functions in the endosome to trans-Golgi
            network transport of cation-independent mannose 6-phosphate
            receptor(CIMPR)and that its knockdown results in the enrichment of
            internalized CIMPR and recycling endosomes near cell protrusions.
REFERENCE   4  (bases 1 to 680)
  AUTHORS   Wu,M., Wang,P.F., Lee,J.S., Martin-Brown,S., Florens,L.,
            Washburn,M. and Shilatifard,A.
  TITLE     Molecular regulation of H3K4 trimethylation by Wdr82, a component
            of human Set1/COMPASS
  JOURNAL   Mol Cell Biol 28 (24), 7337-7344 (2008)
   PUBMED   18838538
REFERENCE   5  (bases 1 to 680)
  AUTHORS   Cho,Y.W., Hong,T., Hong,S., Guo,H., Yu,H., Kim,D., Guszczynski,T.,
            Dressler,G.R., Copeland,T.D., Kalkum,M. and Ge,K.
  TITLE     PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4
            methyltransferase complex
  JOURNAL   J Biol Chem 282 (28), 20395-20406 (2007)
   PUBMED   17500065
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FM121127.1 and BP474453.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FM095537.1, CF109668.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-616               FM121127.1         7-622
            617-680             BP474453.1         6-69                c
FEATURES             Location/Qualifiers
     source          1..680
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q13"
     gene            1..680
                     /gene="Dpy30"
                     /gene_synonym="Aip1"
                     /note="dpy-30 histone methyltransferase complex regulatory
                     subunit"
                     /db_xref="GeneID:286897"
                     /db_xref="RGD:708575"
     exon            1..68
                     /gene="Dpy30"
                     /gene_synonym="Aip1"
                     /inference="alignment:Splign:2.1.0"
     exon            69..141
                     /gene="Dpy30"
                     /gene_synonym="Aip1"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..405
                     /gene="Dpy30"
                     /gene_synonym="Aip1"
                     /note="dpy-30L; protein rAIP1; dpy-30-like protein; dpy-30
                     homolog"
                     /codon_start=1
                     /product="protein dpy-30 homolog"
                     /protein_id="NP_001164016.1"
                     /db_xref="GeneID:286897"
                     /db_xref="RGD:708575"
                     /translation="MESEQMLEGQTQVAENPHSEYGLTDSVERIVENEKINAEKSSKQ
                     KVDLQSLPTRAYLDQTVVPILLQGLAVLAKERPPNPIEFLASYLLKNKAQFEDRN"
     exon            142..189
                     /gene="Dpy30"
                     /gene_synonym="Aip1"
                     /inference="alignment:Splign:2.1.0"
     exon            190..332
                     /gene="Dpy30"
                     /gene_synonym="Aip1"
                     /inference="alignment:Splign:2.1.0"
     exon            333..680
                     /gene="Dpy30"
                     /gene_synonym="Aip1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaagctgttc gcgcttggga gtcggtggcg cggtgcaggg cacttaggaa ccgacagcat
       61 tggcgcggac tggtatccgg ttgattgcgg tttgcagggt ccgccatgga gtcagagcag
      121 atgctggagg gacagacaca ggttgcagaa aaccctcact ctgagtacgg gctcacagac
      181 agcgttgaga gaatagttga aaatgagaag attaatgcag aaaagtcatc aaaacagaag
      241 gtggatctac agtccttgcc cacccgtgcc tacctggacc agacagttgt gcctatctta
      301 ttacagggac ttgctgtgct cgcaaaggaa agaccaccaa atcccatcga gtttctagca
      361 tcttatcttt taaaaaataa ggcacagttt gaagatcgaa attgattctt gggaagaaaa
      421 gaaacatttg gttgctactg tagatttaca tgattacgag gcagcttttg ttgccatgat
      481 tcccctcctc actctggaag tctaagaacc ttcaggacca cggaactcac ttctggagtt
      541 gcagaagaca gcatatccct gtctgattta atcaccatac ttatttaatg agtgtcatct
      601 gtgcaatttt tttctcagat tgtcttttac tttgttttta aaaagacctt caaaataaac
      661 tgttaaagca tctttatttt
//
