LOCUS       NM_001017449            1572 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus diphthamide biosynthesis 5 (Dph5), mRNA.
ACCESSION   NM_001017449 XM_215691
VERSION     NM_001017449.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1572)
  AUTHORS   Moehring,J.M. and Moehring,T.J.
  TITLE     The post-translational trimethylation of diphthamide studied in
            vitro
  JOURNAL   J Biol Chem 263 (8), 3840-3844 (1988)
   PUBMED   3346227
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC092598.1.
            
            On Apr 29, 2005 this sequence version replaced XM_215691.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC092598.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132304, SAMEA5760384
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1572
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q42"
     gene            1..1572
                     /gene="Dph5"
                     /gene_synonym="CGI-30; RGD1307867"
                     /note="diphthamide biosynthesis 5"
                     /db_xref="GeneID:295394"
                     /db_xref="RGD:1307867"
     exon            1..300
                     /gene="Dph5"
                     /gene_synonym="CGI-30; RGD1307867"
                     /inference="alignment:Splign:2.1.0"
     exon            301..458
                     /gene="Dph5"
                     /gene_synonym="CGI-30; RGD1307867"
                     /inference="alignment:Splign:2.1.0"
     CDS             324..1169
                     /gene="Dph5"
                     /gene_synonym="CGI-30; RGD1307867"
                     /EC_number="2.1.1.98"
                     /note="diphthine synthase; DPH5 homolog"
                     /codon_start=1
                     /product="diphthine methyl ester synthase"
                     /protein_id="NP_001017449.1"
                     /db_xref="GeneID:295394"
                     /db_xref="RGD:1307867"
                     /translation="MLYLIGLGLGDAKDITVKGLEVVRRCSRVYLEAYTSVLTVGKEA
                     LEEFYGRKLILADREEVEQEADNIFKDADVSDVAFLVVGDPFGATTHSDLILRATKLG
                     IPYQVIHNASIMNAVGCCGLQLYRFGETVSIVFWTDTWRPESFFDKVKKNRENGMHTL
                     CLLDIKVKEQSLENLIRGRKIYEPPRYMSVNQAAQQLLEIVQNHRARGEAPAITEETL
                     CVGLARVGAEDQKIAAGTLQQMCTVSLGEPLHSLVITGGNLHPLEMEMLSLFSIPESQ
                     STDGL"
     exon            459..583
                     /gene="Dph5"
                     /gene_synonym="CGI-30; RGD1307867"
                     /inference="alignment:Splign:2.1.0"
     exon            584..692
                     /gene="Dph5"
                     /gene_synonym="CGI-30; RGD1307867"
                     /inference="alignment:Splign:2.1.0"
     exon            693..813
                     /gene="Dph5"
                     /gene_synonym="CGI-30; RGD1307867"
                     /inference="alignment:Splign:2.1.0"
     exon            814..853
                     /gene="Dph5"
                     /gene_synonym="CGI-30; RGD1307867"
                     /inference="alignment:Splign:2.1.0"
     exon            854..957
                     /gene="Dph5"
                     /gene_synonym="CGI-30; RGD1307867"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1543
                     /gene="Dph5"
                     /gene_synonym="CGI-30; RGD1307867"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgctgggtcg gttaaggaag tccctctagc tttcctggca agcgtgcatc tggaggacgt
       61 ttgggagcta ccgtcatcga cccggacgcc cttggggatg tttgagccct gtatcgccgg
      121 gagcgtgggc acgctgggtc ctttccagac acacagctgg acccattcct gacccttgac
      181 ccctgctcta gcgtctgcaa gtccgggcgg gccttggcgg gacgcgatcg ctcgctgctg
      241 gaaccgcaat cctcctgcca gtcgtaaagt gctgtaaagg gctctgcgct ttacggcgcc
      301 tctccccctc cctggagttc ggaatgcttt acttgatcgg cttgggcctg ggagatgcca
      361 aggacatcac agtcaagggc ctggaagttg tgagacgctg cagtcgcgtg tatctggaag
      421 cctacacctc agtcctgact gtagggaagg aagccctgga agaattttat ggaagaaaat
      481 tgattcttgc tgacagagaa gaagtagaac aagaagcaga taatattttt aaggatgcag
      541 atgtcagtga tgttgcattc ctcgtggttg gtgatccatt cggggctaca acacacagtg
      601 atcttattct gagagcaacg aagttgggca tcccttatca agttattcac aatgcctcca
      661 taatgaacgc tgtaggctgc tgtggtttac agttgtacag gtttggagaa acagtttcta
      721 ttgttttttg gacggacact tggagaccag agagcttctt tgacaaggtg aagaagaacc
      781 gagaaaatgg catgcacact ttgtgcttac ttgatatcaa ggtgaaggag cagtctctgg
      841 agaacctcat caggggaagg aagatctatg aacctcctcg ttacatgagt gtgaaccagg
      901 cagcacagca gctcctagaa attgttcaaa atcacagagc acgtggggag gcaccagcaa
      961 tcactgagga gacactctgt gtcggcttag ccagagttgg agcggaagac cagaaaattg
     1021 cagcaggcac tttacagcaa atgtgtacag tgagcttggg agaaccattg cattctttgg
     1081 tcattacagg gggcaacctg cacccactgg agatggaaat gctaagtctc ttctctatac
     1141 cggaatccca gagtactgat ggactctgaa catggacatt ttctgttctc acaataattt
     1201 ccgttagatg ggggtctgtg tgatatttat atgacaaatg gcatggttct gccatttatg
     1261 aagaaactag aacagaagtg accaagaaga agcaggttga gcgactgcat ttggtttcct
     1321 gcagcagctt cccgcctccc accatgagtt gtggcgtcag ttggctactt gtgggggttt
     1381 acacatgggc agaccaaact ggaaaagtga aacaagtcaa tgcaaggagg ttgggaccaa
     1441 gaataatgtg aggaaattag acaatgaatc acttgagctc tgtgtttcag ggacaaagca
     1501 gcatgaatca gaaagaaaag caaataaaag attgctaact cttaaaaaaa aaaaaaaaaa
     1561 aaaaaaaaaa aa
//
