LOCUS       NM_001108184            8680 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus dedicator of cyto-kinesis 3 (Dock3), mRNA.
ACCESSION   NM_001108184 XM_001072178 XM_003750582 XM_003754454 XM_236616
VERSION     NM_001108184.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8680)
  AUTHORS   Li,J., Mi,X., Chen,L., Jiang,G., Wang,N., Zhang,Y., Deng,W.,
            Wang,Z., Chen,G. and Wang,X.
  TITLE     Dock3 Participate in Epileptogenesis Through rac1 Pathway in Animal
            Models
  JOURNAL   Mol Neurobiol 53 (4), 2715-2725 (2016)
   PUBMED   26319681
  REMARK    GeneRIF: Inhibition of Dock3 by Dock3 shRNA impaired the severity
            of status epilepticus in the acute stage and decreased the
            spontaneous recurrent seizures times in the chronic stage of
            lithium-pilocarpine model and decreased the expression of rac1-GTP.
REFERENCE   2  (bases 1 to 8680)
  AUTHORS   Namekata,K., Watanabe,H., Guo,X., Kittaka,D., Kawamura,K.,
            Kimura,A., Harada,C. and Harada,T.
  TITLE     Dock3 regulates BDNF-TrkB signaling for neurite outgrowth by
            forming a ternary complex with Elmo and RhoG
  JOURNAL   Genes Cells 17 (8), 688-697 (2012)
   PUBMED   22734669
  REMARK    GeneRIF: Dock3 forms a complex with Elmo and activated RhoG
            downstream of BDNF-TrkB signaling and induces neurite outgrowth via
            Rac1 activation in PC12 cells.
REFERENCE   3  (bases 1 to 8680)
  AUTHORS   Chen,Q., Chen,T.J., Letourneau,P.C., Costa Lda,F. and Schubert,D.
  TITLE     Modifier of cell adhesion regulates N-cadherin-mediated cell-cell
            adhesion and neurite outgrowth
  JOURNAL   J Neurosci 25 (2), 281-290 (2005)
   PUBMED   15647471
REFERENCE   4  (bases 1 to 8680)
  AUTHORS   de Silva,M.G., Elliott,K., Dahl,H.H., Fitzpatrick,E., Wilcox,S.,
            Delatycki,M., Williamson,R., Efron,D., Lynch,M. and Forrest,S.
  TITLE     Disruption of a novel member of a sodium/hydrogen exchanger family
            and DOCK3 is associated with an attention deficit hyperactivity
            disorder-like phenotype
  JOURNAL   J Med Genet 40 (10), 733-740 (2003)
   PUBMED   14569117
REFERENCE   5  (bases 1 to 8680)
  AUTHORS   Chen,Q., Kimura,H. and Schubert,D.
  TITLE     A novel mechanism for the regulation of amyloid precursor protein
            metabolism
  JOURNAL   J Cell Biol 158 (1), 79-89 (2002)
   PUBMED   12093789
REFERENCE   6  (bases 1 to 8680)
  AUTHORS   Kashiwa,A., Yoshida,H., Lee,S., Paladino,T., Liu,Y., Chen,Q.,
            Dargusch,R., Schubert,D. and Kimura,H.
  TITLE     Isolation and characterization of novel presenilin binding protein
  JOURNAL   J Neurochem 75 (1), 109-116 (2000)
   PUBMED   10854253
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1 and AI070118.1.
            
            On or before Aug 22, 2019 this sequence version replaced
            XM_003750582.4, XM_003754454.4, NM_001108184.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments. This transcript is based on
            transcript alignments from orthologous data.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-111               JAXUCZ010000008.1  116782085-116782195 c
            112-195             JAXUCZ010000008.1  116736663-116736746 c
            196-236             JAXUCZ010000008.1  116713169-116713209 c
            237-292             JAXUCZ010000008.1  116689512-116689567 c
            293-389             JAXUCZ010000008.1  116674813-116674909 c
            390-538             JAXUCZ010000008.1  116640389-116640537 c
            539-623             JAXUCZ010000008.1  116628579-116628663 c
            624-665             JAXUCZ010000008.1  116617193-116617234 c
            666-820             JAXUCZ010000008.1  116616474-116616628 c
            821-902             JAXUCZ010000008.1  116591518-116591599 c
            903-963             JAXUCZ010000008.1  116584795-116584855 c
            964-1111            JAXUCZ010000008.1  116583088-116583235 c
            1112-1200           JAXUCZ010000008.1  116563375-116563463 c
            1201-1326           JAXUCZ010000008.1  116561875-116562000 c
            1327-1451           JAXUCZ010000008.1  116552400-116552524 c
            1452-1614           JAXUCZ010000008.1  116550363-116550525 c
            1615-1721           JAXUCZ010000008.1  116549617-116549723 c
            1722-1893           JAXUCZ010000008.1  116548950-116549121 c
            1894-1991           JAXUCZ010000008.1  116548529-116548626 c
            1992-2075           JAXUCZ010000008.1  116545864-116545947 c
            2076-2176           JAXUCZ010000008.1  116544115-116544215 c
            2177-2258           JAXUCZ010000008.1  116525660-116525741 c
            2259-2429           JAXUCZ010000008.1  116507919-116508089 c
            2430-2622           JAXUCZ010000008.1  116503515-116503707 c
            2623-2750           JAXUCZ010000008.1  116498453-116498580 c
            2751-2897           JAXUCZ010000008.1  116495802-116495948 c
            2898-2996           JAXUCZ010000008.1  116493329-116493427 c
            2997-3091           JAXUCZ010000008.1  116487158-116487252 c
            3092-3167           JAXUCZ010000008.1  116484907-116484982 c
            3168-3268           JAXUCZ010000008.1  116484437-116484537 c
            3269-3327           JAXUCZ010000008.1  116484122-116484180 c
            3328-3476           JAXUCZ010000008.1  116481133-116481281 c
            3477-3562           JAXUCZ010000008.1  116476197-116476282 c
            3563-3589           JAXUCZ010000008.1  116473477-116473503 c
            3590-3685           JAXUCZ010000008.1  116473260-116473355 c
            3686-3746           JAXUCZ010000008.1  116469872-116469932 c
            3747-3840           JAXUCZ010000008.1  116469642-116469735 c
            3841-3989           JAXUCZ010000008.1  116465067-116465215 c
            3990-4076           JAXUCZ010000008.1  116463866-116463952 c
            4077-4181           JAXUCZ010000008.1  116462345-116462449 c
            4182-4323           JAXUCZ010000008.1  116453077-116453218 c
            4324-4490           JAXUCZ010000008.1  116451653-116451819 c
            4491-4577           JAXUCZ010000008.1  116451442-116451528 c
            4578-4757           JAXUCZ010000008.1  116450843-116451022 c
            4758-4841           JAXUCZ010000008.1  116450190-116450273 c
            4842-4958           JAXUCZ010000008.1  116449946-116450062 c
            4959-5080           JAXUCZ010000008.1  116447413-116447534 c
            5081-5219           JAXUCZ010000008.1  116446057-116446195 c
            5220-5367           JAXUCZ010000008.1  116445417-116445564 c
            5368-5486           JAXUCZ010000008.1  116439823-116439941 c
            5487-5574           JAXUCZ010000008.1  116438782-116438869 c
            5575-5657           JAXUCZ010000008.1  116434991-116435073 c
            5658-8663           JAXUCZ010000008.1  116431159-116434164 c
            8664-8680           AI070118.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..8680
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..8680
                     /gene="Dock3"
                     /note="dedicator of cyto-kinesis 3"
                     /db_xref="GeneID:315992"
                     /db_xref="RGD:1306677"
     exon            1..111
                     /gene="Dock3"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..6167
                     /gene="Dock3"
                     /codon_start=1
                     /product="dedicator of cytokinesis protein 3"
                     /protein_id="NP_001101654.2"
                     /db_xref="GeneID:315992"
                     /db_xref="RGD:1306677"
                     /translation="MWTPTEEEKYGVVICSFRGSVPQGLVLEIGETVQILEKCEGWYR
                     GVSTKKPNVKGLFPANYIHLKKAIVSNRGQYETVVPLEDSIVTEVTATLQEWASLWKQ
                     LYVKHKVDLFYKLRHVMNELIDLRRQLLSGHLTQDQVREVKRHITVRLDWGNEHLGLD
                     LVPRKDFEVVDSDQISVSDLYKMHLSSRQSVQQSTSQVDTMRPRHGETCRMPVPHHFF
                     FSLKSFTYNTIGEDSDVFFSLYDMREGKQISERFLVRLNKNGGPRNPEKIERMCALFT
                     DLSSKDMKRDLYIVAHVIRIGRMLLNDSKKGPAHLHYRRPYGCAVLSILDVLQSLTEL
                     KEEKDFVLKVYTCNNESEWTQIHENIIRKSSTKYSAPSASHGLIISLQLFRGDMEQIR
                     RENPMIFNRGLAITRKLGFPDVIMPGDIRNDLYLTLEKGDFERGGKSVQKNIEVTMYV
                     LYADGEILKDCISLGSGEPNRSSYHSFVLYHSNSPRWGEIIKLPIPIDRFRGSHLRFE
                     FRHCSTKDKGEKKLFGFSFSPLMRDDGTTLSDDIHELYVYKCDENSTFNNHALYLGLP
                     CCKEDYNGCPNIPSSLIFQRSTKESFFISTQLSSTKLTQNVDLLALLKWKAFPDRIMD
                     ILGRLRHVSGEEIVKFLQDILDTLFVILDDNTEKYGLLVFQSLVFIINLLRDIKYFHF
                     RPVMDTYIQKHFAGALAYKELIRCLKWYMDCSAELIRQDHIQEAMRALEYLFKFIVQS
                     RILYSRATCGMEEEQFRSSIQELFQSIRFVLSLDSRNSETLLFTQAALLNSFPTIFDE
                     LLQMFTVQEVAEFVRGTLGSMPSTVHIGQSMDVVKLQSIARTVDSRLFSFSESRRILL
                     PVVLHHIHLHLRQQKELLICSGILGSIFSIVKTSSLEADVMEEVEMMVESLLDVLLQT
                     LLTIMSKSHAQEAVRGQRCPQCTAEITGEYVSCLLSLLRQMCDTHYQHLLDNFQSKDE
                     LKEFLLKIFCVFRNLMKMSVFPRDWMVMRLLTSNIIVTTVQYLSSALHKNFTETDFDF
                     KVWNSYFSLAVLFINQPSLQLEIITSAKRKKILDKYGDMRVMMAYELFSMWQNLGEHK
                     IHFIPGMIGPFLGVTLVPQPEVRNIMIPIFHDMMDWEQRKNGNFKQVESELIDKLDSM
                     VSEGKGDESYRELFSLLTQLFGPYPSLLEKVEQETWRETGISFVTSVTRLMERLLDYR
                     DCMKGEETENKKVGCTVNLMNFYKSEINKEEMYIRYIHKLCDMHLQAENYTEAAFTLL
                     LYCELLQWEDRPLREFLHYPSQTEWQRKEGLCRKIIHYFNKGKSWEFGIPLCRELACQ
                     YESLYDYQSLSWIRKMEASYYDNIIEQQRLEPEFFRVGFYGRKFPFFLRNKEYVCRGH
                     DYERLEAFQQRMLSEFPQAVAMQHPNHPDDAILQCDAQYLQIYAVTPIPDYVDVLQMD
                     RVPDRVKSFYRVNNVRKFRYDRPFHKGPKDKDNEFKSLWIERTTLTLTHSLPGISRWF
                     EVERRELVEVSPLENAIQVVENKNQELRALISQYQHKQVHGNINLLSMCLNGVIDAAV
                     NGGIARYQEAFFDKDYITKHPGDAEKISQLKELMQEQVHVLGVGLAVHEKFVHPEMRP
                     LHKKLIDQFQMMRASLYHEFPCLDKLSPACSGTSTPRGNVLASHSPMSPENIKMSHRH
                     SPMNLMGTGRHSSSSLSSHASSEAGNMMMMGDNSMGETPEDLYHHMQLAYHNPRYQGS
                     VTNVSVLSSSQASPSSSSLSSTHSAPSQMITSAPSSTRGSPSLPDKYRHAREMMLLLP
                     THRDRPSSAMYPAAILENGQPANFQRALFQQVVGACKPCSDPNLSMAEKGHYSLHFDA
                     FHHPLGDTPPALPARTLRKSPLHPIPASPTSPQSGLDGSNSTLSGSASSGVSSLSESN
                     FGHSSEAPPRTDTMDSMPSQAWNGDEDLEPPYLPVHYSLSESAVLDSIKSQPCRSHSA
                     PGCVIPQDPMDPPALPPKPYHPRLPALEHDEGVLLREEAERPRGLHRKASLPPGSAKE
                     EQARMAWEHGRGEQ"
     exon            112..195
                     /gene="Dock3"
                     /inference="alignment:Splign:2.1.0"
     exon            196..236
                     /gene="Dock3"
                     /inference="alignment:Splign:2.1.0"
     exon            237..292
                     /gene="Dock3"
                     /inference="alignment:Splign:2.1.0"
     exon            293..389
                     /gene="Dock3"
                     /inference="alignment:Splign:2.1.0"
     exon            390..538
                     /gene="Dock3"
                     /inference="alignment:Splign:2.1.0"
     exon            539..623
                     /gene="Dock3"
                     /inference="alignment:Splign:2.1.0"
     exon            624..665
                     /gene="Dock3"
                     /inference="alignment:Splign:2.1.0"
     exon            666..820
                     /gene="Dock3"
                     /inference="alignment:Splign:2.1.0"
     exon            821..902
                     /gene="Dock3"
                     /inference="alignment:Splign:2.1.0"
     exon            903..963
                     /gene="Dock3"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1111
                     /gene="Dock3"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1200
                     /gene="Dock3"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1326
                     /gene="Dock3"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..1451
                     /gene="Dock3"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1614
                     /gene="Dock3"
                     /inference="alignment:Splign:2.1.0"
     exon            1615..1721
                     /gene="Dock3"
                     /inference="alignment:Splign:2.1.0"
     exon            1722..1893
                     /gene="Dock3"
                     /inference="alignment:Splign:2.1.0"
     exon            1894..1991
                     /gene="Dock3"
                     /inference="alignment:Splign:2.1.0"
     exon            1992..2075
                     /gene="Dock3"
                     /inference="alignment:Splign:2.1.0"
     exon            2076..2176
                     /gene="Dock3"
                     /inference="alignment:Splign:2.1.0"
     exon            2177..2258
                     /gene="Dock3"
                     /inference="alignment:Splign:2.1.0"
     exon            2259..2429
                     /gene="Dock3"
                     /inference="alignment:Splign:2.1.0"
     exon            2430..2622
                     /gene="Dock3"
                     /inference="alignment:Splign:2.1.0"
     exon            2623..2750
                     /gene="Dock3"
                     /inference="alignment:Splign:2.1.0"
     exon            2751..2897
                     /gene="Dock3"
                     /inference="alignment:Splign:2.1.0"
     exon            2898..2996
                     /gene="Dock3"
                     /inference="alignment:Splign:2.1.0"
     exon            2997..3091
                     /gene="Dock3"
                     /inference="alignment:Splign:2.1.0"
     exon            3092..3167
                     /gene="Dock3"
                     /inference="alignment:Splign:2.1.0"
     exon            3168..3268
                     /gene="Dock3"
                     /inference="alignment:Splign:2.1.0"
     exon            3269..3327
                     /gene="Dock3"
                     /inference="alignment:Splign:2.1.0"
     exon            3328..3476
                     /gene="Dock3"
                     /inference="alignment:Splign:2.1.0"
     exon            3477..3562
                     /gene="Dock3"
                     /inference="alignment:Splign:2.1.0"
     exon            3563..3589
                     /gene="Dock3"
                     /inference="alignment:Splign:2.1.0"
     exon            3590..3685
                     /gene="Dock3"
                     /inference="alignment:Splign:2.1.0"
     exon            3686..3746
                     /gene="Dock3"
                     /inference="alignment:Splign:2.1.0"
     exon            3747..3840
                     /gene="Dock3"
                     /inference="alignment:Splign:2.1.0"
     exon            3841..3989
                     /gene="Dock3"
                     /inference="alignment:Splign:2.1.0"
     exon            3990..4076
                     /gene="Dock3"
                     /inference="alignment:Splign:2.1.0"
     exon            4077..4181
                     /gene="Dock3"
                     /inference="alignment:Splign:2.1.0"
     exon            4182..4323
                     /gene="Dock3"
                     /inference="alignment:Splign:2.1.0"
     exon            4324..4490
                     /gene="Dock3"
                     /inference="alignment:Splign:2.1.0"
     exon            4491..4577
                     /gene="Dock3"
                     /inference="alignment:Splign:2.1.0"
     exon            4578..4757
                     /gene="Dock3"
                     /inference="alignment:Splign:2.1.0"
     exon            4758..4841
                     /gene="Dock3"
                     /inference="alignment:Splign:2.1.0"
     exon            4842..4958
                     /gene="Dock3"
                     /inference="alignment:Splign:2.1.0"
     exon            4959..5080
                     /gene="Dock3"
                     /inference="alignment:Splign:2.1.0"
     exon            5081..5219
                     /gene="Dock3"
                     /inference="alignment:Splign:2.1.0"
     exon            5220..5367
                     /gene="Dock3"
                     /inference="alignment:Splign:2.1.0"
     exon            5368..5486
                     /gene="Dock3"
                     /inference="alignment:Splign:2.1.0"
     exon            5487..5574
                     /gene="Dock3"
                     /inference="alignment:Splign:2.1.0"
     exon            5575..5657
                     /gene="Dock3"
                     /inference="alignment:Splign:2.1.0"
     exon            5658..8664
                     /gene="Dock3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggccgcccc tgcggccgtc ccctgcgcgc tgtcacccag ccgccgcgct cgcggggctg
       61 tgcccggccc ggccatgtgg acccccacag aggaggagaa atacggcgta gtgatatgca
      121 gctttcgagg atctgtccct caaggcctgg tcttagaaat aggagaaaca gttcagattc
      181 ttgagaaatg tgaaggttgg tacagaggag tttcaacaaa gaagcctaat gtaaaggggc
      241 tctttcctgc gaattatatt catttgaaaa aggcgattgt cagtaacagg gggcagtatg
      301 aaaccgtggt tccactggaa gattctattg tgactgaagt tacagcaact ctacaagaat
      361 gggccagtct gtggaaacaa ctatatgtga aacacaaagt agatcttttc tacaaactac
      421 gccatgtgat gaatgaactt attgacctgc gaaggcagct cctgtctggt cacctgacac
      481 aggatcaggt gcgggaggtt aagcggcaca tcaccgtgcg cctggactgg ggcaatgagc
      541 atttgggcct ggacttggtg cctcggaagg actttgaagt agtggattca gaccagatta
      601 gcgtctcaga tctttataaa atgcatttat ctagccgaca gagtgtacag cagagcacat
      661 cccaagtaga tacaatgcgc ccacggcatg gggaaacctg tcgaatgcca gtaccacatc
      721 atttcttctt cagcctaaag agtttcacct ataataccat tggtgaagat agtgacgtct
      781 tcttttctct gtatgacatg agagaaggca agcagataag tgaacggttt ctggtgagac
      841 tgaacaagaa cggtgggcca aggaatccag agaagataga aagaatgtgt gcccttttta
      901 cagatctgag tagcaaagac atgaagagag atttatacat agttgcccat gtgatccgaa
      961 taggccggat gctcttgaat gactccaaaa agggtcctgc tcacctgcac tacaggcgac
     1021 catatggctg tgcagttctc agcattttgg atgttctaca gtcactaaca gaattaaaag
     1081 aagaaaagga ttttgttctt aaggtttaca catgtaacaa cgagagtgaa tggacccaga
     1141 ttcatgagaa catcatccga aagtcaagta ccaagtactc tgcccccagt gccagccatg
     1201 gtcttattat ttctctacag ctttttcgtg gtgacatgga acagatccgg agagaaaatc
     1261 ccatgatatt taatagagga ctagcaatta caagaaaatt gggattccct gatgttatca
     1321 tgccaggtga tatccgcaat gatttgtacc taacactgga gaagggggac tttgaaagag
     1381 ggggcaagag tgtacaaaag aatattgaag taaccatgta tgtactttat gcagatggag
     1441 aaatcttgaa ggactgtatc agcttgggtt caggagagcc aaataggagc tcctatcact
     1501 cctttgttct ctaccacagt aatagtcctc gttggggaga aattatcaaa ttacctattc
     1561 ccattgacag attccggggc tcccatctcc gctttgagtt cagacattgt tccacaaagg
     1621 acaaagggga aaagaaactc tttggctttt cattctctcc gctgatgcgt gatgatggca
     1681 ccacactctc agatgatatt catgagcttt atgtgtataa gtgtgatgaa aatagcacat
     1741 ttaacaacca tgccctgtac ctgggcttgc cctgctgcaa agaagactac aatggctgcc
     1801 ctaatattcc ctccagcctc atcttccagc gtagcaccaa agagtctttc ttcatttcta
     1861 cacaactttc ttctaccaaa ctcacgcaaa atgtggacct ccttgctctg ctgaaatgga
     1921 aggccttccc agaccggatc atggacatcc tagggcggtt gcggcatgtc agtggggaag
     1981 aaatcgttaa gtttctgcag gatatcttag atacactctt tgtgattttg gatgataata
     2041 cagagaaata cggccttttg gtatttcagt ctctggtttt catcatcaac ctgcttcgag
     2101 acataaaata tttccacttc cgacctgtaa tggacacata tatccagaag cactttgctg
     2161 gagccctggc ctacaaggag ctcatccgct gtttgaagtg gtacatggac tgctcagcag
     2221 aactgattcg acaggaccac attcaagaag ccatgcgggc cctggagtac cttttcaagt
     2281 tcattgtgca gtcacgaatc ttgtattcaa gagccacatg tgggatggaa gaggaacaat
     2341 tccggtctag catccaggaa cttttccagt ccatccggtt tgtgctgagt ttggacagta
     2401 gaaactcaga aacactcctc ttcactcagg ctgcactact taattccttc cccaccatct
     2461 ttgacgagct gctgcagatg tttactgtac aagaggtagc agagtttgtg agaggcacac
     2521 tgggaagcat gcccagtacg gtgcacatcg ggcagtcaat ggacgtggtg aagctgcagt
     2581 ccatcgccag gacagtggac agtcgcctgt tttccttttc agaatcccgc cgcattctac
     2641 ttcctgtggt tcttcatcac attcatcttc acctgaggca gcagaaagaa ttgctaatct
     2701 gctcagggat tctgggcagc attttttcca tcgtcaagac cagctctctg gaggcagatg
     2761 tcatggagga ggtagagatg atggtggaaa gcctcctgga tgtgctccta cagactctac
     2821 tcaccatcat gagtaaatca catgctcagg aggcggtaag agggcagcgg tgcccgcagt
     2881 gcacagccga gatcactggt gaatacgtgt cctgcctcct ctcattgctc cgtcagatgt
     2941 gcgacaccca ttaccaacac ctcttagaca acttccagag caaagatgaa ctcaaggaat
     3001 ttctgctgaa gattttctgt gtgttcagaa acctaatgaa gatgagcgtc ttccctcgag
     3061 actggatggt gatgagactg ttgacaagca acatcatagt cactacagtc cagtacctgt
     3121 cctctgccct gcacaagaat ttcacagaga cggactttga ctttaaggtg tggaattctt
     3181 attttagcct ggcagttctg ttcataaacc agccaagcct tcagctagaa atcattactt
     3241 cagccaagag gaagaagatt ctagataagt atggggacat gcgtgtgatg atggcttatg
     3301 aactgttcag catgtggcag aatctgggtg aacataagat ccactttatt cctggaatga
     3361 ttggtccttt tctgggtgtg acactggtcc cacagccaga agtgcggaat atcatgattc
     3421 ctatctttca tgacatgatg gactgggagc agaggaaaaa tggcaacttc aagcaggtgg
     3481 agtctgaact gattgacaag ctggacagca tggtgtcaga ggggaaaggt gatgagagct
     3541 acagggaact cttcagcctg ctaacccagc tgtttgggcc ctaccccagc cttctggaaa
     3601 aggttgaaca ggaaacatgg cgtgagactg gcatttcctt tgttacctca gtaacccgcc
     3661 tcatggaacg ccttcttgac tacagggact gcatgaaggg agaagaaact gagaacaaga
     3721 aggttggctg cactgttaac ctgatgaact tttacaaatc tgagattaac aaagaggaaa
     3781 tgtatatccg atacatccat aagctttgtg acatgcactt acaggctgaa aactacacag
     3841 aggctgcatt caccctcctg ctttactgtg agctgctgca gtgggaagat cgaccgttac
     3901 gggagttcct acactaccca tcccagactg agtggcagcg gaaggaggga ctgtgtagaa
     3961 agatcatcca ctacttcaac aaaggcaaga gctgggagtt tggaatccct ctatgtagag
     4021 agctggcatg tcagtatgag agcctctatg actaccagag cctcagctgg atccggaaaa
     4081 tggaggccag ctactatgac aacattatag agcagcaacg cctggagcct gagttcttcc
     4141 gggttggctt ttatggcagg aagtttccat tcttccttcg gaataaagag tatgtgtgcc
     4201 gtggtcatga ctatgagagg ctagaagcct tccagcagag gatgctcagc gagttcccac
     4261 aggccgttgc tatgcagcac cccaatcatc ctgatgatgc catcctacag tgtgatgctc
     4321 agtatttaca gatctatgca gtgacaccta ttccagatta tgtggatgtt ctacaaatgg
     4381 acagagtacc cgatcgtgtc aagagcttct atcgtgtcaa caatgtgagg aagttccggt
     4441 atgatagacc tttccacaaa ggccccaagg acaaagacaa tgaattcaag agcctgtgga
     4501 ttgagcgtac cacgctgaca ctgacccaca gtttgcctgg catctctcga tggtttgaag
     4561 tggaaagaag ggaactggtg gaggtaagcc ctctggagaa tgccatccag gtggttgaga
     4621 ataagaacca ggaactgcga gctctgatca gccagtatca gcacaaacaa gtgcatggca
     4681 acatcaatct gctcagcatg tgtctgaatg gtgtcattga tgctgctgtc aatggaggca
     4741 ttgcacgata ccaggaggcc ttttttgata aagattatat caccaagcac ccaggagatg
     4801 ccgagaagat ctcccagctc aaggaactaa tgcaggaaca ggtccatgtt cttggagttg
     4861 ggctggcggt tcatgagaag tttgtgcatc cagaaatgcg acctctgcat aagaagctga
     4921 ttgatcaatt ccagatgatg agggccagtc tgtaccatga gtttccatgt ttggataagc
     4981 tgagtcctgc atgttcaggc accagcaccc cacggggaaa tgttctggca tcccatagtc
     5041 ccatgagccc cgagaacatc aagatgagcc acaggcacag ccccatgaac ttgatgggca
     5101 caggccgcca ttcatcatcc tctctctcct cacatgcatc gagtgaagca ggaaacatga
     5161 tgatgatggg tgacaactct atgggtgaaa ctcctgaaga cctctaccac cacatgcagc
     5221 ttgcatatca caaccccagg taccagggct cagtcaccaa cgtctctgtt ctgtcctcat
     5281 cccaggcaag cccttcttcc tccagcctga gttctactca ctcagcacca tcccagatga
     5341 tcacctccgc cccatctagc acccgaggct ctccctctct gccagataag taccgacatg
     5401 cccgggaaat gatgttgctg ttgcctacac atcgggaccg cccaagcagt gccatgtatc
     5461 cagcagccat cctagagaat ggacagccag caaacttcca gcgggccctg ttccagcaag
     5521 tagttggagc ctgtaaaccc tgcagtgacc ctaatctgtc tatggctgaa aaaggtcatt
     5581 actccctgca ctttgacgcc ttccaccacc ctctgggtga tacccccccg gcccttcccg
     5641 cccggacgct gcgcaagtct cctctccacc ccatcccagc ctcccctaca agcccccaat
     5701 cgggcctgga tggcagcaac tccacgctgt ctggcagcgc cagtagcggt gtatcctcct
     5761 taagtgagag taactttggg cattcctcag aggccccacc tcgaacagac accatggact
     5821 ccatgccaag ccaggcctgg aatggcgatg aagaccttga gccgccctac ctccctgtcc
     5881 actacagtct ctctgagtcc gctgttcttg actccatcaa gtcccagcca tgcaggagcc
     5941 actcagcccc agggtgtgtc atccctcagg atcccatgga cccacctgcg ctgccaccca
     6001 agccctatca cccccgcctg ccagccctag agcacgatga aggtgtgcta ctgcgggagg
     6061 aggctgagag gccaaggggc ctgcaccgca aggcctcact tcctcctggg agtgccaagg
     6121 aggagcaggc ccgcatggcc tgggagcacg gccgagggga acagtgagga gcagagaggc
     6181 agctgcatca ccaccgtcca tgagcagctt gcccaggcac tccaggtctg aaaagcaagt
     6241 ccctcccagg gagctagagg cttggcactc aggagaaacc aacagagtct ctgttctact
     6301 gccgtgaact catgttttgc catgttcaga ggccacagca gcatgaaggg ttgtggcttc
     6361 ttccacttta cttttgtttc cacttttctg gtttttcttt atgcagtagt tgctttcttc
     6421 ctcctgcagt tccagaccac atggagctac atggaaggat tgcacagaca tcattgcttt
     6481 gaggcattac agagcccagg agtaggagcc cagaccctcc ctccagggta gagatttgga
     6541 gaatggaaat tgcactaggg acctcttcct ttgctgtatg gacagaaaaa ttcttgattg
     6601 cattcaggga ttgcaaggac cacatggact acatgtcatg ggtggacaaa ggggccacaa
     6661 gccgttttgc acaaatgctt gcccacctgc ccactcttcc atctaggagt gtgtacctga
     6721 ggggctggtc aggcacatga ctggcctaac tgcatgcctt gggcatactg ccaggcttcc
     6781 atgggccagg cttgtctctt atctcacttg gacgttaatc atcactttta tttcaggcct
     6841 tttgctcctt tccactcaaa acacctcatc atctgcagaa gcctccctgg ctcgaatgga
     6901 cttgaaaggg ttatctctta tgtcctggga cttaatgaaa tgaagctcga agggctttaa
     6961 ctcctgtggg gagttaggtc ccttcgcttg gattagaaag agctggtata agcgtgaggc
     7021 tggagtgtgc caggagccag aaaacctttc tgctttcaca ggtggcccca aacgtctgcc
     7081 atttagagcc tgaatcaggg attttcagca ctacctctga gccgtggggt tggctgccca
     7141 gcctggcttc caggccctga ggatgtgtgg tcaggttcag caagctcctg ggtttaaaat
     7201 atataaacgg cgggaggaaa cgtcaccttt tggaggaaga gccacacagg taaaactgtt
     7261 atcttccaag cagccaagta ctgagccctc tactccaatc ccatagggtc tgcccgccac
     7321 tcagggttca ggacagacag aagggcagtt tttcaaacct ccccagtctg ttaggcaggg
     7381 cacagtggtg actttatagg aaattctttc aagtcagggc actgacttta atcttggtat
     7441 tatggtgggg gtatggtaat atttcaccag ggtgcttcta agttactttt taaaataact
     7501 tgtcttgagg caattgtttt cttttatttg cttacatcca cattagcgat ggccataaaa
     7561 ctgccttctc cttgatgagc aggtacgttg ctcccctagt ccctttaact cgttggcctt
     7621 ctggcctgct atggccacat tctgacccct agctgctcat cccttctcca caattctttc
     7681 caaacagaaa gacccatggt cgcagtgttt ttccttataa acaagtttaa tagaactgcc
     7741 agcaaataac ctatggagaa ggaagaaggc ccatttccgt tcagagttgg ggcccagtta
     7801 ccaacagtgt tgggctttct gataccctca gaatcattca ggcagagcag agcagagact
     7861 gctccaatgg ccccagctcc cagggcccag actcactggc gagcttgtct ctggaccatc
     7921 tgggttcaca ggtatgagcg tcaagtctag ctttgaatgt gattcttagg tagggtggct
     7981 ttaggtttcc aggcatgtct gaccctcagt ccgaggaggc agccagtcat cacatgaaga
     8041 catctccctt ctccacttga tggcacagga gggagggagg ggaatgtagg gtgaagttcc
     8101 ttggccttgc tttacgcgag gtgaaatata tttgtgttgc acctcttcat tttccctaac
     8161 tggatgaaat ggacctattc tgaatacttt ttattgaaaa accagccagt gtgagggaaa
     8221 tgggaggcca gagatcagaa tcctttgaaa agattgtgaa atactgattt tcattcttta
     8281 aagcgtattt gtaaatacct atttgaatgc tgtgtatttg tacaggaatt tgagcaaaaa
     8341 atgtatagag tgtgtctaat tggtaataag cctataaatg tgtttttaac ctctggcatt
     8401 ctgtgcttat ttaaaacaaa aaacttccaa ccatctcttt tgtgtattca tgtctaaaga
     8461 aaaactgact taaaatgatc ttacctgtac cagaaaagtt aaagaaaaaa atttgtgcca
     8521 gtgtcccaag aggcatttta ctgtatatat tgtggtagca tgttataaat ccaacaagaa
     8581 atgtgacttt tagatgtaaa tatctggcaa ttgactcgcc ccatcccttg actgctgtta
     8641 tgtgaattaa agattaatac ctgaaaaaaa aaaaaaaaaa
//
