LOCUS       NM_001014181            2512 bp    mRNA    linear   ROD 05-DEC-2024
DEFINITION  Rattus norvegicus diphthamine biosynthesis 6 (Dph6), mRNA.
ACCESSION   NM_001014181 XM_342492
VERSION     NM_001014181.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2512)
  AUTHORS   Hasson,S.A., Kane,L.A., Yamano,K., Huang,C.H., Sliter,D.A.,
            Buehler,E., Wang,C., Heman-Ackah,S.M., Hessa,T., Guha,R.,
            Martin,S.E. and Youle,R.J.
  TITLE     High-content genome-wide RNAi screens identify regulators of parkin
            upstream of mitophagy
  JOURNAL   Nature 504 (7479), 291-295 (2013)
   PUBMED   24270810
REFERENCE   2  (bases 1 to 2512)
  AUTHORS   Su,X., Lin,Z., Chen,W., Jiang,H., Zhang,S. and Lin,H.
  TITLE     Chemogenomic approach identified yeast YLR143W as diphthamide
            synthetase
  JOURNAL   Proc Natl Acad Sci U S A 109 (49), 19983-19987 (2012)
   PUBMED   23169644
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC087148.1.
            
            On Apr 20, 2005 this sequence version replaced XM_342492.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087148.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2512
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q35"
     gene            1..2512
                     /gene="Dph6"
                     /gene_synonym="Atpbd4; RGD1310006"
                     /note="diphthamine biosynthesis 6"
                     /db_xref="GeneID:362191"
                     /db_xref="RGD:1310006"
     exon            1..70
                     /gene="Dph6"
                     /gene_synonym="Atpbd4; RGD1310006"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..851
                     /gene="Dph6"
                     /gene_synonym="Atpbd4; RGD1310006"
                     /EC_number="6.3.1.14"
                     /note="ATP-binding domain-containing protein 4;
                     diphthamide synthase; diphthamide synthetase; ATP binding
                     domain 4; protein DPH6 homolog"
                     /codon_start=1
                     /product="diphthine--ammonia ligase"
                     /protein_id="NP_001014203.1"
                     /db_xref="GeneID:362191"
                     /db_xref="RGD:1310006"
                     /translation="MRVAALISGGKDSCYNMMRCIAEGHQIVALANLRPDDNQVESDE
                     LDSYMYQTVGHHAIDLYAEAMALPLYRRTIRGRSLETGRVYTRCEGDEVEDLYELLKL
                     VKEKEEIEGVSVGAILSDYQRVRVENVCKRLNLQPLAYLWQRNQEDLLREMIASNIEA
                     IIIKVAALGLDPDKHLGKTLGEMEPYLLELSKKYGVHVCGEGGEYETFTLDCPLFKKK
                     IVVDTSEAVIHSADAFAPVAYLRLSGLHLEEKVSSVPGDDETTSYIHNS"
     exon            71..165
                     /gene="Dph6"
                     /gene_synonym="Atpbd4; RGD1310006"
                     /inference="alignment:Splign:2.1.0"
     exon            166..359
                     /gene="Dph6"
                     /gene_synonym="Atpbd4; RGD1310006"
                     /inference="alignment:Splign:2.1.0"
     exon            360..433
                     /gene="Dph6"
                     /gene_synonym="Atpbd4; RGD1310006"
                     /inference="alignment:Splign:2.1.0"
     exon            434..552
                     /gene="Dph6"
                     /gene_synonym="Atpbd4; RGD1310006"
                     /inference="alignment:Splign:2.1.0"
     exon            553..614
                     /gene="Dph6"
                     /gene_synonym="Atpbd4; RGD1310006"
                     /inference="alignment:Splign:2.1.0"
     exon            615..709
                     /gene="Dph6"
                     /gene_synonym="Atpbd4; RGD1310006"
                     /inference="alignment:Splign:2.1.0"
     exon            710..797
                     /gene="Dph6"
                     /gene_synonym="Atpbd4; RGD1310006"
                     /inference="alignment:Splign:2.1.0"
     exon            798..2486
                     /gene="Dph6"
                     /gene_synonym="Atpbd4; RGD1310006"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggcctggc gtctgtggtg accgcacgca cgctcactga gctcagaatg agggtcgcag
       61 ccctgatcag tggtgggaag gacagctgtt acaacatgat gcggtgcatt gccgaggggc
      121 accaaattgt tgcattagca aatctaagac cagatgacaa ccaagtggag tcagatgaac
      181 tggatagcta catgtatcag acagtgggtc accatgccat tgacttgtat gctgaggcaa
      241 tggccctgcc cctgtatcgc agaaccatca gaggaaggag cttggagacg ggaagagtgt
      301 ataccagatg tgaaggtgat gaggttgaag atctctatga actattaaag ctcgttaagg
      361 aaaaagaaga aatagaaggg gtatcagtag gtgctatact ttctgactat cagcgtgtac
      421 gagtagaaaa tgtatgtaaa cgactcaatc tccagccttt agcttacctt tggcagagaa
      481 accaggaaga tttgctccga gagatgatag catctaatat cgaggctatt atcatcaaag
      541 tagcagcttt gggcttggat cctgataagc atcttggaaa aaccctgggt gaaatggaac
      601 cttatctttt agagctctcc aagaagtatg gtgtccatgt gtgtggagaa ggtggggagt
      661 atgagacgtt cacattggac tgccctctgt tcaagaagaa gatcgttgtg gacacttctg
      721 aggcagtcat ccattcagcc gatgcatttg cacctgtggc ttatctgcgg ctctcagggc
      781 tgcacttgga agagaaggtg tcttcagtac ctggggatga tgaaacaact agttatatac
      841 acaattctta atatttatac tgcattttaa aaattattat gacctacttt tctttttaca
      901 atttttaatt cttaaaaaat attggaaaca ttgaataatt gggagaattt cagtgaactc
      961 ttctctgatt ttgccatttc ttcaacttgc tttcttctac aaacataatt tattttttat
     1021 tcctattaga ttattattat atcacccatc actttcctca gaaccctact atatacccct
     1081 ccttgctcct tttcaaattt atggacacca ttttcattac tgttgttata aaaccctctc
     1141 actgtgtctc actctctgtc tctgcactct cctcctccca cgccttacac acacacacac
     1201 acacacacac acacacacac acacacacac acactttcct aaatacataa atacaacctg
     1261 tccagactgt atagcattgc ctatattgtg ttgtcagggt tggccatttg ctgttggata
     1321 accaagtggt atgctcttcc cccatgggtt ttcccatcca ctttagcatg tccgtcagtg
     1381 ccctcactgt ttagctcatg tttagggagc catgataagc cttcacgggt gcagtttctg
     1441 aggctcctgg gagaagcaaa ctccctggtc ctctggctct cacagtcctc tctccccttt
     1501 actctcatgt tgggaactag tctcttggcc tttgtgtggc gggcccctgt atttcctttg
     1561 attcctctcc agccctcttc atttagcatt tccttgtcat acttttttct cccctctttt
     1621 tcccacccca tgtcctgaaa agaggtatca gaaaatgaag accctgatct ttgtacttag
     1681 ctcattgtaa tcacgtgtca ttgtaatcac gtgtcactgc agtaatttct cttttctatt
     1741 tttttatata atcattcaaa atgttattca tcattggata attagaaaga ttatcataag
     1801 tggctggtta ttttatgatt gattttaaag aaattttaag tatcacttat gaatacctaa
     1861 tatatatttt tttaaaaact atttttctag aataatttta tgttcactgc aaaactgaat
     1921 ggaaaagcac aaagtgccca tgcttatttt ttgtgccact ggaacaccat ctgcctcata
     1981 tcggcatact ataccagaga ggtattttgt aactgataaa ccctcgttgc tagatcctta
     2041 tcaaaggtgc atctttaacc agaaatggtg gttgcccctg taattccaga acttgagaag
     2101 ttgaagcagg agctgtgctg tgagatgtgg cctggatcac cttgtctcaa aaacaaacaa
     2161 aaacatcata gtttgtacaa agtctcacaa ttgtggtttt acattccatg ggatttaaca
     2221 aatgttcaaa accgtagatg catcgttatc cccctataac acaatagttc tgctgtctta
     2281 ataatcctgt gtgctccacc tattcatcct tctgtctgct ccagcccctc cctggcaacc
     2341 actgatctct ctgctctcta gttttgcaac tttgaggata tcatgtggta gcaatcctta
     2401 acttattagt acgtgttttg attcccttgt ttctcattat ggttgtttct actttttgtc
     2461 gagtatgaat aaagctgcta tcaataaaaa aaaaaaaaaa aaaaaaaaaa aa
//
