LOCUS       NM_001108733            6757 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus DOT1 like histone lysine methyltransferase
            (Dot1l), mRNA.
ACCESSION   NM_001108733 XM_001071372 XM_343159
VERSION     NM_001108733.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6757)
  AUTHORS   Huang,Y., Urabe,G., Zhang,M., Li,J., Ozer,H.G., Wang,B., Kent,K.C.
            and Guo,L.W.
  TITLE     Nullifying epigenetic writer DOT1L attenuates neointimal
            hyperplasia
  JOURNAL   Atherosclerosis 308, 22-31 (2020)
   PUBMED   32799103
  REMARK    GeneRIF: Nullifying epigenetic writer DOT1L attenuates neointimal
            hyperplasia.
REFERENCE   2  (bases 1 to 6757)
  AUTHORS   Daigle,S.R., Olhava,E.J., Therkelsen,C.A., Basavapathruni,A.,
            Jin,L., Boriack-Sjodin,P.A., Allain,C.J., Klaus,C.R., Raimondi,A.,
            Scott,M.P., Waters,N.J., Chesworth,R., Moyer,M.P., Copeland,R.A.,
            Richon,V.M. and Pollock,R.M.
  TITLE     Potent inhibition of DOT1L as treatment of MLL-fusion leukemia
  JOURNAL   Blood 122 (6), 1017-1025 (2013)
   PUBMED   23801631
REFERENCE   3  (bases 1 to 6757)
  AUTHORS   Black,J.C., Van Rechem,C. and Whetstine,J.R.
  TITLE     Histone lysine methylation dynamics: establishment, regulation, and
            biological impact
  JOURNAL   Mol Cell 48 (4), 491-507 (2012)
   PUBMED   23200123
  REMARK    Review article
REFERENCE   4  (bases 1 to 6757)
  AUTHORS   He,Y., Korboukh,I., Jin,J. and Huang,J.
  TITLE     Targeting protein lysine methylation and demethylation in cancers
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 44 (1), 70-79 (2012)
   PUBMED   22194015
  REMARK    Review article
REFERENCE   5  (bases 1 to 6757)
  AUTHORS   Shah,S. and Henriksen,M.A.
  TITLE     A novel disrupter of telomere silencing 1-like (DOT1L) interaction
            is required for signal transducer and activator of transcription 1
            (STAT1)-activated gene expression
  JOURNAL   J Biol Chem 286 (48), 41195-41204 (2011)
   PUBMED   22002246
REFERENCE   6  (bases 1 to 6757)
  AUTHORS   Shi,X., Kachirskaia,I., Yamaguchi,H., West,L.E., Wen,H., Wang,E.W.,
            Dutta,S., Appella,E. and Gozani,O.
  TITLE     Modulation of p53 function by SET8-mediated methylation at lysine
            382
  JOURNAL   Mol Cell 27 (4), 636-646 (2007)
   PUBMED   17707234
REFERENCE   7  (bases 1 to 6757)
  AUTHORS   Okada,Y., Feng,Q., Lin,Y., Jiang,Q., Li,Y., Coffield,V.M., Su,L.,
            Xu,G. and Zhang,Y.
  TITLE     hDOT1L links histone methylation to leukemogenesis
  JOURNAL   Cell 121 (2), 167-178 (2005)
   PUBMED   15851025
  REMARK    Erratum:[Cell. 2005 Jun 3;121(5):809]
REFERENCE   8  (bases 1 to 6757)
  AUTHORS   Zhang,W., Hayashizaki,Y. and Kone,B.C.
  TITLE     Structure and regulation of the mDot1 gene, a mouse histone H3
            methyltransferase
  JOURNAL   Biochem J 377 (Pt 3), 641-651 (2004)
   PUBMED   14572310
REFERENCE   9  (bases 1 to 6757)
  AUTHORS   Min,J., Feng,Q., Li,Z., Zhang,Y. and Xu,R.M.
  TITLE     Structure of the catalytic domain of human DOT1L, a non-SET domain
            nucleosomal histone methyltransferase
  JOURNAL   Cell 112 (5), 711-723 (2003)
   PUBMED   12628190
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Apr 10, 2021 this sequence version replaced NM_001108733.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.28302.1,
                                           SRR26643287.17328.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-317               JAXUCZ010000007.1  9606779-9607095     c
            318-361             JAXUCZ010000007.1  9599504-9599547     c
            362-436             JAXUCZ010000007.1  9597891-9597965     c
            437-500             JAXUCZ010000007.1  9595313-9595376     c
            501-729             JAXUCZ010000007.1  9593080-9593308     c
            730-824             JAXUCZ010000007.1  9591280-9591374     c
            825-887             JAXUCZ010000007.1  9590738-9590800     c
            888-943             JAXUCZ010000007.1  9586758-9586813     c
            944-1023            JAXUCZ010000007.1  9586014-9586093     c
            1024-1092           JAXUCZ010000007.1  9583518-9583586     c
            1093-1199           JAXUCZ010000007.1  9582950-9583056     c
            1200-1241           JAXUCZ010000007.1  9582244-9582285     c
            1242-1349           JAXUCZ010000007.1  9581196-9581303     c
            1350-1581           JAXUCZ010000007.1  9580855-9581086     c
            1582-1695           JAXUCZ010000007.1  9580535-9580648     c
            1696-1787           JAXUCZ010000007.1  9580045-9580136     c
            1788-1889           JAXUCZ010000007.1  9579856-9579957     c
            1890-2027           JAXUCZ010000007.1  9579515-9579652     c
            2028-2153           JAXUCZ010000007.1  9579079-9579204     c
            2154-2638           JAXUCZ010000007.1  9578436-9578920     c
            2639-2774           JAXUCZ010000007.1  9578213-9578348     c
            2775-2921           JAXUCZ010000007.1  9577575-9577721     c
            2922-3051           JAXUCZ010000007.1  9576840-9576969     c
            3052-3629           JAXUCZ010000007.1  9575734-9576311     c
            3630-3835           JAXUCZ010000007.1  9575328-9575533     c
            3836-3900           JAXUCZ010000007.1  9574526-9574590     c
            3901-4851           JAXUCZ010000007.1  9573338-9574288     c
            4852-6757           JAXUCZ010000007.1  9569439-9571344     c
FEATURES             Location/Qualifiers
     source          1..6757
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..6757
                     /gene="Dot1l"
                     /note="DOT1 like histone lysine methyltransferase"
                     /db_xref="GeneID:362831"
                     /db_xref="RGD:1306644"
     exon            1..317
                     /gene="Dot1l"
                     /inference="alignment:Splign:2.1.0"
     CDS             237..4859
                     /gene="Dot1l"
                     /EC_number="2.1.1.354"
                     /note="DOT1-like, histone H3 methyltransferase; DOT1-like
                     histone H3K79 methyltransferase"
                     /codon_start=1
                     /product="histone-lysine N-methyltransferase, H3 lysine-79
                     specific"
                     /protein_id="NP_001102203.2"
                     /db_xref="GeneID:362831"
                     /db_xref="RGD:1306644"
                     /translation="MGEKLELRLKSPVGAEPAVYPWPLPVYDKHHDAAHEIIETIRWV
                     CEEIPDLKLAMENYVLIDYDTKSFESMQRLCDKYNRAIDSIHQLWKGTTQPMKLNTRP
                     SNGLLRHILQQVYNHSVTDPEKLNNYEPFSPEVYGETSFDLVAQMIDEIKMTEDDLFV
                     DLGSGVGQVVLQVAAATNCKHHYGVEKADIPAKYAETMDREFRKWMKWYGKKHAEYTL
                     ERGDFLSEEWRERIANTSVIFVNNFAFGPEVDHQLKERFANMKEGGRIVSSKPFAPLN
                     FRINSRNLSDIGTIMRVVELSPLKGSVSWTGKPVSYYLHTIDRTILENYFSSLKNPKL
                     REEQEAARRRQQRENKSNATTPTKVPESKAAATEAPADSGAEEEKSGVATVKKQSPSK
                     ARKKKLNKKGRKMAGRKRGRPKKMSAASADRKSKKSQSTLDLLHSPPPAPPSASPQDA
                     YRAPHSPFYQLPPSTPLHSPDPLLVAPTPPALQKLLESFKIQYLQFLAYTKTPQYKAN
                     LQQLLDQEKEKNTQLLGTAQQLFSHCQAQKEEIRRLFQQKLDELGVKALTYNDLIQAQ
                     KEISAHNQQLREQSEQLEKDNSELRSQSLRLLRARCEELRLDWSTLSLENLRKEKQAL
                     RSQISEKQRHCLELQISIVELEKTQRQQELLQLKSCVPPDDALSLHLRGKGALGRELE
                     SDAGRLRLELDCAKLSLPHLSSMSPELSMNGHAASYELCGAASRPSSKQNTPQYLASP
                     LDQEVVPCTPSHSGRPRLEKLSGLALPDYTRLSPAKIVLRRHLSQDHTGASKAATSEP
                     HPRPEHAKENSLPYQSPGLSNSMKLSPQDPPLASPATSPLTSERGSEKGVKERAYSSH
                     GETITSLPVSIPLSTVQPNKLPVSIPLASVVLPSRAERARSTPSPVPQPRDSSSTLEK
                     QIGASTHGAGGAAAGSRSLTVAPTGFYAGSVAISGALASSPAPLASGMESAVFEESSG
                     PSSLFGTMGSRSTPPQHPPLLPQSRNSGPASPAHQLAASPRLSVTTQGSLPDTGKGEL
                     PADPAFSDPESEAKRRIVFSISAGASSRQSPSTRHSPLTSGTRGDCVQSHGQDSRKRS
                     RRKRASAGTPSLTTGVSPKRRALPTVAGLFTQSSGSPLNLTSMVSNINQPLEITAISS
                     PESSLKSSPTPYQDHDQPPVLRKERPLGPTNGAHYSPLTSDEEPGSEDEPSSARIERK
                     IATISLESKSPPKTLENGGGLVGRKPVPSGEPVNSSKWKSTFSPISDLGLAKAMDSPL
                     QASSALSHSPLFSFRPSLEEPAAEAKPSTHPRKSFAGSLAAAEGPSPGTNPPNSLAFS
                     GGLAADLGLHSFNDGASLSHKGPEVAGLSASLSFPSQRGKDSTTEANPFLSRRQPEGL
                     GGLKGEGNASKESGESLPLCGPSDKVSLPHGSRASKGRDRELDFKGGHNLFISAAAVP
                     PGGLLGGPGLVTVASSAGSATPSAQAPRPFLSTFAPGPQFTLGPMSLQANLGSVAGSS
                     VLQSLFSTVPAAAGLVHVSSTATRLTNSHTMGSFSSGVAGGTVGGN"
     exon            318..361
                     /gene="Dot1l"
                     /inference="alignment:Splign:2.1.0"
     exon            362..436
                     /gene="Dot1l"
                     /inference="alignment:Splign:2.1.0"
     exon            437..500
                     /gene="Dot1l"
                     /inference="alignment:Splign:2.1.0"
     exon            501..729
                     /gene="Dot1l"
                     /inference="alignment:Splign:2.1.0"
     exon            730..824
                     /gene="Dot1l"
                     /inference="alignment:Splign:2.1.0"
     exon            825..887
                     /gene="Dot1l"
                     /inference="alignment:Splign:2.1.0"
     exon            888..943
                     /gene="Dot1l"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1023
                     /gene="Dot1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1092
                     /gene="Dot1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1199
                     /gene="Dot1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1241
                     /gene="Dot1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1349
                     /gene="Dot1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..1581
                     /gene="Dot1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1582..1695
                     /gene="Dot1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..1787
                     /gene="Dot1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1788..1889
                     /gene="Dot1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1890..2027
                     /gene="Dot1l"
                     /inference="alignment:Splign:2.1.0"
     exon            2028..2153
                     /gene="Dot1l"
                     /inference="alignment:Splign:2.1.0"
     exon            2154..2638
                     /gene="Dot1l"
                     /inference="alignment:Splign:2.1.0"
     exon            2639..2774
                     /gene="Dot1l"
                     /inference="alignment:Splign:2.1.0"
     exon            2775..2921
                     /gene="Dot1l"
                     /inference="alignment:Splign:2.1.0"
     exon            2922..3051
                     /gene="Dot1l"
                     /inference="alignment:Splign:2.1.0"
     exon            3052..3629
                     /gene="Dot1l"
                     /inference="alignment:Splign:2.1.0"
     exon            3630..3835
                     /gene="Dot1l"
                     /inference="alignment:Splign:2.1.0"
     exon            3836..3900
                     /gene="Dot1l"
                     /inference="alignment:Splign:2.1.0"
     exon            3901..4851
                     /gene="Dot1l"
                     /inference="alignment:Splign:2.1.0"
     exon            4852..6757
                     /gene="Dot1l"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccttctcct cacgccggcc caagatggcg gcggcgctag acgccccggc tctgtgactc
       61 ctacaaagag gggagctggg gccacacggg agcggtggcc gaggcacagg ccgggccgtc
      121 tgtcctcagc cgtccgcccc gcgtccgccc gagtccgccc gcctgccttc ccgccggcgg
      181 ccccgcccct cccccaaccg cccgcctagc atggtgcggc ggccgcgcgc gccgacatgg
      241 gcgagaagct ggagctgagg ctcaagtcgc ctgtgggcgc ggagcccgcc gtctacccgt
      301 ggccgctgcc ggtctacgac aagcaccatg atgctgctca tgagattatc gagactatcc
      361 gatgggtctg cgaggaaatc ccagatctca agctggccat ggagaactat gtcctgatcg
      421 actacgacac caaaagtttt gaaagcatgc agaggctgtg tgacaaatat aaccgggcca
      481 ttgacagcat ccaccagctg tggaagggca ctacacagcc catgaagctc aatactcggc
      541 cgtccaatgg gctcctgcgg cacatcctgc agcaggtgta caaccactct gtgaccgacc
      601 cagagaagct caacaactac gagcccttct cccccgaggt gtacggggag acctcctttg
      661 acctggtggc ccagatgatc gatgagatca agatgaccga ggatgacctg tttgtagacc
      721 tgggcagtgg tgtggggcag gttgtccttc aggttgcggc ggccaccaac tgcaaacatc
      781 actacggagt ggagaaagcg gacatcccag ccaagtacgc ggagaccatg gatcgagagt
      841 tcaggaagtg gatgaaatgg tatggaaaaa agcatgcaga atacacactg gagcgaggtg
      901 acttcctctc agaggagtgg agggaacgga tcgccaacac gagtgttata tttgtgaata
      961 actttgcctt tggtcctgag gtggatcacc agctgaagga acgattcgca aacatgaagg
     1021 aaggcggcag aatcgtatcc tcaaagccct ttgcccctct gaacttcagg atcaacagca
     1081 ggaacttgag tgacattggc accatcatgc gtgtggtgga gctgtcgccc ctgaagggct
     1141 ctgtgtcatg gactggcaag cctgtctcct actacctgca caccattgac cgcaccatac
     1201 ttgaaaacta tttttctagt ctgaaaaatc caaaactcag ggaggagcag gaggcagcta
     1261 ggcgcaggca gcagcgagag aacaagagca acgcgaccac acccaccaaa gtccctgaga
     1321 gcaaggcagc tgccaccgag gcccctgcgg attctggtgc tgaggaagaa aaatcaggtg
     1381 tggccaccgt caaaaagcaa tctccctcca aagcccggaa gaagaaactg aacaagaaag
     1441 ggagaaaaat ggctggccgg aagcgtgggc gacccaagaa aatgagtgct gccagtgccg
     1501 atcgcaagtc caagaagagc caaagcacac tggatctcct gcactctccg cccccagccc
     1561 caccctcagc ctcaccccag gatgcataca gggcccccca cagcccgttc taccagctac
     1621 ctccgagcac gccgctgcac tcgcccgacc cactgctagt ggctcccacc ccacccgcgc
     1681 tgcagaagct gttagagtcc ttcaagatcc agtacctgca gttcctggcc tacacgaaga
     1741 ccccgcagta caaggccaac ctgcagcagc ttctggacca ggagaaggag aagaacacac
     1801 aactgctggg tacagcccag cagctcttca gccattgcca ggcacaaaag gaagagatcc
     1861 gcaggctgtt ccagcagaag ctggatgagt tgggcgtgaa ggcactgacc tacaatgacc
     1921 tgattcaggc ccagaaggaa atctctgccc acaaccagca gctgcgggag cagtcggaac
     1981 agctggagaa ggacaacagc gagcttcgga gccagagcct gcggctgctc agggcccggt
     2041 gcgaagagct gaggcttgac tggtccacct tgtccctgga gaacctgcgg aaagagaagc
     2101 aggccctgcg gagccagatc tcagagaagc agcggcactg cctagagctg cagatcagca
     2161 tcgtggagct ggagaagacc cagcgccagc aggagctcct gcagttgaag tcctgtgtgc
     2221 caccagatga cgctctgtcc ctgcacctgc gtggcaaggg tgccctgggc cgcgagctgg
     2281 agtctgacgc tgggcgcttg cgccttgagc tggactgtgc caagctctcc ctcccacacc
     2341 tcagcagcat gagccctgag ctgtccatga atggccatgc cgccagctat gagctctgcg
     2401 gtgcagctag tcggccctcg tccaagcaga acacccccca gtatctggcc tcccccttgg
     2461 accaggaggt cgtgccctgc acccctagcc acagtggccg gcctcggctg gagaagctgt
     2521 ctggcctggc tttgcctgac tacacccggt tgtcaccggc caagattgtg ttgaggcggc
     2581 acctgagcca ggaccacacc ggggccagca aagcagctac tagtgagcca caccctcggc
     2641 cagagcatgc caaggagaac agccttccct accagagccc tggcttgtcg aacagcatga
     2701 agctcagccc ccaggatcca ccgctggcct ccccggcaac ctcacccctc acttccgaga
     2761 ggggtagtga gaagggtgta aaggagcgtg cctacagcag ccatggggag accatcacca
     2821 gcctgcctgt cagcattcca ctcagcacag tacagcccaa caagctgcct gtcagcatcc
     2881 cgctagccag cgtggtgctg cccagccgtg ccgagagggc gaggagcact cccagccctg
     2941 tgccccagcc tcgagactcc tcatccacac ttgagaagca gattggtgct tccacccatg
     3001 gtgcaggggg tgctgcggca ggaagcagga gcctcactgt ggcgcccaca ggtttctatg
     3061 ctggttcggt ggccatcagt ggggctctgg ccagcagccc agcacctctg gcctctggaa
     3121 tggaatctgc tgtttttgag gagtcctctg gccccagcag cctctttggc accatggggt
     3181 ctcgcagcac accgccacaa catccacctc tcctgccgca gtctcgcaac tcgggccctg
     3241 cctctcctgc ccaccagctc gcagccagtc cccgcctgag tgtgaccacc cagggctcac
     3301 tgccagacac cggcaaaggg gagctgcctg ctgatcctgc cttctcagac ccagagagtg
     3361 aagctaagag gaggattgtg ttcagcattt cagctggtgc cagctccagg cagtcgcctt
     3421 ccaccaggca cagccccttg acctctggca cccgtgggga ttgtgttcag agccatgggc
     3481 aggacagtcg taagcgtagc agaaggaagc gtgcatcagc tggaacgcct agcctcacca
     3541 cgggtgtgtc ccccaagcgc cgagctctgc caaccgtcgc tggcctcttt acacagtctt
     3601 cggggtcgcc tctcaatctc acctccatgg tcagcaacat caaccagccc ctggagatca
     3661 cagccatctc atccccggag agctcactga agagctcccc cacaccctac caggaccatg
     3721 accagcctcc agtgctcagg aaggagcggc ccctgggccc aactaatggg gcccactact
     3781 ctccgctgac gtcagatgag gagccaggct cggaggacga gcccagcagt gcccgaattg
     3841 agagaaaaat tgcaacaatc tctttagaaa gcaaatctcc cccgaagaca ctggaaaatg
     3901 gtggtggctt agtgggaagg aagccggtcc cctcaggcga gcctgtcaac agcagcaaat
     3961 ggaagtccac cttctcaccc atctccgacc tcggcttggc caaggccatg gacagtccgc
     4021 tacaggccag ctctgcactg agccacagcc ccctcttctc tttccggccg tccttggagg
     4081 agcctgctgc tgaggccaag ccctccaccc acccaaggaa aagttttgcg ggctctctgg
     4141 ctgcagctga ggggccaagc cctggcacca accctcccaa cagcctggcc ttcagtgggg
     4201 gccttgctgc agacctcggt ttacatagct tcaatgacgg tgcttccctc tcccacaagg
     4261 gcccggaggt ggcgggcctg agcgcctccc tgagcttccc atcccagagg ggcaaggaca
     4321 gtaccacaga ggccaacccc ttcctcagca ggcggcagcc ggagggcctg ggtggcctga
     4381 agggtgaggg caatgcaagc aaggagtcag gagagagcct gcccctgtgt gggccctcag
     4441 acaaggtctc actgccacac ggcagcaggg ccagcaaagg ccgtgaccgc gagctggact
     4501 tcaagggcgg ccacaacctc ttcatctctg ctgcagccgt gcctccaggt ggcctccttg
     4561 gtggccctgg tcttgtaact gtggcttcct ctgcgggcag tgcgacaccc tctgcccagg
     4621 ctccccggcc tttcctgagc acctttgccc ctgggcccca gtttactctg ggccccatgt
     4681 ccctgcaggc caacctgggc tctgtggccg gctcctctgt gctgcagtcc ttgttcagca
     4741 ctgtgccagc tgctgcaggc ctggtgcatg tgtcatccac tgcgacccga ctgaccaact
     4801 cacacaccat gggcagcttc tcctctgggg tggccggcgg aaccgttgga ggtaattagg
     4861 acttctacta cctcagccac gacctatgca aggacggtgt ggaccaagcc tgcagcctgc
     4921 gccaggccgg cggagccgga cgtggagcca ctgtgaattg gcggcaccgc aggaggtgct
     4981 ggactggtcc agtttgtact gtcaatagtt ttagataaag tatttatcgt tttttttttt
     5041 ttttaaagta taagcaattc ttactttatt ccatcaaagt cgtccaaggc aacctcttga
     5101 gacgtctaag tgtctgtgag agagaataat atgaagactt ggcctgctgg gctggccacc
     5161 atgaggatgt ctgactccgt cccggtgcta tctcaccagc aagcccaggc ctgcccagac
     5221 ccacctctgc cctggtgctg ccccaaacgt ggactgtggc caaacagttc tcagatgtgc
     5281 ccccaacacc ttgttctgac gccaaaggca cgcctggcat gctcgatggg ggctgatctc
     5341 cagtctccct ccttggaact tgcctgctgt cactgtgaat accccactgt taatcctgtg
     5401 gcttcgggcg tgcctttgca gtgggtgtgg actaggctgg ggcaggaatg ggggttccca
     5461 gctgggctga gtggtgctga caggtgaggg ccactactgc agggctcagt ggctcctgtg
     5521 acaagtgcat ttactttgta attctttgct tttctggctc gggcatgctg gtcaggtgac
     5581 gtggggttgg cccaatctgg gtcccctggc atctgtgtat aagagagtca cacgatcagt
     5641 gacagtattt tatagagatt tgatggagat ttataaattt catagacttg actgcattta
     5701 tttttagatt gtataatgca cagtgaactt taaaggaaag aaaagtgagg aggaaaaata
     5761 cttttattta ttcagatgca caaaaaaaga aaaaaaatgg cgctggccag ggaccctgca
     5821 ggagtgcggc ccagatgtgc tgggctgccc agggcctctg gtcactatgg tcgtcacctg
     5881 cctgtgtcta ggagctgctt cctggtcctg gggataggtg cactgggagt gactgcaggg
     5941 gtcagggcgg acttgacttt ctgagaaggt cctgactgct cacttctagt tgtgggttgg
     6001 tggctatgag gggaaaggtc atgtggctcc acccccaccc caacctactt cccaaagcag
     6061 ttgtgaagat ggtgctggtg tcccctccct ccctccctcc gctcccctcc ccgcgatggt
     6121 gctcatgttt ggcaggcctg tttctgtgca ccacagctca ctaaggtgct gcagaacagg
     6181 gagccgaaac aaaagctagc aaaccccagg cttggaacaa aaccttgagt gaacactgta
     6241 cgcacggccc actatcctgg cagctgcttc agcagtcgct gcctccacct tacttgagag
     6301 ttaggggaca gacactgcat gttcatggcc cagtggccac aggtgctcca ggcacagctg
     6361 caagtcctct cctgagcccg taagaaaggg acccacagta aactgaccat gctgcatggt
     6421 ggccccaggc actctggggc tgatggtcct agtataagat aaggctgcct cagacgtcct
     6481 tgccaaccca aggttgctgc agggctttga gctcaggaac tgatagcaag ccctactccc
     6541 acgctagccc agaggaacac acctcccagt tcccaccctc aacctacaca gctcttttga
     6601 cagcctggcc tgtttgtaac ttgatgcagc atcgctctgc cttgtaatga cctctgtact
     6661 taacgggtgc gttgttctct tcccttggtc tccccaaggc atctcacaca ttgttgctgc
     6721 ctccagacta tgataaataa agccgtttcc acttgaa
//
