LOCUS       NM_001025416            1757 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus docking protein 1 (Dok1), mRNA.
ACCESSION   NM_001025416 XM_232106
VERSION     NM_001025416.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1757)
  AUTHORS   Goel,R.K., Miah,S., Black,K., Kalra,N., Dai,C. and Lukong,K.E.
  TITLE     The unique N-terminal region of SRMS regulates enzymatic activity
            and phosphorylation of its novel substrate docking protein 1
  JOURNAL   FEBS J 280 (18), 4539-4559 (2013)
   PUBMED   23822091
REFERENCE   2  (bases 1 to 1757)
  AUTHORS   Berger,A.H., Niki,M., Morotti,A., Taylor,B.S., Socci,N.D.,
            Viale,A., Brennan,C., Szoke,J., Motoi,N., Rothman,P.B.,
            Teruya-Feldstein,J., Gerald,W.L., Ladanyi,M. and Pandolfi,P.P.
  TITLE     Identification of DOK genes as lung tumor suppressors
  JOURNAL   Nat Genet 42 (3), 216-223 (2010)
   PUBMED   20139980
REFERENCE   3  (bases 1 to 1757)
  AUTHORS   Hiragun,T., Peng,Z. and Beaven,M.A.
  TITLE     Dexamethasone up-regulates the inhibitory adaptor protein Dok-1 and
            suppresses downstream activation of the mitogen-activated protein
            kinase pathway in antigen-stimulated RBL-2H3 mast cells
  JOURNAL   Mol Pharmacol 67 (3), 598-603 (2005)
   PUBMED   15608142
  REMARK    GeneRIF: Dok-1 is the mediator of the antiallergic actions of
            dexamethasone and as a negative regulator of the MAP kinase pathway
            and downstream release of inflammatory mediators.
REFERENCE   4  (bases 1 to 1757)
  AUTHORS   Abramson,J., Rozenblum,G. and Pecht,I.
  TITLE     Dok protein family members are involved in signaling mediated by
            the type 1 Fcepsilon receptor
  JOURNAL   Eur J Immunol 33 (1), 85-91 (2003)
   PUBMED   12594836
REFERENCE   5  (bases 1 to 1757)
  AUTHORS   Berg,K.L., Siminovitch,K.A. and Stanley,E.R.
  TITLE     SHP-1 regulation of p62(DOK) tyrosine phosphorylation in
            macrophages
  JOURNAL   J Biol Chem 274 (50), 35855-35865 (1999)
   PUBMED   10585470
REFERENCE   6  (bases 1 to 1757)
  AUTHORS   Yamanashi,Y. and Baltimore,D.
  TITLE     Identification of the Abl- and rasGAP-associated 62 kDa protein as
            a docking protein, Dok
  JOURNAL   Cell 88 (2), 205-211 (1997)
   PUBMED   9008161
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC097972.1.
            
            On Jul 15, 2005 this sequence version replaced XM_232106.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC097972.1, CV115728.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1757
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q34"
     gene            1..1757
                     /gene="Dok1"
                     /gene_synonym="Dok-1"
                     /note="docking protein 1"
                     /db_xref="GeneID:312477"
                     /db_xref="RGD:1309499"
     exon            1..68
                     /gene="Dok1"
                     /gene_synonym="Dok-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             9..1451
                     /gene="Dok1"
                     /gene_synonym="Dok-1"
                     /note="downstream of tyrosine kinase 1"
                     /codon_start=1
                     /product="docking protein 1"
                     /protein_id="NP_001020587.1"
                     /db_xref="GeneID:312477"
                     /db_xref="RGD:1309499"
                     /translation="MDGALMEGPLFLQSQRFGTKRWKKTWAVLYPASPHGVARLEFFD
                     HKGSSSGGGRGGSRRLDCKMIRLAECVSVVPVTVESPPEPGASAFRLDTAQRSHLLAA
                     DAASSTAWVQILCRTAFPKGGWALAQTENPPKFSALEMLENSLYSPTWEGSQFWVTSQ
                     KTEASERCGLQGSYVLRVEAEKLTLLTLGAQSQILEPLLFWPYTLLRRYGRDKVMFSF
                     EAGRRCPSGPGTFTFQTAQGNDIFQAVEAAIQQQKAQGKVGQGQDITRTDSHDGETEG
                     KMAPTPVPQEPLGSPPALYAEPLDSLRIPPGPSQDSLYSDPLGSTPAGAGEGVQRKKP
                     LYWDLYGHVQQQLLKTKLIDSKEDPIYDEPEGLAPAPLRGLYDLPQEPKDAWWCQARL
                     KEEGYELPYNPATDDYAVPPPRSSKPTPAPKPQGLILPESGTTAGSGSKGSDTALYSQ
                     VQKSGTPGRWDCGLSRVGNDRVGVKSEGST"
     exon            69..368
                     /gene="Dok1"
                     /gene_synonym="Dok-1"
                     /inference="alignment:Splign:2.1.0"
     exon            369..462
                     /gene="Dok1"
                     /gene_synonym="Dok-1"
                     /inference="alignment:Splign:2.1.0"
     exon            463..647
                     /gene="Dok1"
                     /gene_synonym="Dok-1"
                     /inference="alignment:Splign:2.1.0"
     exon            648..1732
                     /gene="Dok1"
                     /gene_synonym="Dok-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccttggccat ggacggggct ttgatggagg gtccgctttt tctgcagagt cagcgcttcg
       61 ggaccaagag gtggaagaaa acttgggctg tgctttaccc agccagccct cacggcgtgg
      121 cgcggctgga attctttgat cacaaggggt cgagctctgg agggggtcga ggcggctctc
      181 gccgtctaga ctgcaagatg atacgcctgg ctgaatgtgt gagcgtggtg cctgtgactg
      241 tggagagtcc ccctgagccc ggcgcctctg ccttccgcct ggacaccgca caacgctcgc
      301 acctgcttgc agcggacgcc gcatccagca ctgcctgggt gcagatttta tgcagaaccg
      361 cttttccgaa aggcggctgg gctttggctc agacggagaa cccacctaag ttttctgccc
      421 tggagatgct ggagaattcg ctgtacagcc ccacctggga aggatcccaa ttctgggtaa
      481 cctcgcagaa gaccgaggct tctgaacgct gcggcttgca aggctcctac gtactgaggg
      541 tagaagctga gaagctgacc cttctgactt tgggtgcaca gagtcaaatc ctggagccgc
      601 tccttttctg gccctacact ctgttgcgac gctatggccg agacaaggta atgttctcct
      661 ttgaagcggg tcgccgctgc ccctctggcc ctgggacctt caccttccag actgcccagg
      721 gaaatgacat ctttcaggca gttgaggctg ctatccagca gcagaaagcc caaggaaagg
      781 tgggacaggg acaagatatc accagaactg actcccatga tggggagaca gaggggaaga
      841 tggctcccac tcctgttccc caggaacccc tgggcagccc tccagcccta tatgcagagc
      901 ctttagactc cctgcgaatt cctccaggcc cttctcagga ctctttgtat tcagaccccc
      961 tgggcagcac ccctgctggg gcaggggaag gggtgcagcg gaagaaacct ctctattggg
     1021 atttgtatgg gcacgtgcag cagcagttgc tgaaaaccaa gctgatagac tccaaagagg
     1081 accccatcta tgatgagcct gagggcctgg cccctgcccc tctccggggc ctttatgatc
     1141 tgcctcagga gcctaaggat gcatggtggt gccaggctcg gctgaaggaa gagggctatg
     1201 agctccctta caaccccgcc accgacgact acgctgtgcc accccctcgg agctcaaagc
     1261 ctacccctgc ccccaagcca cagggcttga tccttcctga atctggtacc acagctggca
     1321 gtggcagcaa aggctcagat acagctctgt acagccaggt ccagaaaagt gggaccccag
     1381 ggagatggga ctgtggactc tctagagtag ggaatgacag ggtgggggtc aagtcagagg
     1441 gttccacctg agacagttgc tgataggagg tccatggggt ggtggcactg aagatcagag
     1501 aaacctgagg gtgggagggg ccgggggacc agaggagtca agtgatgacc agtccccgga
     1561 agttgtggga gtagaagaaa caaggctgct ggactgacta ggcctgtggg agaggtccac
     1621 tggtcagagt gaggacactt tggggaggcc agtatggatc ctcactcttg ttctttgcca
     1681 gatacgtttt aatttataag gcaaatctca ttaaaggtgg cttgattgaa aaaaaaaaaa
     1741 aaaaaaaaaa aaaaaaa
//
