LOCUS       NM_001394092            6567 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus dipeptidylpeptidase 8 (Dpp8), transcript variant
            2, mRNA.
ACCESSION   NM_001394092 XM_006243252
VERSION     NM_001394092.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6567)
  AUTHORS   Harstad,E.B., Rosenblum,J.S., Gorrell,M.D., Achanzar,W.E.,
            Minimo,L., Wu,J., Rosini-Marthaler,L., Gullo,R., Ordway,N.D.,
            Kirby,M.S., Chadwick,K.D., Cosma,G.N. and Moyer,C.F.
  TITLE     DPP8 and DPP9 expression in cynomolgus monkey and Sprague Dawley
            rat tissues
  JOURNAL   Regul Pept 186, 26-35 (2013)
   PUBMED   23850796
  REMARK    GeneRIF: DPP8 and DPP9 may act similarly across tissues, and that
            their actions might in part overlap with DPP4.
REFERENCE   2  (bases 1 to 6567)
  AUTHORS   Dubois,V., Van Ginneken,C., De Cock,H., Lambeir,A.M., Van der
            Veken,P., Augustyns,K., Chen,X., Scharpe,S. and De Meester,I.
  TITLE     Enzyme activity and immunohistochemical localization of dipeptidyl
            peptidase 8 and 9 in male reproductive tissues
  JOURNAL   J Histochem Cytochem 57 (6), 531-541 (2009)
   PUBMED   19188489
  REMARK    GeneRIF: We showed the expression of DPP8 and DPP9 in the testis,
            epididymis, and sperm.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 31, 2021 this sequence version replaced XM_006243252.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643284.11400.1,
                                           SRR22582416.1032443.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-192               JAXUCZ010000008.1  74445835-74446026
            193-326             JAXUCZ010000008.1  74448373-74448506
            327-599             JAXUCZ010000008.1  74450481-74450753
            600-712             JAXUCZ010000008.1  74455945-74456057
            713-886             JAXUCZ010000008.1  74457478-74457651
            887-1055            JAXUCZ010000008.1  74460391-74460559
            1056-1166           JAXUCZ010000008.1  74465472-74465582
            1167-1295           JAXUCZ010000008.1  74467186-74467314
            1296-1357           JAXUCZ010000008.1  74467926-74467987
            1358-1458           JAXUCZ010000008.1  74470593-74470693
            1459-1636           JAXUCZ010000008.1  74471005-74471182
            1637-1796           JAXUCZ010000008.1  74471920-74472079
            1797-1876           JAXUCZ010000008.1  74476189-74476268
            1877-2029           JAXUCZ010000008.1  74478889-74479041
            2030-2165           JAXUCZ010000008.1  74479283-74479418
            2166-2311           JAXUCZ010000008.1  74481990-74482135
            2312-2458           JAXUCZ010000008.1  74489668-74489814
            2459-2611           JAXUCZ010000008.1  74491136-74491288
            2612-2754           JAXUCZ010000008.1  74493109-74493251
            2755-2866           JAXUCZ010000008.1  74493963-74494074
            2867-6567           JAXUCZ010000008.1  74497317-74501017
FEATURES             Location/Qualifiers
     source          1..6567
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..6567
                     /gene="Dpp8"
                     /note="dipeptidylpeptidase 8"
                     /db_xref="GeneID:315758"
                     /db_xref="RGD:1310901"
     exon            1..192
                     /gene="Dpp8"
                     /inference="alignment:Splign:2.1.0"
     exon            193..326
                     /gene="Dpp8"
                     /inference="alignment:Splign:2.1.0"
     CDS             311..2989
                     /gene="Dpp8"
                     /EC_number="3.4.14.5"
                     /note="isoform 1 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="dipeptidyl peptidase 8 isoform 1"
                     /protein_id="NP_001381021.1"
                     /db_xref="GeneID:315758"
                     /db_xref="RGD:1310901"
                     /translation="MKIPSGRCNMAAAMETEQLGVEIFETAECEEGNGESQDRPKLEP
                     FYVERYSWSQLKKLLTDTRKYHGYMMAKAPHDFMFVKRADPDGPHSDRVYYLAMSGEN
                     RENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGI
                     AAYDYHPGSGTFLFQAGSGIYHIKDGGPHGFTQQPLRPNLVETSCPNIRMDPKLCPAD
                     PDWIAFIHSNDIWISNLVTREERRLTYVHNELASMEEDPRSAGVATFVLQEEFDRYSG
                     YWWCPQAERTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPK
                     VTFKMSEIVVDAEGGIIDVIDKELVQPFEILFEGVEYIARAGWTPEGKYAWSILLDRS
                     QTHLQIVLISPELFIPVEDDAMDRQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVF
                     PQTHEDEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAI
                     TSGEWEVLGRHGSNIWVDEARKLVYFEGTKDSPLEHHLYVTSYANPGDVVRLTDRGYS
                     HSCCLSRHCDFFISKYSNQKSPHCVSLYKLSSPDDDPVHKTKEFWATILDSAGPLPDY
                     TPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFR
                     LNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASQYDFIDL
                     DRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQ
                     GYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQ
                     ERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVM"
     exon            327..599
                     /gene="Dpp8"
                     /inference="alignment:Splign:2.1.0"
     exon            600..712
                     /gene="Dpp8"
                     /inference="alignment:Splign:2.1.0"
     exon            713..886
                     /gene="Dpp8"
                     /inference="alignment:Splign:2.1.0"
     exon            887..1055
                     /gene="Dpp8"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1166
                     /gene="Dpp8"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1295
                     /gene="Dpp8"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1357
                     /gene="Dpp8"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1458
                     /gene="Dpp8"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1636
                     /gene="Dpp8"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..1796
                     /gene="Dpp8"
                     /inference="alignment:Splign:2.1.0"
     exon            1797..1876
                     /gene="Dpp8"
                     /inference="alignment:Splign:2.1.0"
     exon            1877..2029
                     /gene="Dpp8"
                     /inference="alignment:Splign:2.1.0"
     exon            2030..2165
                     /gene="Dpp8"
                     /inference="alignment:Splign:2.1.0"
     exon            2166..2311
                     /gene="Dpp8"
                     /inference="alignment:Splign:2.1.0"
     exon            2312..2458
                     /gene="Dpp8"
                     /inference="alignment:Splign:2.1.0"
     exon            2459..2611
                     /gene="Dpp8"
                     /inference="alignment:Splign:2.1.0"
     exon            2612..2754
                     /gene="Dpp8"
                     /inference="alignment:Splign:2.1.0"
     exon            2755..2866
                     /gene="Dpp8"
                     /inference="alignment:Splign:2.1.0"
     exon            2867..6567
                     /gene="Dpp8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaagtgccg aggcctccgg tgctgtcttc tccgccgccg cttttaagtc ccttcgttcg
       61 ccgcctgggt gccgcggggg ccgccgccga ggaagctgct gtggccccga cgggagcgga
      121 ggcggcgcgg catgaagcgg cgtaggcccg ctccatagcg catcgggacg gtccgggcgg
      181 gcccggggga aggattggat ggtgagaaaa ggaaagattc ctgtgagaag agatcaggat
      241 gaacggagag atctgtgctt aaagttgggc caggtgaaaa tgatctcttt gaaagtagag
      301 atctgagcag atgaaaatac catcaggaag atgcaacatg gcagcagcaa tggaaacaga
      361 gcagctgggt gtcgagatat ttgaaactgc agagtgtgag gagggaaatg gtgaatcaca
      421 ggatcgaccc aaactggagc ctttttatgt cgaacggtat tcttggagtc agctgaaaaa
      481 gctgctcact gataccagaa aatatcatgg ctacatgatg gctaaggcgc cacatgactt
      541 tatgtttgtg aagagggcgg atccagatgg acctcactca gacagggtct actatctggc
      601 catgtctggt gagaacagag aaaatacact attttattct gaaatcccta aaaccatcaa
      661 cagagcagca gtcttaatgc tttcttggaa gcctcttttg gatctttttc aggcaacact
      721 agactatggg atgtattctc gagaggaaga gctactcaga gaaagaaagc gcatcgggac
      781 tgtggggatc gcagcttatg attaccaccc gggaagtggg acattcctgt ttcaagctgg
      841 cagcggcatt taccacatca aagatggagg accacatggg ttcacacaac agcctttacg
      901 gcccaattta gtggaaacta gttgtcccaa tatacgaatg gatccaaagt tatgccccgc
      961 tgatccagac tggatagctt tcattcacag caatgatatt tggatatcga acctcgtaac
     1021 cagggaagaa cggaggctca cctatgtgca caatgagcta gccagcatgg aagaggatcc
     1081 caggtcagcc ggggttgcca cctttgttct tcaagaagaa tttgacagat attctggcta
     1141 ctggtggtgt ccacaagccg aaagaactcc tagtggtggt aaaattctta gaattctcta
     1201 tgaagaaaac gatgaatctg aggtggagat tattcatgtt acatccccca tgttggaaac
     1261 aagaagggca gattccttcc ggtaccctaa aacaggcaca gcaaacccaa aggtcacttt
     1321 caagatgtcc gagatagttg ttgatgctga aggagggatt atagatgtca tagataaaga
     1381 actggttcaa cctttcgaga ttctgtttga aggagttgaa tatattgcca gagctggatg
     1441 gactccagag ggaaaatatg cctggtccat ccttctagac cgttcccaga ctcacctgca
     1501 gatagttctg atctcccctg agttattcat cccggtagaa gatgatgcca tggacagaca
     1561 gagactcata gagtcagttc ctgactccgt gacaccgctg atcatctatg aagaaacaac
     1621 agacatctgg ataaacatcc acgatatctt tcatgttttt cctcaaactc atgaagatga
     1681 aattgagttt atttttgcct ctgaatgcaa aacaggtttt cgtcatctgt ataaaatcac
     1741 atccatttta aaggagagca aatacaaacg gtccagtggt ggactccctg ccccaagtga
     1801 tttcaagtgt cccatcaaag aggaaatagc aatcaccagt ggtgaatggg aagtacttgg
     1861 ccgtcatgga tctaacatct gggttgatga agccagaaag ctggtgtact ttgaaggcac
     1921 caaagactct cctttggaac atcatctgta cgtgaccagt tatgcaaacc ctggcgacgt
     1981 ggtgaggctg actgaccgtg gctactcaca ctcctgctgc ctcagccggc actgtgactt
     2041 cttcataagt aagtacagca accagaagag tccacactgc gtgtccctct acaaactctc
     2101 aagtcctgac gatgacccag ttcataaaac aaaggaattt tgggccacca ttttggattc
     2161 agcaggtcct cttcctgact acacccctcc agaaattttt tcttttgaaa gtactactgg
     2221 atttacactg tacggaatgc tgtataagcc tcatgaccta caacctggaa agaaataccc
     2281 cactgtgctc ttcatatatg gtggccccca ggtgcagctg gtgaacaatc ggtttaaagg
     2341 agtcaagtat ttccgcctga acaccctggc ctccctgggt tacgtggttg tggtgataga
     2401 caacagggga tcgtgtcacc gggggcttaa atttgaaggc gcctttaaat ataaaatggg
     2461 ccaaatagaa attgatgatc aggtggaagg actccagtac ctagcctctc agtatgactt
     2521 catcgacttg gatcgtgtgg gcatccatgg ctggtcctat ggtggctacc tctccctgat
     2581 ggcactaatg cagaggtcgg atatcttccg ggttgctatt gccggggccc cagtcactct
     2641 gtggatcttc tatgatacgg gatacacgga gcgctatatg ggtcaccctg accagaatga
     2701 acagggctat tacttaggat ctgtggccat gcaagcggag aagttcccct cagaaccaaa
     2761 ccgcttactc ctcttacacg ggttcttgga tgagaatgtt cactttgcac acaccagtat
     2821 attgctgagc tttttagtga gggctggaaa gccgtatgac ttacagatct accctcagga
     2881 gaggcacagc atccgggttc ccgagtctgg agagcactat gaactgcacc tactgcacta
     2941 ccttcaggag aaccttggat cgcgcatcgc tgctctgaaa gtgatgtaac tctgactcgt
     3001 gtagaacctg cgtacaccgt ctaaccacac aaggagggtt agccaataga gaagccagag
     3061 ttgacgatcc cacttttata cccgccacat aagatctact tctgaaagta aatttggtgc
     3121 catgcagaaa tctgcagctc atggatagta atctaacacc ttaaccatgc acagagaact
     3181 gagtgacgtg ttcccaagac agtgcagtgc ctgagggtac ggaacgcagc accagcgcca
     3241 cacacagacc agcctgcgtc cactttagca gtgtcagcct tgggacttaa ctagtggatt
     3301 tgacagtgta ccctgagttt gttcaaatat gatgatagta gtgattgatt tggttcagtt
     3361 ccaggatctc tgactagtta tggatttgat agcacttacg tctgattgaa tagcttatgc
     3421 ttcctcactt gggttgtatc cagcatgtca tgaactaaat actactaagc ttatgacttt
     3481 cctagtcatt aataattttt caaggataac ttagtggcct cctgaagata cttacttagg
     3541 ctctgaccaa ttttttttaa ccaatttaaa cagcatctag tataagtaaa tgtccttttt
     3601 ctttgatgat gtggggtttt ctttcacata aggcgagtaa ctatgcagca tgagtttaat
     3661 cacaagtctc aagatattga caattagagg caaaaatttt ttaatcagat tatttgaaag
     3721 cttgaaaatt agcaggcaag ttttttctcc ttttaggaac agaacatgta cacatttact
     3781 tgtattctga aaatataatg gtgccgtttc catttggcct ttccttaatt aatgtgttcc
     3841 cgagttccca ggaggtgaaa ggattacagt gggaaggggg aggcctggtg cagggaatga
     3901 ccaggagaga ccaggtcgca aggctctgct taagaactga gcagaaatag ttggccagga
     3961 acactggtga gagagaccag agtaaatgtc agtgtagctg gggaccagag ctaggatgcc
     4021 acgctttgcc accacagcta cagggccagc attcggagcg gttactttta caattccagc
     4081 tttttgttat ttttcctttt aactttaaaa aacttacaaa tctaaacttt accttttttt
     4141 tttatttgaa tgtaatttag atatcactag cttaaaataa aaaggtttcc agactacttc
     4201 tttgccatag ataatccctg acaaaccatg gcactctgtg ttggaagcct atcaacagtt
     4261 gtgttactca gccataacct tctcctgctt cagccttcct gcttgactct gaaggggtgc
     4321 atgaactttc aaatgcagct ggcatctgca ctatggcctt ccagtattag atgggtccca
     4381 ctgcagccag acacctgtgg gtttgaccct cattaatcac aaaccccagt gtttggacag
     4441 ttaccataac ttaaaaatca ctctaagaaa aaccgctgtg tttctttctc actgccacat
     4501 caggtccctt ttcaagaaag cacagtgaag acagggactg ccagagtaga gatgggtgac
     4561 catggggttc tgtcctggga agggagggct gggttttgct ggctgtgtat ttatactgta
     4621 tgatagatcc cacactttta ttgtctatct attttgactt taatgcttat gacattttct
     4681 cgtgccaaaa tttgtttata tttttcaagt taaattaaac tgatttgggt aactttcctt
     4741 cccctacaaa gtatttcccc cctgacttac gtctattttg gctgttgaga gtggcatttg
     4801 caggactaac taacctccaa gagctgctcc ttacattcga ggtaggcatg acatgaagta
     4861 gctcccagcc acccacttga aatctctcac ccttacattt gctttgtact gagacatctc
     4921 ttattttaag tagacaaaac atagaaaacc tcgattgtcc cagattcttt ctgccttctc
     4981 tctggctgtc acaggcgtgc atctacaact gtcctttaaa tgccctccta cttctccaag
     5041 agggtaagtg cttgactgac ttacagaaag aaaggtgact tgaccaggtt tgcttgtcaa
     5101 catcagtgac aaaggcatca gtcagttgga gcaatcagaa accgcatttg tcctctgtct
     5161 ggaggtcagt gaaaagaggc acaagtccct gaaagtacaa gtttagtgga agccaggaca
     5221 cactcattaa ggaccaaagt gtggggtttt cacaggctcg atagcaagag ctactgtacg
     5281 tccagaacag caggactctt aagttcatcc aggaccagtc ttgaagctgc tctcagagga
     5341 atgagctcat cagtttggga ggagacccag agtgcatatt tccagcacag tgagctccct
     5401 gggcacttct cgtcaggtct gcagtctgct ttagtaaact gtaagtgtgc agttgcagcc
     5461 ttacatggtg acctacacgg tggctgacag cagtcaggga aaggcctcag ccgtgatgcc
     5521 tgttgacctc ttgcagaagc agagcaaagc actcttcatg cccttagtct gaaaatgtat
     5581 ttggtcaaga tgacttttcc cattcctggc ccctctaaag cctcacacag aaagacaaag
     5641 ccacgctgca cgcttgttcc ctttaaaatc atgagccaca ggtatgcgtg catggaggtt
     5701 cttcctgcct ttacagttct ctctgctggt gggaggagtc cagtctttaa cataacccag
     5761 tgccctgcta gggggaaaaa gcctgtgttc tagagagaaa gaaacatgcc caatatccac
     5821 agttagtact cagaaccagg gtccaacttt ggcctgcctc atggtggcta tgtgatattt
     5881 aagaaaggta gggtttttaa agaagtattt attaatatat tcctatataa cattttaaag
     5941 gaagccacat aaaaatagtt aattttttcc ttctaagtaa atgctaagca tgcttattaa
     6001 cgaagcagta ccgatgagta tgtggcattc tgaagctaat tgaaatcatt ctattaaatg
     6061 tcttccttgg tgtcatggga gatagggaca cagaatgttt gcataagccc aggaacccat
     6121 cttccatgat gtgagacaag agcctcagcc aggtctacac tctgcatgtg agagcatcct
     6181 ctcctagcac gtggaaggaa ctggaaacat cccgactgtg gccttcccag ccccacccct
     6241 cctctcctac ctgccctccc tgctgttcca gaagcccctt gcagacacag aagctgtgtt
     6301 tgtgtgtttg gttttaagta accctaatac agatttatgc tgttttcagc aaactgggat
     6361 ttggggctgg tggggtcttt aagtttagca cataaagtgc ctgctgtttc agcaccgacc
     6421 tgagcataat ctgcatgtct gtctccagtg agcgtacggg tctcctcctt ttcagcccca
     6481 cggcttttaa ttgtgtggtg tgaagcatta gttttgctgc gttttattac aggttcttgg
     6541 ttgcaataaa gatgctgctg aaatcaa
//
