LOCUS       NM_053748               2614 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus dipeptidylpeptidase 3 (Dpp3), mRNA.
ACCESSION   NM_053748 XM_341988
VERSION     NM_053748.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2614)
  AUTHORS   Kropotova,E.S., Pavlova,E.N., Naryzhny,S.N. and Mosevitsky,M.I.
  TITLE     Dipeptidylamino-tripeptidylcarboxypeptidase NEMP3 and DPP3 (DPP
            III) are the same protein
  JOURNAL   Biochem Biophys Res Commun 616, 110-114 (2022)
   PUBMED   35653825
  REMARK    GeneRIF: Dipeptidylamino-tripeptidylcarboxypeptidase NEMP3 and DPP3
            (DPP III) are the same protein.
REFERENCE   2  (bases 1 to 2614)
  AUTHORS   Hayes,J.D. and Dinkova-Kostova,A.T.
  TITLE     The Nrf2 regulatory network provides an interface between redox and
            intermediary metabolism
  JOURNAL   Trends Biochem Sci 39 (4), 199-218 (2014)
   PUBMED   24647116
  REMARK    Review article
REFERENCE   3  (bases 1 to 2614)
  AUTHORS   Hirose,J., Hata,T., Kawaoka,C., Ikeura,T., Kitahara,S., Horii,K.,
            Tomida,H., Iwamoto,H., Ono,Y. and Fukasawa,K.M.
  TITLE     Flexibility of the coordination geometry around the cupric ions in
            Cu(II)-rat dipeptidyl peptidase III is important for the expression
            of enzyme activity
  JOURNAL   Arch Biochem Biophys 525 (1), 71-81 (2012)
   PUBMED   22683474
  REMARK    GeneRIF: structure and activity of Cu(II)-rat dipeptidyl peptidase
            III
REFERENCE   4  (bases 1 to 2614)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   5  (bases 1 to 2614)
  AUTHORS   Cicin-Sain,L., Simaga,S., Froebe,A. and Abramic,M.
  TITLE     Central aminopeptidase and serotonin system activities: possible
            relationship
  JOURNAL   Neuropeptides 42 (4), 435-440 (2008)
   PUBMED   18547641
  REMARK    GeneRIF: Results suggest that the upregulation of serotonergic
            activity may be related to a lowered brain dipeptidyl peptidase
            III, alanyl- and arginyl aminopeptidase activity which may have an
            influence on the cleavage of their physiological substrates.
REFERENCE   6  (bases 1 to 2614)
  AUTHORS   Abramic,M., Schleuder,D., Dolovcak,L., Schroder,W., Strupat,K.,
            Sagi,D., Peter-Katalini,J. and Vitale,L.
  TITLE     Human and rat dipeptidyl peptidase III: biochemical and mass
            spectrometric arguments for similarities and differences
  JOURNAL   Biol Chem 381 (12), 1233-1243 (2000)
   PUBMED   11209758
REFERENCE   7  (bases 1 to 2614)
  AUTHORS   Li,Y.H., Maeda,T., Yamane,T. and Ohkubo,I.
  TITLE     Alteration of rat dipeptidyl peptidase III by site-directed
            mutagenesis: cysteine(176) is a regulatory residue for the enzyme
            activity
  JOURNAL   Biochem Biophys Res Commun 276 (2), 553-558 (2000)
   PUBMED   11027512
REFERENCE   8  (bases 1 to 2614)
  AUTHORS   Fukasawa,K., Fukasawa,K.M., Iwamoto,H., Hirose,J. and Harada,M.
  TITLE     The HELLGH motif of rat liver dipeptidyl peptidase III is involved
            in zinc coordination and the catalytic activity of the enzyme
  JOURNAL   Biochemistry 38 (26), 8299-8303 (1999)
   PUBMED   10387075
REFERENCE   9  (bases 1 to 2614)
  AUTHORS   Fukasawa,K., Fukasawa,K.M., Kanai,M., Fujii,S., Hirose,J. and
            Harada,M.
  TITLE     Dipeptidyl peptidase III is a zinc metallo-exopeptidase. Molecular
            cloning and expression
  JOURNAL   Biochem J 329 (Pt 2) (Pt 2), 275-282 (1998)
   PUBMED   9425109
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 26, 2020 this sequence version replaced NM_053748.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D89340.2, BC107673.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 JAXUCZ010000001.1  211657875-211657883 c
            10-284              JAXUCZ010000001.1  211656470-211656744 c
            285-374             JAXUCZ010000001.1  211653440-211653529 c
            375-512             JAXUCZ010000001.1  211652825-211652962 c
            513-587             JAXUCZ010000001.1  211652069-211652143 c
            588-681             JAXUCZ010000001.1  211650708-211650801 c
            682-812             JAXUCZ010000001.1  211646704-211646834 c
            813-943             JAXUCZ010000001.1  211646478-211646608 c
            944-1002            JAXUCZ010000001.1  211646340-211646398 c
            1003-1197           JAXUCZ010000001.1  211645357-211645551 c
            1198-1310           JAXUCZ010000001.1  211645067-211645179 c
            1311-1403           JAXUCZ010000001.1  211644610-211644702 c
            1404-1466           JAXUCZ010000001.1  211643336-211643398 c
            1467-1591           JAXUCZ010000001.1  211643109-211643233 c
            1592-1712           JAXUCZ010000001.1  211642880-211643000 c
            1713-1892           JAXUCZ010000001.1  211641154-211641333 c
            1893-2055           JAXUCZ010000001.1  211636961-211637123 c
            2056-2614           JAXUCZ010000001.1  211634067-211634625 c
FEATURES             Location/Qualifiers
     source          1..2614
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..2614
                     /gene="Dpp3"
                     /note="dipeptidylpeptidase 3"
                     /db_xref="GeneID:114591"
                     /db_xref="RGD:621127"
     exon            1..9
                     /gene="Dpp3"
                     /inference="alignment:Splign:2.1.0"
     exon            10..284
                     /gene="Dpp3"
                     /inference="alignment:Splign:2.1.0"
     CDS             15..2231
                     /gene="Dpp3"
                     /EC_number="3.4.14.4"
                     /note="dipeptidyl-peptidase 3; DPP III; dipeptidyl
                     arylamidase III; dipeptidyl aminopeptidase III; dipeptidyl
                     peptidase III; dipeptidylpeptidase III; enkephalinase B"
                     /codon_start=1
                     /product="dipeptidyl peptidase 3"
                     /protein_id="NP_446200.1"
                     /db_xref="GeneID:114591"
                     /db_xref="RGD:621127"
                     /translation="MADTQYILPNDIGVSSLDCREAFRLLSPTERLYAHHLSRAAWYG
                     GLAVLLQTSPEAPYIYALLSRLFRAQDPDQLRQHALAEGLTEEEYQAFLVYAAGVYSN
                     MGNYKSFGDTKFVPNLPKEKLERVILGSKAAQQHPEEVRSLWQTCGELMFSLEPRLRH
                     LGLGKEGVTTYFSGDCAMEDAKLAQDFLDSQNLSAYNTRLFKVVGQEGKYHYEVRLAS
                     VLNTEPALDSELTSKLKSYEFQGNHFQVTRGDYAPILQKVVEHLEKAKAYAANSHQEQ
                     MLAQYVESFTQGSIEAHKRGSRFWIQDKGPIVESYIGFIESYRDPFGSRGEFEGFVAM
                     VNKDMSAKFERLVASAEQLLKELPWPPAFEKDKFLTPDFTSLDVLTFAGSGIPAGINI
                     PNYDDLRQTEGFKNVSLGNVLAVAYATKREKLTFMEEEDKDLYIRWKGPSFDVQVGLH
                     ELLGHGSGKLFVQDEKGAFNFDQETVINPETGEQIQSWYRSGETWDSKFSTIASSYEE
                     CRAESVGLYLCLNPQVLQIFGFEGTDAEDVIYVNWLNMVRAGLLALEFYTPETANWRQ
                     AHMQARFVILRVLLEAGEGLVTVTPTTGSDGRPDARVHLDRSKIRSVGKPALERFLRR
                     LQVLKSTGDVVAGRALYEGYAAVTDAPPECFLTLRDTVLLRKESRKLIVQPNTRLEGS
                     EVQLVEYEASAAGLIRSFCERFPEDGPELEEVLTQLATADAQFWRDQVQEAPSGQA"
     exon            285..374
                     /gene="Dpp3"
                     /inference="alignment:Splign:2.1.0"
     exon            375..512
                     /gene="Dpp3"
                     /inference="alignment:Splign:2.1.0"
     exon            513..587
                     /gene="Dpp3"
                     /inference="alignment:Splign:2.1.0"
     exon            588..681
                     /gene="Dpp3"
                     /inference="alignment:Splign:2.1.0"
     exon            682..812
                     /gene="Dpp3"
                     /inference="alignment:Splign:2.1.0"
     exon            813..943
                     /gene="Dpp3"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1002
                     /gene="Dpp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1197
                     /gene="Dpp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1310
                     /gene="Dpp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1403
                     /gene="Dpp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..1466
                     /gene="Dpp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1467..1591
                     /gene="Dpp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1592..1712
                     /gene="Dpp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1713..1892
                     /gene="Dpp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1893..2055
                     /gene="Dpp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2056..2614
                     /gene="Dpp3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgcagcagg gctcatggca gatacccagt acatcctgcc caatgacatc ggtgtgtcta
       61 gcctggactg ccgggaggca ttccgcctgc tgtcacccac agagcgcctc tatgcccatc
      121 acctgtctag agccgcttgg tatggaggcc tggctgtgct gctccagaca tctcctgaag
      181 ccccctacat ctatgccctg cttagccgcc tcttccgtgc ccaggaccct gaccagctac
      241 gccaacatgc cctggctgag ggcctgactg aagaagagta tcaggcattc ctggtctacg
      301 ctgcaggggt ctactccaac atgggcaact ataagtcctt cggtgacacc aagtttgtcc
      361 ctaacctgcc caaggaaaag ctggagcgtg tgatccttgg gagtaaggct gcccaacagc
      421 atccagaaga agtcaggagc ctttggcaga cctgtgggga gcttatgttc tccctggaac
      481 caaggcttcg acatcttggg ctggggaagg agggagtcac cacctatttc tctggggatt
      541 gtgccatgga agatgccaag ctggcccagg acttcctgga ctctcagaac ctcagtgcat
      601 acaacacccg gctcttcaag gtggtcggcc aggaagggaa gtaccactat gaggtgcgac
      661 tggcttcagt actcaacaca gaacctgctc tcgactctga gttgacttcc aagctgaaga
      721 gctacgagtt ccaggggaat catttccagg tcacccgtgg ggactatgcc cccatcctcc
      781 agaaggtggt agaacacttg gagaaagcta aggcttatgc agccaatagc caccaggagc
      841 aaatgctggc ccagtatgtg gagagcttca cccagggttc cattgaggcc cataagaggg
      901 gctcccgctt ctggattcag gacaaaggtc ccattgtaga gagttacatt ggcttcattg
      961 agagctaccg tgaccccttt ggctcccgag gagaatttga aggcttcgtg gccatggtaa
     1021 acaaagacat gagtgcaaag ttcgagcggc tggttgcaag tgctgagcag ctgctgaagg
     1081 agctgccttg gcctcctgcc tttgagaagg acaagttcct cacccctgac ttcacttccc
     1141 tggatgtcct tacctttgcc ggctctggca tccctgcagg catcaacatc cccaactatg
     1201 atgacctgag acagacagag ggctttaaga atgtgtctct ggggaatgtg ctggctgtgg
     1261 cctatgccac aaagcgggag aaactcacct tcatggagga agaagacaag gacctgtaca
     1321 tccgctggaa ggggccgtcc tttgatgtgc aggtggggtt acatgagctg ttgggccatg
     1381 gcagcggcaa gctctttgta caggatgaga aaggtgcttt caactttgac caggagacag
     1441 tgatcaaccc agagactggg gagcagatcc agagctggta ccggagtgga gagacatggg
     1501 atagcaaatt tagcaccatt gcctccagct acgaagagtg ccgggctgag agcgtgggcc
     1561 tctacctctg tctcaacccc caagtacttc agatctttgg ctttgaggga actgacgcag
     1621 aagatgtcat ctatgtgaac tggctcaaca tggtccgggc tgggctgttg gctttggagt
     1681 tctacacccc agagacggcc aactggcgac aggcccacat gcaggcccgg tttgtgatcc
     1741 tgagggtttt gctggaagct ggcgaaggac tcgttaccgt cacccccacc acaggctctg
     1801 atgggcgccc agatgcccgt gtccacctgg accgcagcaa gatccggtca gtgggcaaac
     1861 ctgctttgga gcggttcctc cggagactgc aggtgctgaa gtccacaggg gatgtggttg
     1921 cagggcgcgc cctgtacgag ggctatgcgg cggtcactga cgcaccccca gagtgcttcc
     1981 tcactctaag ggacacggta ttgctgcgca aggaatcccg gaagcttatt gtccagccca
     2041 acactcgcct ggaaggctca gaagtgcaac ttgtagagta tgaggcctca gcggctggtc
     2101 tcatccgatc cttctgtgaa cggtttccgg aggatgggcc tgagttggag gaggttctta
     2161 cccagctggc cacagcagat gctcaattct ggagggatca ggtccaggag gccccatctg
     2221 gccaggcttg agaagatctg tgtggactct cccctttcat caaaccaggg ctgtctgtgg
     2281 ccctgaattg tgtttaggag gtgggggaag ggcaggagct cagactttgg tgctacctca
     2341 gctgagggtg gtgatgctaa ccccttccat ttgtcagcac tttccagttt accattatgt
     2401 cctcatttcc tggatctgca ctgccatctg tggtgggagc tcaacagggt gcctagtctg
     2461 gttttccaaa tgggaaggtg gcagttctga gaagtaactg ttctagatcc agcaggtggc
     2521 atgtgacaga gccagggctc aaagcattct caccaaatcc agtgctcttc gtgtattact
     2581 tttatagcca gaaaaataaa tatgacaacc acca
//
