LOCUS       NM_001399266            2370 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus DNA replication fork stabilization factor DONSON
            (Donson), transcript variant 1, mRNA.
ACCESSION   NM_001399266 XM_006248047
VERSION     NM_001399266.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2370)
  AUTHORS   Reynolds,J.J., Bicknell,L.S., Carroll,P., Higgs,M.R., Shaheen,R.,
            Murray,J.E., Papadopoulos,D.K., Leitch,A., Murina,O.,
            Tarnauskaite,Z., Wessel,S.R., Zlatanou,A., Vernet,A., von
            Kriegsheim,A., Mottram,R.M., Logan,C.V., Bye,H., Li,Y., Brean,A.,
            Maddirevula,S., Challis,R.C., Skouloudaki,K., Almoisheer,A.,
            Alsaif,H.S., Amar,A., Prescott,N.J., Bober,M.B., Duker,A.,
            Faqeih,E., Seidahmed,M.Z., Al Tala,S., Alswaid,A., Ahmed,S.,
            Al-Aama,J.Y., Altmuller,J., Al Balwi,M., Brady,A.F., Chessa,L.,
            Cox,H., Fischetto,R., Heller,R., Henderson,B.D., Hobson,E.,
            Nurnberg,P., Percin,E.F., Peron,A., Spaccini,L., Quigley,A.J.,
            Thakur,S., Wise,C.A., Yoon,G., Alnemer,M., Tomancak,P., Yigit,G.,
            Taylor,A.M., Reijns,M.A., Simpson,M.A., Cortez,D., Alkuraya,F.S.,
            Mathew,C.G., Jackson,A.P. and Stewart,G.S.
  TITLE     Mutations in DONSON disrupt replication fork stability and cause
            microcephalic dwarfism
  JOURNAL   Nat Genet 49 (4), 537-549 (2017)
   PUBMED   28191891
REFERENCE   2  (bases 1 to 2370)
  AUTHORS   Lau,N.C., Seto,A.G., Kim,J., Kuramochi-Miyagawa,S., Nakano,T.,
            Bartel,D.P. and Kingston,R.E.
  TITLE     Characterization of the piRNA complex from rat testes
  JOURNAL   Science 313 (5785), 363-367 (2006)
   PUBMED   16778019
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Jan 5, 2022 this sequence version replaced XM_006248047.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.29467.1,
                                           SRR21887622.375043.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-358               JAXUCZ010000011.1  44418434-44418791   c
            359-436             JAXUCZ010000011.1  44417816-44417893   c
            437-640             JAXUCZ010000011.1  44416280-44416483   c
            641-819             JAXUCZ010000011.1  44414255-44414433   c
            820-998             JAXUCZ010000011.1  44413652-44413830   c
            999-1077            JAXUCZ010000011.1  44412681-44412759   c
            1078-1182           JAXUCZ010000011.1  44412457-44412561   c
            1183-1381           JAXUCZ010000011.1  44411919-44412117   c
            1382-1594           JAXUCZ010000011.1  44410896-44411108   c
            1595-2370           JAXUCZ010000011.1  44409195-44409970   c
FEATURES             Location/Qualifiers
     source          1..2370
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q11"
     gene            1..2370
                     /gene="Donson"
                     /note="DNA replication fork stabilization factor DONSON"
                     /db_xref="GeneID:288257"
                     /db_xref="RGD:1306823"
     exon            1..358
                     /gene="Donson"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..1732
                     /gene="Donson"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein downstream neighbor of Son; downstream neighbor of
                     SON"
                     /codon_start=1
                     /product="protein downstream neighbor of Son isoform 1"
                     /protein_id="NP_001386195.1"
                     /db_xref="GeneID:288257"
                     /db_xref="RGD:1306823"
                     /translation="MAVSVPGYSPSFKRPPEVVRLRRKRPRDHGTAVSSALPEPALRR
                     AALAAGLPLRPFPTAGGRGGATTTIARRNPFARLDNRPRVADEAPEEPLRGPQGAPGP
                     LLDSNGENNLLWEEASHERTVTELSQSQQVTLSESDTWSSDGTELPVDWSIKTRLLFT
                     SSQPFSWAEHLKAQEEAQGLVQHCRATEVTLPQSIPDPKLSTVLRCAFQQTLVYWLHP
                     AFSWLPLFPRIGADRKMAAKTSPWSTDESLQHALMSDWSVSFTSLYNLLKTKLCPYFY
                     VCSYQFTVLFRAAGLAGSSVITALITPTTRGLREAMKSEGIEFSLPLLEESGHKEKVR
                     EPSLESEEEQAVSDEDEEESLSWLEEIGVQDQIKKPDLISVKLRKEKHEVQMDHRPES
                     VVLVKGLNTFKLLNFLINCKSLVATSGAQAGLPPTLLSPVAFRGASMQMLKARSINVK
                     TQALFGYRDKFSLEITGPVMPHALHSVAMLLRSSQRGSFSAGLYAHEPTAVFNVGLPL
                     DKELDRKGAHKDLANCGLHPKTLEQLSQMPVLGKSSLRNVEMSDYIVNWRS"
     exon            359..436
                     /gene="Donson"
                     /inference="alignment:Splign:2.1.0"
     exon            437..640
                     /gene="Donson"
                     /inference="alignment:Splign:2.1.0"
     exon            641..819
                     /gene="Donson"
                     /inference="alignment:Splign:2.1.0"
     exon            820..998
                     /gene="Donson"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1077
                     /gene="Donson"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1182
                     /gene="Donson"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1381
                     /gene="Donson"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..1594
                     /gene="Donson"
                     /inference="alignment:Splign:2.1.0"
     exon            1595..2370
                     /gene="Donson"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggccggag cgcgcgggaa gccccggcag ggtgctgcct cggtgctgcg caatggctgt
       61 ctcggtcccc ggctactcgc ccagcttcaa gaggccgcct gaggtcgtgc ggctccgccg
      121 gaaaaggcct cgggaccatg gtaccgccgt gtcctccgca ctgccggagc ccgcgctccg
      181 ccgcgccgcg ctggctgctg ggctgccctt gcgtcccttt ccgaccgcgg gcggcagagg
      241 aggcgccacc actaccatcg cccgcaggaa ccctttcgcc cgcctggaca accggccacg
      301 ggtggccgac gaggcccccg aagagccgct ccgcggtcct caaggagcgc cgggcccgct
      361 tctagattct aatggagaaa ataacttgct gtgggaggag gcatctcatg aaagaactgt
      421 cacggaactg tcccagagtc aacaggtaac cttgtctgaa tcggacactt ggtcttcaga
      481 tggtactgag ttacctgtgg actggagtat taaaacccgc ctccttttca cctcttctca
      541 acccttttcc tgggcagaac atttgaaagc acaggaagaa gcccaaggac ttgtccagca
      601 ttgtagggca acagaagtta cattaccaca gagtataccg gatcccaaac tgtccactgt
      661 gctacgttgt gccttccagc agaccctggt ctactggctt caccctgcct tttcatggct
      721 gccactcttc cctcgaattg gagctgatag aaaaatggct gcaaagacaa gtccatggtc
      781 aacggatgaa agcctgcagc atgctttaat gagtgactgg tctgtgagtt ttacgtcttt
      841 atataacctg ctgaagacga agctttgccc ctatttctac gtttgttcct atcagtttac
      901 ggtcctgttc cgggcagcag gattagcagg aagcagtgtg atcacagcgc tcatcacccc
      961 tacaactaga ggcttaagag aagctatgaa aagtgaaggt attgaatttt ctctgccttt
     1021 actagaagag agtggtcata aggagaaagt tcgagaacca agcctggaat ctgaggagga
     1081 gcaggcagtc agtgacgaag atgaagagga aagtttgtct tggctggaag agatcggtgt
     1141 gcaggatcaa attaagaagc cagacttgat ctctgtcaag ctgcgtaaag aaaaacatga
     1201 agtacagatg gatcaccgac cagagtctgt cgtactggtg aaaggactca ataccttcaa
     1261 actgctcaac tttttgatca attgcaagag tttagttgct acctcaggcg cacaggcagg
     1321 tctcccaccc actctcttat ccccagttgc ctttcgaggt gcctcaatgc aaatgcttaa
     1381 ggcacgaagc attaatgtaa agacacaagc tctttttgga tacagagata agtttagttt
     1441 ggagatcaca ggtcctgtca tgcctcacgc tttgcattct gtggccatgc tactccgatc
     1501 ttcacagaga ggctcattct ctgcgggatt gtatgcacat gagccaactg ccgtattcaa
     1561 tgttggccta ccactggata aggaactgga tagaaaaggt gctcataagg accttgctaa
     1621 ctgtgggctg caccctaaaa ccctggagca gctcagtcaa atgccagtgc tggggaagtc
     1681 atccttgcgg aatgtggaaa tgagtgacta cattgtaaat tggagatcct gaacgccaaa
     1741 gtaagcctaa aggaatctga ggaaaaagct tcctaagcaa ggaaattcaa gattgtaggc
     1801 ctctggcttt taaagttcat ttggaagaat atattttaaa atactgaaat gttcctgaac
     1861 atttttatac taacttatta catgcaatag tgttaggttt taaatcagca ttttggtttt
     1921 attattttca tatattttta gagatgaaga tgcaaggtgc ttccttaaaa cctcagataa
     1981 ttcaaatgag aattctaccc ctgcaactca ctgtaaccag aatggagtcg gtgctttatt
     2041 acaaatgaga acttgagatt acctgtagca attattccat tgagactaat tgtcagaaca
     2101 aaaagtatct atattgtatc ttagactagc tgtgagttct ctgaagtcct agggaaatca
     2161 gcattactaa taagttctac ttccctgttc tcaagactgt tcagtcacat gtgtcaagtc
     2221 caagggcagg gtactttgta cttcatctca atgttgggtg ctcggtcatg tcaacttact
     2281 atttatttag tatgcttaca gttaatctgt gtttgcatgt gtgtatatat aaaatcagta
     2341 tttttgaata aacgtgcaga gaaatcacaa
//
