LOCUS       NM_001015007            2192 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus diphthamide biosynthesis 2 (Dph2), mRNA.
ACCESSION   NM_001015007 XM_233439
VERSION     NM_001015007.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2192)
  AUTHORS   Zhang,Y., Zhu,X., Torelli,A.T., Lee,M., Dzikovski,B.,
            Koralewski,R.M., Wang,E., Freed,J., Krebs,C., Ealick,S.E. and
            Lin,H.
  TITLE     Diphthamide biosynthesis requires an organic radical generated by
            an iron-sulphur enzyme
  JOURNAL   Nature 465 (7300), 891-896 (2010)
   PUBMED   20559380
  REMARK    Erratum:[Nature. 2011 May 26;473(7348):544]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC092656.1.
            
            On Apr 20, 2005 this sequence version replaced XM_233439.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC092656.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2192
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2192
                     /gene="Dph2"
                     /gene_synonym="Dph2l2"
                     /note="diphthamide biosynthesis 2"
                     /db_xref="GeneID:298452"
                     /db_xref="RGD:1304634"
     exon            1..235
                     /gene="Dph2"
                     /gene_synonym="Dph2l2"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..1558
                     /gene="Dph2"
                     /gene_synonym="Dph2l2"
                     /EC_number="2.5.1.108"
                     /note="diphthamide biosynthesis protein 2; diptheria toxin
                     resistance protein required for diphthamide biosynthesis
                     (Saccharomyces)-like 2; diphtheria toxin resistance
                     protein 2; DPH2 homolog;
                     S-adenosyl-L-methionine:L-histidine
                     3-amino-3-carboxypropyltransferase 2"
                     /codon_start=1
                     /product="2-(3-amino-3-carboxypropyl)histidine synthase
                     subunit 2"
                     /protein_id="NP_001015007.1"
                     /db_xref="GeneID:298452"
                     /db_xref="RGD:1304634"
                     /translation="MESTFSSPAEAALQREAGVPGQFTPPEDLDRVYELERVTRFICD
                     LGCQRVALQFPDQLLGDAGAVAARLEEVTGSKMFILGDTAYGSCCVDVLGAEQAGAQA
                     LVHFGPACLSPPASLLPITFVLGRRPVALELCAKAFEAQNPDPTALVVLLSEPACAHA
                     LEPLATLLRPKYQDLLISSPALPLPVGSLSSQPESLERFGRRFPLNPGRSLEEYGAFY
                     VGASQASSDPNLDPDLSRLLLGWTPGRPFFSCCPDTGQTQDQGAKAGRLRARRLYLVE
                     RARDARVVGLLVGTLGVAQHLEALAHLRKLTEAAGKRSYVLALGKPTPAKLANFPEMD
                     VFVLLACPLGALTLQPSGGFFRPILTPCELEAACNPAWPPPGLAPHLTHYAELLPGSP
                     FHVPLPPPESELWDTPDVSLISGELRPPPPWKSSDDTKCSALTPRPQLELAESSPAAS
                     FLSSRSWQGLEPRLGQTPVKEAVQGRRGIAIAYEDEGSS"
     exon            236..348
                     /gene="Dph2"
                     /gene_synonym="Dph2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            349..572
                     /gene="Dph2"
                     /gene_synonym="Dph2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            573..1256
                     /gene="Dph2"
                     /gene_synonym="Dph2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1433
                     /gene="Dph2"
                     /gene_synonym="Dph2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..2163
                     /gene="Dph2"
                     /gene_synonym="Dph2l2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacacgttgg tcccgatcca caaagctgct gtgacctcga ggactttgga gggcacagct
       61 gcgtctcgcc ccatccaagc tgcgccccat ggagtctacc ttcagcagtc ccgcggaggc
      121 ggccctgcaa cgggaggcgg gcgttccagg acagttcacc cctcctgaag acctggaccg
      181 agtgtacgag ctggagcgag tcacgagatt tatctgcgat ttaggatgtc agcgggtggc
      241 cttgcagttc ccggaccaat tactaggaga tgctggagcg gtggctgccc ggctggagga
      301 agtcacggga tctaagatgt tcattttagg ggacacagct tatggcagct gctgtgtgga
      361 tgtgctgggc gctgagcagg ctggagctca agcccttgta cactttggtc ctgcctgctt
      421 gagcccccca gcctccctgc tgcccatcac ctttgtcctt ggtcggcgtc ctgttgcttt
      481 agaactctgt gcaaaggcct ttgaagccca gaacccagat cccacagcac tggtagtact
      541 gctgagtgag ccagcctgtg cccacgccct cgagcctttg gccactctcc tgcgtccaaa
      601 gtaccaagat ctgctcatct ccagcccagc tctgcccttg ccagtggggt ccctgagctc
      661 acagcccgag tcactggaac gttttgggag acgcttcccc ctgaacccag ggagaagtct
      721 ggaagaatat ggcgccttct atgtgggggc ttctcaagca agctctgacc ccaaccttga
      781 tccggatctg agcagattgc tcttggggtg gacaccagga cggcccttct tctcctgttg
      841 tccagacaca ggacagacac aagaccaggg tgccaaggct gggagactaa gagcacgaag
      901 actgtatctt gtagagaggg ccagagatgc ccgtgtggta gggctgctgg tgggcacatt
      961 aggtgtggct caacacctgg aggcgctggc acacttgcgg aaactgaccg aagctgctgg
     1021 gaaacgtagc tatgtgttag ccctggggaa gcccacacct gccaagcttg ccaacttccc
     1081 cgagatggat gtctttgtgc tgttagcatg tcctctggga gcactaaccc tccagccttc
     1141 gggtggcttc ttccggccta tattgacacc atgtgagttg gaggccgcct gcaaccctgc
     1201 ctggccccct ccaggcctgg ctccccacct cacccattat gcagagctgt tgcctggctc
     1261 tcccttccat gtgccactcc caccacctga gtcagagtta tgggacaccc cagatgtgtc
     1321 gctcatttct ggggagctcc gaccgccacc tccttggaag tcgtcagatg acactaagtg
     1381 ttctgcccta actccaaggc cccagctgga gctggccgag agcagccctg cggcttcatt
     1441 ccttagttcc cggagctggc aggggctgga gccccgcttg ggccagacac cagtgaaaga
     1501 agctgtccaa gggagacgag gtattgccat tgcctatgaa gatgagggaa gcagctgatc
     1561 accgtgtgtg gccagagtcg cagagtgatg agtcagctgg tgcttgttct ccctaaacca
     1621 gcttctcttc tcactgggat acttgatgcc tagacagagg gagtgtaggt agcttctccc
     1681 tgaggagctg tctagcctgt gctggtgctg actcagcaca tcagtgcagt aaatgcctgt
     1741 acgactggtg ggcggggagg gggctcagga aggggtccca gggccctcct ggacccaact
     1801 gtcagcagtc caggactgtg gctgtcccag ttcctggtat acaggagtag ttctgccctt
     1861 ggtcaggggc aggagtggat gatccagacc atggttcttc tacctcagca ctgttaacag
     1921 ttcgggtaga ataattcttt atttcagagg ctattctgta tagagaagga tgtttaggtt
     1981 cagctgacag aagcacctcc cttcctccct ccccgtcccc ccagctagat aacgcagatt
     2041 atctagatgt tggcagatgt catgtaactg ctcctgattg agaaccactg gtctagacct
     2101 gcactgtcca agacagtatt cattggacac atggccttta ccattaaagt gaatgaaaaa
     2161 ctgaaaaaaa aaaaaaaaaa aaaaaaaaaa aa
//
