LOCUS       NM_012789               4964 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus dipeptidylpeptidase 4 (Dpp4), mRNA.
ACCESSION   NM_012789
VERSION     NM_012789.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4964)
  AUTHORS   Lin,L. and Wang,L.
  TITLE     Knockdown of DPP4 promotes the proliferation and the activation of
            the CREB/aromatase pathway in ovarian granulosa cells
  JOURNAL   Mol Med Rep 25 (2) (2022)
   PUBMED   35014677
  REMARK    GeneRIF: Knockdown of DPP4 promotes the proliferation and the
            activation of the CREB/aromatase pathway in ovarian granulosa
            cells.
REFERENCE   2  (bases 1 to 4964)
  AUTHORS   Zhao,R., Jin,X., Li,A., Xu,B., Shen,Y., Wang,W., Huang,J., Zhang,Y.
            and Li,X.
  TITLE     Precise Diabetic Wound Therapy: PLS Nanospheres Eliminate Senescent
            Cells via DPP4 Targeting and PARP1 Activation
  JOURNAL   Adv Sci (Weinh) 9 (1), e2104128 (2022)
   PUBMED   34738744
  REMARK    GeneRIF: Precise Diabetic Wound Therapy: PLS Nanospheres Eliminate
            Senescent Cells via DPP4 Targeting and PARP1 Activation.
REFERENCE   3  (bases 1 to 4964)
  AUTHORS   Adegoke,T.E., Sabinari,I.W., Areola,E.D., Ajao,F., Asafa,O.O.,
            Soluoku,T.K., Bello,A., Adesanmi,A.M., Yusuf,S.O., Omoleye,A.,
            Ayinla,M.T. and Olatunji,L.A.
  TITLE     Inhibition of dipeptidyl peptidase-4 averts free fatty acids
            deposition in the hearts of oral estrogen-progestin
            contraceptive-induced hyperinsulinemic female rats
  JOURNAL   Can J Physiol Pharmacol 99 (12), 1316-1323 (2021)
   PUBMED   34310895
  REMARK    GeneRIF: Inhibition of dipeptidyl peptidase-4 averts free fatty
            acids deposition in the hearts of oral estrogen-progestin
            contraceptive-induced hyperinsulinemic female rats.
REFERENCE   4  (bases 1 to 4964)
  AUTHORS   Guan,G.Y., Wei,N., Song,T., Zhao,C., Sun,Y., Pan,R.X., Zhang,L.L.,
            Xu,Y.Y., Dai,Y.M. and Han,H.
  TITLE     miR-448-3p alleviates diabetic vascular dysfunction by inhibiting
            endothelial-mesenchymal transition through DPP-4 dysregulation
  JOURNAL   J Cell Physiol 235 (12), 10024-10036 (2020)
   PUBMED   32542696
  REMARK    GeneRIF: miR-448-3p alleviates diabetic vascular dysfunction by
            inhibiting endothelial-mesenchymal transition through DPP-4
            dysregulation.
REFERENCE   5  (bases 1 to 4964)
  AUTHORS   Yip,H.K., Lee,M.S., Li,Y.C., Shao,P.L., Chiang,J.Y., Sung,P.H.,
            Yang,C.H. and Chen,K.H.
  TITLE     Dipeptidyl Peptidase-4 deficiency effectively protects the brain
            and neurological function in rodent after acute Hemorrhagic Stroke
  JOURNAL   Int J Biol Sci 16 (16), 3116-3132 (2020)
   PUBMED   33162819
  REMARK    GeneRIF: Dipeptidyl Peptidase-4 deficiency effectively protects the
            brain and neurological function in rodent after acute Hemorrhagic
            Stroke.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4964)
  AUTHORS   Ogata,S., Misumi,Y., Tsuji,E., Takami,N., Oda,K. and Ikehara,Y.
  TITLE     Identification of the active site residues in dipeptidyl peptidase
            IV by affinity labeling and site-directed mutagenesis
  JOURNAL   Biochemistry 31 (9), 2582-2587 (1992)
   PUBMED   1347701
REFERENCE   7  (bases 1 to 4964)
  AUTHORS   Hong,W.J. and Doyle,D.
  TITLE     Molecular dissection of the NH2-terminal signal/anchor sequence of
            rat dipeptidyl peptidase IV
  JOURNAL   J Cell Biol 111 (2), 323-328 (1990)
   PUBMED   1974258
REFERENCE   8  (bases 1 to 4964)
  AUTHORS   McCaughan,G.W., Wickson,J.E., Creswick,P.F. and Gorrell,M.D.
  TITLE     Identification of the bile canalicular cell surface molecule GP110
            as the ectopeptidase dipeptidyl peptidase IV: an analysis by tissue
            distribution, purification and N-terminal amino acid sequence
  JOURNAL   Hepatology 11 (4), 534-544 (1990)
   PUBMED   1970322
REFERENCE   9  (bases 1 to 4964)
  AUTHORS   Ogata,S., Misumi,Y. and Ikehara,Y.
  TITLE     Primary structure of rat liver dipeptidyl peptidase IV deduced from
            its cDNA and identification of the NH2-terminal signal sequence as
            the membrane-anchoring domain
  JOURNAL   J Biol Chem 264 (6), 3596-3601 (1989)
   PUBMED   2563382
REFERENCE   10 (bases 1 to 4964)
  AUTHORS   Hong,W.J. and Doyle,D.
  TITLE     Membrane orientation of rat gp110 as studied by in vitro
            translation
  JOURNAL   J Biol Chem 263 (32), 16892-16898 (1988)
   PUBMED   3182821
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Mar 11, 2021 this sequence version replaced NM_012789.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J02997.1, SRR26360190.3189808.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760400,
                                           SAMN16676784 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-95                JAXUCZ010000003.1  67452328-67452422   c
            96-180              JAXUCZ010000003.1  67451758-67451842   c
            181-276             JAXUCZ010000003.1  67426938-67427033   c
            277-368             JAXUCZ010000003.1  67426322-67426413   c
            369-449             JAXUCZ010000003.1  67425411-67425491   c
            450-502             JAXUCZ010000003.1  67419953-67420005   c
            503-575             JAXUCZ010000003.1  67419773-67419845   c
            576-696             JAXUCZ010000003.1  67418905-67419025   c
            697-857             JAXUCZ010000003.1  67415014-67415174   c
            858-970             JAXUCZ010000003.1  67413370-67413482   c
            971-1106            JAXUCZ010000003.1  67404625-67404760   c
            1107-1151           JAXUCZ010000003.1  67402475-67402519   c
            1152-1259           JAXUCZ010000003.1  67400457-67400564   c
            1260-1336           JAXUCZ010000003.1  67400145-67400221   c
            1337-1390           JAXUCZ010000003.1  67399134-67399187   c
            1391-1512           JAXUCZ010000003.1  67398613-67398734   c
            1513-1560           JAXUCZ010000003.1  67397082-67397129   c
            1561-1659           JAXUCZ010000003.1  67396751-67396849   c
            1660-1729           JAXUCZ010000003.1  67394228-67394297   c
            1730-1924           JAXUCZ010000003.1  67392084-67392278   c
            1925-1979           JAXUCZ010000003.1  67388673-67388727   c
            1980-2079           JAXUCZ010000003.1  67388011-67388110   c
            2080-2144           JAXUCZ010000003.1  67385297-67385361   c
            2145-2217           JAXUCZ010000003.1  67375321-67375393   c
            2218-2291           JAXUCZ010000003.1  67374979-67375052   c
            2292-4964           JAXUCZ010000003.1  67370794-67373466   c
FEATURES             Location/Qualifiers
     source          1..4964
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q21"
     gene            1..4964
                     /gene="Dpp4"
                     /gene_synonym="CD26; DPPIV"
                     /note="dipeptidylpeptidase 4"
                     /db_xref="GeneID:25253"
                     /db_xref="RGD:2515"
     exon            1..95
                     /gene="Dpp4"
                     /gene_synonym="CD26; DPPIV"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..2393
                     /gene="Dpp4"
                     /gene_synonym="CD26; DPPIV"
                     /EC_number="3.4.14.5"
                     /note="DPP IV; GP110 glycoprotein; dipeptidyl peptidase
                     IV; T-cell activation antigen CD26; bile canaliculus
                     domain-specific membrane glycoprotein"
                     /codon_start=1
                     /product="dipeptidyl peptidase 4"
                     /protein_id="NP_036921.2"
                     /db_xref="GeneID:25253"
                     /db_xref="RGD:2515"
                     /translation="MKTPWKVLLGLLGVAALVTIITVPVVLLNKDEAAADSRRTYTLA
                     DYLKNTFRVKSYSLRWVSDSEYLYKQENNILLFNAEHGNSSIFLENSTFEIFGDSISD
                     YSVSPDRLFVLLEYNYVKQWRHSYTASYSIYDLNKRQLITEEKIPNNTQWITWSQEGH
                     KLAYVWKNDIYVKIEPHLPSHRITSTGKENVIFNGINDWVYEEEIFGAYSALWWSPNG
                     TFLAYAQFNDTGVPLIEYSFYSDESLQYPKTVWIPYPKAGAVNPTVKFFIVNTDSLSS
                     TTTTIPMQITAPASVTTGDHYLCDVAWVSEDRISLQWLRRIQNYSVMAICDYDKTNLV
                     WNCPTTQEHIETSATGWVGRFRPAEPHFTSDGSSFYKIVSDKDGYKHICQFQKDRKPE
                     QDCTFITKGAWEVISIEALTSDYLYYISNEYKEMPGGRNLYKIQLTDHTNKKCLSCDL
                     NPERCQYYSVSLSKEAKYYQLGCRGPGLPLYTLHRSTDQKELRVLEDNSALDKMLQDV
                     QMPSKKLDFIVLNETRFWYQMILPPHFDKSKKYPLLIDVYAGPCSQKADAAFRLNWAT
                     YLASTENIIVASFDGRGSGYQGDKIMHAINKRLGTLEVEDQIEAARQFLKMGFVDSKQ
                     VAIWGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRWEYYDSVYTERYMGLPTPEDNLD
                     HYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQISKALVDAGVDFQAMWYTDED
                     HGIASSTAHQHIYSHMSHFLQQCFSLR"
     exon            96..180
                     /gene="Dpp4"
                     /gene_synonym="CD26; DPPIV"
                     /inference="alignment:Splign:2.1.0"
     exon            181..276
                     /gene="Dpp4"
                     /gene_synonym="CD26; DPPIV"
                     /inference="alignment:Splign:2.1.0"
     exon            277..368
                     /gene="Dpp4"
                     /gene_synonym="CD26; DPPIV"
                     /inference="alignment:Splign:2.1.0"
     exon            369..449
                     /gene="Dpp4"
                     /gene_synonym="CD26; DPPIV"
                     /inference="alignment:Splign:2.1.0"
     exon            450..502
                     /gene="Dpp4"
                     /gene_synonym="CD26; DPPIV"
                     /inference="alignment:Splign:2.1.0"
     exon            503..575
                     /gene="Dpp4"
                     /gene_synonym="CD26; DPPIV"
                     /inference="alignment:Splign:2.1.0"
     exon            576..696
                     /gene="Dpp4"
                     /gene_synonym="CD26; DPPIV"
                     /inference="alignment:Splign:2.1.0"
     exon            697..857
                     /gene="Dpp4"
                     /gene_synonym="CD26; DPPIV"
                     /inference="alignment:Splign:2.1.0"
     exon            858..970
                     /gene="Dpp4"
                     /gene_synonym="CD26; DPPIV"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1106
                     /gene="Dpp4"
                     /gene_synonym="CD26; DPPIV"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1151
                     /gene="Dpp4"
                     /gene_synonym="CD26; DPPIV"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1259
                     /gene="Dpp4"
                     /gene_synonym="CD26; DPPIV"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1336
                     /gene="Dpp4"
                     /gene_synonym="CD26; DPPIV"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1390
                     /gene="Dpp4"
                     /gene_synonym="CD26; DPPIV"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1512
                     /gene="Dpp4"
                     /gene_synonym="CD26; DPPIV"
                     /inference="alignment:Splign:2.1.0"
     exon            1513..1560
                     /gene="Dpp4"
                     /gene_synonym="CD26; DPPIV"
                     /inference="alignment:Splign:2.1.0"
     exon            1561..1659
                     /gene="Dpp4"
                     /gene_synonym="CD26; DPPIV"
                     /inference="alignment:Splign:2.1.0"
     exon            1660..1729
                     /gene="Dpp4"
                     /gene_synonym="CD26; DPPIV"
                     /inference="alignment:Splign:2.1.0"
     exon            1730..1924
                     /gene="Dpp4"
                     /gene_synonym="CD26; DPPIV"
                     /inference="alignment:Splign:2.1.0"
     exon            1925..1979
                     /gene="Dpp4"
                     /gene_synonym="CD26; DPPIV"
                     /inference="alignment:Splign:2.1.0"
     exon            1980..2079
                     /gene="Dpp4"
                     /gene_synonym="CD26; DPPIV"
                     /inference="alignment:Splign:2.1.0"
     exon            2080..2144
                     /gene="Dpp4"
                     /gene_synonym="CD26; DPPIV"
                     /inference="alignment:Splign:2.1.0"
     exon            2145..2217
                     /gene="Dpp4"
                     /gene_synonym="CD26; DPPIV"
                     /inference="alignment:Splign:2.1.0"
     exon            2218..2291
                     /gene="Dpp4"
                     /gene_synonym="CD26; DPPIV"
                     /inference="alignment:Splign:2.1.0"
     exon            2292..4964
                     /gene="Dpp4"
                     /gene_synonym="CD26; DPPIV"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagcagaggc gcaggacgtc cgtctccgcg cgcggtgact tctgcctgcg ctcaagcttc
       61 agagttcagt ttcaaggagc cgcccaacca tgaagacacc gtggaaggtt cttctgggac
      121 tgcttggtgt cgctgcgctt gtcaccatca tcaccgtgcc agtggttctg ctgaacaaag
      181 atgaagcggc cgctgatagc cgcagaactt acacactagc tgactattta aagaatacct
      241 ttcgggtcaa gtcctactcc ttgcggtggg tttcagattc tgaatacctc tacaagcaag
      301 aaaacaatat cttgctattc aatgctgaac acgggaacag ctccattttc ttggagaaca
      361 gtacctttga gatctttgga gattctataa gtgattattc agtgtcaccc gacagactgt
      421 tcgttctctt agaatacaat tatgtgaagc aatggagaca ctcctacacg gcttcataca
      481 gtatttatga cttgaataaa agacagctga tcacagaaga gaagattcca aataatacac
      541 agtggatcac atggtcacaa gaaggtcaca aattggcata tgtctggaag aatgatattt
      601 atgttaaaat tgaaccacat ttgcctagtc ataggatcac atcaacagga aaagaaaatg
      661 taatatttaa cggaataaat gactgggttt atgaagagga aatcttcggt gcctactccg
      721 cactgtggtg gtctccaaac ggcacttttc tagcttatgc ccagtttaac gacaccggag
      781 tgcctctcat tgaatactcc ttctactctg atgagtcact gcagtacccc aagacagtgt
      841 ggattccgta cccaaaggca ggagctgtga atccaactgt aaagttcttt attgtaaata
      901 cagactctct cagctcaact actactacga ttcccatgca aatcaccgct cctgcatctg
      961 tgacaacagg ggatcactac ttgtgtgacg tggcctgggt ttcagaagac agaatctcgt
     1021 tgcagtggct caggaggatt cagaactatt ccgtgatggc gatctgcgac tatgataaga
     1081 ccaacctagt atggaactgt ccaacgacgc aggagcatat tgaaacgagt gccacaggct
     1141 gggtcggaag atttaggcct gcagaacccc acttcacctc cgacggaagc agcttctata
     1201 aaatcgtcag tgacaaagat ggctacaaac acatctgcca gttccagaaa gataggaaac
     1261 ccgaacagga ctgtacattt attacaaaag gagcctggga agtcattagt atcgaagctc
     1321 tgaccagcga ttatctgtac tacattagta atgaatataa agaaatgcca ggaggaagaa
     1381 atctttataa aattcagctt actgaccaca caaataagaa gtgccttagt tgtgacctga
     1441 atccagaaag atgccagtat tactcggtgt cacttagtaa agaggcaaag tactatcagc
     1501 tgggatgccg gggccctggt ctgcccctct acactctgca tcgcagcact gatcaaaaag
     1561 agctgagagt cctggaggac aattctgctt tggataaaat gctgcaagat gtccaaatgc
     1621 cttcaaaaaa attggacttc attgttctga atgaaacaag attttggtat caaatgatct
     1681 tacctcctca ttttgataaa tccaagaaat accctctact aatagatgta tatgcaggtc
     1741 cctgtagtca aaaagcagat gctgccttca gactcaactg ggccacttac cttgcaagca
     1801 cagaaaacat catagtagct agctttgatg gcagaggaag tggttaccaa ggagataaga
     1861 tcatgcatgc aatcaacaaa agacttggaa cactggaagt tgaagatcaa attgaagcag
     1921 ccaggcaatt tttaaaaatg ggatttgtgg acagcaagca agttgcaatt tggggctggt
     1981 catatggagg gtacgtaacc tcaatggtcc tgggatcggg aagtggcgtg ttcaagtgtg
     2041 gaatagccgt ggcgcccgtg tcacggtggg agtactatga ctcagtatac acagagcgtt
     2101 acatgggtct cccaactcca gaggacaacc ttgaccatta caggaactca acagtcatga
     2161 gcagagctga aaattttaag caagttgagt acctccttat tcacggtaca gcagatgata
     2221 atgttcactt tcagcagtca gctcagatct ccaaagccct ggtggatgct ggcgtggatt
     2281 tccaagcaat gtggtacacg gacgaagacc atgggatcgc cagcagcaca gctcaccagc
     2341 acatctattc ccacatgagc catttcctcc agcagtgctt ctccttacgc tagcatggca
     2401 aggctctccg cagcttactc aagagcacac ttgtcctcat tatctcaaaa ctgcactgtt
     2461 aagatgacga ttttaataat gtcgcctcga gaaattccag cctacttccc agttttatac
     2521 ctgcaatcct aactaaggat gcctgtcttc agaacagatt attaccttac agcaatttgg
     2581 atttccccct ctgttttgtt tatcatttaa aaccatttcc acatcagctg ctgaaacaac
     2641 aaatataaat tatttttgca agagctatgc atagatttcc tgagcagaat ttcaattttt
     2701 ttccccctta ctaggctggt ccaaatcttg ttcccttatt taagggggtg gcaagacgtg
     2761 ggtaatgatg tcattaggcc agcaacaaga gaagcgggaa cagagaatat ggctagaaac
     2821 ccaggtccaa gcatacaaac ccaaccaggc tactgtcagc tcgcctcgag aagagctgct
     2881 cactgccaga ctggcaccgt tttctgagaa agactattca aacagtctca ggaaatcata
     2941 tatgcaaagc actgacttct aagtaaaacc acagcagttg aatagactcc aaagaaatgc
     3001 aagggacgct gccagcaatg taagggcccc aggtgccagt tatggctata ggtgctacat
     3061 aaacacagca agggtgatgg gaaagcattg taaatgtgct tttaaaaaat taccaatgtc
     3121 tcctagtgag aagaggcagc ttggaacata gcgacttgcc ccgttaaaag ttgaaaatat
     3181 ttgtgtcaca aattctaaca tgaaggaata cttgcgtcag ttcttcctac ttcctttctt
     3241 tgagcatttt cattaaagca ttttaacttc attatctttc taatggaaaa ctgtatgaga
     3301 atgttttgtg ttattatttc tattctacac actggaatgt tgcctggtca tttagcaagt
     3361 atgcttccat tttttcaaag gtaatgggtt atatcttgaa tcaaacttaa actgcattga
     3421 catatggaca catttgttca aaggttcttg tttaacttgt gtgaaatcca agactgtctt
     3481 gtaaacatgg aaagagttca acttttaaaa aaaaatttag atacataaaa ctgtttaaag
     3541 ttatatgatt cataagagtt tatctaatac ccccagaaat ttctatctca catttatcac
     3601 atagctttgg agaaatcaat caacaataac ttggtcattt acatactatg gaactcataa
     3661 tattatttaa cttaggggag cacgtgaggt tcgtggcacg agatggaatg ctatcagcag
     3721 agtagacatg tttttccagg gtcttgtttt ttgtttttgt ttctggtctc ttcctgtttg
     3781 ggcggagggt aatataatag ataatataca taatagaata cactctgata cctgacttag
     3841 ccgtgttttg acaacttgga aacttgattc aattatttat aacacagctg aaaatttaaa
     3901 atggactcca cacatttaaa tgcagtttca ggccaatttt ctaggtacaa ttaccacaga
     3961 caggtgagct acagcataaa ttccaaacat ggcagaaatg gaaattacct ataaatataa
     4021 atgagtttag atattgatga gcctgatgct atttcccggg cactccactg gttcccctca
     4081 ccttaaggaa ctctcaagtc ctgctcttcc actgcaagca cagctggtcc ttaaatctac
     4141 aggcctctgg ctacagtccg aattttgaac acagttctgt caccgtgtgc agcagcagcc
     4201 atgtgcaaag ttctagatca aggaacaaag gtagcacatg ttcctgacag tgtggaaaca
     4261 taaatgcgaa ttaaatagaa attatccctt ctgaattcat taatctaagg cccgttatat
     4321 aataatcaag gtttttatta ataaatctta tatgatgtat catatgttga tagaatagcc
     4381 aaaccatgaa ttctttttgt tcctttcatt tctaaatagg ttgttcctgg agcctgaatt
     4441 aataaaaaga acacagcaca catttttcag gcgatgaggg tttcacatgg tgataatgtg
     4501 aatacattca gtttttattt gattctcata ggtcaagttt tactgttcgg taagagttgt
     4561 aaattagatt aaaaccctga tgcataagtt gtaaacaaac ttaatttaag agcaagtttg
     4621 aaaagcacaa gagctaataa caccactgag gcatatagac aagtctctta tgggcatatg
     4681 cagctccctg aagcgcatgg atcaagctac cgcctcagag cacaccagca ccaggggcgc
     4741 atgcgctaaa ggaagagctc ccctccccac cccccatgct tcacgatcca tgttgacttc
     4801 agtctgtgcc attctgggca tcatagttct ccttcagatt attagcagtt ccacctcttg
     4861 gcacgtacta cttttgctct aagttggagt gagagtactg gtttataaga ttactggatt
     4921 tgtacaatat ttaagattca ataaattcta agtgaaaaaa cata
//
