LOCUS       NM_001415885            7767 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus dedicator of cytokinesis 7 (Dock7), transcript
            variant 1, mRNA.
ACCESSION   NM_001415885
VERSION     NM_001415885.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7767)
  AUTHORS   Sobczak,M., Chumak,V., Pomorski,P., Wojtera,E., Majewski,L.,
            Nowak,J., Yamauchi,J. and Redowicz,M.J.
  TITLE     Interaction of myosin VI and its binding partner DOCK7 plays an
            important role in NGF-stimulated protrusion formation in PC12 cells
  JOURNAL   Biochim Biophys Acta 1863 (7 Pt A), 1589-1600 (2016)
   PUBMED   27018747
  REMARK    GeneRIF: Interaction of myosin VI and its binding partner DOCK7
            plays an important role in NGF-stimulated protrusion formation in
            PC12 cells.
REFERENCE   2  (bases 1 to 7767)
  AUTHORS   Nagamachi,A., Matsui,H., Asou,H., Ozaki,Y., Aki,D., Kanai,A.,
            Takubo,K., Suda,T., Nakamura,T., Wolff,L., Honda,H. and Inaba,T.
  TITLE     Haploinsufficiency of SAMD9L, an endosome fusion facilitator,
            causes myeloid malignancies in mice mimicking human diseases with
            monosomy 7
  JOURNAL   Cancer Cell 24 (3), 305-317 (2013)
   PUBMED   24029230
REFERENCE   3  (bases 1 to 7767)
  AUTHORS   Motyl,K.J., Bishop,K.A., DeMambro,V.E., Bornstein,S.A., Le,P.,
            Kawai,M., Lotinun,S., Horowitz,M.C., Baron,R., Bouxsein,M.L. and
            Rosen,C.J.
  TITLE     Altered thermogenesis and impaired bone remodeling in Misty mice
  JOURNAL   J Bone Miner Res 28 (9), 1885-1897 (2013)
   PUBMED   23553822
REFERENCE   4  (bases 1 to 7767)
  AUTHORS   Yang,Y.T., Wang,C.L. and Van Aelst,L.
  TITLE     DOCK7 interacts with TACC3 to regulate interkinetic nuclear
            migration and cortical neurogenesis
  JOURNAL   Nat Neurosci 15 (9), 1201-1210 (2012)
   PUBMED   22842144
REFERENCE   5  (bases 1 to 7767)
  AUTHORS   Majewski,L., Sobczak,M., Havrylov,S., Jozwiak,J. and Redowicz,M.J.
  TITLE     Dock7: a GEF for Rho-family GTPases and a novel myosin VI-binding
            partner in neuronal PC12 cells
  JOURNAL   Biochem Cell Biol 90 (4), 565-574 (2012)
   PUBMED   22475431
  REMARK    GeneRIF: in PC12 cells MVI-Dock7 complexes may function at
            different cellular locations during the entire cell cycle. Of note,
            MVI and Dock7 colocalized in primary culture hippocampal neurons
            also, predominantly in the outgrowths
REFERENCE   6  (bases 1 to 7767)
  AUTHORS   Kuo,J.C., Han,X., Hsiao,C.T., Yates,J.R. 3rd and Waterman,C.M.
  TITLE     Analysis of the myosin-II-responsive focal adhesion proteome
            reveals a role for beta-Pix in negative regulation of focal
            adhesion maturation
  JOURNAL   Nat Cell Biol 13 (4), 383-393 (2011)
   PUBMED   21423176
REFERENCE   7  (bases 1 to 7767)
  AUTHORS   Fang,L., Wang,X., Yamoah,K., Chen,P.L., Pan,Z.Q. and Huang,L.
  TITLE     Characterization of the human COP9 signalosome complex using
            affinity purification and mass spectrometry
  JOURNAL   J Proteome Res 7 (11), 4914-4925 (2008)
   PUBMED   18850735
REFERENCE   8  (bases 1 to 7767)
  AUTHORS   Yamauchi,J., Miyamoto,Y., Chan,J.R. and Tanoue,A.
  TITLE     ErbB2 directly activates the exchange factor Dock7 to promote
            Schwann cell migration
  JOURNAL   J Cell Biol 181 (2), 351-365 (2008)
   PUBMED   18426980
REFERENCE   9  (bases 1 to 7767)
  AUTHORS   Watabe-Uchida,M., John,K.A., Janas,J.A., Newey,S.E. and Van
            Aelst,L.
  TITLE     The Rac activator DOCK7 regulates neuronal polarity through local
            phosphorylation of stathmin/Op18
  JOURNAL   Neuron 51 (6), 727-739 (2006)
   PUBMED   16982419
REFERENCE   10 (bases 1 to 7767)
  AUTHORS   Moore,K.J., Swing,D.A., Copeland,N.G. and Jenkins,N.A.
  TITLE     Interaction of the murine dilute suppressor gene (dsu) with
            fourteen coat color mutations
  JOURNAL   Genetics 125 (2), 421-430 (1990)
   PUBMED   2379821
  REMARK    Erratum:[Genetics 1990 Sep;126(1):285]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-180               JAXUCZ010000005.1  118898156-118898335 c
            181-286             JAXUCZ010000005.1  118872977-118873082 c
            287-462             JAXUCZ010000005.1  118866720-118866895 c
            463-531             JAXUCZ010000005.1  118866406-118866474 c
            532-661             JAXUCZ010000005.1  118863475-118863604 c
            662-874             JAXUCZ010000005.1  118863175-118863387 c
            875-960             JAXUCZ010000005.1  118862614-118862699 c
            961-1027            JAXUCZ010000005.1  118854634-118854700 c
            1028-1177           JAXUCZ010000005.1  118853239-118853388 c
            1178-1258           JAXUCZ010000005.1  118845580-118845660 c
            1259-1424           JAXUCZ010000005.1  118844079-118844244 c
            1425-1567           JAXUCZ010000005.1  118840932-118841074 c
            1568-1661           JAXUCZ010000005.1  118836924-118837017 c
            1662-1824           JAXUCZ010000005.1  118836026-118836188 c
            1825-1942           JAXUCZ010000005.1  118808322-118808439 c
            1943-2013           JAXUCZ010000005.1  118805143-118805213 c
            2014-2152           JAXUCZ010000005.1  118801780-118801918 c
            2153-2254           JAXUCZ010000005.1  118800956-118801057 c
            2255-2341           JAXUCZ010000005.1  118797773-118797859 c
            2342-2573           JAXUCZ010000005.1  118796400-118796631 c
            2574-2738           JAXUCZ010000005.1  118792379-118792543 c
            2739-2908           JAXUCZ010000005.1  118790459-118790628 c
            2909-2998           JAXUCZ010000005.1  118782960-118783049 c
            2999-3088           JAXUCZ010000005.1  118781684-118781773 c
            3089-3184           JAXUCZ010000005.1  118780677-118780772 c
            3185-3325           JAXUCZ010000005.1  118778479-118778619 c
            3326-3439           JAXUCZ010000005.1  118778265-118778378 c
            3440-3610           JAXUCZ010000005.1  118776490-118776660 c
            3611-3750           JAXUCZ010000005.1  118774553-118774692 c
            3751-3920           JAXUCZ010000005.1  118763630-118763799 c
            3921-4075           JAXUCZ010000005.1  118761890-118762044 c
            4076-4261           JAXUCZ010000005.1  118755377-118755562 c
            4262-4397           JAXUCZ010000005.1  118755145-118755280 c
            4398-4494           JAXUCZ010000005.1  118751930-118752026 c
            4495-4591           JAXUCZ010000005.1  118750764-118750860 c
            4592-4726           JAXUCZ010000005.1  118748466-118748600 c
            4727-4879           JAXUCZ010000005.1  118747488-118747640 c
            4880-5038           JAXUCZ010000005.1  118742546-118742704 c
            5039-5139           JAXUCZ010000005.1  118741791-118741891 c
            5140-5332           JAXUCZ010000005.1  118740483-118740675 c
            5333-5476           JAXUCZ010000005.1  118739656-118739799 c
            5477-5608           JAXUCZ010000005.1  118734630-118734761 c
            5609-5623           JAXUCZ010000005.1  118733110-118733124 c
            5624-5749           JAXUCZ010000005.1  118726283-118726408 c
            5750-5839           JAXUCZ010000005.1  118725086-118725175 c
            5840-6076           JAXUCZ010000005.1  118724733-118724969 c
            6077-6220           JAXUCZ010000005.1  118724256-118724399 c
            6221-6327           JAXUCZ010000005.1  118722912-118723018 c
            6328-6495           JAXUCZ010000005.1  118718100-118718267 c
            6496-7767           JAXUCZ010000005.1  118714863-118716134 c
FEATURES             Location/Qualifiers
     source          1..7767
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q33"
     gene            1..7767
                     /gene="Dock7"
                     /note="dedicator of cytokinesis 7"
                     /db_xref="GeneID:313388"
                     /db_xref="RGD:1309790"
     exon            1..180
                     /gene="Dock7"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..6538
                     /gene="Dock7"
                     /note="isoform 1 is encoded by transcript variant 1;
                     dedicator of cytokinesis protein 7"
                     /codon_start=1
                     /product="dedicator of cytokinesis protein 7 isoform 1"
                     /protein_id="NP_001402814.1"
                     /db_xref="GeneID:313388"
                     /db_xref="RGD:1309790"
                     /translation="MAERRAFAQKISRTVAAEVRKQISGQYSGSPQLLKNLNIVGNIS
                     HHTTVPLTEAVDPVDLEDYLITHPLAVDSGPLRDLVDFPPDDIEVVYSPRDCRTLVSA
                     VPEESEMDPHVRDCIRSYTEDWAIVVRKYHKLGTGFNPNTLDKQKERQKGLPRQVFES
                     DEAPDGNSYPDEQDDLKRRSMSIDDTPRGSWACSIFDLKNSLPDALLPNLLDRTPNEE
                     IDHQNDDQRKSNRHKELFALHPSPDEEEPIERLSVPDVPKEHFGQRLLVKCLSLKFEI
                     EIEPIFASLALYDVKEKKKISENFYFDLNSEQMKGLLRPHVPPAAITTLARSAIFSIT
                     YPSQDVFLVIKLEKVLQQGDIGECAEPYMIFKEADATKNKEKLEKLKSQADQFCQRLG
                     KYRMPFAWTAIHLMNIVSSAGSLERDSTEVEISTGERKGSWSERRNSSLVGRRSLERT
                     ASGDDACNLTSFRPATLTVANFFKQEGDRLSDEDLYKFLADMRRPSSVLRRLRPITAQ
                     LKIDISPAPENPHYCLTPELLQVKLYPDSRVRPTREILEFPARDVYVPNTTYRNLLYI
                     YPQSLNFANRQGSARNITVKVQFMYGEDPSNAMPVIFGKSSCSEFSKEAYTAVVYHNR
                     SPDFHEEVKVKLPATLTDHHHLLFTFYHVSCQQKQNTPLETPVGYTWIPMLQNGRLKT
                     GQFCLPVSLEKPPQAYSVLSPEVPLPGMKWVDNHKGVFNVEVVAVSSIHTQDPYLDKF
                     FALVNALDEHMFPVRIGDMRIMENNLESELKSSISALNSSQLEPVVRFLHLLLDKLIL
                     LVVRPPVIAGQIVNLGQASFEAMASIINRLHKNLEGNHDQHGRNNLLASYIYYVFRLP
                     NTYPNSPSPGPGGLGGSVHYATMARSAVRPASLNLNRSRSLSNSNPDISGTPTSPDDE
                     VRSIIGSKGLDRSNSWVNTGPKAAPWGSNPSPSAESTQAVDRSCNRMSSHTETSSFLQ
                     TLTGRLPTKKLFHEELALQWVVCSGSVRESALQQAWFFFELMVKSMVHHLYFNDKLDA
                     PRKSRFPERFMDDIAALVSTIAGDVVSRFQKDTEMVERLNTSLAFFLNDLLSVMDRGF
                     VFTLIKSCYKQVSAKLYSLPNPSVLVSLRLDFLRIICSHEHYVTLNLPCSLLTPPASP
                     SPSVSSATSQSSGFSTNVQDQKIANMFELSLPFRQQHYLAGLVLTELALILDPDAEGL
                     FGLHKKVINMVHNLLSSHDSDPRYSDPQIKARVAMLYLPLIGIIMETVPQLYDFTETH
                     NQRGRPICIAPDDYDSESGSMISQTVAMAIAGTSVPQLTRPGSFLLTSTSGRQHTVTF
                     SAESSRSLLICLLWVLKNADETVLQKWFTDLSVLQLNRLLDLLYLCVSCFEYKGKKVF
                     ERMNSLTFKKSKDMRAKLEEAILGSIGARQEMVRRSRGQLERSPSGSAFGSQENLRWR
                     KDMTHWRQNTEKLDKSRAEIEHEALIDGNLATEANLIILDTLEIIVQTVSVTESKESI
                     LGGVLKVLLQSMACNQSAVYLQHCFATQRALVSKFPELLFEEETEQCADLCLRLLRHC
                     SSSISTIRSHASASLYLLMRQNFEIGNNFARVKMQVTMSLSSLVGTSQNFNEEFLRRS
                     LKTILTYAEEDLELRETTFPDQVQDLVFNLHMILSDTVKMKEHQEDPEMLIDLMYRIA
                     KGYQTSPDLRLTWLQNMAGKHSERSNHAEAAQCLVHSAALVAEYLSMLEDRKYLPVGC
                     VTFQNISSNVLEESAVSDDVVSPDEEGICSGKYFTESGLVGLLEQAAASFSMAGMYEA
                     VNEVYKVLIPIHEANRDAKKLSTIHGKLQEAFSKIVHQSTGWERMFGTYFRVGFYGTK
                     FGDLDEQEFVYKEPAITKLAEISHRLEGFYGERFGEDVLEVIKDSNPVDKCKLDPNKA
                     YIQITYVEPFFDTYEMKDRITYFDKNYNLRRFMYCTPFTLDGRAHGELHEQFKRKTIL
                     TTSHAFPYIKTRVNVTHKEEIILTPIEVAIEDMQKKTQELAFATHQDPADPKMLQMVL
                     QGSVGTTVNQGPLEVAQVFLSEIPGDPKLFRHHNKLRLCFKDFTKRCEDALRKNKSLI
                     GPDQKEYQRELERNYHRLKEALQPLINRKIPQLYKAVLPVTCHRDSFSRMSLRKMEL"
     exon            181..286
                     /gene="Dock7"
                     /inference="alignment:Splign:2.1.0"
     exon            287..462
                     /gene="Dock7"
                     /inference="alignment:Splign:2.1.0"
     exon            463..531
                     /gene="Dock7"
                     /inference="alignment:Splign:2.1.0"
     exon            532..661
                     /gene="Dock7"
                     /inference="alignment:Splign:2.1.0"
     exon            662..874
                     /gene="Dock7"
                     /inference="alignment:Splign:2.1.0"
     exon            875..960
                     /gene="Dock7"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1027
                     /gene="Dock7"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1177
                     /gene="Dock7"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1258
                     /gene="Dock7"
                     /inference="alignment:Splign:2.1.0"
     exon            1259..1424
                     /gene="Dock7"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..1567
                     /gene="Dock7"
                     /inference="alignment:Splign:2.1.0"
     exon            1568..1661
                     /gene="Dock7"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..1824
                     /gene="Dock7"
                     /inference="alignment:Splign:2.1.0"
     exon            1825..1942
                     /gene="Dock7"
                     /inference="alignment:Splign:2.1.0"
     exon            1943..2013
                     /gene="Dock7"
                     /inference="alignment:Splign:2.1.0"
     exon            2014..2152
                     /gene="Dock7"
                     /inference="alignment:Splign:2.1.0"
     exon            2153..2254
                     /gene="Dock7"
                     /inference="alignment:Splign:2.1.0"
     exon            2255..2341
                     /gene="Dock7"
                     /inference="alignment:Splign:2.1.0"
     exon            2342..2573
                     /gene="Dock7"
                     /inference="alignment:Splign:2.1.0"
     exon            2574..2738
                     /gene="Dock7"
                     /inference="alignment:Splign:2.1.0"
     exon            2739..2908
                     /gene="Dock7"
                     /inference="alignment:Splign:2.1.0"
     exon            2909..2998
                     /gene="Dock7"
                     /inference="alignment:Splign:2.1.0"
     exon            2999..3088
                     /gene="Dock7"
                     /inference="alignment:Splign:2.1.0"
     exon            3089..3184
                     /gene="Dock7"
                     /inference="alignment:Splign:2.1.0"
     exon            3185..3325
                     /gene="Dock7"
                     /inference="alignment:Splign:2.1.0"
     exon            3326..3439
                     /gene="Dock7"
                     /inference="alignment:Splign:2.1.0"
     exon            3440..3610
                     /gene="Dock7"
                     /inference="alignment:Splign:2.1.0"
     exon            3611..3750
                     /gene="Dock7"
                     /inference="alignment:Splign:2.1.0"
     exon            3751..3920
                     /gene="Dock7"
                     /inference="alignment:Splign:2.1.0"
     exon            3921..4075
                     /gene="Dock7"
                     /inference="alignment:Splign:2.1.0"
     exon            4076..4261
                     /gene="Dock7"
                     /inference="alignment:Splign:2.1.0"
     exon            4262..4397
                     /gene="Dock7"
                     /inference="alignment:Splign:2.1.0"
     exon            4398..4494
                     /gene="Dock7"
                     /inference="alignment:Splign:2.1.0"
     exon            4495..4591
                     /gene="Dock7"
                     /inference="alignment:Splign:2.1.0"
     exon            4592..4726
                     /gene="Dock7"
                     /inference="alignment:Splign:2.1.0"
     exon            4727..4879
                     /gene="Dock7"
                     /inference="alignment:Splign:2.1.0"
     exon            4880..5038
                     /gene="Dock7"
                     /inference="alignment:Splign:2.1.0"
     exon            5039..5139
                     /gene="Dock7"
                     /inference="alignment:Splign:2.1.0"
     exon            5140..5332
                     /gene="Dock7"
                     /inference="alignment:Splign:2.1.0"
     exon            5333..5476
                     /gene="Dock7"
                     /inference="alignment:Splign:2.1.0"
     exon            5477..5608
                     /gene="Dock7"
                     /inference="alignment:Splign:2.1.0"
     exon            5609..5623
                     /gene="Dock7"
                     /inference="alignment:Splign:2.1.0"
     exon            5624..5749
                     /gene="Dock7"
                     /inference="alignment:Splign:2.1.0"
     exon            5750..5839
                     /gene="Dock7"
                     /inference="alignment:Splign:2.1.0"
     exon            5840..6076
                     /gene="Dock7"
                     /inference="alignment:Splign:2.1.0"
     exon            6077..6220
                     /gene="Dock7"
                     /inference="alignment:Splign:2.1.0"
     exon            6221..6327
                     /gene="Dock7"
                     /inference="alignment:Splign:2.1.0"
     exon            6328..6495
                     /gene="Dock7"
                     /inference="alignment:Splign:2.1.0"
     exon            6496..7767
                     /gene="Dock7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 accctcgttc cgggctccag cggccggcct agcctcgcgg tggggtccgg agagcggaca
       61 ggcgagcgcg cgggagggag cgcgagctgg agcgcgagga ggagtagtag gaagaggccg
      121 cccggcccgc gccgccgcag ccatggcgga gcgtcgcgcc ttcgcgcaga agatcagcag
      181 aacggttgct gctgaagtta gaaagcagat ctctggacag tacagtggtt ccccccagct
      241 gctcaaaaac ctcaacatag ttggcaatat atcccaccac accacagtgc cccttacgga
      301 agcagtcgat cctgtggatt tggaagatta cctcatcact caccccttag ctgtggattc
      361 tgggcctctt cgggatttgg ttgactttcc tccagatgac attgaagttg tgtatagtcc
      421 tagggactgc aggacccttg tttcagctgt gcctgaagaa agtgaaatgg atccacatgt
      481 tagagattgt ataagaagtt acacagaaga ctgggcaatt gtggtcagaa aataccataa
      541 actgggaaca ggatttaacc ccaacacgct ggataaacag aaagaaagac aaaaaggact
      601 gcccagacaa gtctttgaat ctgatgaggc cccagacggc aacagctacc cggatgagca
      661 agatgacctt aaaagacgtt cgatgtcaat agatgatact ccaaggggta gctgggcctg
      721 cagtatcttt gacttaaaaa attcacttcc tgatgccttg cttcctaatt tacttgatcg
      781 aactccaaat gaagaaatag atcatcagaa tgatgaccaa agaaaatcaa accgccacaa
      841 ggagctgttt gctttacacc cgtctccaga tgaggaagaa ccaatagaac ggcttagtgt
      901 tcctgatgtg cccaaagagc attttggaca aagacttctt gtgaaatgtt tatcactcaa
      961 gtttgaaatt gaaattgagc ccatttttgc aagtttggct ttatatgacg tcaaggagaa
     1021 gaagaaaatt tcagagaatt tttattttga ccttaattca gaacagatga agggactgtt
     1081 acggccacat gtacctcctg ctgccattac cactctggca agatcagcca ttttttctat
     1141 aacttatcct tcccaagatg tttttcttgt gataaagcta gaaaaagtcc tacagcaagg
     1201 agacattggg gagtgtgcag aaccatatat gattttcaaa gaagctgatg ccaccaagaa
     1261 taaggaaaaa ttggagaagc tgaaaagtca agccgaccag ttttgccaaa gacttgggaa
     1321 ataccgcatg ccctttgctt ggactgcgat ccatttaatg aatattgtta gcagtgctgg
     1381 cagcttagag agagactcca ccgaagtcga gatcagtact ggagaacgaa agggttcttg
     1441 gtcagagagg agaaattcta gtcttgttgg tcgacggtcc cttgagagga cagccagtgg
     1501 cgatgatgct tgcaacctga ccagcttccg gcctgccacc ctcactgtgg caaacttttt
     1561 taagcaggaa ggagaccgct taagcgatga ggatttgtac aagtttcttg ctgatatgag
     1621 aaggccatct tctgtcttac ggaggctgag accaattaca gctcagctga agatagacat
     1681 ctctcctgca cctgaaaatc cccattactg cctaacccca gagctgcttc aggtgaagct
     1741 ctaccccgac agccgagtca ggcccaccag agaaatttta gaatttcctg ccagggatgt
     1801 ctatgttcca aacacgactt acagaaatct tctctacatt taccctcaaa gtcttaattt
     1861 tgccaaccgt caaggctctg ccagaaacat cacagtgaaa gtccagttta tgtatgggga
     1921 agacccgagc aatgcaatgc cggtaatctt tggtaaatct agctgttcag aattttcaaa
     1981 ggaagcctat acagccgtag tatatcataa caggtctcct gattttcacg aggaagtcaa
     2041 ggtcaaactc cccgccacgt taaccgacca tcaccacctg ctctttactt tttatcatgt
     2101 tagttgtcaa cagaaacaaa acactcctct tgaaacccca gttggatata cttggatacc
     2161 aatgctgcag aatggacggt tgaagacggg gcagttctgc ctgccagtct cactggaaaa
     2221 accaccgcag gcttactcag tgctttctcc tgaggttcct ctaccaggta tgaagtgggt
     2281 ggacaaccac aaaggagtat ttaatgttga agttgttgct gtttcatcca ttcacacaca
     2341 agacccttat cttgacaaat tctttgctct tgtcaatgct ctggatgaac acatgttccc
     2401 ggttcgaatt ggggacatgc ggatcatgga aaacaactta gagagtgaac tgaagagcag
     2461 catttcagcc ttgaattcct cacagctgga accagtagtt cggtttcttc atcttctgct
     2521 tgataaactc atacttttag ttgttagacc tcctgtgatt gctggccaaa tagttaatct
     2581 agggcaagca tcctttgaag ctatggcatc aattataaat cgacttcata aaaacttaga
     2641 aggaaatcat gaccagcacg gcagaaacaa ccttctggca tcatatatct attatgtgtt
     2701 ccgcctgcca aatacatacc ctaattctcc gtcaccaggt cccgggggtc tgggaggatc
     2761 agtgcattat gccacaatgg caagatctgc agtgagaccc gcaagcctta acttaaatcg
     2821 ttctcgaagc cttagcaaca gtaatccaga tatatctggg actcccacat caccagatga
     2881 tgaagttcgg tcaatcatcg gcagtaaggg tttagatcgc tccaattcct gggttaacac
     2941 tggtccaaaa gctgccccat ggggatccaa ccccagtcca agtgcagagt caacacaggc
     3001 tgtggatcga agttgtaatc gtatgtcttc gcacacagag acgtcaagtt tcttacaaac
     3061 attaacggga cgcttaccaa ctaaaaagct ctttcacgag gagctggctc tgcagtgggt
     3121 cgtttgcagt ggcagcgtgc gggaatcggc tttgcagcaa gcctggttct tttttgagtt
     3181 gatggtcaag agcatggtgc accacttgta ctttaatgat aagctcgacg ctccgaggaa
     3241 aagccgtttc ccagagcgtt ttatggatga tattgctgcc ctggttagca caattgctgg
     3301 tgatgttgtg tcacggtttc agaaggatac agaaatggtt gagagactca atacaagcct
     3361 tgccttcttt ctcaatgatc tgctgtcggt tatggaccga gggtttgtct ttacccttat
     3421 aaagtcctgc tacaaacagg tgtcagcgaa gctttattca ctaccaaatc caagtgtcct
     3481 ggtgtccctg aggttggact ttttgcgaat catctgcagc cacgagcact atgttacatt
     3541 aaacttaccc tgcagcttgc tcaccccgcc tgcatctccg tcaccttctg tttcttctgc
     3601 aacatctcag agctctggat tttccaccaa tgtgcaggac cagaagatcg caaatatgtt
     3661 tgagttgtcc ttacccttcc gccagcagca ttacctggca ggcctggtgt tgacagagct
     3721 cgcactcatt ttagaccccg atgctgaagg actgtttggg ttgcataaga aagtcatcaa
     3781 catggtacac aacttactgt ccagtcacga ctctgaccca cggtactctg accctcagat
     3841 aaaggctcgg gtggccatgt tgtaccttcc tctgattggt attatcatgg aaactgtgcc
     3901 tcagctgtat gattttacag aaacacacaa ccagcgagga agaccgattt gcatagcccc
     3961 cgatgattat gacagtgaga gtgggagcat gataagccag accgttgcca tggcaattgc
     4021 aggaacatct gtccctcagc tcacaagacc tggcagtttt ctcctcacat caacgagtgg
     4081 caggcagcac accgtgacct tctccgcaga atcaagccgg agccttttga tctgtctgct
     4141 ttgggttctc aagaacgcag atgaaacagt tctgcagaaa tggtttacag acctctcagt
     4201 cctccagctg aaccggctgt tagatctgct ttacctgtgt gtatcttgct ttgaatacaa
     4261 agggaaaaaa gtatttgaaa gaatgaatag tttaaccttt aagaaatcaa aagacatgag
     4321 agccaagctt gaagaagcca ttctggggag catcggtgcc aggcaggaaa tggtacggcg
     4381 gagccgagga caacttgaga gaagcccatc tggaagtgcc tttgggagcc aagaaaacct
     4441 gcggtggaga aaggatatga ctcactggcg tcagaacaca gagaaacttg ataagtcaag
     4501 agcagagata gaacatgaag cactgattga tgggaacctg gctactgaag caaacctcat
     4561 tatcttagac acgctagaga tcatcgtcca gactgtctct gtaacagaat ccaaagagag
     4621 cattctgggt ggtgtgctga aagtgctgct gcagagcatg gcctgcaacc aaagcgcagt
     4681 gtatctgcag cactgctttg ccacacagag ggccctggtc tcaaagtttc ctgagctctt
     4741 gtttgaggaa gagacagagc agtgtgcaga tctctgcctc cggcttctcc gacattgcag
     4801 cagcagcatc agtacaatcc ggtcacatgc tagtgcctcc ctttacctcc tcatgaggca
     4861 gaactttgag atcgggaata actttgccag agtaaaaatg caagtcacaa tgtcactgtc
     4921 ctcattggtg ggtacatctc agaatttcaa tgaagaattc ttaagacgct ctctaaaaac
     4981 tattttgaca tatgctgaag aagatctaga attgagggaa accacatttc ctgatcaggt
     5041 ccaagatctg gttttcaatc tccacatgat cctttctgac accgttaaga tgaaggaaca
     5101 tcaggaggac ccggaaatgc tgatcgacct catgtacaga atcgctaagg gctaccagac
     5161 atctccagac ctgcgcctga cctggctgca gaacatggct ggcaagcact ctgaacgaag
     5221 caatcatgcg gaggccgctc agtgcctggt gcactcagca gcccttgtcg ctgagtacct
     5281 gagcatgctg gaagaccgca agtacctccc tgtcggatgt gtgacattcc agaatatttc
     5341 atctaatgta ttagaagagt ctgctgtctc agatgatgtg gtatctccag atgaggaagg
     5401 catttgctct ggcaagtact tcactgagtc aggactcgtg ggtttactgg aacaagcggc
     5461 tgcttccttc tctatggcgg gcatgtatga agcagttaat gaggtttaca aagtactcat
     5521 tcctattcat gaagctaatc gggatgcaaa gaagctctcc accatccatg gcaaactcca
     5581 ggaagccttc agcaagatcg tgcaccagag tactggctgg gagcggatgt ttggcaccta
     5641 tttccgtgtt ggtttttatg gaaccaagtt cggggatttg gatgaacagg agtttgttta
     5701 caaggagcct gccataacca aactcgcgga gatctctcac agactggagg gattctatgg
     5761 agaaagattt ggagaggatg tgcttgaagt aatcaaggac tctaatcctg tagacaagtg
     5821 taaattagat ccaaacaagg cgtacattca gatcacctac gtggagccat tcttcgacac
     5881 ctatgagatg aaggatagaa tcacttattt tgacaaaaat tataatctcc gccgtttcat
     5941 gtactgtacg cccttcacgt tagatggccg agcccatggg gagcttcatg aacaattcaa
     6001 acggaagacc attctgacaa catctcatgc ctttccttac attaaaacaa gagtcaacgt
     6061 cactcacaaa gaagagataa tcttaacacc aattgaagtt gctatcgaag acatgcagaa
     6121 aaagacacag gaattggcgt ttgcaacaca tcaggatcca gcagacccca aaatgcttca
     6181 aatggtcctc caggggtctg taggaacaac tgtgaaccag ggacctctcg aggtcgccca
     6241 ggtcttcctg tctgagatac ctggggaccc aaagctcttc agacatcaca acaagctgcg
     6301 cctttgcttc aaggacttta ctaaaaggtg tgaggatgcc ttaagaaaaa ataagagctt
     6361 aattgggcca gatcaaaagg agtatcaaag agaactggag agaaattacc atcgccttaa
     6421 agaggctctg cagccactga taaacagaaa aattcctcag ctgtacaagg ctgtgttgcc
     6481 tgtcacttgc cacagggatt ccttcagccg aatgagcctt cggaaaatgg agctctaaca
     6541 tacacagatg tgttctattc atctgcaaag agccatgtat tcaacaccga gtgcaagatc
     6601 tattgaaaag taggacttgg atgtcattct ggaagcaata gcattgattt actccaagaa
     6661 tgtgctccca gatgcaggcc attacatgtg aggcttgtgg ctgtggtttc taaccttctg
     6721 gtaacatggt gtcatcttag aaacaaaaag ttttaatgat tcaaaggtac agtacacatt
     6781 tacaattatt tataccatag ctaatgttaa atttatttac ttttaagttc ttatttttta
     6841 atttatatta ccatttatag attcattcat ttttgaacca ttttaaatgt agtaatgctt
     6901 attttaaagg tactattaaa tatgtgaatg tttacactaa ttttaacgag tgggatttta
     6961 atttctttat aaacaacagg aaaaaaaaaa acaaattgtt caaaaactgg ttctaaactg
     7021 gcatcaaaca gccccaaatt aggcaatggt gcagataacc taccacaaca agacctgtta
     7081 cgaattgcca aaaacagtat ttaataaaac gttcctgtaa gtggttagat agcagaaatc
     7141 taataccagc acatgctagt gacaacactt tgatctttat gagttacttt attagtataa
     7201 cttcatgaac caacagtttg aactgatttc tgtgcctcaa attaatctta tcaagcgttt
     7261 actgactgaa ccattaacta gaaatttgct ttaaggcttc ttgatatcac taaagataac
     7321 accaagctgg ggttcattga ttttaatcta gtaattaaat gagaagtcac atggttttac
     7381 aaatgacata aattagttgc tatcatcaaa taattaactt cagtatgaaa aaggtacaca
     7441 gaaaaaaaaa atgaatgtct tccactcctg gaacaatttc cccatataaa tatccatggt
     7501 ctctgaaatg tttgcaactt ttttgtgata ctgtggctta cagaacagca acaatgatac
     7561 tggtcacttc tgacctctaa ttgcttgaat tggcgttctt tcaaccctct gggggatatg
     7621 gggtggcaaa ggaggtaacc attagggaga aaacacctgt cacttctcat gtggttacct
     7681 gaactgtttg acatctcggt gatagtatga aggcctttta agagtgatgt gtgatttagt
     7741 catgaaatac aggttatttt ctcatga
//
