LOCUS       NM_001130062            2555 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus docking protein 7 (Dok7), transcript variant 1,
            mRNA.
ACCESSION   NM_001130062 XM_001064255 XM_006251239 XM_223532
VERSION     NM_001130062.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2555)
  AUTHORS   Gomez,A.M., Stevens,J.A., Mane-Damas,M., Molenaar,P., Duimel,H.,
            Verheyen,F., Cossins,J., Beeson,D., De Baets,M.H., Losen,M. and
            Martinez-Martinez,P.
  TITLE     Silencing of Dok-7 in Adult Rat Muscle Increases Susceptibility to
            Passive Transfer Myasthenia Gravis
  JOURNAL   Am J Pathol 186 (10), 2559-2568 (2016)
   PUBMED   27658713
  REMARK    GeneRIF: A reduced expression of Dok-7 may play a role in the
            susceptibility to passive transfer Myasthenia gravis (MG), by
            rendering acetylcholine receptor (AChR) clusters less resistant to
            the autoantibody attack.
REFERENCE   2  (bases 1 to 2555)
  AUTHORS   Witzemann,V., Chevessier,F., Pacifici,P.G. and Yampolsky,P.
  TITLE     The neuromuscular junction: selective remodeling of synaptic
            regulators at the nerve/muscle interface
  JOURNAL   Mech Dev 130 (6-8), 402-411 (2013)
   PUBMED   23032192
  REMARK    Review article
REFERENCE   3  (bases 1 to 2555)
  AUTHORS   Bergamin,E., Hallock,P.T., Burden,S.J. and Hubbard,S.R.
  TITLE     The cytoplasmic adaptor protein Dok7 activates the receptor
            tyrosine kinase MuSK via dimerization
  JOURNAL   Mol Cell 39 (1), 100-109 (2010)
   PUBMED   20603078
REFERENCE   4  (bases 1 to 2555)
  AUTHORS   Okada,K., Inoue,A., Okada,M., Murata,Y., Kakuta,S., Jigami,T.,
            Kubo,S., Shiraishi,H., Eguchi,K., Motomura,M., Akiyama,T.,
            Iwakura,Y., Higuchi,O. and Yamanashi,Y.
  TITLE     The muscle protein Dok-7 is essential for neuromuscular
            synaptogenesis
  JOURNAL   Science 312 (5781), 1802-1805 (2006)
   PUBMED   16794080
REFERENCE   5  (bases 1 to 2555)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On or before Dec 21, 2022 this sequence version replaced
            XM_006251239.4, NM_001130062.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.33279.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-129               JAXUCZ010000014.1  79923889-79924017   c
            130-175             JAXUCZ010000014.1  79923740-79923785   c
            176-406             JAXUCZ010000014.1  79916661-79916891   c
            407-607             JAXUCZ010000014.1  79914915-79915115   c
            608-727             JAXUCZ010000014.1  79906061-79906180   c
            728-847             JAXUCZ010000014.1  79903031-79903150   c
            848-1572            JAXUCZ010000014.1  79899404-79900128   c
            1573-1615           JAXUCZ010000014.1  79895915-79895957   c
            1616-1765           JAXUCZ010000014.1  79892488-79892637   c
            1766-2555           JAXUCZ010000014.1  79891367-79892156   c
FEATURES             Location/Qualifiers
     source          1..2555
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..2555
                     /gene="Dok7"
                     /gene_synonym="RGD1566416"
                     /note="docking protein 7"
                     /db_xref="GeneID:305448"
                     /db_xref="RGD:1566416"
     exon            1..129
                     /gene="Dok7"
                     /gene_synonym="RGD1566416"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..1896
                     /gene="Dok7"
                     /gene_synonym="RGD1566416"
                     /note="isoform 1 is encoded by transcript variant 1;
                     downstream of tyrosine kinase 7; protein Dok-7"
                     /codon_start=1
                     /product="protein Dok-7 isoform 1"
                     /protein_id="NP_001123534.2"
                     /db_xref="GeneID:305448"
                     /db_xref="RGD:1566416"
                     /translation="MTEAALVEGQVKLRDGKKWKSRWLVLRKPSPVADCLLMLVYKDR
                     CERSKGLRERSSLTLEDICGLEPALPYEGLAHTLAIICLSQAIMLGFDSHEAMCAWDT
                     RIRYALGEVHRFHVTVAPGTKLESGPATLHLCNDILVLARDIPPTVTGQWKLSDLRRY
                     GAVPNGFIFEGGTRCGYWAGVFFLSSAEGEQISFLFDCIVRGISPTKGPFGLRPVLPD
                     PSSGGPSASEERVAQEALEALQLEKRLSLLSHSGRPGSGGDDRSLSSSSSEASHSDIS
                     ASSRLTAWPEQSSSSASTSQEGPGLVAAQGPGEAMLGASRPPLKPLRPRQLQEVGRQS
                     SSDSGIATGSHSSYSGSFSSYAGSNLDVWRAGEEFGSLLSLPPGASAPEPRLCACPPG
                     AAEYQVPTSLRHHYDTPRSLRQAPRDPSPASQGGSDHSSATDSGGQAPTGSPSSCLGA
                     RRRGQATEGPGSEAVLPSPSPGESWEAGSPHTGPPPAFFLSCSICGGLKVTATSSTGL
                     TVTHPGSPGVAADSPGPERPHGETPTYVNIPISPTSRLQLHYMDLELSGASGGVRGVS
                     ASRYAQIDITATETAHRVGVQHAQNREERLPELEQRKKGP"
     exon            130..175
                     /gene="Dok7"
                     /gene_synonym="RGD1566416"
                     /inference="alignment:Splign:2.1.0"
     exon            176..406
                     /gene="Dok7"
                     /gene_synonym="RGD1566416"
                     /inference="alignment:Splign:2.1.0"
     exon            407..607
                     /gene="Dok7"
                     /gene_synonym="RGD1566416"
                     /inference="alignment:Splign:2.1.0"
     exon            608..727
                     /gene="Dok7"
                     /gene_synonym="RGD1566416"
                     /inference="alignment:Splign:2.1.0"
     exon            728..847
                     /gene="Dok7"
                     /gene_synonym="RGD1566416"
                     /inference="alignment:Splign:2.1.0"
     exon            848..1572
                     /gene="Dok7"
                     /gene_synonym="RGD1566416"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..1615
                     /gene="Dok7"
                     /gene_synonym="RGD1566416"
                     /inference="alignment:Splign:2.1.0"
     exon            1616..1765
                     /gene="Dok7"
                     /gene_synonym="RGD1566416"
                     /inference="alignment:Splign:2.1.0"
     exon            1766..2555
                     /gene="Dok7"
                     /gene_synonym="RGD1566416"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttgaaagtga ccctgggctc gggcgcccag gacgcgtgga gagggcgcag cgggcggcgg
       61 gaaccatgac agaagatgac cgaggcagcg ctggtggagg gccaggtcaa gctgcgggac
      121 ggcaagaagt ggaagagtag gtggctggtg ctgcgcaagc catcgccggt ggcagactgc
      181 ctgctgatgc tggtctacaa ggacaggtgt gaacgttcaa agggcctgcg ggagcgcagc
      241 agcctcaccc tggaggacat ctgtggcctg gagcctgccc tgccctatga gggcctggcc
      301 cacaccctgg ctatcatctg cctgtctcag gccatcatgc tgggctttga cagccacgag
      361 gccatgtgtg cctgggacac tcgtatccgc tatgcattgg gcgaggtgca tcggttccat
      421 gtgacggtag ctcctggcac caaactggag agtggtccag ccactcttca tctctgcaat
      481 gacatcctgg tcctggccag agacatccct ccaactgtca cggggcagtg gaagttgtct
      541 gatctccggc gttatggggc tgtgccaaat ggattcatct ttgaaggcgg gaccaggtgt
      601 gggtactggg ctggagtctt cttcttgtcc tcagctgagg gagagcagat cagcttcctg
      661 tttgactgca ttgtccgagg catctcccca accaaaggcc catttgggct tcggccagtt
      721 ctcccagacc caagttctgg gggaccctca gcctcagaag agcgtgttgc ccaggaagca
      781 ctggaggccc tgcagctaga gaagaggctc agcctgcttt cacactctgg ccggccaggc
      841 agtggagggg atgatcgaag tctatccagt tcctcttctg aggccagcca ctcagacatc
      901 agcgccagca gccggctcac tgcatggcca gagcagtcct cgtcctcagc cagcacatcg
      961 caagaaggac cagggctggt ggctgcccag ggcccagggg aagccatgct gggagcctca
     1021 aggccacccc tcaagccact gcggcctcgg cagttacagg aggttggccg ccagagctcc
     1081 tctgacagtg gcattgccac aggcagccac tcctcctact ctggcagctt ctcatcctat
     1141 gcgggcagca acctggacgt gtggcgggct ggcgaggaat tcggttctct gctcagcctg
     1201 ccccctggag ccagcgcacc tgagcccaga ctgtgcgcct gcccacctgg ggcggccgag
     1261 taccaggtgc ccacttcatt gcgacaccac tacgacacac ctcgaagcct acgccaggcc
     1321 cccagagacc caagccccgc ctctcagggc ggctctgacc acagttcagc tacagactcg
     1381 ggtggtcagg cacccacggg gtctccctcc agttgtctgg gagctcgaag acgggggcag
     1441 gcaacggaag gcccaggcag tgaagctgtg ctgcccagtc catcccctgg cgagtcctgg
     1501 gaagcaggca gccctcatac tgggccacct ccagctttct ttttgtcttg ttcaatctgt
     1561 ggcggactca aggtcacggc tacttcatcc actggactca ctgtgacgca tccaggatcc
     1621 ccaggggtgg ctgctgacag ccctgggcct gaacgaccac acggcgagac gcccacgtat
     1681 gtgaatatcc ccatcagccc cacctccaga ctgcagctgc attacatgga cctagagctc
     1741 tcgggagcca gtgggggtgt gcgaggggtc agcgcctccc gctatgcaca gattgacatc
     1801 acagctacgg agacggcaca tcgcgtaggg gtccagcacg cgcagaaccg ggaggaacga
     1861 ttgccagagt tggagcagcg gaagaaggga ccctgagctg aggctgcagc tcaggctggg
     1921 actggccagc cggactgtcc aacagagaca ggaaggctgt ggttggcctt tgtgcatcgt
     1981 tggaatgagt ggtcgtaggt tctgggccca caccatatca gttcattcca atgtgtgaaa
     2041 gccgtgtagc agcctcctct ttgccagcag gggctcttgc cttactggtg cctaagactt
     2101 gacctgaaca agttctccta ggccacgggg ccaccaacag acccatctcc atgttttggt
     2161 agcctcagtg tcagccaaac agcactgcta agccacccag tgggactggg aagtccccca
     2221 ggcctggaat gcaagctgca ctacccatcc cggacggaag aggtgaccat ggtgacagca
     2281 gagcactcta aagccggttc tgtatccaga gggacctgtg acttgccact gatgagccac
     2341 tgagtggctc tgctgctggg acactgcagc agccttccct accttctcct gcagtgtctc
     2401 ccttgagcta ggccctgtgc cttaggatga aggccacggt ggggacagga ctgttccctc
     2461 ttgtcatcat gttgggacct actccagtag ctgggtaaat tgtcttaaat ccctactgtt
     2521 atatttttaa caatttatat tattttccaa agctg
//
