LOCUS       NP_001381021             892 aa            linear   ROD 30-MAR-2024
DEFINITION  dipeptidyl peptidase 8 isoform 1 [Rattus norvegicus].
ACCESSION   NP_001381021 XP_006243314
VERSION     NP_001381021.1
DBSOURCE    REFSEQ: accession NM_001394092.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 892)
  AUTHORS   Harstad,E.B., Rosenblum,J.S., Gorrell,M.D., Achanzar,W.E.,
            Minimo,L., Wu,J., Rosini-Marthaler,L., Gullo,R., Ordway,N.D.,
            Kirby,M.S., Chadwick,K.D., Cosma,G.N. and Moyer,C.F.
  TITLE     DPP8 and DPP9 expression in cynomolgus monkey and Sprague Dawley
            rat tissues
  JOURNAL   Regul Pept 186, 26-35 (2013)
   PUBMED   23850796
  REMARK    GeneRIF: DPP8 and DPP9 may act similarly across tissues, and that
            their actions might in part overlap with DPP4.
REFERENCE   2  (residues 1 to 892)
  AUTHORS   Dubois,V., Van Ginneken,C., De Cock,H., Lambeir,A.M., Van der
            Veken,P., Augustyns,K., Chen,X., Scharpe,S. and De Meester,I.
  TITLE     Enzyme activity and immunohistochemical localization of dipeptidyl
            peptidase 8 and 9 in male reproductive tissues
  JOURNAL   J Histochem Cytochem 57 (6), 531-541 (2009)
   PUBMED   19188489
  REMARK    GeneRIF: We showed the expression of DPP8 and DPP9 in the testis,
            epididymis, and sperm.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 31, 2021 this sequence version replaced XP_006243314.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643284.11400.1,
                                           SRR22582416.1032443.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..892
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     Protein         1..892
                     /product="dipeptidyl peptidase 8 isoform 1"
                     /EC_number="3.4.14.5"
                     /calculated_mol_wt=102045
     Region          1..156
                     /region_name="Dpp_8_9_N"
                     /note="Dipeptidyl peptidase 8 and 9 N-terminal; pfam19520"
                     /db_xref="CDD:466112"
     Region          169..589
                     /region_name="DPPIV_N"
                     /note="Dipeptidyl peptidase IV (DPP IV) N-terminal region;
                     pfam00930"
                     /db_xref="CDD:395744"
     Region          681..885
                     /region_name="Peptidase_S9"
                     /note="Prolyl oligopeptidase family; pfam00326"
                     /db_xref="CDD:459761"
     CDS             1..892
                     /gene="Dpp8"
                     /coded_by="NM_001394092.1:311..2989"
                     /note="isoform 1 is encoded by transcript variant 2"
                     /db_xref="GeneID:315758"
                     /db_xref="RGD:1310901"
ORIGIN      
        1 mkipsgrcnm aaameteqlg veifetaece egngesqdrp klepfyvery swsqlkkllt
       61 dtrkyhgymm akaphdfmfv kradpdgphs drvyylamsg enrentlfys eipktinraa
      121 vlmlswkpll dlfqatldyg mysreeellr erkrigtvgi aaydyhpgsg tflfqagsgi
      181 yhikdggphg ftqqplrpnl vetscpnirm dpklcpadpd wiafihsndi wisnlvtree
      241 rrltyvhnel asmeedprsa gvatfvlqee fdrysgywwc pqaertpsgg kilrilyeen
      301 deseveiihv tspmletrra dsfrypktgt anpkvtfkms eivvdaeggi idvidkelvq
      361 pfeilfegve yiaragwtpe gkyawsilld rsqthlqivl ispelfipve ddamdrqrli
      421 esvpdsvtpl iiyeettdiw inihdifhvf pqthedeief ifasecktgf rhlykitsil
      481 keskykrssg glpapsdfkc pikeeiaits gewevlgrhg sniwvdeark lvyfegtkds
      541 plehhlyvts yanpgdvvrl tdrgyshscc lsrhcdffis kysnqksphc vslyklsspd
      601 ddpvhktkef watildsagp lpdytppeif sfesttgftl ygmlykphdl qpgkkyptvl
      661 fiyggpqvql vnnrfkgvky frlntlaslg yvvvvidnrg schrglkfeg afkykmgqie
      721 iddqveglqy lasqydfidl drvgihgwsy ggylslmalm qrsdifrvai agapvtlwif
      781 ydtgyterym ghpdqneqgy ylgsvamqae kfpsepnrll llhgfldenv hfahtsills
      841 flvragkpyd lqiypqerhs irvpesgehy elhllhylqe nlgsriaalk vm
//
