LOCUS       NM_019252                837 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus dolichyl-phosphate mannosyltransferase subunit 2,
            regulatory (Dpm2), mRNA.
ACCESSION   NM_019252
VERSION     NM_019252.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 837)
  AUTHORS   Kwitek,A.E., Gullings-Handley,J., Yu,J., Carlos,D.C., Orlebeke,K.,
            Nie,J., Eckert,J., Lemke,A., Andrae,J.W., Bromberg,S., Pasko,D.,
            Chen,D., Scheetz,T.E., Casavant,T.L., Soares,M.B., Sheffield,V.C.,
            Tonellato,P.J. and Jacob,H.J.
  TITLE     High-density rat radiation hybrid maps containing over 24,000
            SSLPs, genes, and ESTs provide a direct link to the rat genome
            sequence
  JOURNAL   Genome Res 14 (4), 750-757 (2004)
   PUBMED   15060019
REFERENCE   2  (bases 1 to 837)
  AUTHORS   Watanabe,R., Murakami,Y., Marmor,M.D., Inoue,N., Maeda,Y., Hino,J.,
            Kangawa,K., Julius,M. and Kinoshita,T.
  TITLE     Initial enzyme for glycosylphosphatidylinositol biosynthesis
            requires PIG-P and is regulated by DPM2
  JOURNAL   EMBO J 19 (16), 4402-4411 (2000)
   PUBMED   10944123
REFERENCE   3  (bases 1 to 837)
  AUTHORS   Maeda,Y., Tanaka,S., Hino,J., Kangawa,K. and Kinoshita,T.
  TITLE     Human dolichol-phosphate-mannose synthase consists of three
            subunits, DPM1, DPM2 and DPM3
  JOURNAL   EMBO J 19 (11), 2475-2482 (2000)
   PUBMED   10835346
REFERENCE   4  (bases 1 to 837)
  AUTHORS   Maeda,Y., Tomita,S., Watanabe,R., Ohishi,K. and Kinoshita,T.
  TITLE     DPM2 regulates biosynthesis of dolichol phosphate-mannose in
            mammalian cells: correct subcellular localization and stabilization
            of DPM1, and binding of dolichol phosphate
  JOURNAL   EMBO J 17 (17), 4920-4929 (1998)
   PUBMED   9724629
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Dec 5, 2020 this sequence version replaced NM_019252.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FM072414.1, SRR26643288.13169.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                JAXUCZ010000003.1  36253677-36253697
            22-111              JAXUCZ010000003.1  36254003-36254092
            112-214             JAXUCZ010000003.1  36255215-36255317
            215-837             JAXUCZ010000003.1  36255970-36256592
FEATURES             Location/Qualifiers
     source          1..837
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p11"
     gene            1..837
                     /gene="Dpm2"
                     /note="dolichyl-phosphate mannosyltransferase subunit 2,
                     regulatory"
                     /db_xref="GeneID:29640"
                     /db_xref="RGD:2514"
     exon            1..21
                     /gene="Dpm2"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..273
                     /gene="Dpm2"
                     /EC_number="2.4.1.83"
                     /note="dolichol-phosphate (beta-D) mannosyltransferase 2;
                     dolichol-phosphate mannosyltransferase 2; DPM synthase
                     subunit 2; dolichyl-phosphate mannosyltransferase
                     polypeptide 2, regulatory subunit; dolichol-phosphate
                     mannose synthase subunit 2"
                     /codon_start=1
                     /product="dolichol phosphate-mannose biosynthesis
                     regulatory protein"
                     /protein_id="NP_062125.1"
                     /db_xref="GeneID:29640"
                     /db_xref="RGD:2514"
                     /translation="MATGTDQAVGFGLVAVSLIIFTYYTTWVILLPFIDSQHVIHKYF
                     LPRAYAVLLPLAAGLLLLLFVGLFITYVLLKSQKVTKKAQ"
     exon            22..111
                     /gene="Dpm2"
                     /inference="alignment:Splign:2.1.0"
     exon            112..214
                     /gene="Dpm2"
                     /inference="alignment:Splign:2.1.0"
     exon            215..837
                     /gene="Dpm2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggcgaaagg ctggagaaat ggccaccggg acagaccaag cggtgggatt tggccttgtc
       61 gccgttagct tgatcatctt cacctactac accacttggg tgattctttt gccattcatt
      121 gacagccagc atgtcatcca caagtacttc ctgccccgtg cctacgctgt cctcctccca
      181 ttggccgcag gcctcctgct gctcctgttt gtggggttgt tcatcaccta tgtgctgctg
      241 aagagccaga aggtgaccaa gaaggctcag tgaaggtcca gcggggatga ggctgcagag
      301 gccgcctcca catctcctcc agggaaggga ccaagggtca cagcctacaa gacaggctgg
      361 ctgcactgca gccctctttg ggacatgggg ctgcttacga ctcagtttga caaactggaa
      421 ccctctctct ctctcggtca tccttttaga agccgagaag aaggtggggt gggaaacctc
      481 ttgctcactc ccttggggct cagaggctga gcagtgctgg tcctgtccac cccacagtca
      541 aagctccctg tcccttctac ggagttgtgt tctctcacct ccgttctcct gctgtgctga
      601 taggccgagc aggctccagg atgtgtgcag ccttctcgcc tctctgtaca aatcctgtcc
      661 cttcacaagg cagctcttcc gagtctgaca cttccaggct ccatgaggac ttctggaccc
      721 acaaagcctg gggaaagacc gataaacccc agaagcacag gggtgcgtcc aggcagccgc
      781 attagacccc agctggcctg tttgggaaaa cttagaaata aatgttaatc atgtgtt
//
