LOCUS       NM_053591               1580 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus dipeptidase 1 (Dpep1), mRNA.
ACCESSION   NM_053591
VERSION     NM_053591.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1580)
  AUTHORS   Cui,X., Liu,X., Han,Q., Zhu,J., Li,J., Ren,Z., Liu,L., Luo,Y.,
            Wang,Z., Zhang,D., Fan,Y., Zhang,D. and Dong,G.
  TITLE     DPEP1 is a direct target of miR-193a-5p and promotes hepatoblastoma
            progression by PI3K/Akt/mTOR pathway
  JOURNAL   Cell Death Dis 10 (10), 701 (2019)
   PUBMED   31541079
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1580)
  AUTHORS   Choudhury,S.R., Babes,L., Rahn,J.J., Ahn,B.Y., Goring,K.R.,
            King,J.C., Lau,A., Petri,B., Hao,X., Chojnacki,A.K.,
            Thanabalasuriar,A., McAvoy,E.F., Tabaries,S., Schraeder,C.,
            Patel,K.D., Siegel,P.M., Kopciuk,K.A., Schriemer,D.C., Muruve,D.A.,
            Kelly,M.M., Yipp,B.G., Kubes,P., Robbins,S.M. and Senger,D.L.
  TITLE     Dipeptidase-1 Is an Adhesion Receptor for Neutrophil Recruitment in
            Lungs and Liver
  JOURNAL   Cell 178 (5), 1205-1221 (2019)
   PUBMED   31442408
REFERENCE   3  (bases 1 to 1580)
  AUTHORS   Toiyama,Y., Inoue,Y., Yasuda,H., Saigusa,S., Yokoe,T., Okugawa,Y.,
            Tanaka,K., Miki,C. and Kusunoki,M.
  TITLE     DPEP1, expressed in the early stages of colon carcinogenesis,
            affects cancer cell invasiveness
  JOURNAL   J Gastroenterol 46 (2), 153-163 (2011)
   PUBMED   20824289
REFERENCE   4  (bases 1 to 1580)
  AUTHORS   Camano,S., Lazaro,A., Moreno-Gordaliza,E., Torres,A.M., de
            Lucas,C., Humanes,B., Lazaro,J.A., Milagros Gomez-Gomez,M.,
            Bosca,L. and Tejedor,A.
  TITLE     Cilastatin attenuates cisplatin-induced proximal tubular cell
            damage
  JOURNAL   J Pharmacol Exp Ther 334 (2), 419-429 (2010)
   PUBMED   20435919
REFERENCE   5  (bases 1 to 1580)
  AUTHORS   Pare,G., Chasman,D.I., Parker,A.N., Zee,R.R., Malarstig,A.,
            Seedorf,U., Collins,R., Watkins,H., Hamsten,A., Miletich,J.P. and
            Ridker,P.M.
  TITLE     Novel associations of CPS1, MUT, NOX4, and DPEP1 with plasma
            homocysteine in a healthy population: a genome-wide evaluation of
            13 974 participants in the Women's Genome Health Study
  JOURNAL   Circ Cardiovasc Genet 2 (2), 142-150 (2009)
   PUBMED   20031578
REFERENCE   6  (bases 1 to 1580)
  AUTHORS   Keynan,S., Habgood,N.T., Hooper,N.M. and Turner,A.J.
  TITLE     Site-directed mutagenesis of conserved cysteine residues in porcine
            membrane dipeptidase. Cys 361 alone is involved in disulfide-linked
            dimerization
  JOURNAL   Biochemistry 35 (38), 12511-12517 (1996)
   PUBMED   8823187
REFERENCE   7  (bases 1 to 1580)
  AUTHORS   Mori,M., Hikida,M., Nishihara,T., Nasu,T. and Mitsuhashi,S.
  TITLE     Comparative stability of carbapenem and penem antibiotics to human
            recombinant dehydropeptidase-I
  JOURNAL   J Antimicrob Chemother 37 (5), 1034-1036 (1996)
   PUBMED   8737157
REFERENCE   8  (bases 1 to 1580)
  AUTHORS   Keynan,S., Hooper,N.M. and Turner,A.J.
  TITLE     Directed mutagenesis of pig renal membrane dipeptidase. His219 is
            critical but the DHXXH motif is not essential for zinc binding or
            catalytic activity
  JOURNAL   FEBS Lett 349 (1), 50-54 (1994)
   PUBMED   8045301
REFERENCE   9  (bases 1 to 1580)
  AUTHORS   Adachi,H., Ishida,N. and Tsujimoto,M.
  TITLE     Primary structure of rat renal dipeptidase and expression of its
            mRNA in rat tissues and COS-1 cells
  JOURNAL   Biochim Biophys Acta 1132 (3), 311-314 (1992)
   PUBMED   1420313
REFERENCE   10 (bases 1 to 1580)
  AUTHORS   Campbell,B.J., Forrester,L.J., Zahler,W.L. and Burks,M.
  TITLE     Beta-lactamase activity of purified and partially characterized
            human renal dipeptidase
  JOURNAL   J Biol Chem 259 (23), 14586-14590 (1984)
   PUBMED   6334084
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC072476.1.
            
            On Jun 3, 2007 this sequence version replaced NM_053591.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC072476.1, L07315.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1580
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..1580
                     /gene="Dpep1"
                     /note="dipeptidase 1"
                     /db_xref="GeneID:94199"
                     /db_xref="RGD:620324"
     exon            1..96
                     /gene="Dpep1"
                     /inference="alignment:Splign:2.1.0"
     exon            97..255
                     /gene="Dpep1"
                     /inference="alignment:Splign:2.1.0"
     CDS             152..1384
                     /gene="Dpep1"
                     /EC_number="3.4.13.19"
                     /EC_number="3.5.2.6"
                     /note="renal dipeptidase; microsomal dipeptidase;
                     dipeptidase 1 (renal); beta-lactamase"
                     /codon_start=1
                     /product="dipeptidase 1 precursor"
                     /protein_id="NP_446043.1"
                     /db_xref="GeneID:94199"
                     /db_xref="RGD:620324"
                     /translation="MLIIWWFWSLLAICASDSFRNQAENIMRTTPVIDGHNDLPWQML
                     TLFNNQLRKSEANLSALAETHTNIPKLRAGFVGGQFWSAYMPCDTQNKDAVKRILEQI
                     DVIHRMCQLYPETFECVTNSSDILQAFRRGKVASLIGVEGGHLIDSSLGVLRTLYHLG
                     MRYLTLTHNCNTPWADNWLVDKGDDEAESQGLSPFGKLVLNEMNRLGVMIDLSHVSVA
                     TMKDALQLSKAPVIFSHSSAYSVCPHRRNVPDDVLQLVKSTNSLVMVNFYNQFVSCSD
                     SATLSQVADHLDHIKKVAGAGAVGLGGDYDGVTNLPVGLEDVSKYPDLIAELLRRNWT
                     ETEVRGLLAENLLRVFSAVELVSNIMQVPEEETIPVEKLDGSCRTFYGHSRAPSIHLQ
                     IGALLASLASLVFSLHLL"
     exon            256..388
                     /gene="Dpep1"
                     /inference="alignment:Splign:2.1.0"
     exon            389..521
                     /gene="Dpep1"
                     /inference="alignment:Splign:2.1.0"
     exon            522..672
                     /gene="Dpep1"
                     /inference="alignment:Splign:2.1.0"
     exon            673..742
                     /gene="Dpep1"
                     /inference="alignment:Splign:2.1.0"
     exon            743..919
                     /gene="Dpep1"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1004
                     /gene="Dpep1"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1080
                     /gene="Dpep1"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1216
                     /gene="Dpep1"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1557
                     /gene="Dpep1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttcgaagct ggaggactga ggagcaggct gtctctctct gggtttcagc cgcaggactg
       61 aagccacctt ctcacccctg acctgcgtgt gctgtggcca ccacggaggt gtcaaggcag
      121 ctgtggaagc agatccctga ggaaccttga aatgttgatc atctggtggt tctggtctct
      181 gctggccatc tgtgcttctg actccttccg gaaccaggcg gagaacatca tgagaaccac
      241 accggtcatt gacgggcaca acgacttgcc ttggcaaatg ctcactctgt tcaacaatca
      301 gctccggaaa tcagaggcca acctgagcgc gctagcggaa acacacacca acatccccaa
      361 gctgagggct ggcttcgtgg gaggccagtt ctggtccgca tacatgcctt gtgacaccca
      421 aaacaaagat gccgtgaaaa gaatattgga acagattgat gtcatacatc gcatgtgcca
      481 gctctatcct gagaccttcg agtgtgtcac caatagttca gacatcctac aggcgtttcg
      541 gagggggaaa gtggccagtc tgattggcgt ggaaggtggc cacttgattg acagcagcct
      601 gggtgttctg cggacactct accatctggg catgcggtac ctgaccctta cgcacaactg
      661 caacacaccc tgggccgaca attggctagt ggacaaagga gacgacgagg ctgagagcca
      721 aggactgtcg ccctttggga agcttgtgct gaatgagatg aaccgtctgg gtgtcatgat
      781 tgacttgtcc cacgtgtctg tggccaccat gaaggacgct ttgcagctat ccaaggcacc
      841 ggtaatcttc agccactcct ctgcctacag cgtgtgtcca cacaggcgga atgtgcctga
      901 cgatgtgctg cagctggtga agagcacaaa cagtttggtg atggtgaact tctataacca
      961 gttcgtgtcc tgctcagaca gcgccacctt gtcccaagtg gctgaccacc tggaccacat
     1021 caagaaggtg gcaggcgcag gggctgtggg ccttggagga gattatgatg gtgttaccaa
     1081 ccttcctgtg ggactggagg atgtctctaa gtacccagac ctgatagcag agcttctcag
     1141 gaggaactgg acagaaaccg aggtcagagg cctgctggct gaaaacctgc ttcgggtctt
     1201 ctctgcagtg gaactggtaa gcaatatcat gcaagttcct gaggaagaga ctatccctgt
     1261 ggagaagctg gatggctcct gcaggacatt ctatggccac tcaagggccc ccagcatcca
     1321 cttgcagata ggggccctgt tggcctctct ggcttccctg gtcttcagtc tgcatcttct
     1381 gtgacatccc aaggaccaga acctcctcca gtgctctctg agctcaggaa gactgagcag
     1441 gctcaaagtc cctgttgtcc atgccaaacc acatcctttc ctgaagaagc agtgggctta
     1501 cctggggaca gctcaagaca caggcacgca ataaacacaa tgtcctttaa gtgctaaaaa
     1561 aaaaaaaaaa aaaaaaaaaa
//
