LOCUS       NM_001025006            1599 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus deoxyhypusine hydroxylase (Dohh), mRNA.
ACCESSION   NM_001025006 XM_234926
VERSION     NM_001025006.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1599)
  AUTHORS   Lemay,S.E., Grobs,Y., Romanet,C., Martineau,S., Salem,M.,
            Shimauchi,T., Breuils-Bonnet,S., Bourgeois,A., Theberge,C.,
            Pelletier,A., Potus,F., Provencher,S., Bonnet,S. and Boucherat,O.
  TITLE     Hypusine Signaling Promotes Pulmonary Vascular Remodeling in
            Pulmonary Arterial Hypertension
  JOURNAL   Am J Respir Crit Care Med 209 (11), 1376-1391 (2024)
   PUBMED   38261723
REFERENCE   2  (bases 1 to 1599)
  AUTHORS   Han,Z., Sakai,N., Bottger,L.H., Klinke,S., Hauber,J.,
            Trautwein,A.X. and Hilgenfeld,R.
  TITLE     Crystal Structure of the Peroxo-diiron(III) Intermediate of
            Deoxyhypusine Hydroxylase, an Oxygenase Involved in Hypusination
  JOURNAL   Structure 23 (5), 882-892 (2015)
   PUBMED   25865244
REFERENCE   3  (bases 1 to 1599)
  AUTHORS   Sievert,H., Pallmann,N., Miller,K.K., Hermans-Borgmeyer,I.,
            Venz,S., Sendoel,A., Preukschas,M., Schweizer,M., Boettcher,S.,
            Janiesch,P.C., Streichert,T., Walther,R., Hengartner,M.O.,
            Manz,M.G., Brummendorf,T.H., Bokemeyer,C., Braig,M., Hauber,J.,
            Duncan,K.E. and Balabanov,S.
  TITLE     A novel mouse model for inhibition of DOHH-mediated hypusine
            modification reveals a crucial function in embryonic development,
            proliferation and oncogenic transformation
  JOURNAL   Dis Model Mech 7 (8), 963-976 (2014)
   PUBMED   24832488
REFERENCE   4  (bases 1 to 1599)
  AUTHORS   Vu,V.V., Emerson,J.P., Martinho,M., Kim,Y.S., Munck,E., Park,M.H.
            and Que,L. Jr.
  TITLE     Human deoxyhypusine hydroxylase, an enzyme involved in regulating
            cell growth, activates O2 with a nonheme diiron center
  JOURNAL   Proc Natl Acad Sci U S A 106 (35), 14814-14819 (2009)
   PUBMED   19706422
REFERENCE   5  (bases 1 to 1599)
  AUTHORS   Kang,K.R., Kim,Y.S., Wolff,E.C. and Park,M.H.
  TITLE     Specificity of the deoxyhypusine hydroxylase-eukaryotic translation
            initiation factor (eIF5A) interaction: identification of amino acid
            residues of the enzyme required for binding of its substrate,
            deoxyhypusine-containing eIF5A
  JOURNAL   J Biol Chem 282 (11), 8300-8308 (2007)
   PUBMED   17213197
REFERENCE   6  (bases 1 to 1599)
  AUTHORS   Kim,Y.S., Kang,K.R., Wolff,E.C., Bell,J.K., McPhie,P. and Park,M.H.
  TITLE     Deoxyhypusine hydroxylase is a Fe(II)-dependent, HEAT-repeat
            enzyme. Identification of amino acid residues critical for Fe(II)
            binding and catalysis [corrected]
  JOURNAL   J Biol Chem 281 (19), 13217-13225 (2006)
   PUBMED   16533814
  REMARK    Erratum:[J Biol Chem. 2007 Apr 6;282(14):10840]
REFERENCE   7  (bases 1 to 1599)
  AUTHORS   Park,J.H., Aravind,L., Wolff,E.C., Kaevel,J., Kim,Y.S. and
            Park,M.H.
  TITLE     Molecular cloning, expression, and structural prediction of
            deoxyhypusine hydroxylase: a HEAT-repeat-containing metalloenzyme
  JOURNAL   Proc Natl Acad Sci U S A 103 (1), 51-56 (2006)
   PUBMED   16371467
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Mar 18, 2021 this sequence version replaced NM_001025006.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087658.1, SRR26360190.1089390.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-156               JAXUCZ010000007.1  8976870-8977025     c
            157-474             JAXUCZ010000007.1  8974512-8974829     c
            475-551             JAXUCZ010000007.1  8974037-8974113     c
            552-792             JAXUCZ010000007.1  8973194-8973434     c
            793-1599            JAXUCZ010000007.1  8972202-8973008     c
FEATURES             Location/Qualifiers
     source          1..1599
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..1599
                     /gene="Dohh"
                     /gene_synonym="RGD1304783"
                     /note="deoxyhypusine hydroxylase"
                     /db_xref="GeneID:314644"
                     /db_xref="RGD:1304783"
     exon            1..156
                     /gene="Dohh"
                     /gene_synonym="RGD1304783"
                     /inference="alignment:Splign:2.1.0"
     exon            157..474
                     /gene="Dohh"
                     /gene_synonym="RGD1304783"
                     /inference="alignment:Splign:2.1.0"
     CDS             201..1109
                     /gene="Dohh"
                     /gene_synonym="RGD1304783"
                     /EC_number="1.14.99.29"
                     /note="deoxyhypusine dioxygenase; deoxyhypusine
                     monooxygenase; deoxyhypusine hydroxylase/monooxygenase"
                     /codon_start=1
                     /product="deoxyhypusine hydroxylase"
                     /protein_id="NP_001020177.1"
                     /db_xref="GeneID:314644"
                     /db_xref="RGD:1304783"
                     /translation="MVTEQEVEAIGKTLVDSTQPLQARFRALFTLRGLGGPDAISWIS
                     RGFEDSSALLKHELAYCLGQMRDPRAIPVLVSVLQDRNQEPMVRHEAGEALGAIGNPK
                     VLGLLKQYSTDPVVEVAETCQLAVRRLEWLQQHPGEATCAGPYLSVDPAPPAAEGDVG
                     RLRETLLDEAQPLFERYRAMFALRNVGGKEAALALAEGLKCGSALFRHEVGYVLGQLQ
                     HEAAVSELAATLARTTESPMVRHECAEALGAIARPACLAALREYITDPERVVRESCEV
                     ALDMYEYENGQDFQYADGLERLRPPP"
     exon            475..551
                     /gene="Dohh"
                     /gene_synonym="RGD1304783"
                     /inference="alignment:Splign:2.1.0"
     exon            552..792
                     /gene="Dohh"
                     /gene_synonym="RGD1304783"
                     /inference="alignment:Splign:2.1.0"
     exon            793..1599
                     /gene="Dohh"
                     /gene_synonym="RGD1304783"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccccgtctg atcacgtggc caccaagatg gcggcgccca gcggacggtg cgcgaggttc
       61 gtcagctgac ttgttctcgg agctgtggcc gcgacccgct tctacctgtc ccgagtgacc
      121 agagctcagt gaccagtcct tatagtcgaa agcaggcagg tttttactgc tgaggacctg
      181 gacccgctgg gaggcttgcc atggtaacag aacaggaggt agaggccata gggaaaaccc
      241 tagtggactc cacgcagccc ctgcaggccc gcttccgtgc cctgtttacc ctgcggggac
      301 ttggtggccc cgatgctatc tcctggatca gccgaggctt tgaggacagc tctgcccttc
      361 tgaagcacga gctagcctac tgcctgggcc agatgaggga cccacgagcc atccctgtgc
      421 tggtgtccgt cctacaggac aggaaccagg agcccatggt gcgtcatgag gcaggggaag
      481 cactgggggc gattggtaac ccgaaagttc taggcctcct gaagcagtat tccaccgacc
      541 cagtggttga ggtggctgag acgtgccagc tcgccgttag gcgtctagag tggctgcagc
      601 agcacccggg ggaggccaca tgtgcaggac cctacctctc agtagatcct gcaccccctg
      661 cggcagaagg tgatgtgggg cggctgcggg agaccctgct ggatgaggcg cagccactct
      721 tcgagcggta ccgtgccatg tttgccctgc gcaatgtggg tggcaaggag gctgccttgg
      781 ccctggctga aggcctgaag tgtggcagtg cgctcttccg acacgaggtg ggctatgtgc
      841 tgggtcagct gcagcacgaa gcagccgtgt ctgaactggc agccacattg gcacggacca
      901 ctgagagccc catggtacga catgagtgcg cagaggccct gggtgccatc gccaggcctg
      961 cctgcctggc tgcactgcgg gagtacatca cggaccctga gcgagtggtg cgggagagct
     1021 gcgaggtagc actggacatg tatgagtatg aaaatggcca ggacttccag tacgcagatg
     1081 ggctcgagcg cctgaggcca ccgccctgac atggcacccg gctcacccag cagcacccag
     1141 gactctgccc ggcacctggt cacctgctgg gactatcacc tgtcctgtga taggctgcct
     1201 cccccaccca ccacggccct ggccacatgg actgtgtggc ctctgctggc tgtgcctccc
     1261 atctagatta gggagcaagt agccaaggga ggggccttgc tttccactct gtgtacctgc
     1321 cctgctgggt gctggtgggc agtgccaccc catgctgtct gctctgtgat tctgtccctc
     1381 gcaccctcca cactagcaca gatggcagtg cagaagcttg cgggcattag gaatgactca
     1441 gctcaggaag ctgtggggaa agttgtgggg cctggggcag gggtgatggt tctgagtcca
     1501 taggggtcag gcgtgggggg gcgcacctca catctgggtc aagcagggag cacaagccag
     1561 ttccagggtg ctgcatgaat aaaatgttat ttctcacaa
//
