LOCUS       NM_022850               2818 bp    mRNA    linear   ROD 28-JUL-2024
DEFINITION  Rattus norvegicus dipeptidyl peptidase like 6 (Dpp6), mRNA.
ACCESSION   NM_022850
VERSION     NM_022850.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2818)
  AUTHORS   Mercer,R.C., Ma,L., Watts,J.C., Strome,R., Wohlgemuth,S., Yang,J.,
            Cashman,N.R., Coulthart,M.B., Schmitt-Ulms,G., Jhamandas,J.H. and
            Westaway,D.
  TITLE     The prion protein modulates A-type K+ currents mediated by Kv4.2
            complexes through dipeptidyl aminopeptidase-like protein 6
  JOURNAL   J Biol Chem 288 (52), 37241-37255 (2013)
   PUBMED   24225951
REFERENCE   2  (bases 1 to 2818)
  AUTHORS   Lin,L., Sun,W., Throesch,B., Kung,F., Decoster,J.T., Berner,C.J.,
            Cheney,R.E., Rudy,B. and Hoffman,D.A.
  TITLE     DPP6 regulation of dendritic morphogenesis impacts hippocampal
            synaptic development
  JOURNAL   Nat Commun 4, 2270 (2013)
   PUBMED   23912628
  REMARK    GeneRIF: Dipeptidyl-peptidase 6 has an unexpected but important
            role in cell adhesion and motility, impacting the hippocampal
            synaptic development and function.
REFERENCE   3  (bases 1 to 2818)
  AUTHORS   Foeger,N.C., Norris,A.J., Wren,L.M. and Nerbonne,J.M.
  TITLE     Augmentation of Kv4.2-encoded currents by accessory dipeptidyl
            peptidase 6 and 10 subunits reflects selective cell surface Kv4.2
            protein stabilization
  JOURNAL   J Biol Chem 287 (12), 9640-9650 (2012)
   PUBMED   22311982
REFERENCE   4  (bases 1 to 2818)
  AUTHORS   Jerng,H.H. and Pfaffinger,P.J.
  TITLE     Incorporation of DPP6a and DPP6K variants in ternary Kv4 channel
            complex reconstitutes properties of A-type K current in rat
            cerebellar granule cells
  JOURNAL   PLoS One 7 (6), e38205 (2012)
   PUBMED   22675523
  REMARK    GeneRIF: The unique N-terminus of DPP6K modulates the effects of
            KChIP proteins, slowing recovery and producing a negative shift in
            the steady-state inactivation curve.
REFERENCE   5  (bases 1 to 2818)
  AUTHORS   Sun,W., Maffie,J.K., Lin,L., Petralia,R.S., Rudy,B. and
            Hoffman,D.A.
  TITLE     DPP6 establishes the A-type K(+) current gradient critical for the
            regulation of dendritic excitability in CA1 hippocampal neurons
  JOURNAL   Neuron 71 (6), 1102-1115 (2011)
   PUBMED   21943606
REFERENCE   6  (bases 1 to 2818)
  AUTHORS   Zagha,E., Ozaita,A., Chang,S.Y., Nadal,M.S., Lin,U., Saganich,M.J.,
            McCormack,T., Akinsanya,K.O., Qi,S.Y. and Rudy,B.
  TITLE     DPP10 modulates Kv4-mediated A-type potassium channels
  JOURNAL   J Biol Chem 280 (19), 18853-18861 (2005)
   PUBMED   15671030
REFERENCE   7  (bases 1 to 2818)
  AUTHORS   Nadal,M.S., Ozaita,A., Amarillo,Y., Vega-Saenz de Miera,E., Ma,Y.,
            Mo,W., Goldberg,E.M., Misumi,Y., Ikehara,Y., Neubert,T.A. and
            Rudy,B.
  TITLE     The CD26-related dipeptidyl aminopeptidase-like protein DPPX is a
            critical component of neuronal A-type K+ channels
  JOURNAL   Neuron 37 (3), 449-461 (2003)
   PUBMED   12575952
  REMARK    GeneRIF: a novel component of A-type K(+) channels
REFERENCE   8  (bases 1 to 2818)
  AUTHORS   Kin,Y., Misumi,Y. and Ikehara,Y.
  TITLE     Biosynthesis and characterization of the brain-specific membrane
            protein DPPX, a dipeptidyl peptidase IV-related protein
  JOURNAL   J Biochem 129 (2), 289-295 (2001)
   PUBMED   11173531
REFERENCE   9  (bases 1 to 2818)
  AUTHORS   Yokotani,N., Doi,K., Wenthold,R.J. and Wada,K.
  TITLE     Non-conservation of a catalytic residue in a dipeptidyl
            aminopeptidase IV-related protein encoded by a gene on human
            chromosome 7
  JOURNAL   Hum Mol Genet 2 (7), 1037-1039 (1993)
   PUBMED   8103397
REFERENCE   10 (bases 1 to 2818)
  AUTHORS   Wada,K., Yokotani,N., Hunter,C., Doi,K., Wenthold,R.J. and
            Shimasaki,S.
  TITLE     Differential expression of two distinct forms of mRNA encoding
            members of a dipeptidyl aminopeptidase family
  JOURNAL   Proc Natl Acad Sci U S A 89 (1), 197-201 (1992)
   PUBMED   1729689
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Nov 26, 2020 this sequence version replaced NM_022850.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M76426.1, SRR26643298.21093.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-421               JAXUCZ010000004.1  8994849-8995269     c
            422-536             JAXUCZ010000004.1  8667215-8667329     c
            537-635             JAXUCZ010000004.1  8651342-8651440     c
            636-730             JAXUCZ010000004.1  8594228-8594322     c
            731-805             JAXUCZ010000004.1  8569810-8569884     c
            806-858             JAXUCZ010000004.1  8524409-8524461     c
            859-940             JAXUCZ010000004.1  8498670-8498751     c
            941-1061            JAXUCZ010000004.1  8452304-8452424     c
            1062-1216           JAXUCZ010000004.1  8427785-8427939     c
            1217-1314           JAXUCZ010000004.1  8426102-8426199     c
            1315-1438           JAXUCZ010000004.1  8401085-8401208     c
            1439-1477           JAXUCZ010000004.1  8399609-8399647     c
            1478-1585           JAXUCZ010000004.1  8391529-8391636     c
            1586-1677           JAXUCZ010000004.1  8390118-8390209     c
            1678-1725           JAXUCZ010000004.1  8388717-8388764     c
            1726-1844           JAXUCZ010000004.1  8384432-8384550     c
            1845-1892           JAXUCZ010000004.1  8352237-8352284     c
            1893-1991           JAXUCZ010000004.1  8339605-8339703     c
            1992-2061           JAXUCZ010000004.1  8336063-8336132     c
            2062-2256           JAXUCZ010000004.1  8334420-8334614     c
            2257-2311           JAXUCZ010000004.1  8333312-8333366     c
            2312-2423           JAXUCZ010000004.1  8329739-8329850     c
            2424-2482           JAXUCZ010000004.1  8328169-8328227     c
            2483-2555           JAXUCZ010000004.1  8327475-8327547     c
            2556-2629           JAXUCZ010000004.1  8327306-8327379     c
            2630-2818           JAXUCZ010000004.1  8324843-8325031     c
FEATURES             Location/Qualifiers
     source          1..2818
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q11"
     gene            1..2818
                     /gene="Dpp6"
                     /gene_synonym="DPP VI"
                     /note="dipeptidyl peptidase like 6"
                     /db_xref="GeneID:29272"
                     /db_xref="RGD:68402"
     exon            1..421
                     /gene="Dpp6"
                     /gene_synonym="DPP VI"
                     /inference="alignment:Splign:2.1.0"
     CDS             197..2776
                     /gene="Dpp6"
                     /gene_synonym="DPP VI"
                     /note="dipeptidyl aminopeptidase-like protein 6;
                     dipeptidylpeptidase 6; DPPX; dipeptidylpeptidase VI;
                     dipeptidyl peptidase IV-like protein; dipeptidyl
                     aminopeptidase-related protein; dipeptidyl peptidase VI"
                     /codon_start=1
                     /product="A-type potassium channel modulatory protein
                     DPP6"
                     /protein_id="NP_074041.2"
                     /db_xref="GeneID:29272"
                     /db_xref="RGD:68402"
                     /translation="MASLYQRFTGKINTSRSFPAPPEASHLLGGQGPEEDAGSKPLGP
                     QAQAVAPRERGGAGGRPRFQYQARSDCDEEDELVGSNPPQRNWKGIAIALLVILVICS
                     LIVTSVILLTPAEDTSLSQKKKVTVEDLFSEDFKIHDPEAKWISDKEFIYRERKGSVI
                     LRNVETNNSTVLIEGKKIESLRAIRYEISPDKEYALFSYNVEPVYQHSHTGYYVLSKI
                     PHGDPQSLDPPEVSNAKLQYAGWGPKGQQLIFIFENNIYYCAHVGKQAIRVVSTGKEG
                     VIYNGLSDWLYEEEILKSHIAHWWSPDGTRLAYATINDSRVPLMELPTYTGSVYPTVK
                     PYHYPKAGSENPSISLHVIGLNGPTHDLEMMPPDDPRMREYYITMVKWATSTKVAVTW
                     LNRAQNVSILTLCDATTGVCTKKHEDESEAWLHRQNEEPVFSKDGRKFFFVRAIPQGG
                     RGKFYHITVSSSQPNSSNDNIQSITSGDWDVTEILTYDEKRNKLYFLSTEDLPRRRHL
                     YSANTVDDFNRQCLSCDLVENCTYVSASFSHNMDFFLLKCEGPGVPTVTVHNTTDKRR
                     MFDLEANEQVQKAINDRQMPKIEYRKIEVEDYSLPMQILKPATFTDTAHYPLLLVVDG
                     TPGSQSVSERFEVTWETVLVSSHGAVVVKCDGRGSGFQGTKLLHEVRRRLGFLEEKDQ
                     MEAVRTMLKEQYIDKTRVAVFGKDYGGYLSTYILPAKGENQGQTFTCGSALSPITDFK
                     LYASAFSERYLGLHGLDNRAYEMTKLAHRVSALEDQQFLIIHATADEKIHFQHTAELI
                     TQLIKGKANYSLQIYPDESHYFHSVALKQHLYRSIIGFFVECFRIQDKLPTATAKEDE
                     EED"
     exon            422..536
                     /gene="Dpp6"
                     /gene_synonym="DPP VI"
                     /inference="alignment:Splign:2.1.0"
     exon            537..635
                     /gene="Dpp6"
                     /gene_synonym="DPP VI"
                     /inference="alignment:Splign:2.1.0"
     exon            636..730
                     /gene="Dpp6"
                     /gene_synonym="DPP VI"
                     /inference="alignment:Splign:2.1.0"
     exon            731..805
                     /gene="Dpp6"
                     /gene_synonym="DPP VI"
                     /inference="alignment:Splign:2.1.0"
     exon            806..858
                     /gene="Dpp6"
                     /gene_synonym="DPP VI"
                     /inference="alignment:Splign:2.1.0"
     exon            859..940
                     /gene="Dpp6"
                     /gene_synonym="DPP VI"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1061
                     /gene="Dpp6"
                     /gene_synonym="DPP VI"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1216
                     /gene="Dpp6"
                     /gene_synonym="DPP VI"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1314
                     /gene="Dpp6"
                     /gene_synonym="DPP VI"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1438
                     /gene="Dpp6"
                     /gene_synonym="DPP VI"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..1477
                     /gene="Dpp6"
                     /gene_synonym="DPP VI"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..1585
                     /gene="Dpp6"
                     /gene_synonym="DPP VI"
                     /inference="alignment:Splign:2.1.0"
     exon            1586..1677
                     /gene="Dpp6"
                     /gene_synonym="DPP VI"
                     /inference="alignment:Splign:2.1.0"
     exon            1678..1725
                     /gene="Dpp6"
                     /gene_synonym="DPP VI"
                     /inference="alignment:Splign:2.1.0"
     exon            1726..1844
                     /gene="Dpp6"
                     /gene_synonym="DPP VI"
                     /inference="alignment:Splign:2.1.0"
     exon            1845..1892
                     /gene="Dpp6"
                     /gene_synonym="DPP VI"
                     /inference="alignment:Splign:2.1.0"
     exon            1893..1991
                     /gene="Dpp6"
                     /gene_synonym="DPP VI"
                     /inference="alignment:Splign:2.1.0"
     exon            1992..2061
                     /gene="Dpp6"
                     /gene_synonym="DPP VI"
                     /inference="alignment:Splign:2.1.0"
     exon            2062..2256
                     /gene="Dpp6"
                     /gene_synonym="DPP VI"
                     /inference="alignment:Splign:2.1.0"
     exon            2257..2311
                     /gene="Dpp6"
                     /gene_synonym="DPP VI"
                     /inference="alignment:Splign:2.1.0"
     exon            2312..2423
                     /gene="Dpp6"
                     /gene_synonym="DPP VI"
                     /inference="alignment:Splign:2.1.0"
     exon            2424..2482
                     /gene="Dpp6"
                     /gene_synonym="DPP VI"
                     /inference="alignment:Splign:2.1.0"
     exon            2483..2555
                     /gene="Dpp6"
                     /gene_synonym="DPP VI"
                     /inference="alignment:Splign:2.1.0"
     exon            2556..2629
                     /gene="Dpp6"
                     /gene_synonym="DPP VI"
                     /inference="alignment:Splign:2.1.0"
     exon            2630..2818
                     /gene="Dpp6"
                     /gene_synonym="DPP VI"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctcagcacc caggcgactc gactcgcgag tggcgcggag cggcagggct cgtctttttt
       61 ctttctccac cgcctccttt tccccccttc tcccttttct gttggagggg gtggggagag
      121 gaaagagaga cagagagaaa ggaaattttt ttttccgaag catcctaacc agtgagctag
      181 cgcagagcgg cggcccatgg cttcgctgta ccaaaggttc accggcaaga tcaacacctc
      241 gcgctccttc ccggcgcccc cggaggccag tcaccttctg ggtggccagg ggccggagga
      301 ggacgccggc tcgaagcccc tcgggccgca ggcgcaggcg gtggcacctc gggagcgcgg
      361 cggtgctggt ggccggcccc ggttccagta ccaggcgcgg agcgactgtg acgaggagga
      421 cgagctggtg gggagtaatc ctccacagag aaactggaaa ggaatcgcca ttgcactgct
      481 tgtcatcctt gtcatctgct ccctgattgt cacctcagtc atcctgctga ccccagcgga
      541 agataccagt ctgtctcaga agaagaaggt gactgtggaa gatcttttca gtgaagactt
      601 caaaatccat gacccagagg caaagtggat aagcgataag gaattcatct acagagaacg
      661 gaaagggagc gtcatactgc ggaacgttga gacaaataat tccacggtgt taatagaagg
      721 caaaaaaatt gaatcgttaa gagccatcag atatgaaata tccccagata aagagtatgc
      781 gttgttttcc tataatgtgg aaccggtata ccaacactcc cacactggat attatgttct
      841 gagcaaaatt cctcacgggg accctcagag tctggaccca ccagaagtca gcaacgcgaa
      901 gcttcagtat gcagggtggg gcccgaaagg ccagcagctg atatttatct ttgagaacaa
      961 catctactac tgtgcccatg ttggaaagca ggcgattcga gtggtctcta cggggaagga
     1021 gggtgtgatc tacaatggcc tcagcgactg gctgtatgaa gaggagattc tgaagagcca
     1081 catcgcacat tggtggtcgc cagatggtac aaggctcgcc tatgccacca tcaatgattc
     1141 ccgagttcca cttatggagc tgccaaccta cacgggctct gtctacccca ctgtgaagcc
     1201 ctaccactat cctaaggctg gcagtgaaaa ccccagcatc tccctccacg tcatcggctt
     1261 gaatggaccc acccacgacc tggagatgat gccacctgac gacccccgca tgagagagta
     1321 ttacatcacc atggtgaagt gggccaccag caccaaggtt gctgtgacct ggctgaaccg
     1381 ggcccagaat gtgtccatcc tgaccctctg tgatgccacc acaggtgtct gcactaagaa
     1441 acacgaggat gaaagtgaag cttggctcca cagacagaat gaagagcccg tgttctccaa
     1501 ggatggccgg aagtttttct ttgtcagagc gatcccacag ggaggccggg gtaaattcta
     1561 ccacatcact gtatcctcat cccagcccaa cagcagcaat gacaacatcc agtccattac
     1621 ctctggggac tgggatgtga ccgagatcct gacctacgat gagaagcgga ataagctcta
     1681 tttcctaagc acagaggacc tgccacgaag acgacacctc tacagcgcca acacggtaga
     1741 cgacttcaac aggcagtgtc tgtcatgtga cctggtggag aactgcacct atgtcagtgc
     1801 ttccttcagt cataacatgg acttcttcct gctcaagtgt gaaggccctg gcgtacccac
     1861 tgttactgtg cacaatacca cggataagag aagaatgttt gacttggaag caaatgagca
     1921 agtgcagaaa gccatcaacg atcggcagat gcctaaaatt gaataccgga aaattgaagt
     1981 ggaagattac agcttgccaa tgcaaatctt gaagccggcc accttcactg acacagccca
     2041 ctacccttta ttgctcgtgg tggatggtac tccagggagt cagagcgtgt cagagaggtt
     2101 tgaagtgacc tgggagacag tgttggtgag cagccatgga gcagtggtgg tcaagtgtga
     2161 cggccgaggc agcggctttc agggaaccaa gctcttgcac gaagtacgga ggcggctagg
     2221 cttcctggag gagaaggacc agatggaagc tgtgagaacc atgctgaagg agcagtacat
     2281 tgacaagact cgggtagctg tgtttgggaa ggattatggt gggtacctga gtacttacat
     2341 cctcccagcc aagggagaaa accaaggcca gactttcacc tgcggctctg cactctctcc
     2401 gataacggac ttcaaactct atgcctcagc attttccgag aggtaccttg gcctccatgg
     2461 actcgacaac agagcgtatg agatgaccaa gctggcacac agagtgtcag cactggagga
     2521 ccagcagttc ctgatcatcc atgctacggc tgacgaaaaa atccatttcc agcacacagc
     2581 agagctcatc acgcagctaa tcaagggaaa ggccaattac agcttacaga tatacccaga
     2641 tgaaagtcac tactttcaca gcgtggcgct caaacagcac ctgtacaggt ccatcatcgg
     2701 attctttgtg gaatgtttca ggatccagga caagctacct acagccacag cgaaagagga
     2761 cgaggaggag gactaaccac gcttgagacc taaacacaga catggctctt tctacaac
//
