LOCUS       XM_039079394            6515 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus DOT1 like histone lysine
            methyltransferase (Dot1l), transcript variant X7, mRNA.
ACCESSION   XM_039079394
VERSION     XM_039079394.1
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051342.1) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6515
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /sex="male"
                     /tissue_type="kidney"
                     /geo_loc_name="USA: Wisconsin, Milwaukee, Medical College
                     of Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..6515
                     /gene="Dot1l"
                     /note="DOT1 like histone lysine methyltransferase; Derived
                     by automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 29 ESTs, 1 Protein, and 100% coverage of the annotated
                     genomic feature by RNAseq alignments, including 8 samples
                     with support for all annotated introns"
                     /db_xref="GeneID:362831"
                     /db_xref="RGD:1306644"
     CDS             16..4617
                     /gene="Dot1l"
                     /codon_start=1
                     /product="histone-lysine N-methyltransferase, H3 lysine-79
                     specific isoform X5"
                     /protein_id="XP_038935322.1"
                     /db_xref="GeneID:362831"
                     /db_xref="RGD:1306644"
                     /translation="MVGGGDLPLLWTPLFSCFFQDKHHDAAHEIIETIRWVCEEIPDL
                     KLAMENYVLIDYDTKSFESMQRLCDKYNRAIDSIHQLWKGTTQPMKLNTRPSNGLLRH
                     ILQQVYNHSVTDPEKLNNYEPFSPEVYGETSFDLVAQMIDEIKMTEDDLFVDLGSGVG
                     QVVLQVAAATNCKHHYGVEKADIPAKYAETMDREFRKWMKWYGKKHAEYTLERGDFLS
                     EEWRERIANTSVIFVNNFAFGPEVDHQLKERFANMKEGGRIVSSKPFAPLNFRINSRN
                     LSDIGTIMRVVELSPLKGSVSWTGKPVSYYLHTIDRTILENYFSSLKNPKLREEQEAA
                     RRRQQRENKSNATTPTKVPESKAAATEAPADSGAEEEKSGVATVKKQSPSKARKKKLN
                     KKGRKMAGRKRGRPKKMSAASADRKSKKSQSTLDLLHSPPPAPPSASPQDAYRAPHSP
                     FYQLPPSTPLHSPDPLLVAPTPPALQKLLESFKIQYLQFLAYTKTPQYKANLQQLLDQ
                     EKEKNTQLLGTAQQLFSHCQAQKEEIRRLFQQKLDELGVKALTYNDLIQAQKEISAHN
                     QQLREQSEQLEKDNSELRSQSLRLLRARCEELRLDWSTLSLENLRKEKQALRSQISEK
                     QRHCLELQISIVELEKTQRQQELLQLKSCVPPDDALSLHLRGKGALGRELESDAGRLR
                     LELDCAKLSLPHLSSMSPELSMNGHAASYELCGAASRPSSKQNTPQYLASPLDQEVVP
                     CTPSHSGRPRLEKLSGLALPDYTRLSPAKIVLRRHLSQDHTGASKAATSEPHPRPEHA
                     KENSLPYQSPGLSNSMKLSPQDPPLASPATSPLTSERGSEKGVKERAYSSHGETITSL
                     PVSIPLSTVQPNKLPVSIPLASVVLPSRAERARSTPSPVPQPRDSSSTLEKQIGASTH
                     GAGGAAAGSRSLTVAPTGFYAGSVAISGALASSPAPLASGMESAVFEESSGPSSLFGT
                     MGSRSTPPQHPPLLPQSRNSGPASPAHQLAASPRLSVTTQGSLPDTGKGELPADPAFS
                     DPESEAKRRIVFSISAGASSRQSPSTRHSPLTSGTRGDCVQSHGQDSRKRSRRKRASA
                     GTPSLTTGVSPKRRALPTVAGLFTQSSGSPLNLTSMVSNINQPLEITAISSPESSLKS
                     SPTPYQDHDQPPVLRKERPLGPTNGAHYSPLTSDEEPGSEDEPSSARIERKIATISLE
                     SKSPPKTLENGGGLVGRKPVPSGEPVNSSKWKSTFSPISDLGLAKAMDSPLQASSALS
                     HSPLFSFRPSLEEPAAEAKPSTHPRKSFAGSLAAAEGPSPGTNPPNSLAFSGGLAADL
                     GLHSFNDGASLSHKGPEVAGLSASLSFPSQRGKDSTTEANPFLSRRQPEGLGGLKGEG
                     NASKESGESLPLCGPSDKVSLPHGSRASKGRDRELDFKGGHNLFISAAAVPPGGLLGG
                     PGLVTVASSAGSATPSAQAPRPFLSTFAPGPQFTLGPMSLQANLGSVAGSSVLQSLFS
                     TVPAAAGLVHVSSTATRLTNSHTMGSFSSGVAGGTVGGN"
ORIGIN      
        1 tctccctctg gacccatggt gggtggaggg gacttgcctc tcctctggac cccacttttc
       61 tcttgtttct ttcaggacaa gcaccatgat gctgctcatg agattatcga gactatccga
      121 tgggtctgcg aggaaatccc agatctcaag ctggccatgg agaactatgt cctgatcgac
      181 tacgacacca aaagttttga aagcatgcag aggctgtgtg acaaatataa ccgggccatt
      241 gacagcatcc accagctgtg gaagggcact acacagccca tgaagctcaa tactcggccg
      301 tccaatgggc tcctgcggca catcctgcag caggtgtaca accactctgt gaccgaccca
      361 gagaagctca acaactacga gcccttctcc cccgaggtgt acggggagac ctcctttgac
      421 ctggtggccc agatgatcga tgagatcaag atgaccgagg atgacctgtt tgtagacctg
      481 ggcagtggtg tggggcaggt tgtccttcag gttgcggcgg ccaccaactg caaacatcac
      541 tacggagtgg agaaagcgga catcccagcc aagtacgcgg agaccatgga tcgagagttc
      601 aggaagtgga tgaaatggta tggaaaaaag catgcagaat acacactgga gcgaggtgac
      661 ttcctctcag aggagtggag ggaacggatc gccaacacga gtgttatatt tgtgaataac
      721 tttgcctttg gtcctgaggt ggatcaccag ctgaaggaac gattcgcaaa catgaaggaa
      781 ggcggcagaa tcgtatcctc aaagcccttt gcccctctga acttcaggat caacagcagg
      841 aacttgagtg acattggcac catcatgcgt gtggtggagc tgtcgcccct gaagggctct
      901 gtgtcatgga ctggcaagcc tgtctcctac tacctgcaca ccattgaccg caccatactt
      961 gaaaactatt tttctagtct gaaaaatcca aaactcaggg aggagcagga ggcagctagg
     1021 cgcaggcagc agcgagagaa caagagcaac gcgaccacac ccaccaaagt ccctgagagc
     1081 aaggcagctg ccaccgaggc ccctgcggat tctggtgctg aggaagaaaa atcaggtgtg
     1141 gccaccgtca aaaagcaatc tccctccaaa gcccggaaga agaaactgaa caagaaaggg
     1201 agaaaaatgg ctggccggaa gcgtgggcga cccaagaaaa tgagtgctgc cagtgccgat
     1261 cgcaagtcca agaagagcca aagcacactg gatctcctgc actctccgcc cccagcccca
     1321 ccctcagcct caccccagga tgcatacagg gccccccaca gcccgttcta ccagctacct
     1381 ccgagcacgc cgctgcactc gcccgaccca ctgctagtgg ctcccacccc acccgcgctg
     1441 cagaagctgt tagagtcctt caagatccag tacctgcagt tcctggccta cacgaagacc
     1501 ccgcagtaca aggccaacct gcagcagctt ctggaccagg agaaggagaa gaacacacaa
     1561 ctgctgggta cagcccagca gctcttcagc cattgccagg cacaaaagga agagatccgc
     1621 aggctgttcc agcagaagct ggatgagttg ggcgtgaagg cactgaccta caatgacctg
     1681 attcaggccc agaaggaaat ctctgcccac aaccagcagc tgcgggagca gtcggaacag
     1741 ctggagaagg acaacagcga gcttcggagc cagagcctgc ggctgctcag ggcccggtgc
     1801 gaagagctga ggcttgactg gtccaccttg tccctggaga acctgcggaa agagaagcag
     1861 gccctgcgga gccagatctc agagaagcag cggcactgcc tagagctgca gatcagcatc
     1921 gtggagctgg agaagaccca gcgccagcag gagctcctgc agttgaagtc ctgtgtgcca
     1981 ccagatgacg ctctgtccct gcacctgcgt ggcaagggtg ccctgggccg cgagctggag
     2041 tctgacgctg ggcgcttgcg ccttgagctg gactgtgcca agctctccct cccacacctc
     2101 agcagcatga gccctgagct gtccatgaat ggccatgccg ccagctatga gctctgcggt
     2161 gcagctagtc ggccctcgtc caagcagaac accccccagt atctggcctc ccccttggac
     2221 caggaggtcg tgccctgcac ccctagccac agtggccggc ctcggctgga gaagctgtct
     2281 ggcctggctt tgcctgacta cacccggttg tcaccggcca agattgtgtt gaggcggcac
     2341 ctgagccagg accacaccgg ggccagcaaa gcagctacta gtgagccaca ccctcggcca
     2401 gagcatgcca aggagaacag ccttccctac cagagccctg gcttgtcgaa cagcatgaag
     2461 ctcagccccc aggatccacc gctggcctcc ccggcaacct cacccctcac ttccgagagg
     2521 ggtagtgaga agggtgtaaa ggagcgtgcc tacagcagcc atggggagac catcaccagc
     2581 ctgcctgtca gcattccact cagcacagta cagcccaaca agctgcctgt cagcatcccg
     2641 ctagccagcg tggtgctgcc cagccgtgcc gagagggcga ggagcactcc cagccctgtg
     2701 ccccagcctc gagactcctc atccacactt gagaagcaga ttggtgcttc cacccatggt
     2761 gcagggggtg ctgcggcagg aagcaggagc ctcactgtgg cgcccacagg tttctatgct
     2821 ggttcggtgg ccatcagtgg ggctctggcc agcagcccag cacctctggc ctctggaatg
     2881 gaatctgctg tttttgagga gtcctctggc cccagcagcc tctttggcac catggggtct
     2941 cgcagcacac cgccacaaca tccacctctc ctgccgcagt ctcgcaactc gggccctgcc
     3001 tctcctgccc accagctcgc agccagtccc cgcctgagtg tgaccaccca gggctcactg
     3061 ccagacaccg gcaaagggga gctgcctgct gatcctgcct tctcagaccc agagagtgaa
     3121 gctaagagga ggattgtgtt cagcatttca gctggtgcca gctccaggca gtcgccttcc
     3181 accaggcaca gccccttgac ctctggcacc cgtggggatt gtgttcagag ccatgggcag
     3241 gacagtcgta agcgtagcag aaggaagcgt gcatcagctg gaacgcctag cctcaccacg
     3301 ggtgtgtccc ccaagcgccg agctctgcca accgtcgctg gcctctttac acagtcttcg
     3361 gggtcgcctc tcaatctcac ctccatggtc agcaacatca accagcccct ggagatcaca
     3421 gccatctcat ccccggagag ctcactgaag agctccccca caccctacca ggaccatgac
     3481 cagcctccag tgctcaggaa ggagcggccc ctgggcccaa ctaatggggc ccactactct
     3541 ccgctgacgt cagatgagga gccaggctcg gaggacgagc ccagcagtgc ccgaattgag
     3601 agaaaaattg caacaatctc tttagaaagc aaatctcccc cgaagacact ggaaaatggt
     3661 ggtggcttag tgggaaggaa gccggtcccc tcaggcgagc ctgtcaacag cagcaaatgg
     3721 aagtccacct tctcacccat ctccgacctc ggcttggcca aggccatgga cagtccgcta
     3781 caggccagct ctgcactgag ccacagcccc ctcttctctt tccggccgtc cttggaggag
     3841 cctgctgctg aggccaagcc ctccacccac ccaaggaaaa gttttgcggg ctctctggct
     3901 gcagctgagg ggccaagccc tggcaccaac cctcccaaca gcctggcctt cagtgggggc
     3961 cttgctgcag acctcggttt acatagcttc aatgacggtg cttccctctc ccacaagggc
     4021 ccggaggtgg cgggcctgag cgcctccctg agcttcccat cccagagggg caaggacagt
     4081 accacagagg ccaacccctt cctcagcagg cggcagccgg agggcctggg tggcctgaag
     4141 ggtgagggca atgcaagcaa ggagtcagga gagagcctgc ccctgtgtgg gccctcagac
     4201 aaggtctcac tgccacacgg cagcagggcc agcaaaggcc gtgaccgcga gctggacttc
     4261 aagggcggcc acaacctctt catctctgct gcagccgtgc ctccaggtgg cctccttggt
     4321 ggccctggtc ttgtaactgt ggcttcctct gcgggcagtg cgacaccctc tgcccaggct
     4381 ccccggcctt tcctgagcac ctttgcccct gggccccagt ttactctggg ccccatgtcc
     4441 ctgcaggcca acctgggctc tgtggccggc tcctctgtgc tgcagtcctt gttcagcact
     4501 gtgccagctg ctgcaggcct ggtgcatgtg tcatccactg cgacccgact gaccaactca
     4561 cacaccatgg gcagcttctc ctctggggtg gccggcggaa ccgttggagg taattaggac
     4621 ttctactacc tcagccacga cctatgcaag gacggtgtgg accaagcctg cagcctgcgc
     4681 caggccggcg gagccggacg tggagccact gtgaattggc ggcaccgcag gaggtgctgg
     4741 actggtccag tttgtactgt caatagtttt agataaagta tttatcgttt tttttttttt
     4801 ttaaagtata agcaattctt actttattcc atcaaagtcg tccaaggcaa cctcttgaga
     4861 cgtctaagtg tctgtgagag agaataatat gaagacttgg cctgctgggc tggccaccat
     4921 gaggatgtct gactccgtcc cggtgctatc tcaccagcaa gcccaggcct gcccagaccc
     4981 acctctgccc tggtgctgcc ccaaacgtgg actgtggcca aacagttctc agatgtgccc
     5041 ccaacacctt gttctgacgc caaaggcacg cctggcatgc tcgatggggg ctgatctcca
     5101 gtctccctcc ttggaacttg cctgctgtca ctgtgaatac cccactgtta atcctgtggc
     5161 ttcgggcgtg cctttgcagt gggtgtggac taggctgggg caggaatggg ggttcccagc
     5221 tgggctgagt ggtgctgaca ggtgagggcc actactgcag ggctcagtgg ctcctgtgac
     5281 aagtgcattt actttgtaat tctttgcttt tctggctcgg gcatgctggt caggtgacgt
     5341 ggggttggcc caatctgggt cccctggcat ctgtgtataa gagagtcaca cgatcagtga
     5401 cagtatttta tagagatttg atggagattt ataaatttca tagacttgac tgcatttatt
     5461 tttagattgt ataatgcaca gtgaacttta aaggaaagaa aagtgaggag gaaaaatact
     5521 tttatttatt cagatgcaca aaaaaagaaa aaaaatggcg ctggccaggg accctgcagg
     5581 agtgcggccc agatgtgctg ggctgcccag ggcctctggt cactatggtc gtcacctgcc
     5641 tgtgtctagg agctgcttcc tggtcctggg gataggtgca ctgggagtga ctgcaggggt
     5701 cagggcggac ttgactttct gagaaggtcc tgactgctca cttctagttg tgggttggtg
     5761 gctatgaggg gaaaggtcat gtggctccac ccccacccca acctacttcc caaagcagtt
     5821 gtgaagatgg tgctggtgtc ccctccctcc ctccctccgc tcccctcccc gcgatggtgc
     5881 tcatgtttgg caggcctgtt tctgtgcacc acagctcact aaggtgctgc agaacaggga
     5941 gccgaaacaa aagctagcaa accccaggct tggaacaaaa ccttgagtga acactgtacg
     6001 cacggcccac tatcctggca gctgcttcag cagtcgctgc ctccacctta cttgagagtt
     6061 aggggacaga cactgcatgt tcatggccca gtggccacag gtgctccagg cacagctgca
     6121 agtcctctcc tgagcccgta agaaagggac ccacagtaaa ctgaccatgc tgcatggtgg
     6181 ccccaggcac tctggggctg atggtcctag tataagataa ggctgcctca gacgtccttg
     6241 ccaacccaag gttgctgcag ggctttgagc tcaggaactg atagcaagcc ctactcccac
     6301 gctagcccag aggaacacac ctcccagttc ccaccctcaa cctacacagc tcttttgaca
     6361 gcctggcctg tttgtaactt gatgcagcat cgctctgcct tgtaatgacc tctgtactta
     6421 acgggtgcgt tgttctcttc ccttggtctc cccaaggcat ctcacacatt gttgctgcct
     6481 ccagactatg ataaataaag ccgtttccac ttgaa
//
