LOCUS       NM_001037793            7495 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus dedicator of cytokinesis 8 (Dock8), mRNA.
ACCESSION   NM_001037793 XM_574645
VERSION     NM_001037793.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7495)
  AUTHORS   Fan,M., Wang,J., Wang,S., Li,T., Pan,H., Liu,H., Xu,H.,
            Zhernakova,D.V., O'Brien,S.J., Feng,Z., Chang,L., Dai,E., Lu,J.,
            Xi,H., Yu,Y., Zhang,J., Wang,B. and Zeng,Z.
  TITLE     New Gene Variants Associated with the Risk of Chronic HBV Infection
  JOURNAL   Virol Sin 35 (4), 378-387 (2020)
   PUBMED   32297155
REFERENCE   2  (bases 1 to 7495)
  AUTHORS   Alroqi,F.J., Charbonnier,L.M., Keles,S., Ghandour,F., Mouawad,P.,
            Sabouneh,R., Mohammed,R., Almutairi,A., Chou,J., Massaad,M.J.,
            Geha,R.S., Baz,Z. and Chatila,T.A.
  TITLE     DOCK8 Deficiency Presenting as an IPEX-Like Disorder
  JOURNAL   J Clin Immunol 37 (8), 811-819 (2017)
   PUBMED   29058101
REFERENCE   3  (bases 1 to 7495)
  AUTHORS   Xu,X., Han,L., Zhao,G., Xue,S., Gao,Y., Xiao,J., Zhang,S., Chen,P.,
            Wu,Z.Y., Ding,J., Hu,R., Wei,B. and Wang,H.
  TITLE     LRCH1 interferes with DOCK8-Cdc42-induced T cell migration and
            ameliorates experimental autoimmune encephalomyelitis
  JOURNAL   J Exp Med 214 (1), 209-226 (2017)
   PUBMED   28028151
REFERENCE   4  (bases 1 to 7495)
  AUTHORS   Arndt,T., Wedekind,D., Jorns,A., Tsiavaliaris,G., Cuppen,E.,
            Hedrich,H.J. and Lenzen,S.
  TITLE     A novel Dock8 gene mutation confers diabetogenic susceptibility in
            the LEW.1AR1/Ztm-iddm rat, an animal model of human type 1 diabetes
  JOURNAL   Diabetologia 58 (12), 2800-2809 (2015)
   PUBMED   26363782
  REMARK    GeneRIF: The Dock8 mutation gave rise to a new type 1 diabetes rat
            model with very close similarity to type 1 diabetes in humans
REFERENCE   5  (bases 1 to 7495)
  AUTHORS   Flesch,I.E., Randall,K.L., Hollett,N.A., Di Law,H., Miosge,L.A.,
            Sontani,Y., Goodnow,C.C. and Tscharke,D.C.
  TITLE     Delayed control of herpes simplex virus infection and impaired
            CD4(+) T-cell migration to the skin in mouse models of DOCK8
            deficiency
  JOURNAL   Immunol Cell Biol 93 (6), 517-521 (2015)
   PUBMED   25776845
REFERENCE   6  (bases 1 to 7495)
  AUTHORS   Harada,Y., Tanaka,Y., Terasawa,M., Pieczyk,M., Habiro,K.,
            Katakai,T., Hanawa-Suetsugu,K., Kukimoto-Niino,M., Nishizaki,T.,
            Shirouzu,M., Duan,X., Uruno,T., Nishikimi,A., Sanematsu,F.,
            Yokoyama,S., Stein,J.V., Kinashi,T. and Fukui,Y.
  TITLE     DOCK8 is a Cdc42 activator critical for interstitial dendritic cell
            migration during immune responses
  JOURNAL   Blood 119 (19), 4451-4461 (2012)
   PUBMED   22461490
REFERENCE   7  (bases 1 to 7495)
  AUTHORS   Lambe,T., Crawford,G., Johnson,A.L., Crockford,T.L.,
            Bouriez-Jones,T., Smyth,A.M., Pham,T.H., Zhang,Q., Freeman,A.F.,
            Cyster,J.G., Su,H.C. and Cornall,R.J.
  TITLE     DOCK8 is essential for T-cell survival and the maintenance of CD8+
            T-cell memory
  JOURNAL   Eur J Immunol 41 (12), 3423-3435 (2011)
   PUBMED   21969276
REFERENCE   8  (bases 1 to 7495)
  AUTHORS   Dasouki,M., Okonkwo,K.C., Ray,A., Folmsbeel,C.K., Gozales,D.,
            Keles,S., Puck,J.M. and Chatila,T.
  TITLE     Deficient T Cell Receptor Excision Circles (TRECs) in autosomal
            recessive hyper IgE syndrome caused by DOCK8 mutation: implications
            for pathogenesis and potential detection by newborn screening
  JOURNAL   Clin Immunol 141 (2), 128-132 (2011)
   PUBMED   21763205
REFERENCE   9  (bases 1 to 7495)
  AUTHORS   Randall,K.L., Chan,S.S., Ma,C.S., Fung,I., Mei,Y., Yabas,M.,
            Tan,A., Arkwright,P.D., Al Suwairi,W., Lugo Reyes,S.O.,
            Yamazaki-Nakashimada,M.A., Garcia-Cruz Mde,L., Smart,J.M.,
            Picard,C., Okada,S., Jouanguy,E., Casanova,J.L., Lambe,T.,
            Cornall,R.J., Russell,S., Oliaro,J., Tangye,S.G., Bertram,E.M. and
            Goodnow,C.C.
  TITLE     DOCK8 deficiency impairs CD8 T cell survival and function in humans
            and mice
  JOURNAL   J Exp Med 208 (11), 2305-2320 (2011)
   PUBMED   22006977
REFERENCE   10 (bases 1 to 7495)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Sep 4, 2008 this sequence version replaced NM_001037793.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.6027.1,
                                           SRR26643295.6318.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-172               JAXUCZ010000001.1  232075677-232075848
            173-275             JAXUCZ010000001.1  232120753-232120855
            276-451             JAXUCZ010000001.1  232130427-232130602
            452-523             JAXUCZ010000001.1  232134647-232134718
            524-647             JAXUCZ010000001.1  232147003-232147126
            648-860             JAXUCZ010000001.1  232148695-232148907
            861-946             JAXUCZ010000001.1  232154893-232154978
            947-1013            JAXUCZ010000001.1  232160087-232160153
            1014-1163           JAXUCZ010000001.1  232163338-232163487
            1164-1244           JAXUCZ010000001.1  232167772-232167852
            1245-1404           JAXUCZ010000001.1  232168859-232169018
            1405-1541           JAXUCZ010000001.1  232170632-232170768
            1542-1635           JAXUCZ010000001.1  232173199-232173292
            1636-1798           JAXUCZ010000001.1  232174382-232174544
            1799-1916           JAXUCZ010000001.1  232188624-232188741
            1917-1987           JAXUCZ010000001.1  232190451-232190521
            1988-2126           JAXUCZ010000001.1  232191533-232191671
            2127-2228           JAXUCZ010000001.1  232192271-232192372
            2229-2324           JAXUCZ010000001.1  232195099-232195194
            2325-2559           JAXUCZ010000001.1  232195508-232195742
            2560-2724           JAXUCZ010000001.1  232197723-232197887
            2725-2897           JAXUCZ010000001.1  232198791-232198963
            2898-2993           JAXUCZ010000001.1  232205318-232205413
            2994-3089           JAXUCZ010000001.1  232208357-232208452
            3090-3239           JAXUCZ010000001.1  232215245-232215394
            3240-3353           JAXUCZ010000001.1  232217089-232217202
            3354-3509           JAXUCZ010000001.1  232221009-232221164
            3510-3649           JAXUCZ010000001.1  232223075-232223214
            3650-3819           JAXUCZ010000001.1  232226743-232226912
            3820-3959           JAXUCZ010000001.1  232229207-232229346
            3960-4142           JAXUCZ010000001.1  232231099-232231281
            4143-4272           JAXUCZ010000001.1  232231612-232231741
            4273-4360           JAXUCZ010000001.1  232232453-232232540
            4361-4457           JAXUCZ010000001.1  232237782-232237878
            4458-4592           JAXUCZ010000001.1  232239918-232240052
            4593-4745           JAXUCZ010000001.1  232240880-232241032
            4746-4904           JAXUCZ010000001.1  232242631-232242789
            4905-5005           JAXUCZ010000001.1  232243741-232243841
            5006-5198           JAXUCZ010000001.1  232245007-232245199
            5199-5342           JAXUCZ010000001.1  232250181-232250324
            5343-5474           JAXUCZ010000001.1  232251487-232251618
            5475-5609           JAXUCZ010000001.1  232252031-232252165
            5610-5699           JAXUCZ010000001.1  232253410-232253499
            5700-5936           JAXUCZ010000001.1  232256867-232257103
            5937-6080           JAXUCZ010000001.1  232260496-232260639
            6081-6187           JAXUCZ010000001.1  232261820-232261926
            6188-6358           JAXUCZ010000001.1  232267123-232267293
            6359-7495           JAXUCZ010000001.1  232267694-232268830
FEATURES             Location/Qualifiers
     source          1..7495
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q51"
     gene            1..7495
                     /gene="Dock8"
                     /note="dedicator of cytokinesis 8"
                     /db_xref="GeneID:499337"
                     /db_xref="RGD:1561588"
     exon            1..172
                     /gene="Dock8"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..6419
                     /gene="Dock8"
                     /codon_start=1
                     /product="dedicator of cytokinesis protein 8"
                     /protein_id="NP_001032882.2"
                     /db_xref="GeneID:499337"
                     /db_xref="RGD:1561588"
                     /translation="MATLPSAERRAFALKINRYSSSEIRKQFTLPPNLGQYHRHSLST
                     SGFPSLQLPQLYEPVEPVDFEGLVMTHLNSLDAELAQELGDLTDDDLHVAFTPKECRT
                     LQHSLPEEGVELDPHVRDCVQTYIREWLIVNRKNQGSPEFCSFRKTGSRRDFHKTLQK
                     QTFESETLECSEPATQTGPRHRFNVLCDVSGKGPITSCDFDLRSLQPDERLENLLQLS
                     AEDFEKEKEEARKTNRTAELFALYPSVDEEDAVEIRPVPECPKEHLGNRILVKVLTLK
                     FEIEIEPLFASIALYDVKERKKISENFHCDLNSDQFKGFLRAHTPSVDPSSQARSAVF
                     SVTYPSSDIYLVVKIEKVLQQGEIADCAEPYMIIKESDGGKSKEKVEKLKLQAESFCQ
                     RLGKYRMPFAWAPISLASFFNVSTLERESTDLEPGAGRNSVGERRSLSQSRRPSERTL
                     SFEENGVGSNFKTTTLATNIFFKQEGDRLSDEDLFKFLADYKRSSSLQRRVKSIPGSL
                     RLEIAPAPDVMNCCLTPEMLPVKPFPENRTRPHKEILEFPIREVYVPHTVYRNLLYVY
                     PQRLNFANKLASARNITIKIQFMCGEDPSNAMPVIFGKSSGPEFLQEVYTAITYHNKS
                     PDFYEEVKIKLPAKLTVNHHLLFTFYHISCQQKQGASGESLLGYSWLPILLNERLQTG
                     SYCLPVALEKLPPNYSIHSAEKVPLQNPPIKWAEGHKGVFNIEVQAVSSVHTQDNHLE
                     KFFTLCHSLESQVTFPIRVLDQKITENTLEHELKLSIICLNSSRLEPLVLFLHLVLDK
                     LFQLSVQPMVIAGQTANFSQFAFESVVAIANSLHNSKDLRKDQHGRNCLLASYVHYVF
                     RLPELHRDAPKSGGPTAVVPDPRYHTYGRTSAAAVSSKLMQARVMSSSNPDLAGTHCA
                     ADEEVKNIMSSKIADRNCSRMSYYCSGNSDVPGSTAAPRPVSKKHFHEELALQMVVST
                     GLVRETVFKYAWFFFELLVKSMAQYVHNLDKRDSFRRTRFSDRFKDDITTIVNVVTSE
                     IAALLVKPQKESEQAEKINISLAFFLYDLLSIMDRGFVFNLIKHYCTQLSAKLNTLPT
                     LISMRLEFLRILCSHEHYLNLNLLFMNPDTAPASPCPSISSQNSSSCSSFQDQKIASM
                     FDLTPEYRQQHFLTGLLFTELAVALDAEGDGISRVQRKAVSAIHSLLSSHDLDPRCLK
                     PEVKVKIAALYLPLVGIILDALPQLYDFTDARSGRSRASGSYEEQDVANGINQNVALA
                     IAGNHFNLKTSGAMLSSLPYKQYNMLNADTTRHLMVCFLWIMKNADQSLIRKWIADLP
                     SMQLNRILDLLFICVSCFEYKGKQSSDKVSNQVLQKSRDVKAKLEEALLRGEGARGEM
                     MRRRIPGTDRFPGLNENLRWRKEQTQWRQANEKLDKTKAELDQEALISGNLATEANLI
                     ILDMQENIIQASSSLDCKDSLLGGVLRVLVNSLSCDQSTTYLTHCFATLRALIAKFGD
                     LLFEEEMEQCADLCQRVLHHCSSSMDVTRSQACATLYLLMRFSFGATSNFARVKMQVT
                     MALASLVGKAPDFNEEHLRKSLRTILAYSEEDTAMRATLFPTQVEELLCNLNSILYDT
                     VKMREFQEDPEMLMDLMYRIAKSYQASPDLRLTWLQNMAEKHTKRKCFTEAAMCLVHA
                     AALVAEYLSMLEDHSYLPVGSVSFQNISSNVLEESAVSDDTLSPDEDGVCSGRYFTES
                     GLVGLLEQAAELFSTGGLYETVNEVYKLVIPILEAHRDFRKLTSTHDKLQKAFDNIIN
                     KDHKRMFGTYFRVGFYGSKFGDLDEQEFVYKEPAITKLPEISHRLEGFYGQCFGAEFV
                     EVIKDSTPVDKTKLDPNKAYIQITFVEPYFDEYEMKDRVTYFEKNFNLRRFMYTTPFT
                     LEGRPRGELHEQHRRNTVLTTMHAFPYIKTRIRVSQKEEFVLTPIEVAIEDMKKKTLQ
                     LAVATHQEPPDAKMLQMVLQGSVGATVNQGPLEVAQVFLAEIPADPKLYRHHNKLRLC
                     FKEFIMRCGEAVEKNRRLITAEQREYQQELKKNYNRLKDSLRPMIERKIPELYKPIFR
                     VDSQKRDSFHRSSFRKCETQLSQGS"
     exon            173..275
                     /gene="Dock8"
                     /inference="alignment:Splign:2.1.0"
     exon            276..451
                     /gene="Dock8"
                     /inference="alignment:Splign:2.1.0"
     exon            452..523
                     /gene="Dock8"
                     /inference="alignment:Splign:2.1.0"
     exon            524..647
                     /gene="Dock8"
                     /inference="alignment:Splign:2.1.0"
     exon            648..860
                     /gene="Dock8"
                     /inference="alignment:Splign:2.1.0"
     exon            861..946
                     /gene="Dock8"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1013
                     /gene="Dock8"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1163
                     /gene="Dock8"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1244
                     /gene="Dock8"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1404
                     /gene="Dock8"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1541
                     /gene="Dock8"
                     /inference="alignment:Splign:2.1.0"
     exon            1542..1635
                     /gene="Dock8"
                     /inference="alignment:Splign:2.1.0"
     exon            1636..1798
                     /gene="Dock8"
                     /inference="alignment:Splign:2.1.0"
     exon            1799..1916
                     /gene="Dock8"
                     /inference="alignment:Splign:2.1.0"
     exon            1917..1987
                     /gene="Dock8"
                     /inference="alignment:Splign:2.1.0"
     exon            1988..2126
                     /gene="Dock8"
                     /inference="alignment:Splign:2.1.0"
     exon            2127..2228
                     /gene="Dock8"
                     /inference="alignment:Splign:2.1.0"
     exon            2229..2324
                     /gene="Dock8"
                     /inference="alignment:Splign:2.1.0"
     exon            2325..2559
                     /gene="Dock8"
                     /inference="alignment:Splign:2.1.0"
     exon            2560..2724
                     /gene="Dock8"
                     /inference="alignment:Splign:2.1.0"
     exon            2725..2897
                     /gene="Dock8"
                     /inference="alignment:Splign:2.1.0"
     exon            2898..2993
                     /gene="Dock8"
                     /inference="alignment:Splign:2.1.0"
     exon            2994..3089
                     /gene="Dock8"
                     /inference="alignment:Splign:2.1.0"
     exon            3090..3239
                     /gene="Dock8"
                     /inference="alignment:Splign:2.1.0"
     exon            3240..3353
                     /gene="Dock8"
                     /inference="alignment:Splign:2.1.0"
     exon            3354..3509
                     /gene="Dock8"
                     /inference="alignment:Splign:2.1.0"
     exon            3510..3649
                     /gene="Dock8"
                     /inference="alignment:Splign:2.1.0"
     exon            3650..3819
                     /gene="Dock8"
                     /inference="alignment:Splign:2.1.0"
     exon            3820..3959
                     /gene="Dock8"
                     /inference="alignment:Splign:2.1.0"
     exon            3960..4142
                     /gene="Dock8"
                     /inference="alignment:Splign:2.1.0"
     exon            4143..4272
                     /gene="Dock8"
                     /inference="alignment:Splign:2.1.0"
     exon            4273..4360
                     /gene="Dock8"
                     /inference="alignment:Splign:2.1.0"
     exon            4361..4457
                     /gene="Dock8"
                     /inference="alignment:Splign:2.1.0"
     exon            4458..4592
                     /gene="Dock8"
                     /inference="alignment:Splign:2.1.0"
     exon            4593..4745
                     /gene="Dock8"
                     /inference="alignment:Splign:2.1.0"
     exon            4746..4904
                     /gene="Dock8"
                     /inference="alignment:Splign:2.1.0"
     exon            4905..5005
                     /gene="Dock8"
                     /inference="alignment:Splign:2.1.0"
     exon            5006..5198
                     /gene="Dock8"
                     /inference="alignment:Splign:2.1.0"
     exon            5199..5342
                     /gene="Dock8"
                     /inference="alignment:Splign:2.1.0"
     exon            5343..5474
                     /gene="Dock8"
                     /inference="alignment:Splign:2.1.0"
     exon            5475..5609
                     /gene="Dock8"
                     /inference="alignment:Splign:2.1.0"
     exon            5610..5699
                     /gene="Dock8"
                     /inference="alignment:Splign:2.1.0"
     exon            5700..5936
                     /gene="Dock8"
                     /inference="alignment:Splign:2.1.0"
     exon            5937..6080
                     /gene="Dock8"
                     /inference="alignment:Splign:2.1.0"
     exon            6081..6187
                     /gene="Dock8"
                     /inference="alignment:Splign:2.1.0"
     exon            6188..6358
                     /gene="Dock8"
                     /inference="alignment:Splign:2.1.0"
     exon            6359..7495
                     /gene="Dock8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgcgcggct gacagatgaa gctggcgacg gacgcgccgg gcgctgcagc ggctgtgcgt
       61 tcgggtcccg tccctccgcc tccctgcgag ccccgaggtc gtggagcggc gcgccggcca
      121 tggccacgct accgagcgcc gagcgccgcg ccttcgcgct caagatcaac aggtattcat
      181 catcagaaat aaggaagcag tttacgctcc cgcccaacct cggacagtac catcggcaca
      241 gcctcagtac ctctggtttc ccttctcttc agctacctca gctgtatgag cccgttgagc
      301 ctgtggactt tgaaggactt gtgatgacgc acttaaacag cttggatgca gagctggccc
      361 aggagctggg ggacctcacc gatgacgacc tgcatgtggc cttcacaccc aaggagtgta
      421 ggactttgca gcactctctg ccagaggaag gagttgaact ggatcctcac gtcagggact
      481 gtgttcagac ctatattcga gagtggctga ttgtgaaccg gaaaaaccaa ggaagtccag
      541 agttttgcag cttcagaaag actggatctc gcagagattt tcacaagacg cttcagaaac
      601 agacgtttga gtcagaaacc ttggagtgca gtgaaccggc cactcagacg ggaccccgcc
      661 atcgcttcaa cgtgctgtgt gatgtgtctg ggaagggccc catcacttct tgtgacttcg
      721 acctccgcag cctgcagcct gacgagcggc tggaaaacct gcttcagctg agtgctgagg
      781 actttgagaa ggagaaagag gaggcccgaa agaccaatcg gacggctgag ctcttcgccc
      841 tctatccatc cgtagatgag gaggatgctg tggaaatccg tccagtacca gaatgtccta
      901 aggaacatct gggcaacaga atattggtga aggtgctgac cctgaagttt gagattgaaa
      961 ttgaacctct gtttgccagt attgccctct atgatgttaa agaaaggaaa aagatctcag
     1021 aaaacttcca ctgtgacctg aactccgacc agttcaaagg gtttctgcga gctcacacac
     1081 cctcggttga cccgtcgagt caggcaaggt ctgcagtgtt ctcggtcacc tacccatctt
     1141 cagacatcta cctggttgtc aagattgaaa aggtccttca gcaaggagag atcgcagact
     1201 gtgcagaacc ctacatgatc atcaaagaaa gcgatggtgg aaagagtaaa gaaaaggttg
     1261 aaaaactaaa actccaagct gaatccttct gccaacgttt ggggaaatac cggatgccct
     1321 tcgcctgggc ccccatcagc ttagcaagct tcttcaacgt ctccaccctt gaaagggaga
     1381 gcacagactt ggagcctggg gctgggagaa actctgtggg ggagaggagg agtttgtccc
     1441 agtccaggag gccttctgag agaaccctct cctttgagga aaatggagtt ggatccaact
     1501 tcaaaaccac caccttggcc actaacatct tcttcaagca ggagggagat cgccttagtg
     1561 atgaagactt gttcaagttt ttagctgact acaagagatc ttcgtcccta cagcgaagag
     1621 tgaaatccat cccaggctca cttaggctgg agatagcccc agctcctgac gtgatgaact
     1681 gctgcctgac acccgagatg ctgccggtca aacccttccc tgaaaatcgg acgcgtcccc
     1741 acaaggagat tttggaattt ccaatccggg aagtgtatgt tccccacacc gtgtacagaa
     1801 accttctgta cgtataccca cagagactga actttgctaa caagctagca tccgcccgga
     1861 acattacaat aaagattcag tttatgtgtg gagaagaccc cagcaatgct atgcctgtca
     1921 tctttgggaa gtccagtggg cctgaatttc tgcaggaagt gtacacagct attacatacc
     1981 ataataagtc tcccgacttt tatgaagaag taaagattaa gcttccggcc aagctcacag
     2041 tgaatcacca cctcctcttc accttctacc acatcagctg tcagcagaag caaggcgcct
     2101 ctggagaaag ccttctggga tactcgtggc tgccgattct cctgaacgaa cgtcttcaaa
     2161 ccggatccta ctgtctacca gttgccttgg aaaaactacc acctaactac tccatacatt
     2221 ctgctgagaa agtcccttta cagaatcctc ccattaagtg ggccgagggc cataaggggg
     2281 tatttaatat tgaagtgcaa gctgtttcct ccgttcacac ccaggataac cacctggaga
     2341 agttcttcac cctttgccac tccctggaga gccaggtgac cttccctatc cgcgtgctgg
     2401 accagaagat cacggagaac acgctggagc atgagcttaa gctcagcatc atctgcctca
     2461 actcctcccg cctggagccc ctcgtgctct tcctccacct ggtgctggat aagctcttcc
     2521 agctctctgt gcagcccatg gtcatcgctg gccaaacagc aaacttctcc cagtttgcct
     2581 tcgaatctgt ggtggccatt gccaatagcc ttcacaacag caaggacctg aggaaggacc
     2641 agcacgggag gaactgcctg ctggcctcct atgtgcacta cgtgttccgg ctgcccgagc
     2701 tgcacaggga tgcacccaag tcaggtggcc ccaccgccgt agtccctgac ccccgatacc
     2761 acacatatgg acgcacgtct gccgctgcag tgagttcaaa gctgatgcag gcccgtgtga
     2821 tgagcagcag taacccagac ctggctggga cacactgtgc agcagatgag gaggttaaga
     2881 acatcatgtc ttccaagatt gctgatcgca actgcagccg gatgtcttac tattgctctg
     2941 gcaacagtga cgttccaggt tcaactgcag ccccaaggcc agtcagcaaa aagcatttcc
     3001 atgaggagct tgccctgcag atggtggtca gcactggact agtgagagaa accgtcttca
     3061 agtacgcctg gttcttcttt gagcttctgg tgaaaagcat ggcacagtac gtccataacc
     3121 tggataaacg ggacagtttt cggaggactc gtttttccga ccgcttcaag gatgacataa
     3181 ctaccattgt taatgtggtc acctcggaga tagcagccct tctagtgaaa cctcagaagg
     3241 aaagtgagca ggccgagaag atcaacatca gcctggcctt cttcctgtat gacctcctct
     3301 caatcatgga cagaggcttc gtgttcaacc tcatcaagca ttactgcact cagctatcag
     3361 ccaagcttaa cacccttcca accctcattt ccatgcggct ggagttcctg agaatcctct
     3421 gcagccacga gcactacctc aacttgaacc tgctcttcat gaatcctgac accgcaccag
     3481 cctctccctg tccctccata tcctcccaga actcaagctc ctgctccagt ttccaggacc
     3541 aaaagattgc cagcatgttc gatctgaccc cagagtaccg ccagcagcac ttcctcacag
     3601 ggctcctctt cacagaactg gccgttgccc tggatgctga aggggacgga attagcagag
     3661 tacagagaaa agccgtgagt gccatccaca gccttctgag ttctcacgac ctggatccac
     3721 ggtgtctcaa accagaagtg aaagtcaaaa tcgctgccct ttacctgccg ttggtcggca
     3781 tcattctgga tgcgctgcca cagctctatg actttacaga tgctcgcagt ggaaggagcc
     3841 gtgccagtgg ctcatatgaa gaacaagatg tggccaatgg aatcaaccag aatgtggccc
     3901 tggccatagc agggaatcat tttaatttga agaccagcgg agcaatgctg tcttccttgc
     3961 cctataagca gtacaacatg ctgaacgcgg acactacccg ccacctcatg gtctgctttc
     4021 tgtggatcat gaaaaacgcg gatcagagcc tcatcaggaa gtggatcgcc gacctgcctt
     4081 ccatgcagct caacaggatt ctagacctgc tgttcatctg tgtctcctgc tttgaataca
     4141 agggaaagca gagttctgac aaagtcagta accaggtcct gcagaagtca agagatgtca
     4201 aggccaagtt ggaagaagcc ctgctccgtg gggaaggagc ccggggggag atgatgcgac
     4261 gtcggattcc aggcactgac cggtttccag gcctaaatga gaatctgagg tggaggaagg
     4321 agcagacaca gtggcggcaa gctaacgaga agctggacaa aacaaaggca gagttagatc
     4381 aagaagcctt gatcagtggc aacctggcta cagaggctaa tttgatcata ctggacatgc
     4441 aggaaaacat catccaggca agctcctccc tggactgtaa agacagcctg ctgggaggtg
     4501 tcctccgggt cctggtgaat tctctgagct gtgatcagag caccacctac ctgactcact
     4561 gttttgcaac tctccgagcc ctcatcgcca agtttggaga cctgctgttc gaggaggaaa
     4621 tggagcagtg tgctgacctg tgtcagcggg tgctccatca ctgcagcagt agcatggatg
     4681 tcacccggag ccaagcctgc gccaccctct atctactcat gcggttcagc ttcggagcca
     4741 ccagtaactt tgcaagagta aagatgcagg taaccatggc actggcatcc ttggtaggca
     4801 aagcaccaga cttcaatgag gagcacctga gaaagtcctt aaggaccatt ctggcctatt
     4861 cagaagagga cacggccatg cgggcaactc tttttcccac gcaggtggag gagcttctct
     4921 gcaatctcaa cagcatttta tacgacacag tgaagatgag ggaattccag gaggaccctg
     4981 agatgctcat ggacctcatg tacagaattg ccaagagcta ccaggcatcc cctgacctgc
     5041 ggctgacctg gctccagaac atggcagaga aacacactaa gaggaagtgc ttcacagagg
     5101 ccgccatgtg cctggtgcat gcagcagcct tggtggcaga gtacctgagc atgctggagg
     5161 accacagtta cctgcctgtg ggcagcgtca gctttcagaa tatttcttcc aatgtgcttg
     5221 aggaatctgc agtctccgat gacaccttgt cacctgatga ggacggtgta tgctctggtc
     5281 gctacttcac tgagagtggc ctggtgggcc tcctggagca ggctgcagag ctcttcagca
     5341 cgggaggctt gtacgagaca gttaatgagg tctacaagct ggtcattccc atcctggaag
     5401 cacatagaga tttccggaag ctgacctcta ctcacgacaa gctgcagaag gcctttgaca
     5461 acatcatcaa caaggaccat aagaggatgt ttggaactta cttccgagtt ggtttctacg
     5521 gatccaaatt tggggatttg gatgagcagg aatttgtgta caaggaacct gcaattacaa
     5581 agctccccga gatctcacat agactagagg gattttatgg ccagtgtttt ggtgccgagt
     5641 ttgtggaagt gataaaggac tctactcccg tggataaaac caagttggat cctaacaagg
     5701 cctacataca gatcactttt gtggagcctt actttgatga gtatgagatg aaagacaggg
     5761 tgacctactt cgagaagaat ttcaaccttc ggaggttcat gtacaccacc cccttcaccc
     5821 tggaggggag gccccgggga gagctgcacg agcagcatcg caggaacacg gtgctcacca
     5881 ccatgcatgc cttcccctac atcaagacca ggatccgagt cagccagaaa gaggagttcg
     5941 tcttgactcc gattgaagtt gccattgaag acatgaagaa gaagaccttg cagttagcgg
     6001 tggccactca ccaggagccc cctgacgcga agatgctcca gatggtactg caaggctctg
     6061 tgggagccac cgtgaatcag ggcccactgg aggtggccca agtgttcttg gctgaaattc
     6121 cggctgaccc aaaactctac cggcatcaca acaagctgag gttatgcttc aaggagttca
     6181 taatgcgatg cggtgaggcc gtagagaaga acaggagact cattaccgca gagcagcggg
     6241 agtaccagca ggaactcaag aagaactaca acaggctgaa ggacagcctc aggcccatga
     6301 ttgagcggaa aatcccagag ctctacaagc ccatattcag ggttgacagt caaaagaggg
     6361 actctttcca cagatctagt ttcaggaaat gtgaaaccca gttgtcacag ggcagctgaa
     6421 aaaagccacc tttgcctgta gtgactgggg ccccactacc tggaaggact cactggtacg
     6481 tccccagcag ccacccaaga ctgactgtcc agccagtgct ctggaaactt gtatttatta
     6541 aaatattttt catactgctg tacaaacaag gcctaagctg tttctgccga gtggccggtc
     6601 atggtcctcc catgaagtga tgtcttctga cctatatctg aattcctaaa ataaactcaa
     6661 accgtggacg gaagagtgga ccactgtcct gcagcctact ccaagtgagc ttcactcatc
     6721 ccttcagtga gaagaaaaga taaactccag agaagtgaaa cgttttccaa atcatctgtg
     6781 agaggaagtc ctacaggaag cctggtctca tgctggctgg gaatctggga atagatggat
     6841 cgatcactct acaagctgct ttttgcccct cctgcattgc tggactgagt gccatctagt
     6901 tatctctgcg ttgttgcttc tgttaagctg agtgagccca cctttatcca ggggacagtt
     6961 gtacaggaca gtacagatca cccggccaca cggcgctgac agcgcattcc ccagagcgga
     7021 agcagttctc ccagaacgtt ttgctggttt cctatacgct tgctctcact gtctcctttc
     7081 tcttctctgg gataaggtga tttatttttt tttatttttt tttataggtg atttttatac
     7141 aagggtaata ctctgccttc gctccagaac attcgtcctc tgtgtgctac aaaatatatg
     7201 cttttgattc tttttacagt gtattttagg aaaaagaaaa acaaagctat ggtttgagaa
     7261 ttaaattata tattttttca tacaactcac gaccttaacg aatactaaag atggaataca
     7321 gacggcaagc aagtgggaag ctggcaccca cctttagtcc tagctctcgg aggccagcct
     7381 ggtcgacaga gcgagctcca ggacagccag atggacacag tgagaccaag tctcataaat
     7441 aaataaataa ataaataaat aaataaataa ataaatcaat caatcaatca atcaa
//
