LOCUS       NM_001305241            3313 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus dipeptidyl peptidase 9 (Dpp9), mRNA.
ACCESSION   NM_001305241
VERSION     NM_001305241.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3313)
  AUTHORS   Huang,M., Zhang,X., Toh,G.A., Gong,Q., Wang,J., Han,Z., Wu,B.,
            Zhong,F. and Chai,J.
  TITLE     Structural and biochemical mechanisms of NLRP1 inhibition by DPP9
  JOURNAL   Nature 592 (7856), 773-777 (2021)
   PUBMED   33731929
  REMARK    GeneRIF: Structural and biochemical mechanisms of NLRP1 inhibition
            by DPP9.
REFERENCE   2  (bases 1 to 3313)
  AUTHORS   Zhang,H., Chen,Y., Wadham,C., McCaughan,G.W., Keane,F.M. and
            Gorrell,M.D.
  TITLE     Dipeptidyl peptidase 9 subcellular localization and a role in cell
            adhesion involving focal adhesion kinase and paxillin
  JOURNAL   Biochim Biophys Acta 1853 (2), 470-480 (2015)
   PUBMED   25486458
REFERENCE   3  (bases 1 to 3313)
  AUTHORS   Harstad,E.B., Rosenblum,J.S., Gorrell,M.D., Achanzar,W.E.,
            Minimo,L., Wu,J., Rosini-Marthaler,L., Gullo,R., Ordway,N.D.,
            Kirby,M.S., Chadwick,K.D., Cosma,G.N. and Moyer,C.F.
  TITLE     DPP8 and DPP9 expression in cynomolgus monkey and Sprague Dawley
            rat tissues
  JOURNAL   Regul Pept 186, 26-35 (2013)
   PUBMED   23850796
  REMARK    GeneRIF: DPP8 and DPP9 may act similarly across tissues, and that
            their actions might in part overlap with DPP4.
REFERENCE   4  (bases 1 to 3313)
  AUTHORS   Tang,H.K., Chen,K.C., Liou,G.G., Cheng,S.C., Chien,C.H., Tang,H.Y.,
            Huang,L.H., Chang,H.P., Chou,C.Y. and Chen,X.
  TITLE     Role of a propeller loop in the quaternary structure and enzymatic
            activity of prolyl dipeptidases DPP-IV and DPP9
  JOURNAL   FEBS Lett 585 (21), 3409-3414 (2011)
   PUBMED   22001206
REFERENCE   5  (bases 1 to 3313)
  AUTHORS   Dubois,V., Van Ginneken,C., De Cock,H., Lambeir,A.M., Van der
            Veken,P., Augustyns,K., Chen,X., Scharpe,S. and De Meester,I.
  TITLE     Enzyme activity and immunohistochemical localization of dipeptidyl
            peptidase 8 and 9 in male reproductive tissues
  JOURNAL   J Histochem Cytochem 57 (6), 531-541 (2009)
   PUBMED   19188489
  REMARK    GeneRIF: We showed the expression of DPP8 and DPP9 in the testis,
            epididymis, and sperm.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments and orthologous data.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643286.27455.1,
                                           SRR26643297.30673.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760434,
                                           SAMEA5760476 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                JAXUCZ010000009.1  1133407-1133446     c
            41-105              JAXUCZ010000009.1  1133342-1133406     c
            106-158             JAXUCZ010000009.1  1132013-1132065     c
            159-412             JAXUCZ010000009.1  1123641-1123894     c
            413-525             JAXUCZ010000009.1  1117833-1117945     c
            526-699             JAXUCZ010000009.1  1116779-1116952     c
            700-868             JAXUCZ010000009.1  1116541-1116709     c
            869-982             JAXUCZ010000009.1  1116311-1116424     c
            983-1111            JAXUCZ010000009.1  1113970-1114098     c
            1112-1173           JAXUCZ010000009.1  1112347-1112408     c
            1174-1274           JAXUCZ010000009.1  1109848-1109948     c
            1275-1452           JAXUCZ010000009.1  1108806-1108983     c
            1453-1615           JAXUCZ010000009.1  1108523-1108685     c
            1616-1695           JAXUCZ010000009.1  1105036-1105115     c
            1696-1848           JAXUCZ010000009.1  1103894-1104046     c
            1849-1984           JAXUCZ010000009.1  1103456-1103591     c
            1985-2130           JAXUCZ010000009.1  1102814-1102959     c
            2131-2277           JAXUCZ010000009.1  1102562-1102708     c
            2278-2430           JAXUCZ010000009.1  1101872-1102024     c
            2431-2573           JAXUCZ010000009.1  1101182-1101324     c
            2574-2685           JAXUCZ010000009.1  1100119-1100230     c
            2686-3313           JAXUCZ010000009.1  1098635-1099262     c
FEATURES             Location/Qualifiers
     source          1..3313
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q11"
     gene            1..3313
                     /gene="Dpp9"
                     /note="dipeptidyl peptidase 9"
                     /db_xref="GeneID:301130"
                     /db_xref="RGD:1588575"
     exon            1..105
                     /gene="Dpp9"
                     /inference="alignment:Splign:2.1.0"
     exon            106..158
                     /gene="Dpp9"
                     /inference="alignment:Splign:2.1.0"
     exon            159..412
                     /gene="Dpp9"
                     /inference="alignment:Splign:2.1.0"
     CDS             190..2778
                     /gene="Dpp9"
                     /EC_number="3.4.14.5"
                     /codon_start=1
                     /product="dipeptidyl peptidase 9"
                     /protein_id="NP_001292170.1"
                     /db_xref="GeneID:301130"
                     /db_xref="RGD:1588575"
                     /translation="MSGGVSPVEQVAAGDMDDTAARFCVQKHSWDGLRNIIHGSRKSS
                     GLIVSKAPHDFQFVQKPDESGPHSHRLYYLGMPYGSRENSLLYSEIPKKVRKEALLLL
                     SWKQMLDHFQATPHHGVYSREEELLRERKRLGVFGITSYDFHSESGLFLFQASNSLFH
                     CRDGGKNGFMVSPMKPLEIKTQCSGPRMDPKICPADPAFFSFINNNDLWVANIETGEE
                     RRLTFCHQGSASVLDNPKSAGVATFVIQEEFDRFTGCWWCPTASWEGSGGLKTLRILY
                     EEVDESEVEVIHVPSPALEERKTDSYRYPRTGSKNPKIALKLAELQTDHQGKIVSSCE
                     KELVQPFSSLFPKVEYIARAGWTRDGRYAWAMFLDRPQQRLQLVLLPPALFIPTLESE
                     AQWQEAARAIPKNVQPFIIYEEVTNVWINVHDIFHPFPQAEGQQDFCFLRANECKTGF
                     CHLYRVTVDLKTNDYDWTEPLSPAEDEFKCPIKEEVALTSGEWEVLSRHGSKIWVNEQ
                     TKLVYFQGTKDTPLEHHLYVVSYESAGEIVRLTTPGFSHSCSMSQNFDMFVSHYSSVS
                     TPPCVHVYKLSGPDDDPLHKQPRFWASMMEAASCPPDYVPPEIFHFHTRADVQLYGMI
                     YKPHTLQPGRKHPTVLFVYGGPQVQLVNNSFKGIKYLRLNTLASLGYAVVVIDGRGSC
                     QRGLHFEGALKNQMGQVEIEDQVEGLQYVAEKYGFIDLSRVAIHGWSYGGFLSLMGLI
                     HKPQVFKVAIAGAPVTVWMAYDTGYTERYMDVPENNQQGYEAGSVALHVEKLPNEPNR
                     LLILHGFLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERHSIRCRESGEHYEVTLLH
                     FLQEHL"
     exon            413..525
                     /gene="Dpp9"
                     /inference="alignment:Splign:2.1.0"
     exon            526..699
                     /gene="Dpp9"
                     /inference="alignment:Splign:2.1.0"
     exon            700..868
                     /gene="Dpp9"
                     /inference="alignment:Splign:2.1.0"
     exon            869..982
                     /gene="Dpp9"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1111
                     /gene="Dpp9"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1173
                     /gene="Dpp9"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1274
                     /gene="Dpp9"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1452
                     /gene="Dpp9"
                     /inference="alignment:Splign:2.1.0"
     exon            1453..1615
                     /gene="Dpp9"
                     /inference="alignment:Splign:2.1.0"
     exon            1616..1695
                     /gene="Dpp9"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..1848
                     /gene="Dpp9"
                     /inference="alignment:Splign:2.1.0"
     exon            1849..1984
                     /gene="Dpp9"
                     /inference="alignment:Splign:2.1.0"
     exon            1985..2130
                     /gene="Dpp9"
                     /inference="alignment:Splign:2.1.0"
     exon            2131..2277
                     /gene="Dpp9"
                     /inference="alignment:Splign:2.1.0"
     exon            2278..2430
                     /gene="Dpp9"
                     /inference="alignment:Splign:2.1.0"
     exon            2431..2573
                     /gene="Dpp9"
                     /inference="alignment:Splign:2.1.0"
     exon            2574..2685
                     /gene="Dpp9"
                     /inference="alignment:Splign:2.1.0"
     exon            2686..3313
                     /gene="Dpp9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgcccgcca cttccgggcc ctcgtcttgg gcatggagcg tcgcgtgtga ggcgccgccg
       61 gccctgggga cgccctgccc agcttgtcct ccgcgccgcg cccgggtccg tacccctcgc
      121 ctgcagctgc catggaagct ccttggaccc tttagaagct tctcgccgcc atcacaggag
      181 ccccagagga tgtctggtgg ggtctcgcca gttgagcagg tggccgcagg cgacatggat
      241 gacacagcag cacgcttctg tgtgcagaag cactcatggg atggacttcg caacattatc
      301 catggtagcc gcaagtcatc gggcctcatc gtcagcaagg ccccccatga cttccagttt
      361 gtgcagaagc ctgatgagtc tggccctcac tctcaccgac tctattacct gggaatgcct
      421 tatggtagcc gagagaactc cctcctctac tccgagatcc ccaagaaggt acggaaggag
      481 gccctgctgc tgctgtcctg gaagcagatg ctggaccact tccaggccac acctcaccat
      541 ggtgtctact cacgagagga ggagctgctg cgggagcgca agcgcctcgg tgtctttggt
      601 atcacttctt atgacttcca cagcgagagt ggcctcttcc tcttccaggc cagcaacagc
      661 ctgttccact gcagggatgg tggcaagaat ggctttatgg tgtctccgat gaagcctctg
      721 gagatcaaga cgcagtgtag tgggccacgc atggacccca agatctgtcc cgcagaccct
      781 gctttctttt ccttcatcaa caacaatgac ctgtgggtag caaacattga gactggggag
      841 gaacggcgtc tcaccttctg tcaccagggt tcagccagtg ttctggacaa tcccaagtca
      901 gcaggtgtgg ccaccttcgt catccaggag gagtttgaca ggttcactgg gtgctggtgg
      961 tgccccacag cctcttggga aggttcggga ggcctcaaga ccctacgcat cctgtatgag
     1021 gaagtggatg agtctgaggt ggaggttatt catgtgccct cccctgccct ggaggagagg
     1081 aagacagatt cctaccgcta ccccaggaca ggcagcaaga atcccaagat tgccctgaag
     1141 ctggctgagc tccagacaga ccatcagggc aaaatcgtgt caagctgcga gaaggaactg
     1201 gtacagccat tcagctcgct tttccccaaa gtggagtaca tcgcccgggc tggctggaca
     1261 cgggatggca gatatgcctg ggccatgttc ctggaccgtc cccagcagcg gctccagctt
     1321 gttctcctgc cccctgctct cttcatccca acccttgaga gtgaggccca gtggcaggag
     1381 gctgccagag ccatccccaa gaacgtgcaa cccttcatca tttatgagga agtcaccaat
     1441 gtctggatca atgtccatga catcttccac ccgttccctc aggctgaggg ccagcaggac
     1501 ttttgtttcc tccgtgccaa cgagtgcaag actggcttct gccacctgta cagggtcacg
     1561 gtggacctta aaaccaatga ctatgactgg acggaacccc tcagccctgc ggaagatgag
     1621 tttaagtgcc ccatcaagga ggaagtcgcc ctgaccagtg gcgagtggga ggtcttgtca
     1681 aggcatggct ctaagatctg ggtcaatgag cagacgaagc tggtgtactt tcaagggaca
     1741 aaggacacac ccctggaaca tcacctctac gtggtcagct acgagtcagc tggggagatc
     1801 gtgcggctca ccacgcctgg cttctcccac agctgctcca tgagtcagaa cttcgacatg
     1861 ttcgtgagtc actacagcag cgtgagcacg ccgccctgtg tgcatgtgta caagctgagt
     1921 ggccccgatg atgacccact gcacaagcag ccgcgcttct gggccagcat gatggaggca
     1981 gccagttgcc ctccagacta tgtaccccct gagatcttcc acttccatac ccgtgcagac
     2041 gtgcagctct atggcatgat ctacaagcca cacaccctgc aacctgggag gaagcaccct
     2101 actgtgctct ttgtctatgg gggcccacag gtgcagttgg tgaacaactc cttcaagggc
     2161 atcaagtacc tgcggctgaa cacactagca tccttgggct atgctgtggt ggttatcgat
     2221 ggtcggggct cctgtcagcg gggcctgcac tttgaggggg ccctgaaaaa tcagatgggc
     2281 caggtggaaa ttgaggacca ggtggaaggc ttgcagtatg tggctgagaa gtatggcttt
     2341 attgacttga gccgtgttgc catccatggc tggtcctatg gtggcttcct ctcgctcatg
     2401 gggctcatcc acaagccaca agtgttcaag gtagccattg cgggtgctcc tgtcactgtg
     2461 tggatggcct atgacacagg gtacacagaa cgatacatgg atgtccccga aaacaatcag
     2521 caaggctacg aggcagggtc tgtagccctg cacgtggaga agctgcccaa tgagcctaac
     2581 cgcttactca ttctccatgg cttcctggat gagaacgttc acttttttca cacgaatttc
     2641 ctggtgtccc agctgatccg agcagggaag ccgtaccagc tccagattta cccaaatgag
     2701 agacacagca ttcgctgccg tgagtccgga gagcattacg aggtgacgtt gctgcacttc
     2761 ctgcaggaac acctgtgacc tcagacctgc gtccttatac cactgctgct tttcttgtgt
     2821 ttttgtaatc ttttaatttt tgaagcttcc aatttgtttg cttgctgctg cctgggggcc
     2881 aggacaaagg tggtgatggc ccccatgcca ccgtccttga gctggtgaga agctgcgact
     2941 gtgcccacag cctctgtcag gctgccatgg ccctgaatgt acagcaccat cccagcgcag
     3001 aagcatgcgc cccccaccgc ctcctgcaga gtcatgtgtg cttggggtgg ggattttaaa
     3061 taattattta aaagacagga agttggcggt accgagcaat gaaattgaag gtacagcact
     3121 gggtggctgg ggaccccacg ctctcccgac acccagactg tggagctgcc aggtccccgt
     3181 ctgggagcct tctgccctac ctgtatgctg cccagctcct ccccactcac cacctagggg
     3241 tgccagggtc aggaatagga cctgtccttc cccaccctct cctaccagag tccagcataa
     3301 agaagtaaaa aaa
//
