LOCUS       NM_001394340            1592 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus diphthamide biosynthesis 7 (Dph7), transcript
            variant 1, mRNA.
ACCESSION   NM_001394340 XR_352174
VERSION     NM_001394340.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1592)
  AUTHORS   Carette,J.E., Guimaraes,C.P., Varadarajan,M., Park,A.S.,
            Wuethrich,I., Godarova,A., Kotecki,M., Cochran,B.H., Spooner,E.,
            Ploegh,H.L. and Brummelkamp,T.R.
  TITLE     Haploid genetic screens in human cells identify host factors used
            by pathogens
  JOURNAL   Science 326 (5957), 1231-1235 (2009)
   PUBMED   19965467
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Apr 13, 2021 this sequence version replaced XR_352174.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643287.7281.1,
                                           SRR26643429.10664.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-205               JAXUCZ010000003.1  28168547-28168751
            206-339             JAXUCZ010000003.1  28169123-28169256
            340-427             JAXUCZ010000003.1  28169587-28169674
            428-522             JAXUCZ010000003.1  28171386-28171480
            523-695             JAXUCZ010000003.1  28171955-28172127
            696-765             JAXUCZ010000003.1  28174450-28174519
            766-831             JAXUCZ010000003.1  28174618-28174683
            832-1004            JAXUCZ010000003.1  28175046-28175218
            1005-1592           JAXUCZ010000003.1  28176586-28177173
FEATURES             Location/Qualifiers
     source          1..1592
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p13"
     gene            1..1592
                     /gene="Dph7"
                     /gene_synonym="RGD1304868"
                     /note="diphthamide biosynthesis 7"
                     /db_xref="GeneID:296550"
                     /db_xref="RGD:1304868"
     exon            1..205
                     /gene="Dph7"
                     /gene_synonym="RGD1304868"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..1450
                     /gene="Dph7"
                     /gene_synonym="RGD1304868"
                     /EC_number="3.1.1.97"
                     /note="isoform 1 is encoded by transcript variant 1;
                     diphthine methyltransferase"
                     /codon_start=1
                     /product="diphthine methyltransferase isoform 1"
                     /protein_id="NP_001381269.1"
                     /db_xref="GeneID:296550"
                     /db_xref="RGD:1304868"
                     /translation="MAGSRTGVLRALQAVDTELTADSVEWCPVEGCQHLLACGTYQLR
                     APKDQPAPDGSEPQVRLGRLYLFSFSEDNTAKPLLEVQRRDSSAVLDMKWCHIPVSGH
                     VLLGLANASGSVELLRLMECEKNSYTLQLISSLALDESCLSLSLDWSTGKSVRAREQP
                     LKIISSDSKGQLHLLLLSEGAAQLQLLASWPAHHFEAWIAAFNYWQTELVYSGGDDCL
                     LRGWDTRMLGKPVFTSKRHSMGVCSIQSSPHREHILATGSYDEHVLLWDTRNVRQPLA
                     DVPVQGGVWRLRWHPVHHHLLLAACMHNGFKILNCQKAIEEKQDITVLTSHTMPNSLV
                     YGADWSWLLFHSVKSTPAWSLDQNDVGVKAADHDSLKAAQQLPAPSQEHTVDHHGEGP
                     ARAHSRAELKDPLLPLTEDRKSNSKGSCSPSVKRSGLSRRPSGHNFDSSLLATCSFYD
                     HVLHLWKLETKQT"
     exon            206..339
                     /gene="Dph7"
                     /gene_synonym="RGD1304868"
                     /inference="alignment:Splign:2.1.0"
     exon            340..427
                     /gene="Dph7"
                     /gene_synonym="RGD1304868"
                     /inference="alignment:Splign:2.1.0"
     exon            428..522
                     /gene="Dph7"
                     /gene_synonym="RGD1304868"
                     /inference="alignment:Splign:2.1.0"
     exon            523..695
                     /gene="Dph7"
                     /gene_synonym="RGD1304868"
                     /inference="alignment:Splign:2.1.0"
     exon            696..765
                     /gene="Dph7"
                     /gene_synonym="RGD1304868"
                     /inference="alignment:Splign:2.1.0"
     exon            766..831
                     /gene="Dph7"
                     /gene_synonym="RGD1304868"
                     /inference="alignment:Splign:2.1.0"
     exon            832..1004
                     /gene="Dph7"
                     /gene_synonym="RGD1304868"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1592
                     /gene="Dph7"
                     /gene_synonym="RGD1304868"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagtgactga gggaagtgga gagggagttc cgcgcacgta tctattggtt ctgcctcgat
       61 ggcgggcagc cgtaccgggg ttttgcgagc gctgcaggca gtggacaccg agcttactgc
      121 ggactcggtg gaatggtgcc cggttgaggg ttgccagcat ctgctggcct gcggaaccta
      181 ccagctgcga gcgcccaagg accagcctgc accggatggc agtgagcctc aagttcgttt
      241 aggtcgtctc tacctgttca gcttcagtga ggacaacacg gctaaacctc tgcttgaggt
      301 ccaaagaagg gattcttctg ctgtcctgga catgaaatgg tgccatatcc cagtgtctgg
      361 ccatgtgctt ttaggcttgg caaatgccag tggatctgta gagctgctcc gcctgatgga
      421 atgtgagaag aacagctata ccctgcagct tatatccagc cttgccctgg atgagagctg
      481 tctatcctta tcactggatt ggtccactgg gaaatctgta agggccagag agcagccgtt
      541 gaagatcatt agcagtgact ctaaggggca gctgcacctc ctgctgctga gtgagggcgc
      601 agctcaacta cagctgctgg cttcttggcc agcccatcac tttgaggcct ggatcgctgc
      661 tttcaattac tggcagaccg aacttgtata ttcaggggga gatgactgcc ttctgagagg
      721 ctgggacact aggatgctgg gcaagcctgt cttcactagc aaaagacact ccatgggcgt
      781 gtgcagcatc cagagcagcc cccatcggga gcacatcctg gctaccggaa gctatgatga
      841 gcatgttctg ctgtgggaca ctcggaatgt aagacaaccg ttggcagatg tgccagtgca
      901 aggaggcgtg tggcggctca ggtggcaccc ggtccaccac catctactcc tggcggcctg
      961 catgcacaac ggcttcaaga tcctcaactg ccagaaggcc atcgaggaga agcaggacat
     1021 aactgttcta acctcccaca cgatgcctaa ctcattagtg tatggggctg actggtcctg
     1081 gcttcttttc cactccgtga agtccacacc tgcctggtcc ttggatcaaa atgacgtggg
     1141 agtcaaagca gcagaccacg atagcctgaa ggctgcacag cagctgccag ccccttctca
     1201 ggagcacaca gtggatcacc acggggaagg ccctgcgaga gctcacagca gagcggaact
     1261 gaaggatcct ctgcttccac taacagagga caggaagagc aacagcaaag gatcctgctc
     1321 accctcagtc aagaggagtg gtcttagccg ccgccctagt ggacacaact ttgacagcag
     1381 cctcctggcc acctgctcct tttatgacca tgttctccac ctttggaagt tggagacaaa
     1441 gcaaacctga ggctgcactc tttgcaggga tactggatgt gatctgggga gtgctggcca
     1501 ttgagaatgg tctctgtgat gctgtcgtgg cagtgagtgg gattttctag ctctaataaa
     1561 gtgtcttggg tatattttta ttttcagctc tt
//
